PT958816E - Medicamento para o tratamento da diabetes mellitus bem como suas doencas subsequentes - Google Patents

Medicamento para o tratamento da diabetes mellitus bem como suas doencas subsequentes

Info

Publication number
PT958816E
PT958816E PT99102285T PT99102285T PT958816E PT 958816 E PT958816 E PT 958816E PT 99102285 T PT99102285 T PT 99102285T PT 99102285 T PT99102285 T PT 99102285T PT 958816 E PT958816 E PT 958816E
Authority
PT
Portugal
Prior art keywords
diabetes mellitus
medicaments
treatment
medicinal product
sequelae
Prior art date
Application number
PT99102285T
Other languages
English (en)
Inventor
Klaus Wessel
Borbe Harald
Heinz Ulrich
Helmut Hettche
Hans Bisswanger
Lester Packer
Amira Klip
Original Assignee
Viatris Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6505606&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT958816(E) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Viatris Gmbh filed Critical Viatris Gmbh
Publication of PT958816E publication Critical patent/PT958816E/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/385—Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
PT99102285T 1993-12-21 1994-12-17 Medicamento para o tratamento da diabetes mellitus bem como suas doencas subsequentes PT958816E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4343593A DE4343593C2 (de) 1993-12-21 1993-12-21 Verwendung von R-(+)-alpha-Liponsäure, R-(-)-Dihydroliponsäure oder der Metabolite sowie deren Salze, Ester, Amide zur Behandlung kompensierter und dekompensierter Insulinresistenz

Publications (1)

Publication Number Publication Date
PT958816E true PT958816E (pt) 2006-06-30

Family

ID=6505606

Family Applications (2)

Application Number Title Priority Date Filing Date
PT94120045T PT659408E (pt) 1993-12-21 1994-12-17 Utilizacao de acido r-(alfa-lipoico, acido r(-) - di-hidrolipoico e metabolitos para o tratamento da diabetes mellitus bem como das doencas secundarias
PT99102285T PT958816E (pt) 1993-12-21 1994-12-17 Medicamento para o tratamento da diabetes mellitus bem como suas doencas subsequentes

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PT94120045T PT659408E (pt) 1993-12-21 1994-12-17 Utilizacao de acido r-(alfa-lipoico, acido r(-) - di-hidrolipoico e metabolitos para o tratamento da diabetes mellitus bem como das doencas secundarias

Country Status (11)

Country Link
US (4) US5693664A (pt)
EP (2) EP0659408B1 (pt)
JP (1) JPH07206676A (pt)
AT (2) ATE203669T1 (pt)
CA (1) CA2138558C (pt)
DE (3) DE4343593C2 (pt)
DK (2) DK0659408T3 (pt)
ES (2) ES2159539T3 (pt)
GR (1) GR3036943T3 (pt)
HK (1) HK1023943A1 (pt)
PT (2) PT659408E (pt)

Families Citing this family (68)

* Cited by examiner, † Cited by third party
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DE4433764A1 (de) * 1994-09-22 1996-03-28 Asta Medica Ag Darreichungsformen enthaltend alpha-Liponsäure, feste Salze von R-Thioctsäure mit verbesserter Freisetzung und Bioverfügbarkeit
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US7438896B2 (en) * 1995-09-20 2008-10-21 N.V. Perricone Llc Method of skin care using lipoic and ascorbic acids
WO1998023606A1 (fr) * 1996-11-27 1998-06-04 Fuji Kagaku Kogyo Kabushiki Kaisha Derives dithio cycliques, remedes contre des maladies renales diabetiques, agents hypoglycemiques, agents hypolipidemiques et agents lenitifs contre les troubles digestifs
EP0855396A1 (en) * 1997-01-22 1998-07-29 ASTA Medica Aktiengesellschaft Thioctic acid metabolites and methods of use thereof
DE19705555A1 (de) * 1997-02-13 1998-08-20 Ulrich Dr Posanski Pharmazeutische Präparate der Thioctsäure zur oralen Anwendung
IL123887A0 (en) 1997-04-02 1998-10-30 Sankyo Co Dithiolan derivatives their use and pharmaceutical compositions containing the same
US5965618A (en) * 1997-11-17 1999-10-12 Perricone; Nicholas V. Treatment of scar tissue using lipoic acid
US6365623B1 (en) 1997-11-17 2002-04-02 Nicholas V. Perricone Treatment of acne using lipoic acid
US6472432B1 (en) 1997-11-17 2002-10-29 Nicholas V. Perricone Treatment of rosacea using lipoic acid
DE19806354B4 (de) * 1998-02-10 2004-09-16 Bdd Group Holding Ag Verwendung von α-Liponsäure oder deren physiologisch verträgliche Salze zur Behandlung von LDL-Hypercholesterinämie
US6090842A (en) * 1998-03-10 2000-07-18 The Regents Of The University Of California Lipoic acid analogs
US6191162B1 (en) 1998-05-28 2001-02-20 Medical Research Institute Method of reducing serum glucose levels
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US6905707B2 (en) * 1998-05-28 2005-06-14 Medical Research Institute Controlled release arginine alpha ketoglutarate
US20060024367A1 (en) * 1998-05-28 2006-02-02 Byrd Edward A Controlled release alpha lipoic acid formulation with an inositol compound
US20050085498A1 (en) * 1998-05-28 2005-04-21 Byrd Edward A. Oral formulation of lipid soluble thiamine, lipoic acid, creatine derivative, and L-arginine alpha-ketoglutarate
US20040259895A1 (en) * 1998-05-28 2004-12-23 Medical Research Institute Oral formulation of lipid soluble thiamine and lipoic acid
JP2000169371A (ja) * 1998-10-02 2000-06-20 Sankyo Co Ltd ジチオラン誘導体を含有する医薬
US20010041187A1 (en) * 1998-10-20 2001-11-15 Carl W Hastings Performance-enhancing dietary supplement
US6288106B1 (en) * 1999-05-25 2001-09-11 Chronorx, Llc Processes for the synthesis and use of various α-lipoic acid complexes
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US6387945B2 (en) * 2000-04-11 2002-05-14 The Regents Of The University Of California Lipoic acid analogs
ATE320833T1 (de) * 2000-06-06 2006-04-15 Verwendung von einem liponsaüren -(r)- enantiomeren in kosmetika und dermatologie
EP1172110A3 (de) * 2000-07-07 2003-09-17 Basf Aktiengesellschaft Verwendung von Liponsäure zur Verbesserung der Bioverfügbarkeit von Mineralsalzen
DE10045059A1 (de) * 2000-09-12 2002-03-21 Basf Ag Therapeutische Kombination von Liponsäure und Konjuensäuren zur Behandlung diabetischer Störungen
DE10048531C1 (de) * 2000-09-30 2002-04-25 Porsche Ag Kühlluftführung für Kraftfahrzeuge
WO2002044163A2 (de) 2000-11-30 2002-06-06 Basf Aktiengesellschaft Verfahren zur herstellung von liponsäure und dihydroliponsaüre
US6359075B1 (en) 2001-01-09 2002-03-19 Bridgestone/Firestone, Inc. Means of producing high diblock content thermoplastic elastomers via chain transfer
DE10113974B4 (de) * 2001-03-22 2008-05-29 Alzchem Trostberg Gmbh Verwendung von racemischer und enantiomerenreiner Dihydroliponsäure oder deren Derivate zur Körpergewichtsreduzierung und/oder zur Verringerung des Appetits
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DE10125882B4 (de) * 2001-05-28 2007-03-29 Esparma Gmbh Arzneimittel enthaltend Ambroxol, dessen Salze und/oder Prodrugs zusammen mit α-Liponsäure im Rahmen der Behandlung des Diabetes mellitus
DE10137381A1 (de) * 2001-07-31 2003-02-13 Viatris Gmbh Neue Modifikationen des Trometamolsalzes der R-Thioctsäure sowie Verfahren zu ihrer Herstellung
US20030144219A1 (en) 2001-11-15 2003-07-31 Phinney Stephen Dodge Formulations and methods for treatment or amelioration of inflammatory conditions
WO2003084532A1 (en) * 2002-04-03 2003-10-16 Avery Mitchell A Lipoic acid analogs useful as provitamins and antioxidants
US6733793B2 (en) 2002-06-04 2004-05-11 Metaproteomics, Llc Oral composition with insulin-like activities and methods of use
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JP4716666B2 (ja) * 2003-05-21 2011-07-06 有限会社オガ リサーチ α−リポ酸含有水性製剤
ITMI20032528A1 (it) * 2003-12-19 2005-06-20 Francesco Santangelo Uso di cistina o di cisteina per la prevenzione e il
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DE102004050353A1 (de) * 2004-10-15 2006-04-20 Basf Ag Verwendung stabiler Ammoniumsalze der Liponsäure zur Behandlung diabetischer und weiterer Störungen
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US20070083054A1 (en) * 2005-10-12 2007-04-12 Lawrence Lowell J Novel amides of lipoic acid
US20070196442A1 (en) * 2006-02-10 2007-08-23 Heuer Marvin A Method for improving the oral administration of alpha-lipoic acid
US20070225354A1 (en) * 2006-03-21 2007-09-27 Eric Marchewitz Use of dihydrolipoamide for enhancing physical performance
JP2010520333A (ja) * 2007-03-01 2010-06-10 セダーズ−シナイ メディカル センター 〔１，２〕−ジチオラン部分を含有する抗酸化剤重合体およびその使用
DE102007038849A1 (de) 2007-08-16 2009-02-19 Adscil Gmbh Verwendung von R(+)-alpha-Liponsäure zur Behandlung der kryptogenen Neuropathie
US20090054513A1 (en) * 2007-08-22 2009-02-26 Response Scientific, Inc. Method of managing blood glucose levels, insulin levels and/or insulin receptor functionality in individuals with diabetes, polycystic ovarian syndrome and/or alzheimer's disease
US7943163B2 (en) * 2007-08-22 2011-05-17 Response Scientific, Inc. Medical food or nutritional supplement, method of manufacturing same, and method of managing diabetes
US9028874B2 (en) * 2008-01-03 2015-05-12 Cedars-Sinai Medical Center Antioxidant nanosphere comprising [1,2]-dithiolane moieties
KR20110004846A (ko) * 2008-03-04 2011-01-14 로버트 쇼어 효소의 구조, 활성 및/또는 발현 정도의 조절
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US8603531B2 (en) * 2008-06-02 2013-12-10 Cedars-Sinai Medical Center Nanometer-sized prodrugs of NSAIDs
US20100099751A1 (en) * 2008-10-21 2010-04-22 Al-Mulla Fahd Method of treating diabetes-related vascular complications
CN102245765B (zh) 2008-10-21 2015-01-07 通用医院公司 细胞移植
EP2364304A1 (en) * 2008-11-07 2011-09-14 ISTITUTO BIOCHIMICO NAZIONALE SAVIO s.r.l. Alpha-lipoic acid derivatives and their use in drug preparation
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KR100935554B1 (ko) * 2009-06-24 2010-01-07 주식회사 셀트리온제약 피페라진 다이티옥트산염 및 이를 포함하는 약제학적 조성물
KR101208955B1 (ko) * 2010-06-01 2012-12-06 주식회사 셀트리온제약 피페라진 다이티옥트산염 및 글리메피리드를 포함하는 약제학적 조성물
CN103153376B (zh) 2010-08-06 2018-04-20 通用医院公司以麻省总医院名义经营 用于细胞处理相关应用的***和设备
WO2015001568A2 (en) * 2013-07-01 2015-01-08 Laurus Labs Private Limited Sitagliptin lipoate salt, process for the preparation and pharmaceutical composition thereof
FR3027228B1 (fr) * 2014-10-20 2016-12-09 Valbiotis Composition comprenant un melange d'extraits vegetaux et utilisation pour agir sur le metabolisme glucidique et/ou lipidique
CN115536631B (zh) * 2021-06-30 2024-01-30 江苏同禾药业有限公司 一种高纯度的右旋硫辛酸镁盐的制备方法

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IT1213141B (it) * 1984-02-17 1989-12-14 Dobrivoje Tomic Composizioni farmaceutiche per il trattamento del diabete e di malattie e disfunzioni epatiche.
DE4218572A1 (de) * 1992-06-05 1993-12-09 Asta Medica Ag Synergistische Kombination von Arzneimitteln enthaltend als Wirkstoff alpha-Liponsäure, Dihydroliponsäure, deren Metaboliten sowie die oxidierten und reduzierten Enantiomere der alpha-Liponsäure wie die R-alpha-Liponsäure oder S-alpha-Liponsäure sowie Metaboliten der alpha-Liponsäure mit den Vitaminen A, B1-6, B12, C und E
DE4343593C2 (de) * 1993-12-21 1998-05-20 Asta Medica Ag Verwendung von R-(+)-alpha-Liponsäure, R-(-)-Dihydroliponsäure oder der Metabolite sowie deren Salze, Ester, Amide zur Behandlung kompensierter und dekompensierter Insulinresistenz

Also Published As

Publication number Publication date
US5948810A (en) 1999-09-07
DE4343593C2 (de) 1998-05-20
DK0958816T3 (da) 2006-07-17
HK1023943A1 (en) 2000-09-29
ES2258302T3 (es) 2006-08-16
EP0659408B1 (de) 2001-08-01
ES2159539T3 (es) 2001-10-16
EP0958816A3 (de) 1999-12-15
GR3036943T3 (en) 2002-01-31
US5693664A (en) 1997-12-02
PT659408E (pt) 2001-12-28
DK0659408T3 (da) 2001-10-01
EP0958816A2 (de) 1999-11-24
EP0958816B1 (de) 2006-03-08
DE4343593A1 (de) 1995-06-22
US6117899A (en) 2000-09-12
DE59410429D1 (de) 2006-05-04
EP0659408A1 (de) 1995-06-28
CA2138558A1 (en) 1995-06-22
ATE319444T1 (de) 2006-03-15
ATE203669T1 (de) 2001-08-15
US6284787B1 (en) 2001-09-04
CA2138558C (en) 2009-02-10
DE59409810D1 (de) 2001-09-06
JPH07206676A (ja) 1995-08-08

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