PT99409A - Processo para a preparacao de benzimidazois polissubstituidos - Google Patents
Processo para a preparacao de benzimidazois polissubstituidosInfo
- Publication number
- PT99409A PT99409A PT99409A PT9940991A PT99409A PT 99409 A PT99409 A PT 99409A PT 99409 A PT99409 A PT 99409A PT 9940991 A PT9940991 A PT 9940991A PT 99409 A PT99409 A PT 99409A
- Authority
- PT
- Portugal
- Prior art keywords
- benzimidazoes
- preparing polysubstituted
- polysubstituted
- preparing
- polysubstituted benzimidazoes
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/26—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/052—Imidazole radicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/607,899 US5248672A (en) | 1990-11-01 | 1990-11-01 | Polysubstituted benzimidazole nucleosides as antiviral agents |
Publications (2)
Publication Number | Publication Date |
---|---|
PT99409A true PT99409A (pt) | 1992-12-31 |
PT99409B PT99409B (pt) | 1999-04-30 |
Family
ID=24434171
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT99409A PT99409B (pt) | 1990-11-01 | 1991-10-31 | Processo para a preparacao de benzimidazois polissubstituidos |
Country Status (10)
Country | Link |
---|---|
US (9) | US5248672A (pt) |
EP (1) | EP0556334A4 (pt) |
AU (1) | AU657934B2 (pt) |
CA (1) | CA2100098A1 (pt) |
IE (1) | IE913818A1 (pt) |
IL (1) | IL99933A (pt) |
NZ (1) | NZ240434A (pt) |
PT (1) | PT99409B (pt) |
WO (1) | WO1992007867A1 (pt) |
ZA (1) | ZA918685B (pt) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5248672A (en) * | 1990-11-01 | 1993-09-28 | The Regents Of The University Of Michigan | Polysubstituted benzimidazole nucleosides as antiviral agents |
GB9205071D0 (en) * | 1992-03-09 | 1992-04-22 | Wellcome Found | Therapeutic nucleosides |
US5605919A (en) * | 1993-02-26 | 1997-02-25 | Takeda Chemical Industries, Ltd. | Treatment for viral diseases |
ES2072193B1 (es) * | 1993-05-21 | 1996-02-16 | Espanola Prod Quimicos | Nuevos derivados del1-fenilmetil bencimidazol piperacinas. |
US5945425A (en) * | 1994-04-29 | 1999-08-31 | G.D. Searle & Co. | Method of using (H+ /K+)ATPase inhibitors as antiviral agents |
GB9413724D0 (en) * | 1994-07-07 | 1994-08-24 | Wellcome Found | Therapeutic nucleosides |
US5656449A (en) * | 1995-03-06 | 1997-08-12 | Molecular Probes, Inc. | Neutral unsymmetrical cyanine dyes |
US6228871B1 (en) | 1995-07-10 | 2001-05-08 | Merck & Co., Inc. | Angiogenesis inhibitors |
US5874413A (en) * | 1995-08-18 | 1999-02-23 | University Of Michigan | 5'-substituted-ribofuranosyl benzimidazoles as antiviral agents |
WO1997008150A1 (en) * | 1995-08-22 | 1997-03-06 | The Du Pont Merck Pharmaceutical Company | Substituted cyclic ureas and derivatives thereof useful as retroviral protease inhibitors |
GB9600142D0 (en) * | 1996-01-05 | 1996-03-06 | Wellcome Found | Chemical compounds |
GB9600143D0 (en) | 1996-01-05 | 1996-03-06 | Wellcome Found | Therapeutic compounds |
KR19990081940A (ko) * | 1996-01-23 | 1999-11-15 | 그레이엄 브레레톤, 레슬리 에드워즈 | 항바이러스제로서 변형된 벤즈이미다졸 누클레오시드 |
US6413938B1 (en) | 1997-02-13 | 2002-07-02 | The Regents Of The University Of Michigan | Benzimidazole derivatives for the treatment of viral infections |
JP2001513084A (ja) | 1997-02-25 | 2001-08-28 | ザ ガバメント オブ ザ ユナイテッド ステーツ オブ アメリカ,レプリゼンテッド バイ ザ セクレタリー,デパートメント オブ ヘルス アンド ヒューマン サービシズ | 逆転写酵素の非ヌクレオシド阻害剤としての置換ベンズイミダゾール |
WO1998056761A2 (en) | 1997-06-10 | 1998-12-17 | Glaxo Group Limited | Benzimidazole derivatives |
US6455506B1 (en) | 1997-07-30 | 2002-09-24 | Smithkline Beecham Corporation | Lyxofuranosyl benzimidazoles as antiviral agents |
US6162804A (en) * | 1997-09-26 | 2000-12-19 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
WO2000012089A1 (en) * | 1998-08-31 | 2000-03-09 | Merck & Co., Inc. | Novel angiogenesis inhibitors |
US6465484B1 (en) | 1997-09-26 | 2002-10-15 | Merck & Co., Inc. | Angiogenesis inhibitors |
GB9806937D0 (en) | 1998-03-31 | 1998-05-27 | Procter & Gamble | A spray device |
WO1999051619A1 (en) * | 1998-04-03 | 1999-10-14 | The Regents Of The University Of Michigan | Arabinofuranosyl benzimidazoles as antiviral agents |
GB9807354D0 (en) * | 1998-04-07 | 1998-06-03 | Glaxo Group Ltd | Antiviral compound |
GB9807355D0 (en) | 1998-04-07 | 1998-06-03 | Glaxo Group Ltd | Antiviral compound |
GB0008939D0 (en) | 2000-04-11 | 2000-05-31 | Glaxo Group Ltd | Process for preparing substituted benzimidazole compounds |
CN1300165C (zh) * | 2001-11-27 | 2007-02-14 | 安那迪斯药品股份有限公司 | 3-β-呋喃核糖基噻唑并[4,5-d]嘧啶核苷及其应用 |
US7321033B2 (en) * | 2001-11-27 | 2008-01-22 | Anadys Pharmaceuticals, Inc. | 3-B-D-ribofuranosylthiazolo [4,5-d] pyrimidine nucleosides and uses thereof |
US20070167353A1 (en) * | 2003-10-24 | 2007-07-19 | John Hilfinger | Prodrug composition |
US7776529B2 (en) | 2003-12-05 | 2010-08-17 | Life Technologies Corporation | Methine-substituted cyanine dye compounds |
ES2516644T3 (es) * | 2004-11-19 | 2014-10-31 | Glaxosmithkline Llc | Producto farmacéutico |
PL1836665T3 (pl) * | 2004-11-19 | 2013-06-28 | Glaxosmithkline Llc | Sposób dostosowywania dozowania zmiennych dawek leków w produktach skojarzonych w celu indywidualizowania terapii |
CA2589529C (en) * | 2004-12-17 | 2013-09-10 | Anadys Pharmaceuticals, Inc. | 3,5-disubstituted and 3,5,7-trisubstituted-3h-oxazolo and 3h-thiazolo [4,5-d]pyrimidin-2-one compounds and prodrugs thereof |
US9029345B2 (en) * | 2005-03-16 | 2015-05-12 | Case Western Reserve University | Selective inhibitors of translesion DNA replication |
US8114847B2 (en) | 2005-03-16 | 2012-02-14 | Case Western Reserve University | Selective inhibitors of translesion DNA replication |
JP5306811B2 (ja) | 2005-05-11 | 2013-10-02 | ライフ テクノロジーズ コーポレーション | 2本鎖dnaへの高い選択性を有する蛍光化学物質及びそれらの使用 |
AU2006318260B2 (en) | 2005-11-21 | 2012-05-17 | Anadys Pharmaceuticals, Inc. | Process for the preparation of 5-amino-3H- thiazolo [4 , 5 -d] pyrimidin- 2 -one |
GB0608899D0 (en) * | 2006-05-05 | 2006-06-14 | Leuven K U Res & Dev | Novel viral replication inhibitors |
TWI418561B (zh) * | 2006-06-22 | 2013-12-11 | Anadys Pharmaceuticals Inc | 5-胺基-3-(3’-去氧-β-D-核糖呋喃糖基(ribofuranosyl))-噻唑并〔4,5-d〕嘧啶-2,7-二酮之前藥 |
JP5225991B2 (ja) | 2006-07-18 | 2013-07-03 | アナディス ファーマシューティカルズ インク | チアゾロ[4,5−d]ピリミジンのカーボネート及びカルバメートプロドラッグ |
EP2259027B1 (en) * | 2009-06-04 | 2012-12-05 | Sensirion AG | Method and apparatus for processing individual sensor devices |
CN102344469A (zh) * | 2011-07-26 | 2012-02-08 | 江西科技师范学院 | 固体酸SO42-/γ-AL2O3催化合成1, 2, 3-O-三乙酰基-5-脱氧-D-呋喃核糖的方法 |
US10292390B2 (en) | 2011-11-04 | 2019-05-21 | Wisconsin Alumni Research Foundation | Inhibition and dispersion of bacterial biofilms with 2-aminobenzimidazole derivatives |
WO2016086060A1 (en) * | 2014-11-26 | 2016-06-02 | The J. David Gladstone Institutes | Methods for treating a cytomegalovirus infection |
RU2629670C2 (ru) * | 2016-08-04 | 2017-08-31 | Федеральное государственное бюджетное учреждение науки институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Российской академии наук (ИБХ РАН) | 2-Амино-5,6-дифтор-1-(бета-D-рибофуранозил)-бензимидазол, способ получения и противовирусная активность его в отношении вируса герпеса простого 1-го типа |
CN114096549A (zh) * | 2020-06-23 | 2022-02-25 | 博美利克斯技术公司 | 新型苯并咪唑衍生物、其制备方法及其作为抗癌剂或者抗病毒剂的用途 |
Family Cites Families (28)
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US2860131A (en) * | 1953-05-05 | 1958-11-11 | Merck & Co Inc | Benzimidazole derivatives |
GB783306A (en) * | 1954-04-12 | 1957-09-18 | Merck & Co Inc | Trihalo-1-d-ribofuranosyl-benzimidazole compounds |
US3037980A (en) * | 1955-08-18 | 1962-06-05 | Burroughs Wellcome Co | Pyrrolopyrimidine vasodilators and method of making them |
US2935508A (en) * | 1956-11-23 | 1960-05-03 | Merck & Co Inc | Benzimidazole derivatives and processes for preparing the same |
US3311628A (en) * | 1965-03-09 | 1967-03-28 | Bristol Myers Co | Derivatives of pyrrolo [2, 3-d] pyrimidine |
US3914310A (en) * | 1965-08-06 | 1975-10-21 | Ciba Geigy Corp | Phenoxy-substituted ortho-nitroanilines and ortho-phenylenediamines |
CH443777A (de) * | 1965-08-06 | 1968-02-15 | Agripat Sa | Verfahren zum Schützen textiler Keratinfasern vor Insektenfrass und Mittel zur Durchführung dieses Verfahrens |
CH494533A (de) * | 1969-04-25 | 1970-08-15 | Agripat Sa | Verfahren zur Bekämpfung von Mikroorganismen, die nichttextile organische Materialien und Gebrauchsgegenstände schädigen und zerstören |
US3867386A (en) * | 1969-11-04 | 1975-02-18 | American Home Prod | 5-amino-2,6-substituted-7h-pyrrolo(2,3-d)pyrimidines and related compounds |
US3631036A (en) * | 1969-11-04 | 1971-12-28 | American Home Prod | 5-amino-2 6-substituted-7h-pyrrolo(2 3-d) pyrimidines and related compounds |
US3655901A (en) * | 1970-07-30 | 1972-04-11 | Merck & Co Inc | Method of inhibiting the formation of phenylethanalamine-n-methyl transferase with 2-aminobenzimidazoles |
US3817982A (en) * | 1971-12-29 | 1974-06-18 | Syntex Inc | 2{40 ,3{40 -unsaturated nucleosides and method of making |
US4199574A (en) * | 1974-09-02 | 1980-04-22 | Burroughs Wellcome Co. | Methods and compositions for treating viral infections and guanine acyclic nucleosides |
US3962211A (en) * | 1975-01-13 | 1976-06-08 | The University Of Utah | 7-substituted nucleoside compounds |
DE2818676A1 (de) * | 1978-04-27 | 1979-11-08 | Troponwerke Gmbh & Co Kg | Substituierte 5,6-dimethylpyrrolo 2,3-d pyrimidine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
DE3036390A1 (de) * | 1980-09-26 | 1982-05-13 | Troponwerke GmbH & Co KG, 5000 Köln | Neue pyrrolo-pyrimidine, verfahren zu ihrer herstellung und ihre verwendung bei der herstellung von biologischen wirkstoffen |
DE3145287A1 (de) * | 1981-11-14 | 1983-05-19 | Troponwerke GmbH & Co KG, 5000 Köln | Pyrrolo (2.3-d)pyrimidine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
US4596798A (en) * | 1982-03-30 | 1986-06-24 | The United States Of America As Represented By The Secretary Of The Army | 2-acetylpyridine thiosemicarbazones as antiviral agents |
US4482708A (en) * | 1982-08-09 | 1984-11-13 | Nguyen Nicolas C | 3', 5'-Dinucleoside phosphates of 5,6-dichloro-1-β-D-ribofuranosyl-1-benzimidazole and methods of making and using the same |
US5077407A (en) * | 1983-07-01 | 1991-12-31 | The Upjohn Company | Substituted 2-[monoannelated (3,4-,4,5-, and 5,6-) pyridylalkylenesulfinyl]benzimidazoles |
US4777129A (en) * | 1983-12-12 | 1988-10-11 | Molecular Diagnostics, Inc. | Nucleic acid probe detectable by specific nucleic acid binding protein |
CA1294960C (en) * | 1986-10-24 | 1992-01-28 | Thomas C. Malone | 7-deazaguanines as immunomodulators |
JP2894610B2 (ja) * | 1987-10-28 | 1999-05-24 | プロ−ニューロン,インコーポレーテッド | アシル化ウリジンおよびシチジンならびにその使用 |
US4892865A (en) * | 1987-12-01 | 1990-01-09 | The Regents Of The University Of Michigan | Pyrrolo[2,3-d]pyrimidine nucleosides as antiviral agents |
US4968686A (en) * | 1988-04-08 | 1990-11-06 | The Regents Of The University Of Michigan | Acyclic pyrrolo [2,3-d]pyrimidine analogs as antiviral agents |
US4927830A (en) * | 1988-04-08 | 1990-05-22 | The Regents Of The University Of Michigan | Acyclic pyrrolo[2,3-D]pyrimidine analogs as antiviral agents |
US5149700A (en) * | 1990-05-30 | 1992-09-22 | American Home Products Corporation | Substituted arylsulfonamides and benzamides |
US5248672A (en) * | 1990-11-01 | 1993-09-28 | The Regents Of The University Of Michigan | Polysubstituted benzimidazole nucleosides as antiviral agents |
-
1990
- 1990-11-01 US US07/607,899 patent/US5248672A/en not_active Expired - Fee Related
-
1991
- 1991-10-31 IE IE381891A patent/IE913818A1/en not_active Application Discontinuation
- 1991-10-31 PT PT99409A patent/PT99409B/pt not_active IP Right Cessation
- 1991-10-31 ZA ZA918685A patent/ZA918685B/xx unknown
- 1991-10-31 WO PCT/US1991/008124 patent/WO1992007867A1/en not_active Application Discontinuation
- 1991-10-31 NZ NZ240434A patent/NZ240434A/en unknown
- 1991-10-31 CA CA002100098A patent/CA2100098A1/en not_active Abandoned
- 1991-10-31 EP EP92901986A patent/EP0556334A4/en not_active Withdrawn
- 1991-10-31 AU AU90809/91A patent/AU657934B2/en not_active Ceased
- 1991-11-01 IL IL9993391A patent/IL99933A/en active IP Right Grant
-
1992
- 1992-10-21 US US07/964,345 patent/US5360795A/en not_active Expired - Lifetime
-
1993
- 1993-05-03 US US08/050,470 patent/US5574058A/en not_active Expired - Fee Related
-
1995
- 1995-06-01 US US08/457,391 patent/US5712255A/en not_active Expired - Fee Related
- 1995-06-06 US US08/473,037 patent/US5646125A/en not_active Expired - Fee Related
- 1995-06-06 US US08/471,059 patent/US5705490A/en not_active Expired - Fee Related
- 1995-06-06 US US08/467,946 patent/US5654283A/en not_active Expired - Fee Related
- 1995-06-07 US US08/472,982 patent/US5665709A/en not_active Expired - Fee Related
-
1997
- 1997-10-28 US US08/959,246 patent/US6093698A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
PT99409B (pt) | 1999-04-30 |
IE913818A1 (en) | 1992-05-22 |
US5712255A (en) | 1998-01-27 |
US5248672A (en) | 1993-09-28 |
ZA918685B (en) | 1992-08-26 |
US5360795A (en) | 1994-11-01 |
AU9080991A (en) | 1992-05-26 |
US5646125A (en) | 1997-07-08 |
IL99933A (en) | 1996-09-12 |
CA2100098A1 (en) | 1992-05-02 |
IL99933A0 (en) | 1992-08-18 |
AU657934B2 (en) | 1995-03-30 |
EP0556334A4 (en) | 1995-03-29 |
US5574058A (en) | 1996-11-12 |
NZ240434A (en) | 1997-06-24 |
US6093698A (en) | 2000-07-25 |
US5665709A (en) | 1997-09-09 |
US5654283A (en) | 1997-08-05 |
US5705490A (en) | 1998-01-06 |
EP0556334A1 (en) | 1993-08-25 |
WO1992007867A1 (en) | 1992-05-14 |
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