IT1245736B - Processo per preparare alfa-glicerofosforilcolina - Google Patents

Processo per preparare alfa-glicerofosforilcolina

Info

Publication number
IT1245736B
IT1245736B IT02206990A IT2206990A IT1245736B IT 1245736 B IT1245736 B IT 1245736B IT 02206990 A IT02206990 A IT 02206990A IT 2206990 A IT2206990 A IT 2206990A IT 1245736 B IT1245736 B IT 1245736B
Authority
IT
Italy
Prior art keywords
glycerophosphorylcholine
preparing alpha
alpha
preparing
Prior art date
Application number
IT02206990A
Other languages
English (en)
Other versions
IT9022069A1 (it
IT9022069A0 (it
Inventor
Laura Puricelli
Original Assignee
Magis Farmaceutici
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Magis Farmaceutici filed Critical Magis Farmaceutici
Priority to IT02206990A priority Critical patent/IT1245736B/it
Publication of IT9022069A0 publication Critical patent/IT9022069A0/it
Priority to EP91202922A priority patent/EP0486100A1/en
Publication of IT9022069A1 publication Critical patent/IT9022069A1/it
Application granted granted Critical
Publication of IT1245736B publication Critical patent/IT1245736B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/6574—Esters of oxyacids of phosphorus
    • C07F9/65742—Esters of oxyacids of phosphorus non-condensed with carbocyclic rings or heterocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
IT02206990A 1990-11-15 1990-11-15 Processo per preparare alfa-glicerofosforilcolina IT1245736B (it)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IT02206990A IT1245736B (it) 1990-11-15 1990-11-15 Processo per preparare alfa-glicerofosforilcolina
EP91202922A EP0486100A1 (en) 1990-11-15 1991-11-09 Process for preparing alpha-glycerophosphorylcholine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT02206990A IT1245736B (it) 1990-11-15 1990-11-15 Processo per preparare alfa-glicerofosforilcolina

Publications (3)

Publication Number Publication Date
IT9022069A0 IT9022069A0 (it) 1990-11-15
IT9022069A1 IT9022069A1 (it) 1992-05-15
IT1245736B true IT1245736B (it) 1994-10-14

Family

ID=11191013

Family Applications (1)

Application Number Title Priority Date Filing Date
IT02206990A IT1245736B (it) 1990-11-15 1990-11-15 Processo per preparare alfa-glicerofosforilcolina

Country Status (2)

Country Link
EP (1) EP0486100A1 (it)
IT (1) IT1245736B (it)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5044965B2 (ja) * 2006-03-30 2012-10-10 日油株式会社 α−グリセロホスホリルコリン結晶の製造方法
KR100951108B1 (ko) 2008-04-15 2010-04-07 엔자이텍 주식회사 라세믹 또는 광학적으로 활성이 있는 α-글리세로포스포릴콜린 및 그 유도체의 제조방법
DE102009052034A1 (de) 2009-11-05 2011-05-12 Merck Patent Gmbh Synthese von Phosphorestern
CN101967160B (zh) * 2010-09-09 2013-04-10 常熟富士莱医药化工有限公司 一步法制备外消旋体DL、D或L-α-甘油磷酰基胆碱的方法
CN103282368B (zh) 2010-12-24 2015-04-08 日油株式会社 含有氨基的磷酰胆碱化合物及其制备方法
KR101287423B1 (ko) 2011-03-14 2013-07-19 주식회사 한서켐 글리세릴 포스포릴 콜린의 ii형 결정
US8981141B1 (en) 2011-03-14 2015-03-17 Hanseochem Co., Ltd. I-and II-type crystals of L-A-glyceryl phosphoryl choline, and method for preparing same
CN103429603A (zh) * 2011-03-14 2013-12-04 株式会社韩西克慕 甘油磷酰胆碱的i型和ii型结晶及其制造方法
CN102260286B (zh) * 2011-05-27 2014-01-15 合肥工业大学 一种分离纯化粗产品L-α-甘油磷酸胆碱的方法
CN104356160A (zh) * 2014-11-05 2015-02-18 合肥创新医药技术有限公司 L-α-甘油磷酰胆碱的纯化工艺
RU2685238C1 (ru) * 2016-07-01 2019-04-17 Общество с ограниченной ответственностью "ФАРМАЦЕЛЬ" Способ получения кристаллического глицерофосфатидилхолина
CN107383085A (zh) * 2017-08-18 2017-11-24 湖南托阳制药有限公司 一种L‑α‑甘磷酸胆碱的化学合成方法
CN108101937B (zh) * 2017-11-13 2020-03-10 湖南华纳大药厂手性药物有限公司 一种制备L-α-甘油磷脂酰胆碱的方法
CN108191908B (zh) * 2017-12-28 2020-04-21 上海科一生物医药有限公司 一种L-α-甘油磷酸胆碱的制备方法
CN109021010B (zh) * 2018-06-25 2020-08-07 金久奇(抚顺)药业有限公司 一种L-α-甘磷酸胆碱的制备方法
KR102531373B1 (ko) 2022-02-21 2023-05-12 이광미 난황 레시틴으로부터 콜린 알포세레이트를 제조하는 방법

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4710580A (en) * 1986-08-12 1987-12-01 American Home Products Corporation 2-[1,3,2-dioxaphospholan-2-yloxy]ethyl compounds

Also Published As

Publication number Publication date
IT9022069A1 (it) 1992-05-15
IT9022069A0 (it) 1990-11-15
EP0486100A1 (en) 1992-05-20

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