PT89494A - Processo para a preparacao de 4-alquil-1,4-dihidropiridinas com actividade antagonista do factor activador de plaquetas - Google Patents

Processo para a preparacao de 4-alquil-1,4-dihidropiridinas com actividade antagonista do factor activador de plaquetas

Info

Publication number: PT89494A
Authority: PT; Portugal
Prior art keywords: pyridines; platelets; dihydro; alkyl; preparation
Prior art date: 1988-01-21

Application number

PT89494A

Other languages

English (en)

Other versions

PT89494B (pt

Inventor

Carlos Sunkel

Miguel Fau De Casa-Juana

Luis Santos

Pilar Ortega

Jaime Priego

Mariano Sanchez-Crespo

Original Assignee

Alter Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-01-21

Filing date

1989-01-20

Publication date

1989-10-04

1989-01-20 Application filed by Alter Sa filed Critical Alter Sa

1989-10-04 Publication of PT89494A publication Critical patent/PT89494A/pt

1994-03-31 Publication of PT89494B publication Critical patent/PT89494B/pt

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Immunology (AREA)
Pulmonology (AREA)
Transplantation (AREA)
Diabetes (AREA)
Hematology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Plural Heterocyclic Compounds (AREA)

PT89494A 1988-01-21 1989-01-20 Processo para a preparacao de 4-alquil-1,4-dihidropiridinas com actividade antagonista do factor activador de plaquetas PT89494B (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE3801717A DE3801717C1 (pt)	1988-01-21	1988-01-21
EP91500103A EP0531598A1 (en)	1988-01-21	1991-09-09	1,4-Dihydropyridines with paf-antagonistic activity

Publications (2)

Publication Number	Publication Date
PT89494A true PT89494A (pt)	1989-10-04
PT89494B PT89494B (pt)	1994-03-31

Family

ID=40279084

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
PT89494A PT89494B (pt)	1988-01-21	1989-01-20	Processo para a preparacao de 4-alquil-1,4-dihidropiridinas com actividade antagonista do factor activador de plaquetas
PT100848A PT100848A (pt)	1988-01-21	1992-09-08	1,4-di-hidropiridinas com actividade antagonista do factor agregador das plaquetas (paf)

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
PT100848A PT100848A (pt)	1988-01-21	1992-09-08	1,4-di-hidropiridinas com actividade antagonista do factor agregador das plaquetas (paf)

Country Status (19)

Country	Link
EP (2)	EP0325187B1 (pt)
JP (2)	JPH01233273A (pt)
KR (1)	KR910008348B1 (pt)
AR (1)	AR248137A1 (pt)
BR (1)	BR9203580A (pt)
CA (2)	CA1332838C (pt)
CZ (1)	CZ278692A3 (pt)
DE (1)	DE3801717C1 (pt)
DK (1)	DK25989A (pt)
ES (1)	ES2052783T3 (pt)
FI (1)	FI924018A (pt)
GR (1)	GR3006934T3 (pt)
HU (1)	HUT65253A (pt)
IE (2)	IE890136L (pt)
MX (1)	MX9204642A (pt)
NO (1)	NO923489L (pt)
PL (1)	PL295861A1 (pt)
PT (2)	PT89494B (pt)
ZA (2)	ZA89519B (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3801717C1 (pt) *	1988-01-21	1989-05-24	Alter S.A., Madrid, Es
US5843950A (en) *	1994-07-29	1998-12-01	Nikken Chemicals Co., Ltd.	1,4-dihydropyridine compound and pharmaceutical composition containing the same
WO1999025347A2 (en)	1997-11-14	1999-05-27	Neurosearch A/S	Chemical compounds having ion channel blocking activity for the treatment of immune dysfunction
US6566359B1 (en)	2002-05-20	2003-05-20	Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College	2,4,6-trimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid esters as neuroprotective drugs
US20180104251A1 (en) *	2015-03-09	2018-04-19	Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College	Compositions and methods for the treatment of glioblastoma

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2747513A1 (de) *	1977-10-22	1979-05-03	Bayer Ag	Dihydropyridine mit schwefelhaltigen estergruppierungen
US4761420A (en) *	1986-06-13	1988-08-02	Laboratoires Syntex S.A.	Antihypertensive dihydropyridine derivatives
DE3801717C1 (pt) *	1988-01-21	1989-05-24	Alter S.A., Madrid, Es

1988
- 1988-01-21 DE DE3801717A patent/DE3801717C1/de not_active Expired
1989
- 1989-01-16 EP EP89100656A patent/EP0325187B1/en not_active Expired - Lifetime
- 1989-01-16 ES ES89100656T patent/ES2052783T3/es not_active Expired - Lifetime
- 1989-01-17 AR AR89312998A patent/AR248137A1/es active
- 1989-01-18 IE IE890136A patent/IE890136L/xx unknown
- 1989-01-19 CA CA000588668A patent/CA1332838C/en not_active Expired - Fee Related
- 1989-01-20 PT PT89494A patent/PT89494B/pt not_active IP Right Cessation
- 1989-01-20 DK DK025989A patent/DK25989A/da not_active Application Discontinuation
- 1989-01-20 JP JP1013011A patent/JPH01233273A/ja active Granted
- 1989-01-21 KR KR1019890000654A patent/KR910008348B1/ko not_active IP Right Cessation
- 1989-01-23 ZA ZA89519A patent/ZA89519B/xx unknown
1991
- 1991-09-09 EP EP91500103A patent/EP0531598A1/en not_active Withdrawn
1992
- 1992-07-22 CA CA002074419A patent/CA2074419A1/en not_active Abandoned
- 1992-07-24 IE IE241292A patent/IE922412A1/en not_active Application Discontinuation
- 1992-07-29 ZA ZA925692A patent/ZA925692B/xx unknown
- 1992-08-11 MX MX9204642A patent/MX9204642A/es unknown
- 1992-08-27 JP JP4228409A patent/JPH0742271B2/ja not_active Expired - Lifetime
- 1992-09-08 FI FI924018A patent/FI924018A/fi not_active Application Discontinuation
- 1992-09-08 HU HU9202873A patent/HUT65253A/hu unknown
- 1992-09-08 NO NO92923489A patent/NO923489L/no unknown
- 1992-09-08 PL PL29586192A patent/PL295861A1/xx unknown
- 1992-09-08 PT PT100848A patent/PT100848A/pt not_active Application Discontinuation
- 1992-09-09 BR BR929203580A patent/BR9203580A/pt not_active Application Discontinuation
- 1992-09-09 CZ CS922786A patent/CZ278692A3/cs unknown
1993
- 1993-01-28 GR GR930400181T patent/GR3006934T3/el unknown

Also Published As

Publication number	Publication date
ZA89519B (en)	1989-10-25
EP0531598A1 (en)	1993-03-17
CA1332838C (en)	1994-11-01
JPH0742271B2 (ja)	1995-05-10
DE3801717C1 (pt)	1989-05-24
GR3006934T3 (pt)	1993-06-30
NO923489L (no)	1993-03-10
IE922412A1 (en)	1993-03-10
KR910008348B1 (ko)	1991-10-12
ES2052783T3 (es)	1994-07-16
CZ278692A3 (en)	1993-12-15
PT89494B (pt)	1994-03-31
ZA925692B (en)	1993-03-02
EP0325187A1 (en)	1989-07-26
FI924018A0 (fi)	1992-09-08
JPH01233273A (ja)	1989-09-19
IE890136L (en)	1989-07-21
JPH05208958A (ja)	1993-08-20
MX9204642A (es)	1993-12-01
JPH0552827B2 (pt)	1993-08-06
BR9203580A (pt)	1993-04-13
EP0325187B1 (en)	1992-11-11
CA2074419A1 (en)	1993-03-10
NO923489D0 (no)	1992-09-08
DK25989D0 (da)	1989-01-20
PT100848A (pt)	1993-10-29
FI924018A (fi)	1993-03-10
PL295861A1 (en)	1993-05-04
HU9202873D0 (en)	1992-11-30
KR890011842A (ko)	1989-08-22
HUT65253A (en)	1994-05-02
AR248137A1 (es)	1995-06-30
DK25989A (da)	1989-07-22

Legal Events

Date

Code

Title

Description

1994-03-31

FG3A

Patent granted, date of granting

Effective date: 19930923

1997-07-31

MM3A

Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19970331

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