IN2012DN02370A - - Google Patents
Download PDFInfo
- Publication number
- IN2012DN02370A IN2012DN02370A IN2370DEN2012A IN2012DN02370A IN 2012DN02370 A IN2012DN02370 A IN 2012DN02370A IN 2370DEN2012 A IN2370DEN2012 A IN 2370DEN2012A IN 2012DN02370 A IN2012DN02370 A IN 2012DN02370A
- Authority
- IN
- India
- Prior art keywords
- derivatized
- piperazine
- useful
- treatment
- nicotinic acid
- Prior art date
Links
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 abstract 2
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000926 neurological effect Effects 0.000 abstract 1
- 229960003512 nicotinic acid Drugs 0.000 abstract 1
- 235000001968 nicotinic acid Nutrition 0.000 abstract 1
- 239000011664 nicotinic acid Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23647709P | 2009-08-24 | 2009-08-24 | |
PCT/US2010/046537 WO2011028548A1 (en) | 2009-08-24 | 2010-08-24 | Synthesis of a neurostimulative piperazine |
Publications (1)
Publication Number | Publication Date |
---|---|
IN2012DN02370A true IN2012DN02370A (pt) | 2015-08-21 |
Family
ID=43649584
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IN2370DEN2012 IN2012DN02370A (pt) | 2009-08-24 | 2010-08-24 |
Country Status (23)
Country | Link |
---|---|
US (2) | US9278933B2 (pt) |
EP (1) | EP2470182B1 (pt) |
JP (1) | JP5727482B2 (pt) |
KR (1) | KR101701362B1 (pt) |
CN (2) | CN102711764A (pt) |
AU (1) | AU2010289802C1 (pt) |
BR (1) | BR112012004161B1 (pt) |
CA (1) | CA2772080C (pt) |
CL (1) | CL2012000493A1 (pt) |
DK (1) | DK2470182T3 (pt) |
ES (1) | ES2475721T3 (pt) |
HK (1) | HK1172844A1 (pt) |
HR (1) | HRP20140621T1 (pt) |
IL (1) | IL218298A (pt) |
IN (1) | IN2012DN02370A (pt) |
MX (1) | MX2012002335A (pt) |
NZ (1) | NZ598891A (pt) |
PL (1) | PL2470182T3 (pt) |
PT (1) | PT2470182E (pt) |
RU (1) | RU2567390C2 (pt) |
SG (1) | SG178867A1 (pt) |
SI (1) | SI2470182T1 (pt) |
WO (1) | WO2011028548A1 (pt) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011028548A1 (en) * | 2009-08-24 | 2011-03-10 | Neuralstem, Inc. | Synthesis of a neurostimulative piperazine |
JP7204640B2 (ja) * | 2016-09-12 | 2023-01-16 | ニューラルステム・インコーポレーテッド | 糖尿病に関連する神経障害の改善 |
WO2018075667A1 (en) * | 2016-10-18 | 2018-04-26 | Neuralstem, Inc. | Amelioration of radiation-induced cognitive dysfunction |
US10042957B2 (en) | 2017-01-12 | 2018-08-07 | Innovationdock, Inc. | Devices and methods for implementing dynamic collaborative workflow systems |
WO2018148733A1 (en) * | 2017-02-13 | 2018-08-16 | Neuralstem, Inc. | Amelioration of certain deficiencies due to stroke |
US20240067625A1 (en) * | 2020-12-23 | 2024-02-29 | Baylor College Of Medicine | Small-molecule modulators of the orphan nuclear receptor tlx |
MX2023014442A (es) | 2021-06-03 | 2024-03-05 | Alto Neuroscience Inc | Metodo de tratamiento de pacientes deprimidos con cognicion deficiente y seleccion de otros pacientes que se beneficiarian de un agente de bencilpiperazin-aminopiridina. |
US20240197721A1 (en) | 2022-12-05 | 2024-06-20 | Alto Neuroscience, Inc. | Effective treatment of depression in patients having impaired learning and/or memory or certain eeg characteristics with a benzylpiperazine-aminopyridine agent |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU175075B (hu) * | 1977-06-30 | 1980-05-28 | Egyt Gyogyszervegyeszeti Gyar | Sposob poluchenija piperazidov piridin-karbonovoj kisloty |
JPS54122283A (en) * | 1978-03-13 | 1979-09-21 | Sumitomo Chem Co Ltd | Novel quinazoline derivative and its preparation |
US6995162B2 (en) | 2001-01-12 | 2006-02-07 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
CN100343240C (zh) * | 2002-03-29 | 2007-10-17 | 先灵公司 | 手性2-甲基-4-保护的哌嗪的立体选择性烷基化 |
GB0222493D0 (en) * | 2002-09-27 | 2002-11-06 | Glaxo Group Ltd | Compounds |
US20040185429A1 (en) * | 2002-12-09 | 2004-09-23 | Judith Kelleher-Andersson | Method for discovering neurogenic agents |
CA2537292C (en) * | 2003-09-09 | 2013-04-02 | F. Hoffmann-La Roche Ag | 1- (2-amino-benzol) -piperazine derivatives as glycine uptake inhibitors for the treatment of psychoses |
PE20060600A1 (es) * | 2004-10-29 | 2006-07-14 | Banyu Pharma Co Ltd | Derivados de aminopiridina como inhibidores selectivos de la aurora a quinasa |
US7754724B2 (en) | 2005-06-30 | 2010-07-13 | Dow Agrosciences Llc | N-substituted piperazines |
KR20080076962A (ko) * | 2005-12-20 | 2008-08-20 | 노파르티스 아게 | 대사성 글루타메이트 수용체 조절제로서의 니코틴산 유도체 |
WO2011028548A1 (en) * | 2009-08-24 | 2011-03-10 | Neuralstem, Inc. | Synthesis of a neurostimulative piperazine |
-
2010
- 2010-08-24 WO PCT/US2010/046537 patent/WO2011028548A1/en active Application Filing
- 2010-08-24 US US13/392,489 patent/US9278933B2/en active Active
- 2010-08-24 SG SG2012012878A patent/SG178867A1/en unknown
- 2010-08-24 CN CN2010800465155A patent/CN102711764A/zh active Pending
- 2010-08-24 CN CN201511009541.1A patent/CN105693601A/zh active Pending
- 2010-08-24 CA CA2772080A patent/CA2772080C/en active Active
- 2010-08-24 MX MX2012002335A patent/MX2012002335A/es active IP Right Grant
- 2010-08-24 KR KR1020127007653A patent/KR101701362B1/ko active IP Right Grant
- 2010-08-24 RU RU2012111227/04A patent/RU2567390C2/ru not_active IP Right Cessation
- 2010-08-24 DK DK10814260.5T patent/DK2470182T3/da active
- 2010-08-24 SI SI201030669T patent/SI2470182T1/sl unknown
- 2010-08-24 JP JP2012526928A patent/JP5727482B2/ja active Active
- 2010-08-24 EP EP10814260.5A patent/EP2470182B1/en active Active
- 2010-08-24 PL PL10814260T patent/PL2470182T3/pl unknown
- 2010-08-24 BR BR112012004161A patent/BR112012004161B1/pt active IP Right Grant
- 2010-08-24 PT PT108142605T patent/PT2470182E/pt unknown
- 2010-08-24 IN IN2370DEN2012 patent/IN2012DN02370A/en unknown
- 2010-08-24 ES ES10814260.5T patent/ES2475721T3/es active Active
- 2010-08-24 AU AU2010289802A patent/AU2010289802C1/en active Active
- 2010-08-24 NZ NZ598891A patent/NZ598891A/en not_active IP Right Cessation
-
2012
- 2012-02-23 IL IL218298A patent/IL218298A/en active IP Right Grant
- 2012-02-24 CL CL2012000493A patent/CL2012000493A1/es unknown
-
2013
- 2013-01-04 HK HK13100159.2A patent/HK1172844A1/xx unknown
-
2014
- 2014-06-30 HR HRP20140621AT patent/HRP20140621T1/hr unknown
-
2015
- 2015-12-09 US US14/964,397 patent/US9481649B2/en active Active
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IN2012DN02370A (pt) | ||
MY156274A (en) | COMPOUNDS FOR THE REDUCTION OF ß-AMYLOID PRODUCTION | |
MX2012003343A (es) | Proceso para preparar compuestos azabiciclicos. | |
GB0910003D0 (en) | Novel compounds for the treatment of neurodegenerative diseases | |
IL202154A0 (en) | Novel amide derivative for inhibiting the growth of cancer cells | |
EP1887880A4 (en) | PROCESS FOR PRODUCING ANIMAL FEED AND ETHANOL AND NEW FOOD | |
EP2189435A4 (en) | PROCESS FOR PREPARING A PROPYLENE | |
ZA201004217B (en) | Use of bacteria for the production of bioenergy | |
ZA201102782B (en) | Sporulation-deficient termophilic microorganisms for the production of ethanol | |
EP2488025A4 (en) | SEPIAPTERIC INTREDUCTASE INHIBITION FOR PAIN TREATMENT | |
EP2491125A4 (en) | MICROORGANISMS FOR ANILINE PRODUCTION | |
ZA201005116B (en) | 6.7-dialkoxy ouinazoline derivatives useful for treatment of cancer related disorders | |
EP2238239A4 (en) | BIOLOGICAL SYSTEMS FOR THE PRODUCTION OF COMPOUNDS WITH COMMERCIAL VALUE | |
IL201245A0 (en) | An improved process for the synthesis of solifenacin | |
FR2950889B1 (fr) | Procede de synthese de l'ergothioneine et analogues | |
IL213761A0 (en) | Novel ortho-aminoamides for the treatment of cancer | |
MY160392A (en) | Triptolide prodrugs | |
ZA201104707B (en) | Process for the production of paper or paperboard | |
ZA201105709B (en) | Process for the synthesis of cleistanthin | |
EP2484466A4 (en) | Stock feeding apparatus | |
EP2158160A4 (en) | PROCESS FOR PRODUCING POLYALUMINUM SALTS | |
EP2322499A4 (en) | PROCESS FOR PRODUCING A BICYCLOÝ2.2.2¨OCTYLAMINE DERIVATIVE | |
FR2921921B1 (fr) | Procede de synthese de composes polyhydroxystilbeniques. | |
EP2501712A4 (en) | PROCESS FOR SYNTHESIS OF AC-ARG-CYCLO- (CYS-D-ALA-HIS-D-PHE-ARG-TRP-CYS-) NH2 | |
EP2275423B8 (en) | Process for the synthesis of paliperidone |