PT2268612E - Inibidores de metaloprotease de matriz à base de arilsulfonamidas - Google Patents

Inibidores de metaloprotease de matriz à base de arilsulfonamidas Download PDF

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Publication number
PT2268612E
PT2268612E PT97244834T PT09724483T PT2268612E PT 2268612 E PT2268612 E PT 2268612E PT 97244834 T PT97244834 T PT 97244834T PT 09724483 T PT09724483 T PT 09724483T PT 2268612 E PT2268612 E PT 2268612E
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PT
Portugal
Prior art keywords
arylsulfonamide
based matrix
matrix metalloprotease
metalloprotease inhibitors
inhibitors
Prior art date
Application number
PT97244834T
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English (en)
Inventor
Michael Shultz
Claus Ehrhardt
Leslie Wighton Mcquire
Pascal Rigollier
Olivier Rogel
Ruben Alberto Tommasi
Original Assignee
Novartis Ag
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Publication of PT2268612E publication Critical patent/PT2268612E/pt

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    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
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    • A61K31/18—Sulfonamides
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BRPI0908603A2 (pt) 2020-08-18
EP2268612A1 (en) 2011-01-05
US20130096105A1 (en) 2013-04-18
US20120258954A1 (en) 2012-10-11
JP5490092B2 (ja) 2014-05-14
CN102036953A (zh) 2011-04-27
WO2009118292A1 (en) 2009-10-01
EA201001523A1 (ru) 2011-06-30
KR20100127291A (ko) 2010-12-03
KR101673621B1 (ko) 2016-11-07
ES2524259T3 (es) 2014-12-04
CA2719457C (en) 2017-05-02
US8975439B2 (en) 2015-03-10
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US9822092B2 (en) 2017-11-21
US8222424B2 (en) 2012-07-17
CA2719457A1 (en) 2009-10-01
MX2010010525A (es) 2010-10-25
US20150045398A1 (en) 2015-02-12
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CN102036953B (zh) 2015-05-06
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