PT83450B - Processo para a preparacao de esteres do acido di-hidrolisergico - Google Patents

Processo para a preparacao de esteres do acido di-hidrolisergico

Info

Publication number: PT83450B
Authority: PT; Portugal
Prior art keywords: preparation; acid esters; dihydrolysergic acid; dihydrolysergic; esters
Prior art date: 1985-10-01

Application number

PT83450A

Other languages

English (en)

Other versions

PT83450A (en

Inventor

Ray Ward Fuller

Marlene Lois Cohen

William Lee Garbrecht

Gifford Purnell Marzoni

Kathleen Rose Whitten

Carol John Parli

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-10-01

Filing date

1986-09-29

Publication date

1989-05-12

1985-10-01 Priority claimed from US06/782,342 external-priority patent/US4772709A/en

1985-10-01 Priority claimed from US06/782,340 external-priority patent/US4714704A/en

1985-10-01 Priority claimed from US06/782,337 external-priority patent/US4683236A/en

1985-10-01 Priority claimed from US06/782,338 external-priority patent/US4713384A/en

1985-10-01 Priority claimed from US06/782,341 external-priority patent/US4713385A/en

1986-09-29 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1986-10-01 Publication of PT83450A publication Critical patent/PT83450A/pt

1989-05-12 Publication of PT83450B publication Critical patent/PT83450B/pt

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/48—Ergoline derivatives, e.g. lysergic acid, ergotamine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

PT83450A 1985-10-01 1986-09-29 Processo para a preparacao de esteres do acido di-hidrolisergico PT83450B (pt)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US06/782,342 US4772709A (en)	1985-10-01	1985-10-01	Process of making ketoalkanol esters of dihydrolysergic acid
US06/782,340 US4714704A (en)	1985-10-01	1985-10-01	Alkoxy cycloalkanol esters of dihydrolysergic acid useful as 5HT receptor antagonists
US06/782,337 US4683236A (en)	1985-10-01	1985-10-01	Cycloalkanol esters of dihydrolysergic acid useful as 5Ht2 receptor antagonists
US06/782,338 US4713384A (en)	1985-10-01	1985-10-01	Selective method for blocking 5HT2 receptors
US06/782,341 US4713385A (en)	1985-10-01	1985-10-01	Alkoxy and dialkoxyalkyl esters of dihydrolysergic acid and related compounds useful as 5HT receptor antagonists

Publications (2)

Publication Number	Publication Date
PT83450A PT83450A (en)	1986-10-01
PT83450B true PT83450B (pt)	1989-05-12

Family

ID=27542204

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT83450A PT83450B (pt)	1985-10-01	1986-09-29	Processo para a preparacao de esteres do acido di-hidrolisergico

Country Status (17)

Country	Link
EP (1)	EP0219257B1 (pt)
JP (1)	JPH0723376B2 (pt)
KR (1)	KR880001009B1 (pt)
AR (1)	AR244687A1 (pt)
AU (1)	AU594373B2 (pt)
CY (1)	CY1784A (pt)
DE (1)	DE3689702T2 (pt)
DK (1)	DK466886A (pt)
ES (1)	ES2002392A6 (pt)
GR (1)	GR862466B (pt)
HK (1)	HK51894A (pt)
HU (1)	HU206711B (pt)
IE (1)	IE61976B1 (pt)
IL (1)	IL80193A0 (pt)
MY (1)	MY102598A (pt)
NZ (1)	NZ217724A (pt)
PT (1)	PT83450B (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4734501A (en) *	1985-10-01	1988-03-29	Eli Lilly And Company	N-alkylation of dihydrolysergic acid
US4782063A (en) *	1987-05-11	1988-11-01	Eli Lilly And Company	Ergoline esters useful as serotonin antagonists
GB8824744D0 (en) *	1988-10-21	1988-11-30	Erba Carlo Spa	Antiemesis ergoline derivatives
JPH11503757A (ja) *	1995-04-18	1999-03-30	イーライ・リリー・アンド・カンパニー	５−ｈｔ▲下７▼レセプターにおいて生理学的および病理学的機能を生じるエルゴリン化合物の使用方法
US5880134A (en) *	1996-03-20	1999-03-09	Eli Lilly And Company	Method for using ergoline compounds to effect physiological and pathological functions at the 5-HT7 receptor
WO2013167220A1 (de) *	2012-05-08	2013-11-14	Merck Patent Gmbh	Verwendung von cyclohexanolethers mit antimikrobiellen eigenschaften

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3580916A (en) *	1969-02-20	1971-05-25	Lilly Co Eli	Hydroxyesters of hexa- and octahydroindoloquinolines
CH549571A (de) *	1970-09-16	1974-05-31	Lilly Co Eli	Verfahren zur herstellung von estern der lysergsaeure bzw. dihydrolysergsaeure und deren verwendung.
US4563461A (en) *	1983-03-10	1986-01-07	Eli Lilly And Company	Selective method for blocking 5HT2 receptors
US4734501A (en) *	1985-10-01	1988-03-29	Eli Lilly And Company	N-alkylation of dihydrolysergic acid
US4713384A (en) *	1985-10-01	1987-12-15	Eli Lilly And Company	Selective method for blocking 5HT2 receptors

1986
- 1986-09-29 NZ NZ217724A patent/NZ217724A/xx unknown
- 1986-09-29 GR GR862466A patent/GR862466B/el unknown
- 1986-09-29 IL IL80193A patent/IL80193A0/xx not_active IP Right Cessation
- 1986-09-29 DE DE3689702T patent/DE3689702T2/de not_active Expired - Fee Related
- 1986-09-29 EP EP86307443A patent/EP0219257B1/en not_active Expired - Lifetime
- 1986-09-29 AU AU63210/86A patent/AU594373B2/en not_active Ceased
- 1986-09-29 PT PT83450A patent/PT83450B/pt not_active IP Right Cessation
- 1986-09-30 IE IE258886A patent/IE61976B1/en not_active IP Right Cessation
- 1986-09-30 JP JP61234256A patent/JPH0723376B2/ja not_active Expired - Lifetime
- 1986-09-30 ES ES8602320A patent/ES2002392A6/es not_active Expired
- 1986-09-30 KR KR1019860008205A patent/KR880001009B1/ko not_active IP Right Cessation
- 1986-09-30 AR AR86305427A patent/AR244687A1/es active
- 1986-09-30 DK DK466886A patent/DK466886A/da not_active Application Discontinuation
- 1986-09-30 HU HU864146A patent/HU206711B/hu not_active IP Right Cessation
1987
- 1987-09-24 MY MYPI87001918A patent/MY102598A/en unknown
1994
- 1994-05-19 HK HK51894A patent/HK51894A/xx unknown
1995
- 1995-10-20 CY CY178495A patent/CY1784A/xx unknown

Also Published As

Publication number	Publication date
EP0219257A3 (en)	1988-12-28
AU594373B2 (en)	1990-03-08
KR870004028A (ko)	1987-05-07
GR862466B (en)	1987-02-02
PT83450A (en)	1986-10-01
ES2002392A6 (es)	1988-08-01
DE3689702T2 (de)	1994-07-28
EP0219257B1 (en)	1994-03-09
HU206711B (en)	1992-12-28
DE3689702D1 (de)	1994-04-14
JPH0723376B2 (ja)	1995-03-15
DK466886A (da)	1987-04-02
AU6321086A (en)	1987-04-02
IL80193A0 (en)	1986-12-31
HK51894A (en)	1994-05-27
KR880001009B1 (ko)	1988-06-13
IE61976B1 (en)	1994-12-14
JPS6284084A (ja)	1987-04-17
NZ217724A (en)	1989-02-24
HUT41780A (en)	1987-05-28
EP0219257A2 (en)	1987-04-22
DK466886D0 (da)	1986-09-30
IE862588L (en)	1987-04-01
MY102598A (en)	1992-08-17
CY1784A (en)	1995-10-20
AR244687A1 (es)	1993-11-30

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Legal Events

Date

Code

Title

Description

1996-08-30

MM3A

Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19960430