BR112012007179A8 - composto, composição farmacêutica, e método para inibir di-hidro-orotato desidrogenase em um parasita - Google Patents

composto, composição farmacêutica, e método para inibir di-hidro-orotato desidrogenase em um parasita

Info

Publication number
BR112012007179A8
BR112012007179A8 BR112012007179A BR112012007179A BR112012007179A8 BR 112012007179 A8 BR112012007179 A8 BR 112012007179A8 BR 112012007179 A BR112012007179 A BR 112012007179A BR 112012007179 A BR112012007179 A BR 112012007179A BR 112012007179 A8 BR112012007179 A8 BR 112012007179A8
Authority
BR
Brazil
Prior art keywords
compound
parasite
dihydroorotate dehydrogenase
pharmaceutical composition
inhibiting dihydroorotate
Prior art date
Application number
BR112012007179A
Other languages
English (en)
Other versions
BR112012007179A2 (pt
BR112012007179B1 (pt
BR112012007179B8 (pt
Inventor
Marwaha Alka
Floyd David
Matthews David
Burrows Jeremy
Coteron-Lopez Jose
Phillips Margaret
K Rathod Pradipsinh
Gujjar Ramesh
A Charman Susan
Original Assignee
Univ Texas
Glaxosmithkline Investig Y Desarrolo S L
Medicines Malaria Venture Mmv
Univ Monash
Univ Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Texas, Glaxosmithkline Investig Y Desarrolo S L, Medicines Malaria Venture Mmv, Univ Monash, Univ Washington filed Critical Univ Texas
Publication of BR112012007179A2 publication Critical patent/BR112012007179A2/pt
Publication of BR112012007179A8 publication Critical patent/BR112012007179A8/pt
Publication of BR112012007179B1 publication Critical patent/BR112012007179B1/pt
Publication of BR112012007179B8 publication Critical patent/BR112012007179B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

composto, composição farmacêutica, e, método para inibir di-hidro-orotato desidrogenase em um parasita. inibidores de enzima de di-hidro-orotato desidrogenase (dhod) parasítica são terapêuticos candidatos para tratar a malária. ilustrativo de tais agentes terapêuticos incluem o composto: e uma classe de triazolopiridina de composto que se conformam com a fórmula ix: e seus solvatos, estereoisômeros, tautômeros e sais farmaceuticamente aceitáveis.
BR112012007179A 2009-09-29 2010-09-28 composto inibidor da di-hidro-orotato desidrogenase, e, formulação farmacêutica BR112012007179B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24686309P 2009-09-29 2009-09-29
US61/246863 2009-09-29
PCT/US2010/050532 WO2011041304A2 (en) 2009-09-29 2010-09-28 Antimalarial agents that are inhibitors of dihydroorotate dehydrogenase

Publications (4)

Publication Number Publication Date
BR112012007179A2 BR112012007179A2 (pt) 2017-07-25
BR112012007179A8 true BR112012007179A8 (pt) 2018-01-23
BR112012007179B1 BR112012007179B1 (pt) 2020-12-01
BR112012007179B8 BR112012007179B8 (pt) 2021-05-25

Family

ID=43826848

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012007179A BR112012007179B8 (pt) 2009-09-29 2010-09-28 composto inibidor da di-hidro-orotato desidrogenase, e, formulação farmacêutica

Country Status (16)

Country Link
US (1) US9238653B2 (pt)
EP (1) EP2483274B1 (pt)
JP (1) JP5818266B2 (pt)
CN (1) CN102741255B (pt)
BR (1) BR112012007179B8 (pt)
CA (1) CA2775354C (pt)
DK (1) DK2483274T3 (pt)
ES (1) ES2527835T3 (pt)
HK (1) HK1174639A1 (pt)
HR (1) HRP20150066T1 (pt)
ME (1) ME02020B (pt)
PL (1) PL2483274T3 (pt)
PT (1) PT2483274E (pt)
SI (1) SI2483274T1 (pt)
SM (1) SMT201500071B (pt)
WO (1) WO2011041304A2 (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT3083627T (lt) * 2013-12-19 2018-12-27 Novartis Ag [1,2,4]triazolo[1,5-a]pirimidino dariniai kaip protozoano proteasomos inhibitoriai, skirti parazitinių ligų tokių kaip leišmaniozė, gydymui
EP3072894A1 (en) 2015-03-26 2016-09-28 Board Of Regents Of the University Of Texas System New substituted triazolopyrimidines as anti-malarial agents
EP3254679A1 (de) 2016-06-09 2017-12-13 Christian-Albrechts-Universität zu Kiel Wirkstoffe gegen protozoen und bakterien
EP3525786A4 (en) * 2016-10-12 2020-03-18 Merck Sharp & Dohme Corp. KDM5 INHIBITORS
WO2018102552A1 (en) 2016-11-30 2018-06-07 Case Western Reserve University Combinations of 15-pgdh inhibitors with corcosteroids and/or tnf inhibitors and uses thereof
CA3052466A1 (en) 2017-02-06 2018-08-09 Case Western Reserve University Compositions and methods of modulating short-chain dehydrogenase activity
WO2018187810A1 (en) 2017-04-07 2018-10-11 Case Western Reserve University Inhibitors of short-chain dehydrogenase activity for treating coronary disorders
EP3842100A1 (en) 2019-12-24 2021-06-30 The Board Of Regents Of The University Of Texas System Anti-malarial agents

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5478825A (en) 1991-02-22 1995-12-26 Egis Gyogyszergyar 5-(substituted amino)-1,2,4-triazolo (1,5-A) pyrimidine derivatives
HU208693B (en) 1991-02-22 1993-12-28 Egyt Gyogyszervegyeszeti Gyar Process for producing 1,2,4-triazolo (1,5-a) pyrimidinis derivatives and their carbicycli-tetrahydro-thiofurane-tetrahydrothiopyrane-, or tetrahydropyridine- condensated derivatives or medical preparatives containing them
US8490825B2 (en) 1999-12-08 2013-07-23 Metal Container Corporation Can lid closure and method of joining a can lid closure to a can body
CZ294535B6 (cs) * 2001-08-02 2005-01-12 Ústav Experimentální Botaniky Avčr Heterocyklické sloučeniny na bázi N6-substituovaného adeninu, způsoby jejich přípravy, jejich použití pro přípravu léčiv, kosmetických přípravků a růstových regulátorů, farmaceutické přípravky, kosmetické přípravky a růstové regulátory tyto sloučeniny obsahující
US20080027079A1 (en) 2006-06-22 2008-01-31 Board Of Regents, University Of Texas System Dihydroorotate dehydrogenase inhibitors with selective anti-malarial activity
EP2124954A2 (en) * 2007-01-26 2009-12-02 Irm Llc Purine compounds and compositions as kinase inhibitors for the treatment of plasmodium related diseases
WO2009082691A1 (en) 2007-12-21 2009-07-02 Board Of Regents, University Of Texas System Dihydroorotate dehydrogenase inhibitors with selective anti-malarial activity

Also Published As

Publication number Publication date
US20120302586A1 (en) 2012-11-29
SI2483274T1 (sl) 2015-02-27
WO2011041304A3 (en) 2011-08-04
BR112012007179A2 (pt) 2017-07-25
EP2483274A2 (en) 2012-08-08
JP5818266B2 (ja) 2015-11-18
HRP20150066T1 (hr) 2015-02-27
US9238653B2 (en) 2016-01-19
WO2011041304A2 (en) 2011-04-07
ES2527835T3 (es) 2015-01-30
CA2775354C (en) 2019-01-15
SMT201500071B (it) 2015-05-05
CN102741255B (zh) 2015-10-07
EP2483274A4 (en) 2013-03-06
CN102741255A (zh) 2012-10-17
EP2483274B1 (en) 2014-10-29
HK1174639A1 (en) 2013-06-14
BR112012007179B1 (pt) 2020-12-01
ME02020B (me) 2015-05-20
CA2775354A1 (en) 2011-04-07
DK2483274T3 (en) 2015-01-19
PL2483274T3 (pl) 2015-04-30
PT2483274E (pt) 2015-02-04
BR112012007179B8 (pt) 2021-05-25
JP2013506004A (ja) 2013-02-21

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B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
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B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

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B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

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