HUP2100077A1 - Eljárás avapritinib és intermedierek elõállítására - Google Patents
Eljárás avapritinib és intermedierek elõállításáraInfo
- Publication number
- HUP2100077A1 HUP2100077A1 HU2100077A HUP2100077A HUP2100077A1 HU P2100077 A1 HUP2100077 A1 HU P2100077A1 HU 2100077 A HU2100077 A HU 2100077A HU P2100077 A HUP2100077 A HU P2100077A HU P2100077 A1 HUP2100077 A1 HU P2100077A1
- Authority
- HU
- Hungary
- Prior art keywords
- avapritinib
- intermediates
- preparation
- Prior art date
Links
- DWYRIWUZIJHQKQ-SANMLTNESA-N (1S)-1-(4-fluorophenyl)-1-[2-[4-[6-(1-methylpyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]piperazin-1-yl]pyrimidin-5-yl]ethanamine Chemical compound Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@](C)(N)c1ccc(F)cc1 DWYRIWUZIJHQKQ-SANMLTNESA-N 0.000 title 1
- 229950009576 avapritinib Drugs 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F24—HEATING; RANGES; VENTILATING
- F24F—AIR-CONDITIONING; AIR-HUMIDIFICATION; VENTILATION; USE OF AIR CURRENTS FOR SCREENING
- F24F5/00—Air-conditioning systems or apparatus not covered by F24F1/00 or F24F3/00, e.g. using solar heat or combined with household units such as an oven or water heater
- F24F5/0007—Air-conditioning systems or apparatus not covered by F24F1/00 or F24F3/00, e.g. using solar heat or combined with household units such as an oven or water heater cooling apparatus specially adapted for use in air-conditioning
- F24F5/0017—Air-conditioning systems or apparatus not covered by F24F1/00 or F24F3/00, e.g. using solar heat or combined with household units such as an oven or water heater cooling apparatus specially adapted for use in air-conditioning using cold storage bodies, e.g. ice
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F24—HEATING; RANGES; VENTILATING
- F24F—AIR-CONDITIONING; AIR-HUMIDIFICATION; VENTILATION; USE OF AIR CURRENTS FOR SCREENING
- F24F5/00—Air-conditioning systems or apparatus not covered by F24F1/00 or F24F3/00, e.g. using solar heat or combined with household units such as an oven or water heater
- F24F5/0007—Air-conditioning systems or apparatus not covered by F24F1/00 or F24F3/00, e.g. using solar heat or combined with household units such as an oven or water heater cooling apparatus specially adapted for use in air-conditioning
- F24F5/0017—Air-conditioning systems or apparatus not covered by F24F1/00 or F24F3/00, e.g. using solar heat or combined with household units such as an oven or water heater cooling apparatus specially adapted for use in air-conditioning using cold storage bodies, e.g. ice
- F24F2005/0025—Air-conditioning systems or apparatus not covered by F24F1/00 or F24F3/00, e.g. using solar heat or combined with household units such as an oven or water heater cooling apparatus specially adapted for use in air-conditioning using cold storage bodies, e.g. ice using heat exchange fluid storage tanks
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F24—HEATING; RANGES; VENTILATING
- F24F—AIR-CONDITIONING; AIR-HUMIDIFICATION; VENTILATION; USE OF AIR CURRENTS FOR SCREENING
- F24F2221/00—Details or features not otherwise provided for
- F24F2221/54—Heating and cooling, simultaneously or alternatively
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Sustainable Development (AREA)
- Combustion & Propulsion (AREA)
- Mechanical Engineering (AREA)
- General Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HUP2100077A HU231413B1 (hu) | 2021-02-26 | 2021-02-26 | Eljárás avapritinib és intermedierek előállítására |
EP22759019.7A EP4298100A1 (en) | 2021-02-26 | 2022-02-28 | Process for obtaining avapritinib and its intermediates |
PCT/HU2022/050019 WO2022180416A1 (en) | 2021-02-26 | 2022-02-28 | Process for obtaining avapritinib and its intermediates |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HUP2100077A HU231413B1 (hu) | 2021-02-26 | 2021-02-26 | Eljárás avapritinib és intermedierek előállítására |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP2100077A1 true HUP2100077A1 (hu) | 2022-08-28 |
HU231413B1 HU231413B1 (hu) | 2023-08-28 |
Family
ID=89993301
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HUP2100077A HU231413B1 (hu) | 2021-02-26 | 2021-02-26 | Eljárás avapritinib és intermedierek előállítására |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP4298100A1 (hu) |
HU (1) | HU231413B1 (hu) |
WO (1) | WO2022180416A1 (hu) |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3409674B1 (en) * | 2013-10-17 | 2022-04-06 | Blueprint Medicines Corporation | Process for preparing compositions useful for treating disorders related to kit |
DK3856341T3 (da) * | 2019-04-12 | 2023-12-04 | Blueprint Medicines Corp | Krystallinske former af (s)-1-(4-fluorphenyl)-1-(2-(4-(6-(1-methyl-1h-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)piperazinyl)-pyrimidin-5-yl)ethan-1-amin og fremgangsmåder til fremstilling deraf |
CN110938077B (zh) * | 2019-12-25 | 2021-04-27 | 武汉九州钰民医药科技有限公司 | 合成Avapritinib的方法 |
CN110950872A (zh) * | 2019-12-25 | 2020-04-03 | 武汉九州钰民医药科技有限公司 | 制备靶向抗癌药avapritinib的方法 |
-
2021
- 2021-02-26 HU HUP2100077A patent/HU231413B1/hu unknown
-
2022
- 2022-02-28 EP EP22759019.7A patent/EP4298100A1/en active Pending
- 2022-02-28 WO PCT/HU2022/050019 patent/WO2022180416A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
WO2022180416A1 (en) | 2022-09-01 |
HU231413B1 (hu) | 2023-08-28 |
EP4298100A1 (en) | 2024-01-03 |
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