PT66865B - PROCESS FOR PREPARING NOVEL SUBSTITUTED 2,3-ALKYLENE BIS (OXY) BENZAMIDES AND DERIVATIVES THEREOF - Google Patents
PROCESS FOR PREPARING NOVEL SUBSTITUTED 2,3-ALKYLENE BIS (OXY) BENZAMIDES AND DERIVATIVES THEREOFInfo
- Publication number
- PT66865B PT66865B PT6686577A PT6686577A PT66865B PT 66865 B PT66865 B PT 66865B PT 6686577 A PT6686577 A PT 6686577A PT 6686577 A PT6686577 A PT 6686577A PT 66865 B PT66865 B PT 66865B
- Authority
- PT
- Portugal
- Prior art keywords
- substd
- opt
- alkyl
- alkenyl
- forms
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, ***e
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D321/00—Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00
- C07D321/02—Seven-membered rings
- C07D321/10—Seven-membered rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
Abstract
2,3-Alkylenedioxybenzamides of formula (I) and their acid -addn. salts, quat. ammonium salts, oxides and optical isomers are new. In (I), A is 1-3C alkylene opt. substd by 1-4C alkyl, 2-4C alkenyl or 1-4C hydroxyalkyl. R is H, 1-4C alkyl or -B-NR1R2; B is a direct bond or a 1-3C alkylene gp. opt. substd. by 1-4C alkyl or 2-4C alkenyl; R1 is H, 1-4C alkyl, 2-4C alkenyl, 2-4C alkynyl, substd. alkyl, or forms a heterocyclic ring with B, and R2 is H, 1-4C alkyl, 2-4C alkenyl or alkynyl, substd. alkyl, an opt. substd. heterocyclic gp., or a phenyl, adamantyl, cycloalkyl, bicycloalkyl or cycloalkenyl gp. bonded directly to the N atom or via an opt. substd. alkylene chain, or NR1R2 is a heterocycle opt. contg. other heteroatoms (including NR'', where R'' is H- 1-4C alkyl, 2-4C alkenyl or alkynyl, phenyl, benzyl, cycloalkyl, cycloalkenyl, cycloalkylalkyl, cycloalkenylalkyl, adamantyl, bicycloalkyl or alkyl substd by OH, SH, acyl, thioacyl, alkoxy or alkylthio). - R' is H, 1-4c alkyl, 2-4C alkenyl or alkynyl, adamantyl, pyrimidinyl, pyrazinyl, diazepinyl, quinuclidinyl, azabicycloalkyl, diazabicycloalkyl, bicycloalkyl, or opt. substd. phenyl or aralkyl, or R'+B forms an opt. substd. heterocycle contg. a single N atom, or R'+R1 forms an opt. substd. heterocycle contg. two heteroatoms, X is H, halogen, OH, 1-4C alkoxy, 1-4C alkyl, amino opt. mono- or disubstd. by 1-4C alkyl, acyl, aralkyl, furyl, pyranyl or alkoxycacarbonyl, or forms an A' chain with Y. Y is as defined for X or is NO2, 1-4C alkylsulphonyl, adamantyl-sulphonyl, cycloalkyl sulphonyl or SO2NR3R'; R3 and R4 are H, 1-4C alkyl, 2-4C alkenyl, 2-4C alkynyl, phenyl, benzyl, cycloalkyl, cycloalkenyl, cycloalkylalkyl, cycloalkenylalkyl, bicycloalkyl, adamantyl, pyrimidinyl, pyrazinyl, or alkyl substd. by OH, SH, acyl, thioacyl, alkoxy or alkylthio, or NR3R4 is an opt. substd. heterocycle opt. congt. another heteroatom; or Y forms an A chain with X or Z. Z is as defined for X or is NO2, or forms an A chain with Y. A is a carbon chain opt. substd. or opt. interrupted by one or more opt. substd. heteroatoms. - Cpds. (I) have anxiolytic, antidepressant and antiemetic activity with little or no cataleptic activity. A typical cpd. of N-(1-allyl-2-pyrrolidinylmethyl)-7-methylsulphamoyl-1, 4-benzodioxan-5-carboxamide. In an example, this is prepd. from 1,4-benzodioxan-5-carboxylic acid.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7623835A FR2360305A1 (en) | 1976-08-04 | 1976-08-04 | NEW 2,3-ALKYLENE BIS (OXY) BENZAMIDE SUBSTITUTES, THEIR DERIVATIVES AND THEIR PREPARATION METHODS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT66865A PT66865A (en) | 1977-08-01 |
| PT66865B true PT66865B (en) | 1978-12-29 |
Family
ID=9176558
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT6686577A PT66865B (en) | 1976-08-04 | 1977-07-29 | PROCESS FOR PREPARING NOVEL SUBSTITUTED 2,3-ALKYLENE BIS (OXY) BENZAMIDES AND DERIVATIVES THEREOF |
Country Status (37)
| Country | Link |
|---|---|
| JP (1) | JPS57167914A (en) |
| AR (1) | AR219709A1 (en) |
| AT (1) | AT358034B (en) |
| AU (1) | AU516033B2 (en) |
| BE (1) | BE857350A (en) |
| BG (1) | BG36496A3 (en) |
| CA (1) | CA1114371A (en) |
| CH (1) | CH629198A5 (en) |
| CS (1) | CS216246B2 (en) |
| DD (1) | DD133237A5 (en) |
| DE (1) | DE2760414C2 (en) |
| DK (1) | DK152366C (en) |
| EG (1) | EG12716A (en) |
| ES (1) | ES461175A1 (en) |
| FI (1) | FI63938C (en) |
| GR (1) | GR61351B (en) |
| HK (2) | HK40382A (en) |
| HU (1) | HU179064B (en) |
| IE (2) | IE45646B1 (en) |
| IL (2) | IL52644A0 (en) |
| IN (1) | IN145473B (en) |
| LU (1) | LU77897A1 (en) |
| MC (1) | MC1154A1 (en) |
| MW (1) | MW2077A1 (en) |
| NL (1) | NL172063C (en) |
| NO (1) | NO152133C (en) |
| NZ (1) | NZ184816A (en) |
| OA (1) | OA05728A (en) |
| PH (3) | PH22114A (en) |
| PL (1) | PL111071B1 (en) |
| PT (1) | PT66865B (en) |
| RO (1) | RO72963A (en) |
| SE (2) | SE440776B (en) |
| SU (1) | SU716523A3 (en) |
| YU (1) | YU40005B (en) |
| ZA (1) | ZA774701B (en) |
| ZM (1) | ZM6077A1 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9027098D0 (en) * | 1990-12-13 | 1991-02-06 | Beecham Group Plc | Pharmaceuticals |
| US10083697B2 (en) | 2015-05-27 | 2018-09-25 | Google Llc | Local persisting of data for selectively offline capable voice action in a voice-enabled electronic device |
| JP6452575B2 (en) * | 2015-08-19 | 2019-01-16 | 株式会社トクヤマ | Manufacturing method of mirtazapine |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1473829A (en) * | 1964-06-09 | 1967-03-24 | Ile De France | Nu- (tertiary-aminoalkyl) -methylene dioxybenzamides and their preparation |
-
1977
- 1977-07-11 MC MC771250A patent/MC1154A1/en unknown
- 1977-07-29 DE DE19772760414 patent/DE2760414C2/de not_active Expired - Fee Related
- 1977-07-29 ES ES461175A patent/ES461175A1/en not_active Expired
- 1977-07-29 GR GR54066A patent/GR61351B/en unknown
- 1977-07-29 BG BG3704777A patent/BG36496A3/en unknown
- 1977-07-29 PT PT6686577A patent/PT66865B/en unknown
- 1977-07-29 IN IN1165/CAL/77A patent/IN145473B/en unknown
- 1977-08-01 YU YU188277A patent/YU40005B/en unknown
- 1977-08-01 OA OA56243A patent/OA05728A/en unknown
- 1977-08-01 BE BE1008313A patent/BE857350A/en not_active IP Right Cessation
- 1977-08-01 AU AU27507/77A patent/AU516033B2/en not_active Expired
- 1977-08-02 IE IE1600/77A patent/IE45646B1/en not_active IP Right Cessation
- 1977-08-02 EG EG45577A patent/EG12716A/en active
- 1977-08-02 IE IE2409/80A patent/IE45647B1/en not_active IP Right Cessation
- 1977-08-02 LU LU77897A patent/LU77897A1/xx unknown
- 1977-08-02 RO RO9124577A patent/RO72963A/en unknown
- 1977-08-02 AT AT569677A patent/AT358034B/en not_active IP Right Cessation
- 1977-08-03 DK DK346977A patent/DK152366C/en not_active IP Right Cessation
- 1977-08-03 SE SE7708849A patent/SE440776B/en not_active IP Right Cessation
- 1977-08-03 HU HUSO001195 patent/HU179064B/en not_active IP Right Cessation
- 1977-08-03 DD DD20042077A patent/DD133237A5/en not_active IP Right Cessation
- 1977-08-03 NZ NZ18481677A patent/NZ184816A/en unknown
- 1977-08-03 CH CH956277A patent/CH629198A5/en not_active IP Right Cessation
- 1977-08-03 CA CA283,994A patent/CA1114371A/en not_active Expired
- 1977-08-03 MW MW2077A patent/MW2077A1/en unknown
- 1977-08-03 IL IL52644A patent/IL52644A0/en not_active IP Right Cessation
- 1977-08-03 NO NO772739A patent/NO152133C/en unknown
- 1977-08-03 NL NL7708616A patent/NL172063C/en not_active IP Right Cessation
- 1977-08-03 ZA ZA00774701A patent/ZA774701B/en unknown
- 1977-08-04 CS CS775179A patent/CS216246B2/en unknown
- 1977-08-04 SU SU772507701A patent/SU716523A3/en active
- 1977-08-04 PL PL1977200066A patent/PL111071B1/en not_active IP Right Cessation
- 1977-08-04 ZM ZM6077A patent/ZM6077A1/en unknown
- 1977-08-04 FI FI772362A patent/FI63938C/en not_active IP Right Cessation
- 1977-08-04 PH PH20078A patent/PH22114A/en unknown
- 1977-08-08 AR AR26867377A patent/AR219709A1/en active
-
1981
- 1981-03-25 PH PH25426-AA patent/PH18629A/en unknown
- 1981-08-07 PH PH26025A patent/PH17710A/en unknown
-
1982
- 1982-03-19 JP JP4547682A patent/JPS57167914A/en active Granted
- 1982-06-25 IL IL66138A patent/IL66138A0/en not_active IP Right Cessation
- 1982-09-16 HK HK40382A patent/HK40382A/en unknown
- 1982-09-16 HK HK40482A patent/HK40482A/en unknown
- 1982-11-17 SE SE8206546A patent/SE453390B/en not_active IP Right Cessation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2087721T3 (en) | GUANIDINES SUBSTITUTED WITH (BENZODIOXANE, BENZOFURANE OR BENZOPYRANE) -ALKYLAMINE-RENT AS SELECTIVE VASOCONSTRICTORS. | |
| ATE74352T1 (en) | DECAHYDROCHINOLINE DERIVATIVES, PROCESS FOR THEIR MANUFACTURE, INTERMEDIATE PRODUCTS FOR THEIR MANUFACTURE, THEIR USE AS MEDICINAL PRODUCTS AND PREPARATIONS CONTAINING THEM. | |
| BR8303898A (en) | COMPOUNDS, PROCESS FOR THE MANUFACTURE OF THE SAME, MEDICINE AND USE OF SUCH COMPOUNDS | |
| PT66865B (en) | PROCESS FOR PREPARING NOVEL SUBSTITUTED 2,3-ALKYLENE BIS (OXY) BENZAMIDES AND DERIVATIVES THEREOF | |
| FR2360305B1 (en) | ||
| FR2367055A1 (en) | NEW DERIVATIVES OF ALCANOLAMINES, THEIR PREPARATION PROCESS AND PHARMACEUTICAL COMPOSITION CONTAINING THEM | |
| JPS5328181A (en) | Production of nove substituted 2*33alkylenebis *oxy* benzoic acid | |
| ATE18203T1 (en) | (-)-15-DEOXYSPERGUALIN, ITS MANUFACTURE AND MEDICATIONS CONTAINING THIS ACTIVE SUBSTANCE. | |
| DE3880304D1 (en) | 2-HYDROXY-3-ARYLOXY PROPYLAMINE DERIVATIVES WITH CARDIOVASCULAR EFFECT. | |
| ES480560A1 (en) | Bridged catharanthus alkaloid dimers, their preparation and formulations containing them. | |
| ATA501280A (en) | 6-Aminomethyl-5,6-di:hydro-1,2,4-oxadiazine derivs. - with cardiovascular, antiinflammatory, diuretic and antiarrhythmic activity | |
| TH508EX (en) | New dihydropyrone additives Process for producing these substances Starting substances used in the production of such The new diidropyrone formulation was used as an active ingredient and the use of it for weed control. | |
| AR247563A1 (en) | New pyridinilpyrimidine derivatives and a protector for illnesses of plants that contain them as an active ingredient | |
| GB989191A (en) | Benzimidazole derivatives and process for making them |