PL2440661T3 - Synteza hmo - Google Patents

Synteza hmo

Info

Publication number
PL2440661T3
PL2440661T3 PL09776698T PL09776698T PL2440661T3 PL 2440661 T3 PL2440661 T3 PL 2440661T3 PL 09776698 T PL09776698 T PL 09776698T PL 09776698 T PL09776698 T PL 09776698T PL 2440661 T3 PL2440661 T3 PL 2440661T3
Authority
PL
Poland
Prior art keywords
hmo
synthesis
hmo synthesis
Prior art date
Application number
PL09776698T
Other languages
English (en)
Inventor
Stefan Jennewein
Eric HÜFNER
Julia Parkot
Original Assignee
Jennewein Biotechnologie Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40941939&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2440661(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Jennewein Biotechnologie Gmbh filed Critical Jennewein Biotechnologie Gmbh
Publication of PL2440661T3 publication Critical patent/PL2440661T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
PL09776698T 2009-06-08 2009-06-08 Synteza hmo PL2440661T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09776698.4A EP2440661B1 (en) 2009-06-08 2009-06-08 Hmo synthesis
PCT/EP2009/004112 WO2010142305A1 (en) 2009-06-08 2009-06-08 Hmo synthesis

Publications (1)

Publication Number Publication Date
PL2440661T3 true PL2440661T3 (pl) 2018-06-29

Family

ID=40941939

Family Applications (1)

Application Number Title Priority Date Filing Date
PL09776698T PL2440661T3 (pl) 2009-06-08 2009-06-08 Synteza hmo

Country Status (15)

Country Link
US (2) US8652808B2 (pl)
EP (1) EP2440661B1 (pl)
JP (1) JP5580408B2 (pl)
CN (2) CN106978382A (pl)
AU (1) AU2009347610B2 (pl)
BR (1) BRPI0924899B8 (pl)
DK (1) DK2440661T3 (pl)
ES (1) ES2660698T3 (pl)
MX (1) MX2011013231A (pl)
MY (1) MY182355A (pl)
NZ (1) NZ597129A (pl)
PL (1) PL2440661T3 (pl)
RU (1) RU2517602C2 (pl)
SG (1) SG176651A1 (pl)
WO (1) WO2010142305A1 (pl)

Families Citing this family (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0924899B8 (pt) * 2009-06-08 2023-01-31 Jennewein Biotechnologie Gmbh Síntese hmo
MY180803A (en) 2010-06-02 2020-12-09 Evolva Inc Recombinant production of steviol glycosides
EP2455387A1 (en) * 2010-11-23 2012-05-23 Nestec S.A. Oligosaccharide mixture and food product comprising this mixture, especially infant formula
CN103732753B (zh) 2011-08-08 2018-03-30 埃沃尔瓦公司 甜菊醇糖苷类的重组生产
CN102839157A (zh) * 2012-07-12 2012-12-26 扬州大学 稳定共表达hST3GalIV和β1-4GalT1的MDCK细胞系及构建方法和应用
WO2014086373A1 (en) 2012-12-07 2014-06-12 Glycom A/S Crystallisation of human milk oligosaccharides (hmo)
JP6379112B2 (ja) 2013-02-06 2018-08-22 エヴォルヴァ エスアー．Ｅｖｏｌｖａ Ｓａ． レバウディオサイドｄおよびレバウディオサイドｍの改良された産生方法
KR20150128705A (ko) 2013-02-11 2015-11-18 에볼바 에스아 재조합 숙주에서 스테비올 글리코시드의 효율적인 생성
WO2014135167A1 (en) * 2013-03-08 2014-09-12 Glycom A/S Purification of oligosaccaharides by reversible derivatization
US9902984B2 (en) 2013-09-06 2018-02-27 Glycom A/S Fermentative production of oligosaccharides
EP3572520A1 (en) * 2013-09-10 2019-11-27 Jennewein Biotechnologie GmbH Production of oligosaccharides
EP2857410A1 (en) * 2013-10-04 2015-04-08 Jennewein Biotechnologie GmbH Process for purification of 2´-fucosyllactose using simulated moving bed chromatography
DK2896628T3 (en) * 2014-01-20 2019-01-14 Jennewein Biotechnologie Gmbh Process for Effective Purification of Neutral Milk Oligosaccharides (HMOs) from Microbial Fermentation
EP2905341B1 (en) * 2014-02-07 2020-04-29 Jennewein Biotechnologie GmbH Methods for producing GDP-fucose using nucleotide sugar transporters and recombinant microorganism host cells used therefor
PL2927316T3 (pl) 2014-03-31 2019-05-31 Jennewein Biotechnologie Gmbh Całkowita fermentacja oligosacharydów
SG10201901007PA (en) 2014-08-11 2019-03-28 Evolva Sa Production of steviol glycosides in recombinant hosts
EP3190905A2 (en) 2014-09-09 2017-07-19 Evolva SA Production of steviol glycosides in recombinant hosts
US9616114B1 (en) 2014-09-18 2017-04-11 David Gordon Bermudes Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity
JP2018504142A (ja) * 2015-01-26 2018-02-15 カデナ・バイオ・インコーポレイテッド 食物成分として使用するためのオリゴ糖組成物及びその生成方法
BR112017016338A2 (pt) 2015-01-30 2018-03-27 Evolva Sa produção de glicosídeos de esteviol em hospedeiros recombinantes
WO2016146711A1 (en) 2015-03-16 2016-09-22 Dsm Ip Assets B.V. Udp-glycosyltransferases
MX2018001620A (es) 2015-08-07 2018-06-11 Evolva Sa Produccion de glucosidos de esteviol en hospedadores recombinantes.
EP3141610A1 (en) * 2015-09-12 2017-03-15 Jennewein Biotechnologie GmbH Production of human milk oligosaccharides in microbial hosts with engineered import / export
CA3020671A1 (en) 2016-04-13 2017-10-19 Evolva Sa Production of steviol glycosides in recombinant hosts
EP3458599A1 (en) 2016-05-16 2019-03-27 Evolva SA Production of steviol glycosides in recombinant hosts
CN106190937B9 (zh) * 2016-07-18 2020-12-01 南开大学 一种构建重组大肠杆菌生物合成2’-岩藻乳糖的方法
ES2856749T3 (es) 2016-10-29 2021-09-28 Chr Hansen Hmo Gmbh Proceso para la producción de oligosacáridos fucosilados
EP3535406A1 (en) 2016-11-07 2019-09-11 Evolva SA Production of steviol glycosides in recombinant hosts
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
WO2018181774A1 (ja) * 2017-03-31 2018-10-04 株式会社カネカ 新規モノオキシゲナーゼおよびその利用
EP3645146A4 (en) 2017-06-30 2021-05-05 Glycom A/S SYNTHESIS OF OLIGOSACCHARIDES
EP3425052A1 (en) 2017-07-07 2019-01-09 Jennewein Biotechnologie GmbH Fucosyltransferases and their use in producing fucosylated oligosaccharides
US11505567B2 (en) 2017-07-12 2022-11-22 Glycom A/S Amorphous mixture comprising a neutral mono- or oligosaccharide and an acidic non-carbohydrate component
EP3438122A1 (en) 2017-08-01 2019-02-06 OligoScience Biotechnology GmbH Microorganism for producing human milk oligosaccharide
CN111356461A (zh) 2017-10-04 2020-06-30 加利福尼亚大学董事会 免疫调节性低聚糖
CN107805622B (zh) * 2017-11-08 2021-04-30 光明乳业股份有限公司 一种合成鸟苷二磷酸岩藻糖的重组枯草芽孢杆菌及其构建方法与应用
EP3486326A1 (en) 2017-11-21 2019-05-22 Jennewein Biotechnologie GmbH Method for the purification of n-acetylneuraminic acid from a fermentation broth
WO2019209245A1 (en) * 2018-04-23 2019-10-31 Dupont Nutrition Biosciences Aps Increasing activity of 2' fucosyllactose transporters endogenous to microbial cells
EP3784791A1 (en) * 2018-04-23 2021-03-03 DuPont Nutrition Biosciences ApS Increasing export of 2' fucosyllactose from microbial cells through the expression of a heterologous nucleic acid
CN109735479B (zh) * 2019-01-30 2022-04-01 光明乳业股份有限公司 一种合成2’-岩藻糖基乳糖的重组枯草芽孢杆菌及其构建方法与应用
EP3702468A1 (en) * 2019-03-01 2020-09-02 Jennewein Biotechnologie GmbH Fermentative production of carbohydrates by microbial cells utilizing a mixed feedstock
KR102254548B1 (ko) * 2019-04-26 2021-05-24 고려대학교 산학협력단 돌연변이 대장균을 이용한 콜라닉 산 생산
EP3751003A1 (en) 2019-06-12 2020-12-16 Jennewein Biotechnologie GmbH Production of fucosylated oligosaccharides in bacillus
AU2020317557A1 (en) * 2019-07-19 2022-03-10 Inbiose N.V. Production of fucosyllactose in host cells
US20220298536A1 (en) * 2019-08-13 2022-09-22 Amyris, Inc. Improved oligosaccharide production in yeast
CN110396532A (zh) * 2019-08-23 2019-11-01 中国科学院合肥物质科学研究院 一种制备唾液酸乳糖的方法
KR20220080178A (ko) * 2019-10-14 2022-06-14 인바이오스 엔.브이. 숙주 세포에서 바이오산물의 생산
CN114901825A (zh) * 2019-12-18 2022-08-12 因比奥斯公司 在宿主细胞中产生唾液酸化寡糖
WO2021148615A1 (en) 2020-01-23 2021-07-29 Glycom A/S Hmo production
CN115003814A (zh) 2020-01-23 2022-09-02 格礼卡姆股份公司 Hmo产生
WO2021148610A1 (en) 2020-01-23 2021-07-29 Glycom A/S Hmo production
BR112022014367A2 (pt) 2020-01-23 2022-09-13 Glycom As Produção de hmo
EP3929300A1 (en) * 2020-06-26 2021-12-29 Chr. Hansen HMO GmbH Improved export of oligosaccharides from bacterial cells
DK180952B1 (en) 2020-12-22 2022-08-10 Glycom As A dfl-producing strain
EP4281564A1 (en) 2021-01-22 2023-11-29 Glycom A/S New major facilitator superfamily (mfs) protein (fred) in production of sialylated hmos
CN116848248A (zh) 2021-02-08 2023-10-03 协和发酵生化株式会社 具有含有岩藻糖的糖质的转运活性的蛋白和含有岩藻糖的糖质的制造方法
WO2022243311A1 (en) 2021-05-17 2022-11-24 Dsm Ip Assets B.V. Microbial strain expressing an invertase/sucrose hydrolase
DK181497B1 (en) 2021-05-17 2024-03-12 Dsm Ip Assets Bv ENHANCING FORMATION OF THE HMOS LNT AND/OR LNnT BY MODIFYING LACTOSE IMPORT IN THE CELL
DK181242B1 (en) 2021-05-17 2023-05-30 Dsm Ip Assets Bv GENETICALLY ENGINEERED CELLS COMPRISING A RECOMBINANT NUCLEIC ACID SEQUNCE ENCODING AN α-1,2-FUCOSYLTRANSFERASE CAPABLE OF PRODUCING LNFP-I, NUCLEIC ACID SEQUENCES ENCODING SAME AND METHODS FOR USE OF SAME
WO2023120615A1 (ja) 2021-12-21 2023-06-29 協和発酵バイオ株式会社 コア３糖としてラクト－ｎ－トリオースｉｉを含む糖質の製造方法および該糖質の結晶の製造方法
CN115029371B (zh) * 2022-06-14 2024-01-02 大连工业大学 一种微生物生产的天然活性产物的高效分离方法
DK202200689A1 (en) 2022-07-15 2024-02-27 Dsm Ip Assets Bv New fucosyltransferases for in vivo synthesis of lnfp-iii
WO2024042235A1 (en) 2022-08-25 2024-02-29 Dsm Ip Assets B.V. Hybrid method for producing complex hmos
WO2024110667A1 (en) 2022-11-25 2024-05-30 Dsm Ip Assets B.V. Two-strain system for producing oligosaccharides

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US6204431B1 (en) * 1994-03-09 2001-03-20 Abbott Laboratories Transgenic non-human mammals expressing heterologous glycosyltransferase DNA sequences produce oligosaccharides and glycoproteins in their milk
WO2006034225A2 (en) 2004-09-17 2006-03-30 Neose Technologies, Inc. Production of oligosaccharides by microorganisms
WO2010070104A1 (en) 2008-12-19 2010-06-24 Jennewein Biotechnologie Gmbh Synthesis of fucosylated compounds
BRPI0924899B8 (pt) * 2009-06-08 2023-01-31 Jennewein Biotechnologie Gmbh Síntese hmo

Also Published As

Publication number Publication date
CN106978382A (zh) 2017-07-25
ES2660698T3 (es) 2018-03-23
EP2440661A1 (en) 2012-04-18
SG176651A1 (en) 2012-01-30
NZ597129A (en) 2012-12-21
JP5580408B2 (ja) 2014-08-27
MX2011013231A (es) 2012-01-20
US8652808B2 (en) 2014-02-18
AU2009347610A1 (en) 2012-01-12
RU2517602C2 (ru) 2014-05-27
BRPI0924899B8 (pt) 2023-01-31
BRPI0924899B1 (pt) 2022-03-22
US20120135467A1 (en) 2012-05-31
JP2012529274A (ja) 2012-11-22
US9512433B2 (en) 2016-12-06
WO2010142305A1 (en) 2010-12-16
EP2440661B1 (en) 2017-12-06
BRPI0924899A2 (pt) 2021-02-23
CN102459605A (zh) 2012-05-16
MY182355A (en) 2021-01-20
US20140120611A1 (en) 2014-05-01
DK2440661T3 (en) 2018-03-12
AU2009347610B2 (en) 2013-02-21
RU2011153792A (ru) 2013-07-20

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