PT3956332T - Processo diasterosselectivo para a preparação de ésteres de maitansinoides contendo tiol ou dissulfeto e seus intermediários - Google Patents

Processo diasterosselectivo para a preparação de ésteres de maitansinoides contendo tiol ou dissulfeto e seus intermediários

Info

Publication number
PT3956332T
PT3956332T PT207191602T PT20719160T PT3956332T PT 3956332 T PT3956332 T PT 3956332T PT 207191602 T PT207191602 T PT 207191602T PT 20719160 T PT20719160 T PT 20719160T PT 3956332 T PT3956332 T PT 3956332T
Authority
PT
Portugal
Prior art keywords
diasteroselective
thiol
intermediates
disulfide
preparation
Prior art date
Application number
PT207191602T
Other languages
English (en)
Original Assignee
Indena Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indena Spa filed Critical Indena Spa
Publication of PT3956332T publication Critical patent/PT3956332T/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PT207191602T 2019-04-18 2020-04-09 Processo diasterosselectivo para a preparação de ésteres de maitansinoides contendo tiol ou dissulfeto e seus intermediários PT3956332T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP19170052 2019-04-18

Publications (1)

Publication Number Publication Date
PT3956332T true PT3956332T (pt) 2023-04-24

Family

ID=66396993

Family Applications (1)

Application Number Title Priority Date Filing Date
PT207191602T PT3956332T (pt) 2019-04-18 2020-04-09 Processo diasterosselectivo para a preparação de ésteres de maitansinoides contendo tiol ou dissulfeto e seus intermediários

Country Status (12)

Country Link
US (1) US11420981B2 (pt)
EP (1) EP3956332B1 (pt)
JP (1) JP2022529064A (pt)
CN (1) CN113710674B (pt)
DK (1) DK3956332T3 (pt)
ES (1) ES2942915T3 (pt)
FI (1) FI3956332T3 (pt)
HU (1) HUE061695T2 (pt)
PL (1) PL3956332T3 (pt)
PT (1) PT3956332T (pt)
SI (1) SI3956332T1 (pt)
WO (1) WO2020212256A1 (pt)

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3896111A (en) 1973-02-20 1975-07-22 Research Corp Ansa macrolides
US4162940A (en) 1977-03-31 1979-07-31 Takeda Chemical Industries, Ltd. Method for producing Antibiotic C-15003 by culturing nocardia
US4151042A (en) 1977-03-31 1979-04-24 Takeda Chemical Industries, Ltd. Method for producing maytansinol and its derivatives
JPS56102793A (en) 1979-12-28 1981-08-17 Takeda Chem Ind Ltd Preparation of antibiotic c-15003 p-3
US5208020A (en) 1989-10-25 1993-05-04 Immunogen Inc. Cytotoxic agents comprising maytansinoids and their therapeutic use
US6573074B2 (en) 2000-04-12 2003-06-03 Smithkline Beecham Plc Methods for ansamitocin production
US6333410B1 (en) 2000-08-18 2001-12-25 Immunogen, Inc. Process for the preparation and purification of thiol-containing maytansinoids
AR030612A1 (es) * 2000-09-12 2003-08-27 Smithkline Beecham Corp Procedimiento e intermedios
US6790954B2 (en) 2002-01-29 2004-09-14 Immunogen, Inc. Mutant Actinosynnema pretiosum strain with increased maytansinoid production
US7276497B2 (en) 2003-05-20 2007-10-02 Immunogen Inc. Cytotoxic agents comprising new maytansinoids
BRPI0410748B8 (pt) * 2003-05-20 2021-05-25 Immunogen Inc compostos de maitansinóides, suas composições farmacêuticas, métodos de esterificação de maitansinóides, bem como métodos para a sua produção, e conjugado de maitansinóide-agente de ligação celular
US7301019B2 (en) 2005-01-21 2007-11-27 Immunogen, Inc. Method for the preparation of maytansinoid esters
WO2007021674A2 (en) 2005-08-09 2007-02-22 Millennium Pharmaceuticals, Inc. Method of acylating maytansinol with chiral amino acids
JP5117390B2 (ja) 2005-11-08 2013-01-16 イミュノジェン・インコーポレーテッド メイタンシノールの調製法
SI2900676T1 (sl) * 2012-09-26 2019-04-30 Immunogen, Inc. Izboljšana metoda za aciliranje majtanzinola
CN103254213B (zh) * 2012-12-21 2015-02-25 百奥泰生物科技(广州)有限公司 类美登素酯的制备方法及用于所述方法的组合物
CN105585579A (zh) * 2014-10-24 2016-05-18 南京联宁生物制药有限公司 一种化合物及其制备方法以及美登素dm1的制备方法

Also Published As

Publication number Publication date
JP2022529064A (ja) 2022-06-16
DK3956332T3 (da) 2023-05-01
US11420981B2 (en) 2022-08-23
US20220119408A1 (en) 2022-04-21
CN113710674B (zh) 2024-03-15
EP3956332B1 (en) 2023-02-22
PL3956332T3 (pl) 2023-05-29
EP3956332A1 (en) 2022-02-23
FI3956332T3 (fi) 2023-05-09
WO2020212256A1 (en) 2020-10-22
ES2942915T3 (es) 2023-06-07
HUE061695T2 (hu) 2023-08-28
SI3956332T1 (sl) 2023-05-31
CN113710674A (zh) 2021-11-26

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