PL2440661T3 - Synteza hmo - Google Patents
Synteza hmoInfo
- Publication number
- PL2440661T3 PL2440661T3 PL09776698T PL09776698T PL2440661T3 PL 2440661 T3 PL2440661 T3 PL 2440661T3 PL 09776698 T PL09776698 T PL 09776698T PL 09776698 T PL09776698 T PL 09776698T PL 2440661 T3 PL2440661 T3 PL 2440661T3
- Authority
- PL
- Poland
- Prior art keywords
- hmo
- synthesis
- hmo synthesis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP09776698.4A EP2440661B1 (en) | 2009-06-08 | 2009-06-08 | Hmo synthesis |
PCT/EP2009/004112 WO2010142305A1 (en) | 2009-06-08 | 2009-06-08 | Hmo synthesis |
Publications (1)
Publication Number | Publication Date |
---|---|
PL2440661T3 true PL2440661T3 (pl) | 2018-06-29 |
Family
ID=40941939
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL09776698T PL2440661T3 (pl) | 2009-06-08 | 2009-06-08 | Synteza hmo |
Country Status (15)
Country | Link |
---|---|
US (2) | US8652808B2 (pl) |
EP (1) | EP2440661B1 (pl) |
JP (1) | JP5580408B2 (pl) |
CN (2) | CN106978382A (pl) |
AU (1) | AU2009347610B2 (pl) |
BR (1) | BRPI0924899B8 (pl) |
DK (1) | DK2440661T3 (pl) |
ES (1) | ES2660698T3 (pl) |
MX (1) | MX2011013231A (pl) |
MY (1) | MY182355A (pl) |
NZ (1) | NZ597129A (pl) |
PL (1) | PL2440661T3 (pl) |
RU (1) | RU2517602C2 (pl) |
SG (1) | SG176651A1 (pl) |
WO (1) | WO2010142305A1 (pl) |
Families Citing this family (65)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BRPI0924899B8 (pt) * | 2009-06-08 | 2023-01-31 | Jennewein Biotechnologie Gmbh | Síntese hmo |
MY180803A (en) | 2010-06-02 | 2020-12-09 | Evolva Inc | Recombinant production of steviol glycosides |
EP2455387A1 (en) * | 2010-11-23 | 2012-05-23 | Nestec S.A. | Oligosaccharide mixture and food product comprising this mixture, especially infant formula |
CN103732753B (zh) | 2011-08-08 | 2018-03-30 | 埃沃尔瓦公司 | 甜菊醇糖苷类的重组生产 |
CN102839157A (zh) * | 2012-07-12 | 2012-12-26 | 扬州大学 | 稳定共表达hST3GalIV和β1-4GalT1的MDCK细胞系及构建方法和应用 |
WO2014086373A1 (en) | 2012-12-07 | 2014-06-12 | Glycom A/S | Crystallisation of human milk oligosaccharides (hmo) |
JP6379112B2 (ja) | 2013-02-06 | 2018-08-22 | エヴォルヴァ エスアー.Evolva Sa. | レバウディオサイドdおよびレバウディオサイドmの改良された産生方法 |
KR20150128705A (ko) | 2013-02-11 | 2015-11-18 | 에볼바 에스아 | 재조합 숙주에서 스테비올 글리코시드의 효율적인 생성 |
WO2014135167A1 (en) * | 2013-03-08 | 2014-09-12 | Glycom A/S | Purification of oligosaccaharides by reversible derivatization |
US9902984B2 (en) | 2013-09-06 | 2018-02-27 | Glycom A/S | Fermentative production of oligosaccharides |
EP3572520A1 (en) * | 2013-09-10 | 2019-11-27 | Jennewein Biotechnologie GmbH | Production of oligosaccharides |
EP2857410A1 (en) * | 2013-10-04 | 2015-04-08 | Jennewein Biotechnologie GmbH | Process for purification of 2´-fucosyllactose using simulated moving bed chromatography |
DK2896628T3 (en) * | 2014-01-20 | 2019-01-14 | Jennewein Biotechnologie Gmbh | Process for Effective Purification of Neutral Milk Oligosaccharides (HMOs) from Microbial Fermentation |
EP2905341B1 (en) * | 2014-02-07 | 2020-04-29 | Jennewein Biotechnologie GmbH | Methods for producing GDP-fucose using nucleotide sugar transporters and recombinant microorganism host cells used therefor |
PL2927316T3 (pl) | 2014-03-31 | 2019-05-31 | Jennewein Biotechnologie Gmbh | Całkowita fermentacja oligosacharydów |
SG10201901007PA (en) | 2014-08-11 | 2019-03-28 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
EP3190905A2 (en) | 2014-09-09 | 2017-07-19 | Evolva SA | Production of steviol glycosides in recombinant hosts |
US9616114B1 (en) | 2014-09-18 | 2017-04-11 | David Gordon Bermudes | Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity |
JP2018504142A (ja) * | 2015-01-26 | 2018-02-15 | カデナ・バイオ・インコーポレイテッド | 食物成分として使用するためのオリゴ糖組成物及びその生成方法 |
BR112017016338A2 (pt) | 2015-01-30 | 2018-03-27 | Evolva Sa | produção de glicosídeos de esteviol em hospedeiros recombinantes |
WO2016146711A1 (en) | 2015-03-16 | 2016-09-22 | Dsm Ip Assets B.V. | Udp-glycosyltransferases |
MX2018001620A (es) | 2015-08-07 | 2018-06-11 | Evolva Sa | Produccion de glucosidos de esteviol en hospedadores recombinantes. |
EP3141610A1 (en) * | 2015-09-12 | 2017-03-15 | Jennewein Biotechnologie GmbH | Production of human milk oligosaccharides in microbial hosts with engineered import / export |
CA3020671A1 (en) | 2016-04-13 | 2017-10-19 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
EP3458599A1 (en) | 2016-05-16 | 2019-03-27 | Evolva SA | Production of steviol glycosides in recombinant hosts |
CN106190937B9 (zh) * | 2016-07-18 | 2020-12-01 | 南开大学 | 一种构建重组大肠杆菌生物合成2’-岩藻乳糖的方法 |
ES2856749T3 (es) | 2016-10-29 | 2021-09-28 | Chr Hansen Hmo Gmbh | Proceso para la producción de oligosacáridos fucosilados |
EP3535406A1 (en) | 2016-11-07 | 2019-09-11 | Evolva SA | Production of steviol glycosides in recombinant hosts |
US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
WO2018181774A1 (ja) * | 2017-03-31 | 2018-10-04 | 株式会社カネカ | 新規モノオキシゲナーゼおよびその利用 |
EP3645146A4 (en) | 2017-06-30 | 2021-05-05 | Glycom A/S | SYNTHESIS OF OLIGOSACCHARIDES |
EP3425052A1 (en) | 2017-07-07 | 2019-01-09 | Jennewein Biotechnologie GmbH | Fucosyltransferases and their use in producing fucosylated oligosaccharides |
US11505567B2 (en) | 2017-07-12 | 2022-11-22 | Glycom A/S | Amorphous mixture comprising a neutral mono- or oligosaccharide and an acidic non-carbohydrate component |
EP3438122A1 (en) | 2017-08-01 | 2019-02-06 | OligoScience Biotechnology GmbH | Microorganism for producing human milk oligosaccharide |
CN111356461A (zh) | 2017-10-04 | 2020-06-30 | 加利福尼亚大学董事会 | 免疫调节性低聚糖 |
CN107805622B (zh) * | 2017-11-08 | 2021-04-30 | 光明乳业股份有限公司 | 一种合成鸟苷二磷酸岩藻糖的重组枯草芽孢杆菌及其构建方法与应用 |
EP3486326A1 (en) | 2017-11-21 | 2019-05-22 | Jennewein Biotechnologie GmbH | Method for the purification of n-acetylneuraminic acid from a fermentation broth |
WO2019209245A1 (en) * | 2018-04-23 | 2019-10-31 | Dupont Nutrition Biosciences Aps | Increasing activity of 2' fucosyllactose transporters endogenous to microbial cells |
EP3784791A1 (en) * | 2018-04-23 | 2021-03-03 | DuPont Nutrition Biosciences ApS | Increasing export of 2' fucosyllactose from microbial cells through the expression of a heterologous nucleic acid |
CN109735479B (zh) * | 2019-01-30 | 2022-04-01 | 光明乳业股份有限公司 | 一种合成2’-岩藻糖基乳糖的重组枯草芽孢杆菌及其构建方法与应用 |
EP3702468A1 (en) * | 2019-03-01 | 2020-09-02 | Jennewein Biotechnologie GmbH | Fermentative production of carbohydrates by microbial cells utilizing a mixed feedstock |
KR102254548B1 (ko) * | 2019-04-26 | 2021-05-24 | 고려대학교 산학협력단 | 돌연변이 대장균을 이용한 콜라닉 산 생산 |
EP3751003A1 (en) | 2019-06-12 | 2020-12-16 | Jennewein Biotechnologie GmbH | Production of fucosylated oligosaccharides in bacillus |
AU2020317557A1 (en) * | 2019-07-19 | 2022-03-10 | Inbiose N.V. | Production of fucosyllactose in host cells |
US20220298536A1 (en) * | 2019-08-13 | 2022-09-22 | Amyris, Inc. | Improved oligosaccharide production in yeast |
CN110396532A (zh) * | 2019-08-23 | 2019-11-01 | 中国科学院合肥物质科学研究院 | 一种制备唾液酸乳糖的方法 |
KR20220080178A (ko) * | 2019-10-14 | 2022-06-14 | 인바이오스 엔.브이. | 숙주 세포에서 바이오산물의 생산 |
CN114901825A (zh) * | 2019-12-18 | 2022-08-12 | 因比奥斯公司 | 在宿主细胞中产生唾液酸化寡糖 |
WO2021148615A1 (en) | 2020-01-23 | 2021-07-29 | Glycom A/S | Hmo production |
CN115003814A (zh) | 2020-01-23 | 2022-09-02 | 格礼卡姆股份公司 | Hmo产生 |
WO2021148610A1 (en) | 2020-01-23 | 2021-07-29 | Glycom A/S | Hmo production |
BR112022014367A2 (pt) | 2020-01-23 | 2022-09-13 | Glycom As | Produção de hmo |
EP3929300A1 (en) * | 2020-06-26 | 2021-12-29 | Chr. Hansen HMO GmbH | Improved export of oligosaccharides from bacterial cells |
DK180952B1 (en) | 2020-12-22 | 2022-08-10 | Glycom As | A dfl-producing strain |
EP4281564A1 (en) | 2021-01-22 | 2023-11-29 | Glycom A/S | New major facilitator superfamily (mfs) protein (fred) in production of sialylated hmos |
CN116848248A (zh) | 2021-02-08 | 2023-10-03 | 协和发酵生化株式会社 | 具有含有岩藻糖的糖质的转运活性的蛋白和含有岩藻糖的糖质的制造方法 |
WO2022243311A1 (en) | 2021-05-17 | 2022-11-24 | Dsm Ip Assets B.V. | Microbial strain expressing an invertase/sucrose hydrolase |
DK181497B1 (en) | 2021-05-17 | 2024-03-12 | Dsm Ip Assets Bv | ENHANCING FORMATION OF THE HMOS LNT AND/OR LNnT BY MODIFYING LACTOSE IMPORT IN THE CELL |
DK181242B1 (en) | 2021-05-17 | 2023-05-30 | Dsm Ip Assets Bv | GENETICALLY ENGINEERED CELLS COMPRISING A RECOMBINANT NUCLEIC ACID SEQUNCE ENCODING AN α-1,2-FUCOSYLTRANSFERASE CAPABLE OF PRODUCING LNFP-I, NUCLEIC ACID SEQUENCES ENCODING SAME AND METHODS FOR USE OF SAME |
WO2023120615A1 (ja) | 2021-12-21 | 2023-06-29 | 協和発酵バイオ株式会社 | コア3糖としてラクト-n-トリオースiiを含む糖質の製造方法および該糖質の結晶の製造方法 |
CN115029371B (zh) * | 2022-06-14 | 2024-01-02 | 大连工业大学 | 一种微生物生产的天然活性产物的高效分离方法 |
DK202200689A1 (en) | 2022-07-15 | 2024-02-27 | Dsm Ip Assets Bv | New fucosyltransferases for in vivo synthesis of lnfp-iii |
WO2024042235A1 (en) | 2022-08-25 | 2024-02-29 | Dsm Ip Assets B.V. | Hybrid method for producing complex hmos |
WO2024110667A1 (en) | 2022-11-25 | 2024-05-30 | Dsm Ip Assets B.V. | Two-strain system for producing oligosaccharides |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6204431B1 (en) * | 1994-03-09 | 2001-03-20 | Abbott Laboratories | Transgenic non-human mammals expressing heterologous glycosyltransferase DNA sequences produce oligosaccharides and glycoproteins in their milk |
WO2006034225A2 (en) | 2004-09-17 | 2006-03-30 | Neose Technologies, Inc. | Production of oligosaccharides by microorganisms |
WO2010070104A1 (en) | 2008-12-19 | 2010-06-24 | Jennewein Biotechnologie Gmbh | Synthesis of fucosylated compounds |
BRPI0924899B8 (pt) * | 2009-06-08 | 2023-01-31 | Jennewein Biotechnologie Gmbh | Síntese hmo |
-
2009
- 2009-06-08 BR BRPI0924899A patent/BRPI0924899B8/pt active IP Right Grant
- 2009-06-08 CN CN201710200038.7A patent/CN106978382A/zh active Pending
- 2009-06-08 RU RU2011153792/10A patent/RU2517602C2/ru active
- 2009-06-08 MX MX2011013231A patent/MX2011013231A/es active IP Right Grant
- 2009-06-08 WO PCT/EP2009/004112 patent/WO2010142305A1/en active Application Filing
- 2009-06-08 PL PL09776698T patent/PL2440661T3/pl unknown
- 2009-06-08 MY MYPI2011005908A patent/MY182355A/en unknown
- 2009-06-08 SG SG2011089521A patent/SG176651A1/en unknown
- 2009-06-08 ES ES09776698.4T patent/ES2660698T3/es active Active
- 2009-06-08 CN CN2009801597553A patent/CN102459605A/zh active Pending
- 2009-06-08 NZ NZ597129A patent/NZ597129A/xx unknown
- 2009-06-08 JP JP2012514353A patent/JP5580408B2/ja active Active
- 2009-06-08 DK DK09776698.4T patent/DK2440661T3/en active
- 2009-06-08 EP EP09776698.4A patent/EP2440661B1/en not_active Revoked
- 2009-06-08 AU AU2009347610A patent/AU2009347610B2/en active Active
-
2011
- 2011-11-30 US US13/308,082 patent/US8652808B2/en active Active
-
2013
- 2013-12-09 US US14/100,825 patent/US9512433B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
CN106978382A (zh) | 2017-07-25 |
ES2660698T3 (es) | 2018-03-23 |
EP2440661A1 (en) | 2012-04-18 |
SG176651A1 (en) | 2012-01-30 |
NZ597129A (en) | 2012-12-21 |
JP5580408B2 (ja) | 2014-08-27 |
MX2011013231A (es) | 2012-01-20 |
US8652808B2 (en) | 2014-02-18 |
AU2009347610A1 (en) | 2012-01-12 |
RU2517602C2 (ru) | 2014-05-27 |
BRPI0924899B8 (pt) | 2023-01-31 |
BRPI0924899B1 (pt) | 2022-03-22 |
US20120135467A1 (en) | 2012-05-31 |
JP2012529274A (ja) | 2012-11-22 |
US9512433B2 (en) | 2016-12-06 |
WO2010142305A1 (en) | 2010-12-16 |
EP2440661B1 (en) | 2017-12-06 |
BRPI0924899A2 (pt) | 2021-02-23 |
CN102459605A (zh) | 2012-05-16 |
MY182355A (en) | 2021-01-20 |
US20140120611A1 (en) | 2014-05-01 |
DK2440661T3 (en) | 2018-03-12 |
AU2009347610B2 (en) | 2013-02-21 |
RU2011153792A (ru) | 2013-07-20 |
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