PT2470182E - Síntese de uma piperazina neuroestimulativa - Google Patents

Síntese de uma piperazina neuroestimulativa Download PDF

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Publication number
PT2470182E
PT2470182E PT108142605T PT10814260T PT2470182E PT 2470182 E PT2470182 E PT 2470182E PT 108142605 T PT108142605 T PT 108142605T PT 10814260 T PT10814260 T PT 10814260T PT 2470182 E PT2470182 E PT 2470182E
Authority
PT
Portugal
Prior art keywords
neurostimulative
piperazine
synthesis
neurostimulative piperazine
Prior art date
Application number
PT108142605T
Other languages
English (en)
Inventor
Sripathy Venkatraman
Syed Mahmood
Bingidimi I Mobele
Olga Lapina
Kellie Vercoe
Ying Li
Jonathan Salsbury
Mark Mclaws
Original Assignee
Neuralstem Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43649584&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT2470182(E) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Neuralstem Inc filed Critical Neuralstem Inc
Publication of PT2470182E publication Critical patent/PT2470182E/pt

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72Nitrogen atoms
    • C07D213/74Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81Amides; Imides
    • C07D213/82Amides; Imides in position 3
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PT108142605T 2009-08-24 2010-08-24 Síntese de uma piperazina neuroestimulativa PT2470182E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US23647709P 2009-08-24 2009-08-24

Publications (1)

Publication Number Publication Date
PT2470182E true PT2470182E (pt) 2014-07-24

Family

ID=43649584

Family Applications (1)

Application Number Title Priority Date Filing Date
PT108142605T PT2470182E (pt) 2009-08-24 2010-08-24 Síntese de uma piperazina neuroestimulativa

Country Status (23)

Country Link
US (2) US9278933B2 (pt)
EP (1) EP2470182B1 (pt)
JP (1) JP5727482B2 (pt)
KR (1) KR101701362B1 (pt)
CN (2) CN102711764A (pt)
AU (1) AU2010289802C1 (pt)
BR (1) BR112012004161B1 (pt)
CA (1) CA2772080C (pt)
CL (1) CL2012000493A1 (pt)
DK (1) DK2470182T3 (pt)
ES (1) ES2475721T3 (pt)
HK (1) HK1172844A1 (pt)
HR (1) HRP20140621T1 (pt)
IL (1) IL218298A (pt)
IN (1) IN2012DN02370A (pt)
MX (1) MX2012002335A (pt)
NZ (1) NZ598891A (pt)
PL (1) PL2470182T3 (pt)
PT (1) PT2470182E (pt)
RU (1) RU2567390C2 (pt)
SG (1) SG178867A1 (pt)
SI (1) SI2470182T1 (pt)
WO (1) WO2011028548A1 (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ598891A (en) * 2009-08-24 2014-05-30 Neuralstem Inc Synthesis of a neurostimulative piperazine
JP7204640B2 (ja) * 2016-09-12 2023-01-16 ニューラルステム・インコーポレーテッド 糖尿病に関連する神経障害の改善
US20180104240A1 (en) * 2016-10-18 2018-04-19 Neuralstem, Inc. Amelioration of radiation-induced cognitive dysfunction
US10042957B2 (en) 2017-01-12 2018-08-07 Innovationdock, Inc. Devices and methods for implementing dynamic collaborative workflow systems
US10413534B2 (en) * 2017-02-13 2019-09-17 Neuralstem, Inc. Amelioration of certain deficiencies due to stroke
WO2022140643A1 (en) * 2020-12-23 2022-06-30 Baylor College Of Medicine Small-molecule modulators of the orphan nuclear receptor tlx
US20220387424A1 (en) 2021-06-03 2022-12-08 Alto Neuroscience, Inc. Method of treatment of depressed patients with poor cognition and selection of other patients benefiting from a benzylpiperazine-aminopyridine agent
WO2024123695A1 (en) 2022-12-05 2024-06-13 Alto Neuroscience, Inc. Effective treatment of depression in patients having impaired learning and/or memory or certain eeg characteristics with a benzylpiperazine-aminopyridine agent

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU175075B (hu) * 1977-06-30 1980-05-28 Egyt Gyogyszervegyeszeti Gyar Sposob poluchenija piperazidov piridin-karbonovoj kisloty
JPS54122283A (en) * 1978-03-13 1979-09-21 Sumitomo Chem Co Ltd Novel quinazoline derivative and its preparation
US6995162B2 (en) * 2001-01-12 2006-02-07 Amgen Inc. Substituted alkylamine derivatives and methods of use
CN100343240C (zh) * 2002-03-29 2007-10-17 先灵公司 手性2-甲基-4-保护的哌嗪的立体选择性烷基化
GB0222493D0 (en) * 2002-09-27 2002-11-06 Glaxo Group Ltd Compounds
US20040185429A1 (en) * 2002-12-09 2004-09-23 Judith Kelleher-Andersson Method for discovering neurogenic agents
MXPA06002727A (es) * 2003-09-09 2006-06-05 Hoffmann La Roche Derivados de 1-(2-amino-benzol)-piperazina como inhibidores de la captacion de glicina para el tratamiento de psicosis.
TW200621759A (en) 2004-10-29 2006-07-01 Banyu Pharma Co Ltd Novel aminopyridine derivatives having aurora A selective inhibitory action
US7754724B2 (en) * 2005-06-30 2010-07-13 Dow Agrosciences Llc N-substituted piperazines
CA2627630A1 (en) * 2005-12-20 2007-06-28 Novartis Ag Nicotinic acid derivatives as modulators of metabotropic glutamate receptors
NZ598891A (en) * 2009-08-24 2014-05-30 Neuralstem Inc Synthesis of a neurostimulative piperazine

Also Published As

Publication number Publication date
PL2470182T3 (pl) 2015-05-29
US9278933B2 (en) 2016-03-08
AU2010289802C1 (en) 2015-04-16
US20160090358A1 (en) 2016-03-31
BR112012004161B1 (pt) 2020-04-07
BR112012004161A2 (pt) 2016-03-29
CA2772080A1 (en) 2011-03-10
EP2470182B1 (en) 2014-06-04
JP2013502462A (ja) 2013-01-24
US9481649B2 (en) 2016-11-01
IN2012DN02370A (pt) 2015-08-21
AU2010289802B2 (en) 2014-10-02
IL218298A (en) 2017-03-30
US20130005974A1 (en) 2013-01-03
CN102711764A (zh) 2012-10-03
EP2470182A4 (en) 2013-04-24
SI2470182T1 (sl) 2014-10-30
HRP20140621T1 (hr) 2014-11-21
ES2475721T3 (es) 2014-07-11
MX2012002335A (es) 2012-07-04
EP2470182A1 (en) 2012-07-04
RU2012111227A (ru) 2013-10-10
CL2012000493A1 (es) 2012-09-28
CA2772080C (en) 2017-05-30
DK2470182T3 (da) 2014-07-21
RU2567390C2 (ru) 2015-11-10
NZ598891A (en) 2014-05-30
AU2010289802A1 (en) 2012-04-12
SG178867A1 (en) 2012-04-27
JP5727482B2 (ja) 2015-06-03
IL218298A0 (en) 2012-04-30
KR101701362B1 (ko) 2017-02-01
CN105693601A (zh) 2016-06-22
HK1172844A1 (en) 2013-05-03
WO2011028548A1 (en) 2011-03-10
KR20120054642A (ko) 2012-05-30

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