PT2483274E - Agentes antimaláricos que são inibidores de di-hidro-orotato desidrogenase - Google Patents

Agentes antimaláricos que são inibidores de di-hidro-orotato desidrogenase Download PDF

Info

Publication number: PT2483274E
Authority: PT; Portugal
Prior art keywords: inhibitors; dihydroorotate dehydrogenase; antimalarial agents; antimalarial; agents
Prior art date: 2009-09-29

Application number

PT108211053T

Other languages

English (en)

Original Assignee

Univ Texas

Univ Washington

Univ Monash

Glaxosmithkline Investigacion Y Desarrollo S L

Medicines For Malaria Venture Mmv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-09-29

Filing date

2010-09-28

Publication date

2015-02-04

2010-09-28 Application filed by Univ Texas, Univ Washington, Univ Monash, Glaxosmithkline Investigacion Y Desarrollo S L, Medicines For Malaria Venture Mmv filed Critical Univ Texas

2015-02-04 Publication of PT2483274E publication Critical patent/PT2483274E/pt

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

PT108211053T 2009-09-29 2010-09-28 Agentes antimaláricos que são inibidores de di-hidro-orotato desidrogenase PT2483274E (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US24686309P	2009-09-29	2009-09-29

Publications (1)

Publication Number	Publication Date
PT2483274E true PT2483274E (pt)	2015-02-04

Family

ID=43826848

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT108211053T PT2483274E (pt)	2009-09-29	2010-09-28	Agentes antimaláricos que são inibidores de di-hidro-orotato desidrogenase

Country Status (16)

Country	Link
US (1)	US9238653B2 (pt)
EP (1)	EP2483274B1 (pt)
JP (1)	JP5818266B2 (pt)
CN (1)	CN102741255B (pt)
BR (1)	BR112012007179B8 (pt)
CA (1)	CA2775354C (pt)
DK (1)	DK2483274T3 (pt)
ES (1)	ES2527835T3 (pt)
HK (1)	HK1174639A1 (pt)
HR (1)	HRP20150066T1 (pt)
ME (1)	ME02020B (pt)
PL (1)	PL2483274T3 (pt)
PT (1)	PT2483274E (pt)
SI (1)	SI2483274T1 (pt)
SM (1)	SMT201500071B (pt)
WO (1)	WO2011041304A2 (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TN2016000253A1 (en) *	2013-12-19	2017-10-06	Novartis Ag	[1,2,4]triazolo[1,5-a]pyrimidine derivatives as protozoan proteasome inhibitors for the treatment of parasitic diseases such as leishmaniasis.
EP3072894A1 (en)	2015-03-26	2016-09-28	Board Of Regents Of the University Of Texas System	New substituted triazolopyrimidines as anti-malarial agents
EP3254679A1 (de)	2016-06-09	2017-12-13	Christian-Albrechts-Universität zu Kiel	Wirkstoffe gegen protozoen und bakterien
WO2018071282A1 (en) *	2016-10-12	2018-04-19	Merck Sharp & Dohme Corp.	Kdm5 inhibitors
US11690847B2 (en)	2016-11-30	2023-07-04	Case Western Reserve University	Combinations of 15-PGDH inhibitors with corticosteroids and/or TNF inhibitors and uses thereof
AU2018215678A1 (en) *	2017-02-06	2019-08-22	Board Of Regents Of The University Of Texas System	Compositions and methods of modulating short-chain dehydrogenase activity
CN110891568A (zh)	2017-04-07	2020-03-17	凯斯西储大学	用于治疗冠状动脉病症的短链脱氢酶活性的抑制剂
EP3842100A1 (en) *	2019-12-24	2021-06-30	The Board Of Regents Of The University Of Texas System	Anti-malarial agents

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU208693B (en)	1991-02-22	1993-12-28	Egyt Gyogyszervegyeszeti Gyar	Process for producing 1,2,4-triazolo (1,5-a) pyrimidinis derivatives and their carbicycli-tetrahydro-thiofurane-tetrahydrothiopyrane-, or tetrahydropyridine- condensated derivatives or medical preparatives containing them
US5478825A (en)	1991-02-22	1995-12-26	Egis Gyogyszergyar	5-(substituted amino)-1,2,4-triazolo (1,5-A) pyrimidine derivatives
US8490825B2 (en)	1999-12-08	2013-07-23	Metal Container Corporation	Can lid closure and method of joining a can lid closure to a can body
CZ294535B6 (cs) *	2001-08-02	2005-01-12	Ústav Experimentální Botaniky Avčr	Heterocyklické sloučeniny na bázi N6-substituovaného adeninu, způsoby jejich přípravy, jejich použití pro přípravu léčiv, kosmetických přípravků a růstových regulátorů, farmaceutické přípravky, kosmetické přípravky a růstové regulátory tyto sloučeniny obsahující
WO2007149211A1 (en) *	2006-06-22	2007-12-27	Board Of Regents, University Of Texas System	Dihydroorotate dehydrogenase inhibitors with selective anti-malarial activity
CN101622001A (zh) *	2007-01-26	2010-01-06	Irm责任有限公司	作为激酶抑制剂用于治疗疟原虫相关疾病的嘌呤化合物和组合物
US9216983B2 (en)	2007-12-21	2015-12-22	Board Of Regents, University Of Texas System	Dihydroorotate dehydrogenase inhibitors with selective anti-malarial activity

2010
- 2010-09-28 JP JP2012532236A patent/JP5818266B2/ja not_active Expired - Fee Related
- 2010-09-28 EP EP10821105.3A patent/EP2483274B1/en active Active
- 2010-09-28 US US13/499,031 patent/US9238653B2/en not_active Expired - Fee Related
- 2010-09-28 PT PT108211053T patent/PT2483274E/pt unknown
- 2010-09-28 PL PL10821105T patent/PL2483274T3/pl unknown
- 2010-09-28 BR BR112012007179A patent/BR112012007179B8/pt not_active IP Right Cessation
- 2010-09-28 WO PCT/US2010/050532 patent/WO2011041304A2/en active Application Filing
- 2010-09-28 ES ES10821105.3T patent/ES2527835T3/es active Active
- 2010-09-28 DK DK10821105.3T patent/DK2483274T3/en active
- 2010-09-28 CA CA2775354A patent/CA2775354C/en not_active Expired - Fee Related
- 2010-09-28 SI SI201030853T patent/SI2483274T1/sl unknown
- 2010-09-28 ME MEP-2015-8A patent/ME02020B/me unknown
- 2010-09-28 CN CN201080043385.XA patent/CN102741255B/zh not_active Expired - Fee Related
2013
- 2013-02-15 HK HK13101950.1A patent/HK1174639A1/xx not_active IP Right Cessation
2015
- 2015-01-19 HR HRP20150066AT patent/HRP20150066T1/hr unknown
- 2015-03-18 SM SM201500071T patent/SMT201500071B/xx unknown

Also Published As

Publication number	Publication date
EP2483274B1 (en)	2014-10-29
ME02020B (me)	2015-05-20
ES2527835T3 (es)	2015-01-30
HK1174639A1 (en)	2013-06-14
PL2483274T3 (pl)	2015-04-30
SI2483274T1 (sl)	2015-02-27
CN102741255B (zh)	2015-10-07
CN102741255A (zh)	2012-10-17
HRP20150066T1 (hr)	2015-02-27
CA2775354A1 (en)	2011-04-07
JP5818266B2 (ja)	2015-11-18
WO2011041304A2 (en)	2011-04-07
DK2483274T3 (en)	2015-01-19
SMT201500071B (it)	2015-05-05
BR112012007179A8 (pt)	2018-01-23
CA2775354C (en)	2019-01-15
US9238653B2 (en)	2016-01-19
EP2483274A2 (en)	2012-08-08
EP2483274A4 (en)	2013-03-06
BR112012007179A2 (pt)	2017-07-25
WO2011041304A3 (en)	2011-08-04
BR112012007179B8 (pt)	2021-05-25
JP2013506004A (ja)	2013-02-21
US20120302586A1 (en)	2012-11-29
BR112012007179B1 (pt)	2020-12-01

Publication	Publication Date	Title
SG10201401169QA (en)	2014-05-29	Dihydroorotate dehydrogenase inhibitors
ZA201206424B (en)	2013-06-26	Inhibitors of semicarabazide-sensitive amine oxidase
HK1174639A1 (en)	2013-06-14	Antimalarial agents that are inhibitors of dihydroorotate dehydrogenase
EP2678018A4 (en)	2015-09-30	COMBINATION OF CHINESE HEMMER AND USES THEREOF
ZA201000318B (en)	2010-10-27	Inhibitors of 11b-hydroxysteroid dehydrogenase
ZA201307331B (en)	2015-01-28	Herbicidal composition comprising plazasulfuron and an inhibitor of protoporphyrinogen oxidase
IL220956A (en)	2015-09-24	Inhibitors of s-nitrosoglutathione reductase
PL2389352T3 (pl)	2019-10-31	Inhibitory arginazy oraz sposoby zastosowania
HK1200029A1 (en)	2015-07-31	Nadph oxidase 4 inhibitors and use thereof nadph 4
HK1159102A1 (en)	2012-07-27	Inhibitors of ssao activity ssao
ZA201206456B (en)	2013-05-29	Uses of dgati inhibitors
ZA201104146B (en)	2012-08-29	Dispersions comprising inhibitors of the hydroxyphenylpyruvate-dioxygenase
HK1167999A1 (en)	2012-12-21	Lysosomotropic inhibitors of acid ceramidase
HK1171624A1 (en)	2013-04-05	Inhibitors of cognitive decline
HK1167323A1 (en)	2013-01-04	Inhibitors of cognitive decline
EP2635287A4 (en)	2014-06-04	NEDD8 ACTIVATOR ENZYME INHIBITOR ADMINISTRATION
EP2688901A4 (en)	2015-04-15	INHIBITORS OF 17SS-HSD1, 17SS-HSD3 AND 17SS-HSD10
IL217756A0 (en)	2012-03-29	Inhibitors of jnk
EP2616057A4 (en)	2014-03-12	COMBINATION OF B-RAF AND VEGFR INHIBITORS
PL2411376T3 (pl)	2015-10-30	Inhibitory nf-kb
IL215486A0 (en)	2011-12-29	Compositions of cholinesterase inhibitors
LU91725B1 (en)	2012-03-05	Novel uses of V-ATPASE inhibitors
GB0908609D0 (en)	2009-06-24	New use of isoQC inhibitors
GB201012144D0 (en)	2010-09-01	P13K inhibitors and uses thereof
GB201009704D0 (en)	2010-07-21	P13K inhibitors and uses thereof