ME02020B - Anti-malarijski agensi kao inhibitori dihidroorotat dehidrogenaze - Google Patents

Anti-malarijski agensi kao inhibitori dihidroorotat dehidrogenaze

Info

Publication number: ME02020B
Authority: ME; Montenegro
Prior art keywords: inhibitors; dihydroorotate dehydrogenase; antimalarial agents; antimalarial; agents
Prior art date: 2009-09-29

Application number

MEP-2015-8A

Other languages

English (en)

Inventor

Pradipsinh K Rathod

David Floyd

Jeremy Burrows

Alka Marwaha

Ramesh Gujjar

Jose Coteron-Lopez

Margaret Phillips

Susan A Charman

David Matthews

Original Assignee

Univ Texas

Univ Monash

Medicines For Malaria Venture Mmv

Univ Washington

Glaxosmithkline Investig Y Desarrollo S L

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-09-29

Filing date

2010-09-28

Publication date

2015-05-20

2010-09-28 Application filed by Univ Texas, Univ Monash, Medicines For Malaria Venture Mmv, Univ Washington, Glaxosmithkline Investig Y Desarrollo S L filed Critical Univ Texas

2015-05-20 Publication of ME02020B publication Critical patent/ME02020B/me

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Tropical Medicine & Parasitology (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

MEP-2015-8A 2009-09-29 2010-09-28 Anti-malarijski agensi kao inhibitori dihidroorotat dehidrogenaze ME02020B (me)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US24686309P	2009-09-29	2009-09-29
PCT/US2010/050532 WO2011041304A2 (en)	2009-09-29	2010-09-28	Antimalarial agents that are inhibitors of dihydroorotate dehydrogenase
EP10821105.3A EP2483274B1 (en)	2009-09-29	2010-09-28	Antimalarial agents that are inhibitors of dihydroorotate dehydrogenase

Publications (1)

Publication Number	Publication Date
ME02020B true ME02020B (me)	2015-05-20

Family

ID=43826848

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MEP-2015-8A ME02020B (me)	2009-09-29	2010-09-28	Anti-malarijski agensi kao inhibitori dihidroorotat dehidrogenaze

Country Status (16)

Country	Link
US (1)	US9238653B2 (me)
EP (1)	EP2483274B1 (me)
JP (1)	JP5818266B2 (me)
CN (1)	CN102741255B (me)
BR (1)	BR112012007179B8 (me)
CA (1)	CA2775354C (me)
DK (1)	DK2483274T3 (me)
ES (1)	ES2527835T3 (me)
HK (1)	HK1174639A1 (me)
HR (1)	HRP20150066T1 (me)
ME (1)	ME02020B (me)
PL (1)	PL2483274T3 (me)
PT (1)	PT2483274E (me)
SI (1)	SI2483274T1 (me)
SM (1)	SMT201500071B (me)
WO (1)	WO2011041304A2 (me)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
LT3083627T (lt) *	2013-12-19	2018-12-27	Novartis Ag	[1,2,4]triazolo[1,5-a]pirimidino dariniai kaip protozoano proteasomos inhibitoriai, skirti parazitinių ligų tokių kaip leišmaniozė, gydymui
EP3072894A1 (en)	2015-03-26	2016-09-28	Board Of Regents Of the University Of Texas System	New substituted triazolopyrimidines as anti-malarial agents
EP3254679A1 (de)	2016-06-09	2017-12-13	Christian-Albrechts-Universität zu Kiel	Wirkstoffe gegen protozoen und bakterien
EP3525786A4 (en) *	2016-10-12	2020-03-18	Merck Sharp & Dohme Corp.	KDM5 INHIBITORS
WO2018102552A1 (en)	2016-11-30	2018-06-07	Case Western Reserve University	Combinations of 15-pgdh inhibitors with corcosteroids and/or tnf inhibitors and uses thereof
CA3052466A1 (en)	2017-02-06	2018-08-09	Case Western Reserve University	Compositions and methods of modulating short-chain dehydrogenase activity
WO2018187810A1 (en)	2017-04-07	2018-10-11	Case Western Reserve University	Inhibitors of short-chain dehydrogenase activity for treating coronary disorders
EP3842100A1 (en)	2019-12-24	2021-06-30	The Board Of Regents Of The University Of Texas System	Anti-malarial agents

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5478825A (en)	1991-02-22	1995-12-26	Egis Gyogyszergyar	5-(substituted amino)-1,2,4-triazolo (1,5-A) pyrimidine derivatives
HU208693B (en)	1991-02-22	1993-12-28	Egyt Gyogyszervegyeszeti Gyar	Process for producing 1,2,4-triazolo (1,5-a) pyrimidinis derivatives and their carbicycli-tetrahydro-thiofurane-tetrahydrothiopyrane-, or tetrahydropyridine- condensated derivatives or medical preparatives containing them
US8490825B2 (en)	1999-12-08	2013-07-23	Metal Container Corporation	Can lid closure and method of joining a can lid closure to a can body
CZ294535B6 (cs) *	2001-08-02	2005-01-12	Ústav Experimentální Botaniky Avčr	Heterocyklické sloučeniny na bázi N6-substituovaného adeninu, způsoby jejich přípravy, jejich použití pro přípravu léčiv, kosmetických přípravků a růstových regulátorů, farmaceutické přípravky, kosmetické přípravky a růstové regulátory tyto sloučeniny obsahující
US20080027079A1 (en)	2006-06-22	2008-01-31	Board Of Regents, University Of Texas System	Dihydroorotate dehydrogenase inhibitors with selective anti-malarial activity
EP2124954A2 (en) *	2007-01-26	2009-12-02	Irm Llc	Purine compounds and compositions as kinase inhibitors for the treatment of plasmodium related diseases
WO2009082691A1 (en)	2007-12-21	2009-07-02	Board Of Regents, University Of Texas System	Dihydroorotate dehydrogenase inhibitors with selective anti-malarial activity

2010
- 2010-09-28 PT PT108211053T patent/PT2483274E/pt unknown
- 2010-09-28 WO PCT/US2010/050532 patent/WO2011041304A2/en active Application Filing
- 2010-09-28 US US13/499,031 patent/US9238653B2/en not_active Expired - Fee Related
- 2010-09-28 CA CA2775354A patent/CA2775354C/en not_active Expired - Fee Related
- 2010-09-28 BR BR112012007179A patent/BR112012007179B8/pt not_active IP Right Cessation
- 2010-09-28 CN CN201080043385.XA patent/CN102741255B/zh not_active Expired - Fee Related
- 2010-09-28 JP JP2012532236A patent/JP5818266B2/ja not_active Expired - Fee Related
- 2010-09-28 SI SI201030853T patent/SI2483274T1/sl unknown
- 2010-09-28 ME MEP-2015-8A patent/ME02020B/me unknown
- 2010-09-28 PL PL10821105T patent/PL2483274T3/pl unknown
- 2010-09-28 DK DK10821105.3T patent/DK2483274T3/en active
- 2010-09-28 ES ES10821105.3T patent/ES2527835T3/es active Active
- 2010-09-28 EP EP10821105.3A patent/EP2483274B1/en active Active
2013
- 2013-02-15 HK HK13101950.1A patent/HK1174639A1/xx not_active IP Right Cessation
2015
- 2015-01-19 HR HRP20150066AT patent/HRP20150066T1/hr unknown
- 2015-03-18 SM SM201500071T patent/SMT201500071B/xx unknown

Also Published As

Publication number	Publication date
US20120302586A1 (en)	2012-11-29
SI2483274T1 (sl)	2015-02-27
WO2011041304A3 (en)	2011-08-04
BR112012007179A2 (pt)	2017-07-25
EP2483274A2 (en)	2012-08-08
JP5818266B2 (ja)	2015-11-18
HRP20150066T1 (hr)	2015-02-27
US9238653B2 (en)	2016-01-19
BR112012007179A8 (pt)	2018-01-23
WO2011041304A2 (en)	2011-04-07
ES2527835T3 (es)	2015-01-30
CA2775354C (en)	2019-01-15
SMT201500071B (it)	2015-05-05
CN102741255B (zh)	2015-10-07
EP2483274A4 (en)	2013-03-06
CN102741255A (zh)	2012-10-17
EP2483274B1 (en)	2014-10-29
HK1174639A1 (en)	2013-06-14
BR112012007179B1 (pt)	2020-12-01
CA2775354A1 (en)	2011-04-07
DK2483274T3 (en)	2015-01-19
PL2483274T3 (pl)	2015-04-30
PT2483274E (pt)	2015-02-04
BR112012007179B8 (pt)	2021-05-25
JP2013506004A (ja)	2013-02-21

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