PT2343286E - Derivados de dibenzo[b,f][1,4]oxazepina como inibidores de histona-desacetilase - Google Patents

Derivados de dibenzo[b,f][1,4]oxazepina como inibidores de histona-desacetilase Download PDF

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Publication number
PT2343286E
PT2343286E PT111525762T PT11152576T PT2343286E PT 2343286 E PT2343286 E PT 2343286E PT 111525762 T PT111525762 T PT 111525762T PT 11152576 T PT11152576 T PT 11152576T PT 2343286 E PT2343286 E PT 2343286E
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PT
Portugal
Prior art keywords
dibenzo
inhibitors
histone deacetylase
oxazepine derivatives
oxazepine
Prior art date
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PT111525762T
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English (en)
Inventor
Robert Deziel
Gideon Shapiro
Richard Chesworth
Silvana Leit
Patrick Beaulieu
Yves Andre Chantigny
John Mancuso
Pierre Tessier
David Smil
Original Assignee
Methylgene Inc
Forum Pharmaceuticals Inc
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Application filed by Methylgene Inc, Forum Pharmaceuticals Inc filed Critical Methylgene Inc
Publication of PT2343286E publication Critical patent/PT2343286E/pt

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    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
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    • C07D267/02—Seven-membered rings
    • C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D267/16—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D267/20—[b, f]-condensed
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
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    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/20—Dibenz [b, e] azepines; Hydrogenated dibenz [b, e] azepines
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    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
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    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
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    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
    • C07D223/26—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom having a double bond between positions 10 and 11
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    • C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
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