PT975597E - Derivados de quinoleínas enquanto inibidores da vih integrase - Google Patents
Derivados de quinoleínas enquanto inibidores da vih integrase Download PDFInfo
- Publication number
- PT975597E PT975597E PT98920581T PT98920581T PT975597E PT 975597 E PT975597 E PT 975597E PT 98920581 T PT98920581 T PT 98920581T PT 98920581 T PT98920581 T PT 98920581T PT 975597 E PT975597 E PT 975597E
- Authority
- PT
- Portugal
- Prior art keywords
- aryl
- group
- different
- alkyl
- substituents
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/24—Oxygen atoms attached in position 8
- C07D215/26—Alcohols; Ethers thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D215/14—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- AIDS & HIV (AREA)
- Engineering & Computer Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9704289A FR2761687B1 (fr) | 1997-04-08 | 1997-04-08 | Derives de quinoleines, possedant notamment des proprietes antivirales, leurs preparations et leurs applications biologiques |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT975597E true PT975597E (pt) | 2010-01-04 |
Family
ID=9505648
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT98920581T PT975597E (pt) | 1997-04-08 | 1998-04-07 | Derivados de quinoleínas enquanto inibidores da vih integrase |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6670377B1 (pt) |
| EP (1) | EP0975597B1 (pt) |
| JP (1) | JP4697679B2 (pt) |
| AT (1) | ATE441634T1 (pt) |
| CA (1) | CA2286385C (pt) |
| CY (1) | CY1109553T1 (pt) |
| DE (1) | DE69841119D1 (pt) |
| DK (1) | DK0975597T3 (pt) |
| ES (1) | ES2332434T3 (pt) |
| FR (1) | FR2761687B1 (pt) |
| PT (1) | PT975597E (pt) |
| WO (1) | WO1998045269A1 (pt) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2321348A1 (en) | 2000-09-27 | 2002-03-27 | Blaise Magloire N'zemba | Aromatic derivatives with hiv integrase inhibitory properties |
| FR2819507B1 (fr) | 2001-01-17 | 2007-09-28 | Inst Rech Developpement Ird | Quinoleines substituees pour le traitement de co-infections a protozoaires et a retrovirus |
| IL157638A0 (en) | 2001-03-01 | 2004-03-28 | Shionogi & Co | Nitrogen-containing heteroaryl compounds having hiv integrase inhibitory activity |
| FR2830863B1 (fr) * | 2001-10-12 | 2004-01-30 | Bioalliance Pharma | Derives de quinoleine, procede de synthese, et medicaments renfermant ces derives |
| FR2839646B1 (fr) | 2002-05-17 | 2008-04-11 | Bioalliance Pharma | Utilisation de derives de quinoleine a effet anti-integrase et ses applications |
| WO2004024693A1 (ja) | 2002-08-13 | 2004-03-25 | Shionogi & Co., Ltd. | Ｈｉｖインテグラーゼ阻害活性を有するヘテロ環化合物 |
| EP4059923A1 (en) * | 2002-11-20 | 2022-09-21 | Japan Tobacco Inc. | 4-oxoquinoline compound and use thereof as hiv integrase inhibitor |
| KR100866296B1 (ko) * | 2004-05-20 | 2008-11-11 | 니뽄 다바코 산교 가부시키가이샤 | ４―옥소퀴놀린 화합물의 안정한 결정체 |
| MY134672A (en) * | 2004-05-20 | 2007-12-31 | Japan Tobacco Inc | Stable crystal of 4-oxoquinoline compound |
| WO2005113509A1 (en) | 2004-05-20 | 2005-12-01 | Japan Tobacco Inc. | Novel 4-oxoquinoline compound and use thereof as hiv integrase inhibitor |
| US20080280849A1 (en) * | 2005-06-01 | 2008-11-13 | Herve Leh | Synergic Combinations Comprising a Quinoline Compound and Other Hiv Infection Therapeutic Agents |
| AU2007223260C1 (en) | 2006-03-06 | 2011-02-03 | Japan Tobacco Inc. | Method for producing 4-oxoquinoline compound |
| CN103450077B (zh) | 2007-06-08 | 2016-07-06 | 满康德股份有限公司 | IRE-1α抑制剂 |
| ES2402322T3 (es) * | 2007-11-15 | 2013-04-30 | Gilead Sciences, Inc. | Inhibidores de la replicación del virus de la inmunodeficiencia humana |
| EP2220076B1 (en) * | 2007-11-15 | 2012-01-18 | Boehringer Ingelheim International GmbH | Inhibitors of human immunodeficiency virus replication |
| EP2220046B1 (en) | 2007-11-16 | 2014-06-18 | Gilead Sciences, Inc. | Inhibitors of human immunodeficiency virus replication |
| CA2705338A1 (en) * | 2007-11-16 | 2009-05-22 | Boehringer Ingelheim International Gmbh | Inhibitors of human immunodeficiency virus replication |
| EP2147912A1 (en) | 2008-07-23 | 2010-01-27 | BioAlliance Pharma | Styrylquinolines, their process of preparation and their therapeutic uses |
| EP2149557A1 (en) | 2008-07-23 | 2010-02-03 | BioAlliance Pharma | Styrylquinolines, their process of preparation and their therapeutic uses |
| EP2147913A1 (en) * | 2008-07-23 | 2010-01-27 | BioAlliance Pharma | Styrylquinolines, their process of preparation and their therapeutic uses |
| CN103209963A (zh) * | 2010-07-02 | 2013-07-17 | 吉里德科学公司 | 作为hiv抗病毒化合物的2-喹啉基-乙酸衍生物 |
| WO2013091089A1 (en) * | 2011-12-22 | 2013-06-27 | UNIVERSITé LAVAL | Three-dimensional cavities of dendritic cell immunoreceptor (dcir), compounds binding thereto and therapeutic applications related to inhibition of human immunodeficiency virus type-1 (hiv-1) |
| AP2015008721A0 (en) | 2013-03-15 | 2015-09-30 | Global Blood Therapeutics Inc | Compounds and uses thereof for the modulation of hemoglobin |
| EA201992707A1 (ru) | 2013-11-18 | 2020-06-30 | Глобал Блад Терапьютикс, Инк. | Соединения и их применения для модуляции гемоглобина |
| AR108435A1 (es) | 2016-05-12 | 2018-08-22 | Global Blood Therapeutics Inc | Proceso para sintetizar 2-hidroxi-6-((2-(1-isopropil-1h-pirazol-5-il)-piridin-3-il)metoxi)benzaldehído |
| KR20210060556A (ko) | 2018-09-18 | 2021-05-26 | 니캉 테라퓨틱스 인코포레이티드 | Src 호몰로지-2 포스파타아제 억제제로서의 3-치환된 헤테로아릴 유도체 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59152891A (ja) * | 1983-02-18 | 1984-08-31 | Yamada Kagaku Kogyo Kk | 発色性記録材料 |
| IE861607L (en) * | 1985-06-18 | 1986-12-18 | Bunce Roger A | 2-substituted quinolines |
| EP0219307A3 (en) * | 1985-10-16 | 1987-10-14 | Merck Frosst Canada Inc. | 2-substituted quinolines |
| JPS61189988A (ja) * | 1986-08-11 | 1986-08-23 | Yamada Kagaku Kogyo Kk | 発色性記録材料 |
| JPH01199979A (ja) * | 1987-04-07 | 1989-08-11 | Kanebo Ltd | 新規キノリンカルボン酸誘導体および該化合物を有効成分とする抗菌剤 |
| IL88433A0 (en) | 1987-11-25 | 1989-06-30 | Merck Frosst Canada Inc | Diarylstyrylquinoline diacids and pharmaceutical compositions containing them |
| US5438141A (en) * | 1993-05-21 | 1995-08-01 | Merck Frosst Canada, Inc. | Heteroaryl and haloaryl quinoline derivatives of cyclopropaneacetic acid as leukotriene antagonists |
| EP0643045B1 (de) * | 1993-09-10 | 2000-03-08 | Novartis AG | Chinolin-Verbindungen als Leukotriene Antagonisten |
| GB9414590D0 (en) * | 1994-07-20 | 1994-09-07 | Leo Pharm Prod Ltd | Chemical compounds |
| ES2103180B1 (es) * | 1994-08-01 | 1998-04-01 | Menarini Lab | Fenilacetamidas con accion antagonista de los leucotrienos. |
| EP0725063A1 (de) * | 1995-02-01 | 1996-08-07 | Ciba-Geigy Ag | Chinolin-Derivate |
| US6310211B1 (en) * | 1996-09-10 | 2001-10-30 | Pharmacia & Upjohn Company | 8-hydroxy-7-substituted quinolines as anti-viral agents |
-
1997
- 1997-04-08 FR FR9704289A patent/FR2761687B1/fr not_active Expired - Fee Related
-
1998
- 1998-04-07 DK DK98920581T patent/DK0975597T3/da active
- 1998-04-07 CA CA2286385A patent/CA2286385C/fr not_active Expired - Fee Related
- 1998-04-07 EP EP98920581A patent/EP0975597B1/fr not_active Expired - Lifetime
- 1998-04-07 AT AT98920581T patent/ATE441634T1/de active
- 1998-04-07 ES ES98920581T patent/ES2332434T3/es not_active Expired - Lifetime
- 1998-04-07 WO PCT/FR1998/000701 patent/WO1998045269A1/fr active Application Filing
- 1998-04-07 PT PT98920581T patent/PT975597E/pt unknown
- 1998-04-07 JP JP54245998A patent/JP4697679B2/ja not_active Expired - Fee Related
- 1998-04-07 DE DE69841119T patent/DE69841119D1/de not_active Expired - Lifetime
- 1998-04-07 US US09/402,858 patent/US6670377B1/en not_active Expired - Fee Related
-
2009
- 2009-12-01 CY CY20091101257T patent/CY1109553T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2332434T3 (es) | 2010-02-04 |
| WO1998045269A1 (fr) | 1998-10-15 |
| EP0975597A1 (fr) | 2000-02-02 |
| FR2761687A1 (fr) | 1998-10-09 |
| JP4697679B2 (ja) | 2011-06-08 |
| JP2001518890A (ja) | 2001-10-16 |
| FR2761687B1 (fr) | 2000-09-15 |
| ATE441634T1 (de) | 2009-09-15 |
| CY1109553T1 (el) | 2014-08-13 |
| DE69841119D1 (de) | 2009-10-15 |
| US6670377B1 (en) | 2003-12-30 |
| CA2286385C (fr) | 2011-02-01 |
| CA2286385A1 (fr) | 1998-10-15 |
| EP0975597B1 (fr) | 2009-09-02 |
| DK0975597T3 (da) | 2009-11-02 |
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