PT2963127T - Detecção de alto rendimento de marcadores moleculares com base em fragmentos de restrição - Google Patents

Detecção de alto rendimento de marcadores moleculares com base em fragmentos de restrição

Info

Publication number
PT2963127T
PT2963127T PT151586211T PT15158621T PT2963127T PT 2963127 T PT2963127 T PT 2963127T PT 151586211 T PT151586211 T PT 151586211T PT 15158621 T PT15158621 T PT 15158621T PT 2963127 T PT2963127 T PT 2963127T
Authority
PT
Portugal
Prior art keywords
high throughput
molecular markers
restriction fragments
markers based
throughput detection
Prior art date
Application number
PT151586211T
Other languages
English (en)
Inventor
Josephus Theresia Van Eijk Michael
Cornelis Josephus Hogers René
Original Assignee
Keygene Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Keygene Nv filed Critical Keygene Nv
Publication of PT2963127T publication Critical patent/PT2963127T/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/6853Nucleic acid amplification reactions using modified primers or templates
    • C12Q1/6855Ligating adaptors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/6853Nucleic acid amplification reactions using modified primers or templates

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
PT151586211T 2006-04-04 2007-04-04 Detecção de alto rendimento de marcadores moleculares com base em fragmentos de restrição PT2963127T (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78870606P 2006-04-04 2006-04-04
US88005207P 2007-01-12 2007-01-12

Publications (1)

Publication Number Publication Date
PT2963127T true PT2963127T (pt) 2017-10-06

Family

ID=38508899

Family Applications (1)

Application Number Title Priority Date Filing Date
PT151586211T PT2963127T (pt) 2006-04-04 2007-04-04 Detecção de alto rendimento de marcadores moleculares com base em fragmentos de restrição

Country Status (9)

Country Link
US (6) US20090253581A1 (pt)
EP (3) EP2963127B1 (pt)
JP (2) JP5389638B2 (pt)
DK (2) DK3239304T3 (pt)
ES (3) ES2545264T3 (pt)
HK (2) HK1219761A1 (pt)
PL (1) PL2963127T3 (pt)
PT (1) PT2963127T (pt)
WO (1) WO2007114693A2 (pt)

Families Citing this family (106)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1885882T3 (da) 2005-05-10 2011-04-11 State Of Oregon Acting By & Through The State Board Of Higher Eduction On Behalf Of The University O Fremgangsmåder til kortlægning af polymorfier og polymorfi-mikroarray
ES2387878T3 (es) 2005-06-23 2012-10-03 Keygene N.V. Estrategias para la identificación de alto rendimiento y la detección de polimorfismos
US10316364B2 (en) 2005-09-29 2019-06-11 Keygene N.V. Method for identifying the source of an amplicon
ATE453728T1 (de) 2005-09-29 2010-01-15 Keygene Nv Screening mutagenisierter populationen mit hohem durchsatz
JP5452021B2 (ja) 2005-12-22 2014-03-26 キージーン ナムローゼ フェンノートシャップ ハイスループットaflp系多型検出法
US8628927B2 (en) 2008-11-07 2014-01-14 Sequenta, Inc. Monitoring health and disease status using clonotype profiles
US9365901B2 (en) 2008-11-07 2016-06-14 Adaptive Biotechnologies Corp. Monitoring immunoglobulin heavy chain evolution in B-cell acute lymphoblastic leukemia
EP2364368B1 (en) * 2008-11-07 2014-01-15 Sequenta, Inc. Methods of monitoring conditions by sequence analysis
US8748103B2 (en) 2008-11-07 2014-06-10 Sequenta, Inc. Monitoring health and disease status using clonotype profiles
US9506119B2 (en) 2008-11-07 2016-11-29 Adaptive Biotechnologies Corp. Method of sequence determination using sequence tags
US9528160B2 (en) 2008-11-07 2016-12-27 Adaptive Biotechnolgies Corp. Rare clonotypes and uses thereof
DK2387627T3 (en) 2009-01-15 2016-07-04 Adaptive Biotechnologies Corp Adaptive immunity profiling and methods for producing monoclonal antibodies
US20120058468A1 (en) 2009-01-30 2012-03-08 Oxford Nanopore Technolgies Limited Adaptors for nucleic acid constructs in transmembrane sequencing
GB2472371B (en) * 2009-04-24 2011-10-26 Selectamark Security Systems Plc Synthetic nucleotide containing compositions for use in security marking of property and/or for marking a thief or attacker
US9085798B2 (en) 2009-04-30 2015-07-21 Prognosys Biosciences, Inc. Nucleic acid constructs and methods of use
EP2248914A1 (en) * 2009-05-05 2010-11-10 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. The use of class IIB restriction endonucleases in 2nd generation sequencing applications
EP2446052B1 (en) 2009-06-25 2018-08-08 Fred Hutchinson Cancer Research Center Method of measuring adaptive immunity
US9043160B1 (en) 2009-11-09 2015-05-26 Sequenta, Inc. Method of determining clonotypes and clonotype profiles
US10787701B2 (en) 2010-04-05 2020-09-29 Prognosys Biosciences, Inc. Spatially encoded biological assays
US20190300945A1 (en) 2010-04-05 2019-10-03 Prognosys Biosciences, Inc. Spatially Encoded Biological Assays
CA2794522C (en) 2010-04-05 2019-11-26 Prognosys Biosciences, Inc. Spatially encoded biological assays
US8766054B2 (en) 2010-12-08 2014-07-01 Hm.Clause Phytophthora resistance in sweet peppers
GB201106254D0 (en) 2011-04-13 2011-05-25 Frisen Jonas Method and product
US9957560B2 (en) 2011-07-25 2018-05-01 Oxford Nanopore Technologies Ltd. Hairpin loop method for double strand polynucleotide sequencing using transmembrane pores
US10385475B2 (en) 2011-09-12 2019-08-20 Adaptive Biotechnologies Corp. Random array sequencing of low-complexity libraries
US9279159B2 (en) 2011-10-21 2016-03-08 Adaptive Biotechnologies Corporation Quantification of adaptive immune cell genomes in a complex mixture of cells
CA2858070C (en) 2011-12-09 2018-07-10 Adaptive Biotechnologies Corporation Diagnosis of lymphoid malignancies and minimal residual disease detection
US9499865B2 (en) 2011-12-13 2016-11-22 Adaptive Biotechnologies Corp. Detection and measurement of tissue-infiltrating lymphocytes
EP2802666B1 (en) 2012-01-13 2018-09-19 Data2Bio Genotyping by next-generation sequencing
RS61631B1 (sr) 2012-02-17 2021-04-29 Hutchinson Fred Cancer Res Kompozicije i postupci za preciznu identifikaciju mutacija
DK2823060T3 (en) 2012-03-05 2018-05-28 Adaptive Biotechnologies Corp Determination of associated immune receptor chains from frequency-matched subunits
WO2013142389A1 (en) 2012-03-20 2013-09-26 University Of Washington Through Its Center For Commercialization Methods of lowering the error rate of massively parallel dna sequencing using duplex consensus sequencing
ES2582554T3 (es) 2012-05-08 2016-09-13 Adaptive Biotechnologies Corporation Composiciones y método para medir y calibrar el sesgo de la amplificación en reacciones de PCR multiplexadas
DK2904111T3 (en) 2012-10-01 2018-03-12 Adaptive Biotechnologies Corp Immune competence evaluation of adaptive immune receptor diversity and clonality characterization
CN105209634B (zh) 2013-03-08 2020-05-12 牛津纳米孔技术公司 酶停滞方法
GB201314695D0 (en) 2013-08-16 2013-10-02 Oxford Nanopore Tech Ltd Method
US9879313B2 (en) 2013-06-25 2018-01-30 Prognosys Biosciences, Inc. Methods and systems for determining spatial patterns of biological targets in a sample
US9708657B2 (en) 2013-07-01 2017-07-18 Adaptive Biotechnologies Corp. Method for generating clonotype profiles using sequence tags
AU2015227054A1 (en) 2014-03-05 2016-09-22 Adaptive Biotechnologies Corporation Methods using randomer-containing synthetic molecules
US11390921B2 (en) 2014-04-01 2022-07-19 Adaptive Biotechnologies Corporation Determining WT-1 specific T cells and WT-1 specific T cell receptors (TCRs)
US10066265B2 (en) 2014-04-01 2018-09-04 Adaptive Biotechnologies Corp. Determining antigen-specific t-cells
EP3132059B1 (en) 2014-04-17 2020-01-08 Adaptive Biotechnologies Corporation Quantification of adaptive immune cell genomes in a complex mixture of cells
GB201418159D0 (en) 2014-10-14 2014-11-26 Oxford Nanopore Tech Ltd Method
ES2784343T3 (es) 2014-10-29 2020-09-24 Adaptive Biotechnologies Corp Detección simultánea altamente multiplexada de ácidos nucleicos que codifican heterodímeros de receptores inmunes adaptativos emparejados de muchas muestras
US10246701B2 (en) 2014-11-14 2019-04-02 Adaptive Biotechnologies Corp. Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture
AU2015353581A1 (en) 2014-11-25 2017-06-15 Adaptive Biotechnologies Corporation Characterization of adaptive immune response to vaccination or infection using immune repertoire sequencing
EP3262196B1 (en) 2015-02-24 2020-12-09 Adaptive Biotechnologies Corp. Method for determining hla status using immune repertoire sequencing
EP3277294B1 (en) 2015-04-01 2024-05-15 Adaptive Biotechnologies Corp. Method of identifying human compatible t cell receptors specific for an antigenic target
EP4119677B1 (en) 2015-04-10 2023-06-28 Spatial Transcriptomics AB Spatially distinguished, multiplex nucleic acid analysis of biological specimens
ES2911421T3 (es) 2015-12-08 2022-05-19 Twinstrand Biosciences Inc Adaptadores, métodos y composiciones mejorados para secuenciación dúplex
CN105441572B (zh) * 2016-01-07 2019-10-22 南京中医药大学 鉴别当归早薹的dna分子标记及其应用
GB201609220D0 (en) 2016-05-25 2016-07-06 Oxford Nanopore Tech Ltd Method
JP7343264B2 (ja) * 2016-06-29 2023-09-12 トヨタ自動車株式会社 Dnaライブラリーの作製方法及びdnaライブラリーを用いたゲノムdna解析方法
JP6515884B2 (ja) 2016-06-29 2019-05-22 トヨタ自動車株式会社 Dnaプローブの作製方法及びdnaプローブを用いたゲノムdna解析方法
US10428325B1 (en) 2016-09-21 2019-10-01 Adaptive Biotechnologies Corporation Identification of antigen-specific B cell receptors
EP3601611B1 (en) * 2017-03-24 2022-01-05 Life Technologies Corporation Polynucleotide adapters and methods of use thereof
WO2018183942A1 (en) 2017-03-31 2018-10-04 Grail, Inc. Improved library preparation and use thereof for sequencing-based error correction and/or variant identification
JP7056012B2 (ja) 2017-05-19 2022-04-19 トヨタ自動車株式会社 ランダムプライマーセット、及びこれを用いたdnaライブラリーの作製方法
SG11202003885UA (en) 2017-11-08 2020-05-28 Twinstrand Biosciences Inc Reagents and adapters for nucleic acid sequencing and methods for making such reagents and adapters
US11254980B1 (en) 2017-11-29 2022-02-22 Adaptive Biotechnologies Corporation Methods of profiling targeted polynucleotides while mitigating sequencing depth requirements
WO2019121603A1 (en) 2017-12-18 2019-06-27 Keygene N.V. Chemical mutagenesis of cassava
JP7047373B2 (ja) 2017-12-25 2022-04-05 トヨタ自動車株式会社 次世代シーケンサー用プライマー並びにその製造方法、次世代シーケンサー用プライマーを用いたdnaライブラリー並びにその製造方法、及びdnaライブラリーを用いたゲノムdna解析方法
GB201807793D0 (en) 2018-05-14 2018-06-27 Oxford Nanopore Tech Ltd Method
BR112021000409A2 (pt) 2018-07-12 2021-04-06 Twinstrand Biosciences, Inc. Métodos e reagentes para caracterizar edição genômica, expansão clonal e aplicações associadas
US11519033B2 (en) 2018-08-28 2022-12-06 10X Genomics, Inc. Method for transposase-mediated spatial tagging and analyzing genomic DNA in a biological sample
US20220025447A1 (en) 2018-12-10 2022-01-27 10X Genomics, Inc. Generating spatial arrays with gradients
US11926867B2 (en) 2019-01-06 2024-03-12 10X Genomics, Inc. Generating capture probes for spatial analysis
US11649485B2 (en) 2019-01-06 2023-05-16 10X Genomics, Inc. Generating capture probes for spatial analysis
CN113474466A (zh) 2019-02-21 2021-10-01 主基因有限公司 多倍体基因分型
WO2020243579A1 (en) 2019-05-30 2020-12-03 10X Genomics, Inc. Methods of detecting spatial heterogeneity of a biological sample
EP4055185A1 (en) 2019-11-08 2022-09-14 10X Genomics, Inc. Spatially-tagged analyte capture agents for analyte multiplexing
WO2021092433A2 (en) 2019-11-08 2021-05-14 10X Genomics, Inc. Enhancing specificity of analyte binding
EP4073245A1 (en) 2019-12-12 2022-10-19 Keygene N.V. Semi-solid state nucleic acid manipulation
EP4077661A1 (en) 2019-12-20 2022-10-26 Keygene N.V. Ngs library preparation using covalently closed nucleic acid molecule ends
EP3891300B1 (en) 2019-12-23 2023-03-29 10X Genomics, Inc. Methods for spatial analysis using rna-templated ligation
US11702693B2 (en) 2020-01-21 2023-07-18 10X Genomics, Inc. Methods for printing cells and generating arrays of barcoded cells
US11732299B2 (en) 2020-01-21 2023-08-22 10X Genomics, Inc. Spatial assays with perturbed cells
US11821035B1 (en) 2020-01-29 2023-11-21 10X Genomics, Inc. Compositions and methods of making gene expression libraries
US11898205B2 (en) 2020-02-03 2024-02-13 10X Genomics, Inc. Increasing capture efficiency of spatial assays
US11732300B2 (en) 2020-02-05 2023-08-22 10X Genomics, Inc. Increasing efficiency of spatial analysis in a biological sample
US11835462B2 (en) 2020-02-11 2023-12-05 10X Genomics, Inc. Methods and compositions for partitioning a biological sample
US11211144B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Methods and systems for refining copy number variation in a liquid biopsy assay
US11211147B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing
US11475981B2 (en) 2020-02-18 2022-10-18 Tempus Labs, Inc. Methods and systems for dynamic variant thresholding in a liquid biopsy assay
US11891654B2 (en) 2020-02-24 2024-02-06 10X Genomics, Inc. Methods of making gene expression libraries
US11926863B1 (en) 2020-02-27 2024-03-12 10X Genomics, Inc. Solid state single cell method for analyzing fixed biological cells
US11768175B1 (en) 2020-03-04 2023-09-26 10X Genomics, Inc. Electrophoretic methods for spatial analysis
CN111304341A (zh) * 2020-04-10 2020-06-19 西北民族大学 一种鉴定食品中猪源性成分的pcr-aflp方法
ES2965354T3 (es) 2020-04-22 2024-04-12 10X Genomics Inc Métodos para análisis espacial que usan eliminación de ARN elegido como diana
WO2021237087A1 (en) 2020-05-22 2021-11-25 10X Genomics, Inc. Spatial analysis to detect sequence variants
EP4153775A1 (en) 2020-05-22 2023-03-29 10X Genomics, Inc. Simultaneous spatio-temporal measurement of gene expression and cellular activity
WO2021242834A1 (en) 2020-05-26 2021-12-02 10X Genomics, Inc. Method for resetting an array
AU2021283174A1 (en) 2020-06-02 2023-01-05 10X Genomics, Inc. Nucleic acid library methods
CN116249785A (zh) 2020-06-02 2023-06-09 10X基因组学有限公司 用于抗原-受体的空间转录组学
EP4162074B1 (en) 2020-06-08 2024-04-24 10X Genomics, Inc. Methods of determining a surgical margin and methods of use thereof
EP4165207A1 (en) 2020-06-10 2023-04-19 10X Genomics, Inc. Methods for determining a location of an analyte in a biological sample
AU2021294334A1 (en) 2020-06-25 2023-02-02 10X Genomics, Inc. Spatial analysis of DNA methylation
US11981960B1 (en) 2020-07-06 2024-05-14 10X Genomics, Inc. Spatial analysis utilizing degradable hydrogels
US11761038B1 (en) 2020-07-06 2023-09-19 10X Genomics, Inc. Methods for identifying a location of an RNA in a biological sample
US11981958B1 (en) 2020-08-20 2024-05-14 10X Genomics, Inc. Methods for spatial analysis using DNA capture
US11926822B1 (en) 2020-09-23 2024-03-12 10X Genomics, Inc. Three-dimensional spatial analysis
US11827935B1 (en) 2020-11-19 2023-11-28 10X Genomics, Inc. Methods for spatial analysis using rolling circle amplification and detection probes
EP4121555A1 (en) 2020-12-21 2023-01-25 10X Genomics, Inc. Methods, compositions, and systems for capturing probes and/or barcodes
AU2022238446A1 (en) 2021-03-18 2023-09-07 10X Genomics, Inc. Multiplex capture of gene and protein expression from a biological sample
EP4196605A1 (en) 2021-09-01 2023-06-21 10X Genomics, Inc. Methods, compositions, and kits for blocking a capture probe on a spatial array
WO2024121354A1 (en) 2022-12-08 2024-06-13 Keygene N.V. Duplex sequencing with covalently closed dna ends

Family Cites Families (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04504356A (ja) 1989-01-31 1992-08-06 ユニバーシティ オブ マイアミ 染色体dnaの顕微解剖と増幅
US20100267023A1 (en) * 1992-09-24 2010-10-21 Keygene N.V. Selective restriction fragment amplification: fingerprinting
ZA927323B (en) 1991-09-24 1993-08-30 Keygene Nv Selective restriction fragment amplification: A general method for DNA fingerprinting
AU1682595A (en) 1994-01-21 1995-08-08 North Carolina State University Methods for within family selection in woody perennials using genetic markers
EG23907A (en) 1994-08-01 2007-12-30 Delta & Pine Land Co Control of plant gene expression
US6013445A (en) 1996-06-06 2000-01-11 Lynx Therapeutics, Inc. Massively parallel signature sequencing by ligation of encoded adaptors
JPH10509594A (ja) * 1994-11-28 1998-09-22 イー・アイ・デユポン・ドウ・ヌムール・アンド・カンパニー 遺伝的多型の検出のための複合ミクロサテライトプライマー
US5565340A (en) 1995-01-27 1996-10-15 Clontech Laboratories, Inc. Method for suppressing DNA fragment amplification during PCR
AU6024598A (en) * 1997-01-10 1998-08-03 Pioneer Hi-Bred International, Inc. Hybridization-based genetic amplification and analysis
US6090556A (en) 1997-04-07 2000-07-18 Japan Science & Technology Corporation Method for quantitatively determining the expression of a gene
DK0981609T3 (da) 1997-05-13 2001-11-12 Azign Bioscience As Fremgangsmåde til kloning af mRNA'er og display af differentielt udtrykte transkripter (DODET)
DE69838210T2 (de) 1997-12-15 2008-05-15 Csl Behring Gmbh Markierter Primer, geeignet für die Detektion von Nukleinsäuren
CA2273616A1 (en) 1998-06-08 1999-12-08 The Board Of Trustees Of The Leland Stanford Junior University Method for parallel screening of allelic variation
DE69816286T2 (de) 1998-07-29 2004-05-27 Keygene N.V. Verfahren zur Erkennung von Nukleinsäuremethylierungen durch AFLP
JP2002521064A (ja) 1998-07-30 2002-07-16 ソレックサ リミテッド アレイ生体分子およびシークエンシングにおけるその使用
GB0002310D0 (en) 2000-02-01 2000-03-22 Solexa Ltd Polynucleotide sequencing
US6232067B1 (en) * 1998-08-17 2001-05-15 The Perkin-Elmer Corporation Adapter directed expression analysis
US6703228B1 (en) 1998-09-25 2004-03-09 Massachusetts Institute Of Technology Methods and products related to genotyping and DNA analysis
EP1001037A3 (en) 1998-09-28 2003-10-01 Whitehead Institute For Biomedical Research Pre-selection and isolation of single nucleotide polymorphisms
AU2144000A (en) 1998-10-27 2000-05-15 Affymetrix, Inc. Complexity management and analysis of genomic dna
US6480791B1 (en) 1998-10-28 2002-11-12 Michael P. Strathmann Parallel methods for genomic analysis
CA2348696A1 (en) 1998-11-06 2000-05-18 Solexa Ltd. A method for reproducing molecular arrays
EP1141384A2 (en) 1999-01-06 2001-10-10 Cornell Research Foundation, Inc. Method for accelerating identification of single nucleotide polymorphisms and alignment of clones in genomic sequencing
US20040029155A1 (en) 1999-01-08 2004-02-12 Curagen Corporation Method for identifying a biomolecule
DE19911130A1 (de) 1999-03-12 2000-09-21 Hager Joerg Verfahren zur Identifikation chromosomaler Regionen und Gene
AU3567900A (en) 1999-03-30 2000-10-16 Solexa Ltd. Polynucleotide sequencing
EP1190092A2 (en) * 1999-04-06 2002-03-27 Yale University Fixed address analysis of sequence tags
AU773855B2 (en) 1999-04-09 2004-06-10 Keygene N.V. Method for the analysis of AFLP reaction mixtures using primer extension techniques
US20020119448A1 (en) 1999-06-23 2002-08-29 Joseph A. Sorge Methods of enriching for and identifying polymorphisms
US20030204075A9 (en) 1999-08-09 2003-10-30 The Snp Consortium Identification and mapping of single nucleotide polymorphisms in the human genome
AU7712400A (en) 1999-09-23 2001-04-24 Gene Logic, Inc. Indexing populations
EP1218543A2 (en) 1999-09-29 2002-07-03 Solexa Ltd. Polynucleotide sequencing
US6287778B1 (en) 1999-10-19 2001-09-11 Affymetrix, Inc. Allele detection using primer extension with sequence-coded identity tags
US6958225B2 (en) 1999-10-27 2005-10-25 Affymetrix, Inc. Complexity management of genomic DNA
WO2001038572A1 (fr) 1999-11-19 2001-05-31 Takara Bio Inc. Methode d'amplification d'acides nucleiques
GB0002389D0 (en) 2000-02-02 2000-03-22 Solexa Ltd Molecular arrays
AU2001253063A1 (en) 2000-03-31 2001-10-15 Fred Hutchinson Cancer Research Center Reverse genetic strategy for identifying functional mutations in genes of known sequence
WO2001088189A2 (en) 2000-05-15 2001-11-22 Keygene N.V. Microsatellite-aflp®
US7300751B2 (en) 2000-06-30 2007-11-27 Syngenta Participations Ag Method for identification of genetic markers
AU2002246612B2 (en) 2000-10-24 2007-11-01 The Board Of Trustees Of The Leland Stanford Junior University Direct multiplex characterization of genomic DNA
GB2389904A (en) 2001-01-30 2003-12-24 Solexa Ltd Arrayed polynucleotides and their use in genome analysis
US20040053236A1 (en) * 2001-03-30 2004-03-18 Mccallum Claire M. Reverse genetic strategy for identifying functional mutations in genes of known sequences
EP1386005A1 (en) 2001-04-20 2004-02-04 Karolinska Innovations AB Methods for high throughput genome analysis using restriction site tagged microarrays
US20050009022A1 (en) 2001-07-06 2005-01-13 Weiner Michael P. Method for isolation of independent, parallel chemical micro-reactions using a porous filter
GB0119719D0 (en) 2001-08-13 2001-10-03 Solexa Ltd DNA sequence analysis
US6902921B2 (en) 2001-10-30 2005-06-07 454 Corporation Sulfurylase-luciferase fusion proteins and thermostable sulfurylase
US7057026B2 (en) 2001-12-04 2006-06-06 Solexa Limited Labelled nucleotides
US6815167B2 (en) 2002-04-25 2004-11-09 Geneohm Sciences Amplification of DNA to produce single-stranded product of defined sequence and length
US20070065816A1 (en) 2002-05-17 2007-03-22 Affymetrix, Inc. Methods for genotyping
US7108976B2 (en) 2002-06-17 2006-09-19 Affymetrix, Inc. Complexity management of genomic DNA by locus specific amplification
US20040086912A1 (en) * 2002-06-21 2004-05-06 Shujun Luo Method for detecting foreign DNA in a host Genome
EP2119722B1 (en) 2002-08-23 2016-10-26 Illumina Cambridge Limited Labelled nucleotides
SI3587433T1 (sl) 2002-08-23 2020-08-31 Illumina Cambridge Limited Modificirani nukleotidi
US20060281082A1 (en) 2002-09-05 2006-12-14 Jiahui Zhu Genome partitioning
US20040157238A1 (en) 2002-09-20 2004-08-12 Quinn John J. Method for detection of multiple nucleic acid sequence variations
DE60331852D1 (de) 2002-12-02 2010-05-06 Illumina Cambridge Ltd Bestimmung der methylierung von nukleinsäuresequenzen
EP1573009B1 (en) 2002-12-18 2011-09-21 Third Wave Technologies, Inc. Detection of small nucleic acids
JP2004208586A (ja) 2002-12-27 2004-07-29 Wakunaga Pharmaceut Co Ltd Hlaの検出
WO2004063323A2 (en) 2003-01-10 2004-07-29 Keygene N.V. Aflp-based method for integrating physical and genetic maps
JP4480715B2 (ja) 2003-01-29 2010-06-16 454 コーポレーション 二重末端シーケンシング
CN103289893B (zh) 2003-02-26 2015-11-18 凯利达基因组股份有限公司 通过杂交进行的随机阵列dna分析
GB0304371D0 (en) 2003-02-26 2003-04-02 Solexa Ltd DNA Sequence analysis
JP4888876B2 (ja) 2003-06-13 2012-02-29 田平 武 アルツハイマー病の治療のための組換えアデノ随伴ウィルスベクター
GB0320059D0 (en) 2003-08-27 2003-10-01 Solexa Ltd A method of sequencing
US7365179B2 (en) 2003-09-09 2008-04-29 Compass Genetics, Llc Multiplexed analytical platform
US20050153317A1 (en) 2003-10-24 2005-07-14 Metamorphix, Inc. Methods and systems for inferring traits to breed and manage non-beef livestock
GB0326073D0 (en) 2003-11-07 2003-12-10 Solexa Ltd Improvements in or relating to polynucleotide arrays
WO2005065814A1 (en) * 2004-01-07 2005-07-21 Solexa Limited Modified molecular arrays
GB0400584D0 (en) 2004-01-12 2004-02-11 Solexa Ltd Nucleic acid chacterisation
GB0400974D0 (en) 2004-01-16 2004-02-18 Solexa Ltd Multiple inexact matching
US20050233354A1 (en) * 2004-01-22 2005-10-20 Affymetrix, Inc. Genotyping degraded or mitochandrial DNA samples
GB0402895D0 (en) 2004-02-10 2004-03-17 Solexa Ltd Arrayed polynucleotides
US7217522B2 (en) 2004-02-12 2007-05-15 Campass Genetics Llc Genetic analysis by sequence-specific sorting
WO2006019407A2 (en) 2004-02-18 2006-02-23 The Trustees Of Boston University Method for detecting and quantifying rare mutations/polymorphisms
EP1574585A1 (en) 2004-03-12 2005-09-14 Plant Research International B.V. Method for selective amplification of DNA fragments for genetic fingerprinting
US7220549B2 (en) 2004-12-30 2007-05-22 Helicos Biosciences Corporation Stabilizing a nucleic acid for nucleic acid sequencing
US7407757B2 (en) 2005-02-10 2008-08-05 Population Genetics Technologies Genetic analysis by sequence-specific sorting
US7393665B2 (en) 2005-02-10 2008-07-01 Population Genetics Technologies Ltd Methods and compositions for tagging and identifying polynucleotides
DK1885882T3 (da) 2005-05-10 2011-04-11 State Of Oregon Acting By & Through The State Board Of Higher Eduction On Behalf Of The University O Fremgangsmåder til kortlægning af polymorfier og polymorfi-mikroarray
ES2387878T3 (es) * 2005-06-23 2012-10-03 Keygene N.V. Estrategias para la identificación de alto rendimiento y la detección de polimorfismos
US20090142758A1 (en) 2005-06-23 2009-06-04 Keygene N V Strategies for sequencing complex genomes using high throughput sequencing technologies
US20070020640A1 (en) 2005-07-21 2007-01-25 Mccloskey Megan L Molecular encoding of nucleic acid templates for PCR and other forms of sequence analysis
ATE453728T1 (de) 2005-09-29 2010-01-15 Keygene Nv Screening mutagenisierter populationen mit hohem durchsatz
EP1960541B1 (en) 2005-11-14 2013-04-24 Keygene N.V. Method for high throughput screening of transposon tagging populations and massive parallel sequence identification of insertion sites
US7537897B2 (en) 2006-01-23 2009-05-26 Population Genetics Technologies, Ltd. Molecular counting

Also Published As

Publication number Publication date
US20180291439A1 (en) 2018-10-11
EP3239304A1 (en) 2017-11-01
US20200181694A1 (en) 2020-06-11
EP2002017B1 (en) 2015-06-10
US20120202698A1 (en) 2012-08-09
HK1219761A1 (zh) 2017-04-13
WO2007114693A3 (en) 2007-12-21
US10023907B2 (en) 2018-07-17
US20140303007A1 (en) 2014-10-09
WO2007114693A2 (en) 2007-10-11
DK2002017T3 (en) 2015-09-07
US20120135871A1 (en) 2012-05-31
ES2645661T3 (es) 2017-12-07
JP2009536817A (ja) 2009-10-22
EP2963127B1 (en) 2017-08-16
JP2013215212A (ja) 2013-10-24
US20090253581A1 (en) 2009-10-08
ES2545264T3 (es) 2015-09-09
EP2002017A2 (en) 2008-12-17
EP2963127A1 (en) 2016-01-06
ES2829295T3 (es) 2021-05-31
HK1244301A1 (zh) 2018-08-03
EP3239304B1 (en) 2020-08-19
JP5389638B2 (ja) 2014-01-15
PL2963127T3 (pl) 2018-01-31
DK3239304T3 (da) 2020-10-26

Similar Documents

Publication Publication Date Title
HK1219761A1 (zh) 基於限制酶斷片的分子標記的高通量檢測
EG24917A (en) Hydrocarbon gas processing
BRPI0717082A2 (pt) Processamento de gás de hidrocarboneto
EP2100114A4 (en) Impact detection system
GB0621625D0 (en) Location detection
EP2069779A4 (en) Multi-detector gas identification system
GB0821683D0 (en) Spsis detection microarray
ZA200810140B (en) Detection Method
GB0512743D0 (en) Range detection
EP2097740A4 (en) DETECTION SYSTEM
PL2140269T3 (pl) Podpis białkowy/znaczniki do wykrywania gruczolakoraka
IL197543A0 (en) Molecular switches and methods for their use
EP2041689A4 (en) ANOMALY DETECTION
GB0624148D0 (en) Detection method
EP2076417A4 (en) ROAD EXIT DETECTION SYSTEM
GB0625478D0 (en) Detection apparatus
GB0610045D0 (en) Improved uracil-excision based molecular cloning
GB0603190D0 (en) Detection system
GB0621990D0 (en) Detection
GB0618669D0 (en) Detection
EP2100122A4 (en) POLY (ETHYLENE GLYCOL) ASSAYS FOR DETECTION OF ANTIBODIES AND KITS FOR CARRYING OUT SAID ASSAYS
GB0502144D0 (en) Detection apparatus
GB2444145B (en) Temperature detection
DE502006001236D1 (de) Schaltung zur Kurzschluss- bzw. Überstromerkennung
PL2082215T3 (pl) System do diagnostyki molekularnej