PT1888556E - Methods for synthesizing heterocyclic compounds - Google Patents

Methods for synthesizing heterocyclic compounds Download PDF

Info

Publication number
PT1888556E
PT1888556E PT06760144T PT06760144T PT1888556E PT 1888556 E PT1888556 E PT 1888556E PT 06760144 T PT06760144 T PT 06760144T PT 06760144 T PT06760144 T PT 06760144T PT 1888556 E PT1888556 E PT 1888556E
Authority
PT
Portugal
Prior art keywords
solvent
methods
heterocyclic compounds
synthesizing
nitroaniline
Prior art date
Application number
PT06760144T
Other languages
Portuguese (pt)
Inventor
David Ryckman
Gabriel Calvin
Eric Harwood
Shuguang Zhu
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PT1888556E publication Critical patent/PT1888556E/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

A method for synthesizing a heterocyclic compound includes: reacting 1-methylpiperazine with 5-chloro-2-nitroaniline at an internal temperature sufficient to provide a compound of Formula VIH The 1-methylpiperazine and the 5-chloro-2-nitroaniline are reacted in a solvent that comprises water in an amount greater than 50 percent by volume based on the amount of the solvent and/or are reacted in a solvent that comprises an organic solvent component that has a boiling point of greater than 100°C at atmospheric pressure.
PT06760144T 2005-05-17 2006-05-17 Methods for synthesizing heterocyclic compounds PT1888556E (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US68189305P 2005-05-17 2005-05-17

Publications (1)

Publication Number Publication Date
PT1888556E true PT1888556E (en) 2012-02-03

Family

ID=37431595

Family Applications (1)

Application Number Title Priority Date Filing Date
PT06760144T PT1888556E (en) 2005-05-17 2006-05-17 Methods for synthesizing heterocyclic compounds

Country Status (15)

Country Link
US (1) US8222413B2 (en)
EP (2) EP1888556B1 (en)
JP (2) JP5545925B2 (en)
KR (1) KR101324863B1 (en)
CN (1) CN101223157B (en)
AT (1) ATE530533T1 (en)
AU (1) AU2006247062A1 (en)
BR (1) BRPI0610355A2 (en)
CA (1) CA2608087C (en)
ES (1) ES2376347T3 (en)
MX (1) MX2007014381A (en)
PL (1) PL1888556T3 (en)
PT (1) PT1888556E (en)
RU (1) RU2437878C2 (en)
WO (1) WO2006125130A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1888556E (en) * 2005-05-17 2012-02-03 Novartis Ag Methods for synthesizing heterocyclic compounds
JP5541454B2 (en) * 2009-09-16 2014-07-09 Ｊｓｒ株式会社 Liquid crystal aligning agent and liquid crystal display element
KR102087662B1 (en) 2018-06-20 2020-03-11 강원대학교산학협력단 Composition for prevention or treatment of chronic obstructive pulmonary disease comprising 4-[[4-[3-(Cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-2-thiazolyl]amino]-phenol compound
KR102087661B1 (en) 2018-07-27 2020-03-11 강원대학교산학협력단 Composition for prevention or treatment of chronic obstructive pulmonary disease comprising GEBR-7B compound

Family Cites Families (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3663606A (en) 1966-06-21 1972-05-16 Mitsui Toatsu Chemicals Organic imino-compounds
DE2363459A1 (en) 1973-12-20 1975-06-26 Basf Ag 7-Amino-quinoline cpds. - for use as optical brighteners, dyes, colour formers in copying and in printing pastes
US4659657A (en) 1982-12-24 1987-04-21 Bayer Aktiengesellschaft Chromogenic and fluorogenic esters for photometric or fluorimetric determination of phosphatases or sulphatases
DE3248043A1 (en) 1982-12-24 1984-06-28 Bayer Ag, 5090 Leverkusen Fluorogenic phosphoric esters, process for their preparation, and process and composition for the detection and fluorometric determination of phosphates
DE3634066A1 (en) 1986-10-07 1988-04-21 Boehringer Mannheim Gmbh NEW 5-ALKYLBENZIMIDAZOLES, PROCESS FOR THEIR PRODUCTION AND MEDICINAL PRODUCTS
JPH07121937B2 (en) 1987-03-18 1995-12-25 大塚製薬株式会社 Carbostyril derivative
JPH0699497B2 (en) 1987-04-16 1994-12-07 富士写真フイルム株式会社 Photopolymerizable composition
GB8709448D0 (en) 1987-04-21 1987-05-28 Pfizer Ltd Heterobicyclic quinoline derivatives
DE3932953A1 (en) 1989-10-03 1991-04-11 Boehringer Mannheim Gmbh NEW 2-BICYCLO-BENZIMIDAZOLES, METHOD FOR THEIR PRODUCTION AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
GB9107742D0 (en) 1991-04-11 1991-05-29 Rhone Poulenc Agriculture New compositions of matter
GB9108369D0 (en) 1991-04-18 1991-06-05 Rhone Poulenc Agriculture Compositions of matter
GB9108547D0 (en) 1991-04-22 1991-06-05 Fujisawa Pharmaceutical Co Quinoline derivatives
US5480883A (en) 1991-05-10 1996-01-02 Rhone-Poulenc Rorer Pharmaceuticals Inc. Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
US5710158A (en) 1991-05-10 1998-01-20 Rhone-Poulenc Rorer Pharmaceuticals Inc. Aryl and heteroaryl quinazoline compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
USRE37650E1 (en) 1991-05-10 2002-04-09 Aventis Pharmacetical Products, Inc. Aryl and heteroaryl quinazoline compounds which inhibit CSF-1R receptor tyrosine kinase
US5409930A (en) 1991-05-10 1995-04-25 Rhone-Poulenc Rorer Pharmaceuticals Inc. Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
US5856115A (en) 1991-05-24 1999-01-05 Fred Hutchinson Cancer Research Center Assay for identification therapeutic agents
JP3142378B2 (en) 1992-06-22 2001-03-07 ティーディーケイ株式会社 Organic EL device
US5330992A (en) 1992-10-23 1994-07-19 Sterling Winthrop Inc. 1-cyclopropyl-4-pyridyl-quinolinones
US5792771A (en) 1992-11-13 1998-08-11 Sugen, Inc. Quinazoline compounds and compositions thereof for the treatment of disease
US5763441A (en) 1992-11-13 1998-06-09 Sugen, Inc. Compounds for the treatment of disorders related to vasculogenesis and/or angiogenesis
US5981569A (en) 1992-11-13 1999-11-09 Yissum Research Development Company Of The Hebrew University Of Jerusalem Substituted phenylacrylonitrile compounds and compositions thereof for the treatment of disease
JPH0743896A (en) 1993-07-28 1995-02-14 Toyobo Co Ltd Photopolymerizable composition
WO1995018801A1 (en) 1994-01-08 1995-07-13 Rhone-Poulenc Agriculture Ltd. Benzimidazolyl quinoline-3-carboxylate derivatives, intermediates thereto, and their use as herbicides
JPH0829973A (en) 1994-07-11 1996-02-02 Toyobo Co Ltd Photopolymerized composition
JP3441246B2 (en) 1995-06-07 2003-08-25 富士写真フイルム株式会社 Photopolymerizable composition
GB9514265D0 (en) 1995-07-13 1995-09-13 Wellcome Found Hetrocyclic compounds
GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
DE69734149T2 (en) 1996-03-15 2006-07-06 Astrazeneca Ab CINOLINE DERIVATIVES AND USE AS CEREALS
DE19610723A1 (en) 1996-03-19 1997-09-25 Bayer Ag Electroluminescent devices using glare systems
CA2258728C (en) 1996-06-19 2011-09-27 Rhone Poulenc Rorer Limited Substituted azabicylic compounds and their use as inhibitors of the production of tnf and cyclic amp phosphodiesterase
HUP9904567A3 (en) 1996-06-20 2001-10-29 Univ Texas Use of azo, thioalkyl, thiocarbonyl derivatives substituted by fused heterocycles and/or phenyl group for the preparation of pharmaceutical compositions stimulating bone growth
AU733551B2 (en) 1996-09-25 2001-05-17 Astrazeneca Ab Qinoline derivatives inhibiting the effect of growth factors such as VEGF
AU8816298A (en) 1997-08-22 1999-03-16 Zeneca Limited Oxindolylquinazoline derivatives as angiogenesis inhibitors
DE19756235A1 (en) 1997-12-17 1999-07-01 Klinge Co Chem Pharm Fab New piperidinyl-substituted pyridylalkane alkene and alkane carboxylic acid amides
BR9815786A (en) 1998-03-31 2000-11-21 Warner Lambert Co Quinolones as serine protease inhibitors
AU3850299A (en) 1998-05-20 1999-12-06 Kyowa Hakko Kogyo Co. Ltd. Vegf activity inhibitors
WO1999065897A1 (en) 1998-06-19 1999-12-23 Chiron Corporation Inhibitors of glycogen synthase kinase 3
WO2000000481A1 (en) 1998-06-29 2000-01-06 Du Pont Pharmaceuticals Company Cyclic carbamates and isoxazolidines as iib/iiia antagonists
FR2781218B1 (en) 1998-07-15 2001-09-07 Lafon Labor PHARMACEUTICAL COMPOSITIONS COMPRISING 2-QUINOLONES
US6174912B1 (en) 1998-08-21 2001-01-16 Dupont Pharmaceuticals Company Nitrogen substituted imidazo[4,5-C]pyrazoles as corticotropin releasing hormone antagonists
DE19841985A1 (en) 1998-09-03 2000-03-09 Schering Ag New heterocyclic alkanesulfonic and alkane carboxylic acid derivatives are VEGF receptor blockers useful in treatment of e.g. psoriasis, rheumatoid arthritis, stroke, tumors and endometriosis
WO2000020400A1 (en) 1998-10-05 2000-04-13 Axys Pharmaceuticals, Inc. Novel compounds and compositions for treating hepatitis c infections
IL126953A0 (en) 1998-11-08 1999-09-22 Yeda Res & Dev Pharmaceutical compositions comprising porphyrins and some novel porphyrin derivatives
KR100373203B1 (en) 1999-03-31 2003-02-25 주식회사 엘지화학 New organometallic complexes for use in light emitting devices
TR200103352T2 (en) 1999-05-21 2005-03-21 Bristol-Myers Squibb Company Kinase pyrolotriazine inhibitors
PE20010306A1 (en) 1999-07-02 2001-03-29 Agouron Pharma INDAZOLE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM USEFUL FOR THE INHIBITION OF PROTEIN KINASE
US6423734B1 (en) 1999-08-13 2002-07-23 The Procter & Gamble Company Method of preventing cancer
KR100298572B1 (en) 1999-08-19 2001-09-22 박찬구 The method for preparing 4-nitrodiphenylamine and 4-nitrosodiphenylamine from carbanilide
JP3822494B2 (en) 1999-10-19 2006-09-20 メルク エンド カムパニー インコーポレーテッド Tyrosine kinase inhibitor
AU778042B2 (en) 1999-10-19 2004-11-11 Merck & Co., Inc. Tyrosine kinase inhibitors
AU783683B2 (en) 2000-01-18 2005-11-24 Vegenics Limited VEGF-D/VEGF-C/VEGF peptidomimetic inhibitor
YU54202A (en) 2000-01-18 2006-01-16 Agouron Pharmaceuticals Inc. Indazole compounds,pharmaceutical compositions,and methods for mediating or inhibiting cell proliferation
AU2925401A (en) 2000-01-19 2001-07-31 Parkash S Gill Methods and compositions for antisense vegf oligonucleotides
GB0001930D0 (en) 2000-01-27 2000-03-22 Novartis Ag Organic compounds
US6420382B2 (en) 2000-02-25 2002-07-16 Merck & Co., Inc. Tyrosine kinase inhibitors
US6313138B1 (en) 2000-02-25 2001-11-06 Merck & Co., Inc. Tyrosine kinase inhibitors
JP2003523390A (en) 2000-02-25 2003-08-05 メルク エンド カムパニー インコーポレーテッド Tyrosine kinase inhibitor
US7179912B2 (en) * 2000-09-01 2007-02-20 Icos Corporation Materials and methods to potentiate cancer treatment
ATE448226T1 (en) 2000-09-01 2009-11-15 Novartis Vaccines & Diagnostic AZA HETEROCYCLIC DERIVATIVES AND THEIR THERAPEUTIC USE
WO2002022598A1 (en) * 2000-09-11 2002-03-21 Chiron Corporation Quinolinone derivatives as tyrosine kinase inhibitors
US20030028018A1 (en) 2000-09-11 2003-02-06 Chiron Coporation Quinolinone derivatives
MXPA03002601A (en) 2000-09-26 2005-02-25 Univ Arizona Foundation Benzimidazoles and methods for use thereof in the treatment of cancer or viral infections.
CA2424689A1 (en) 2000-10-17 2002-04-25 Merck & Co., Inc. Orally active salts with tyrosine kinase activity
US6693125B2 (en) 2001-01-24 2004-02-17 Combinatorx Incorporated Combinations of drugs (e.g., a benzimidazole and pentamidine) for the treatment of neoplastic disorders
US7081454B2 (en) 2001-03-28 2006-07-25 Bristol-Myers Squibb Co. Tyrosine kinase inhibitors
WO2003004488A1 (en) 2001-07-03 2003-01-16 Chiron Corporation Indazole benzimidazole compounds as tyrosine and serine/threonine kinase inhibitors
WO2003033472A1 (en) 2001-10-17 2003-04-24 Kirin Beer Kabushiki Kaisha Quinoline or quinazoline derivatives inhibiting auto- phosphorylation of fibroblast growth factor receptors
US20050256157A1 (en) 2002-08-23 2005-11-17 Chiron Corporation Combination therapy with CHK1 inhibitors
EP1539754A4 (en) * 2002-08-23 2009-02-25 Novartis Vaccines & Diagnostic Benzimidazole quinolinones and uses thereof
US7825132B2 (en) 2002-08-23 2010-11-02 Novartis Vaccines And Diagnostics, Inc. Inhibition of FGFR3 and treatment of multiple myeloma
US7232826B2 (en) 2002-09-30 2007-06-19 Bristol-Myers Squibb Company Tyrosine kinase inhibitors
JP2006511616A (en) 2002-11-13 2006-04-06 カイロン コーポレイション Methods for treating cancer and related methods
WO2004063151A2 (en) 2003-01-03 2004-07-29 Bristol-Myers Squibb Company Novel tyrosine kinase inhibitors
AU2003263586A1 (en) * 2003-01-09 2004-08-10 University Of Delhi A process for the synthesis of bisbenzimidazoles and its derivations
ES2423800T3 (en) 2003-03-28 2013-09-24 Novartis Vaccines And Diagnostics, Inc. Use of organic compounds for immunopotentiation
EA012621B1 (en) * 2003-11-07 2009-10-30 Чирон Корпорейшн Pharmaceutically acceptable salts of quinolinone compounds having improved pharmaceutical properties
AU2005216904B2 (en) 2004-02-20 2010-11-25 Novartis Vaccines And Diagnostics, Inc. Modulation of inflammatory and metastatic processes
PT1888556E (en) * 2005-05-17 2012-02-03 Novartis Ag Methods for synthesizing heterocyclic compounds

Also Published As

Publication number Publication date
BRPI0610355A2 (en) 2010-06-15
EP2465857A1 (en) 2012-06-20
ES2376347T3 (en) 2012-03-13
CA2608087A1 (en) 2006-11-23
US8222413B2 (en) 2012-07-17
JP5545925B2 (en) 2014-07-09
US20110046376A1 (en) 2011-02-24
EP1888556A1 (en) 2008-02-20
KR20080026106A (en) 2008-03-24
KR101324863B1 (en) 2013-11-01
RU2007146394A (en) 2009-06-27
EP2465857B1 (en) 2014-06-04
EP1888556A4 (en) 2009-12-02
MX2007014381A (en) 2008-02-06
JP2008540675A (en) 2008-11-20
PL1888556T3 (en) 2012-03-30
WO2006125130A1 (en) 2006-11-23
CN101223157B (en) 2013-03-06
CA2608087C (en) 2013-12-10
AU2006247062A1 (en) 2006-11-23
RU2437878C2 (en) 2011-12-27
JP2014012682A (en) 2014-01-23
ATE530533T1 (en) 2011-11-15
CN101223157A (en) 2008-07-16
EP1888556B1 (en) 2011-10-26

Similar Documents

Publication Publication Date Title
EP1968131A4 (en) Material for organic electroluminescent device and organic electroluminescent device
MX2009008858A (en) Fluorine-containing pyrazolecarbonitrile derivative and method for producing the same, and fluorine-containing pyrazolecarboxylic acid derivative obtained by using the fluorine-containing pyrazolecarbonitrile derivative and method for producing the s
WO2008126804A1 (en) Composition for forming under-resist film
TW200724528A (en) Carbazole derivative, light-emitting element material obtained by using carbazole derivative, light-emitting element, and electronic device
WO2008128934A3 (en) Fluorinated dyes and their use in electrophoretic display devices
HK1114101A1 (en)
PT1888556E (en) Methods for synthesizing heterocyclic compounds
TW200612959A (en) Method for preparing hydroxamic acids
ZA201003751B (en) Process for the synthesis of propargylated aminoindan derivatives
MY146360A (en) Process for producing 1-(3,4-dichlorobenzyl)-5-octylbiguanide or a salt thereof
TW200740823A (en) Oxadiazole-substituted Sym-triindole derivative and organic el element employing the same
TW200740763A (en) A method for preparing 5-hydroxy-1-alkyl pyrazole derivatives
MY158638A (en) 2-benzly-4-(3,4-dichlorophenyl)-5-methylimidazole compound
WO2008143016A1 (en) Epoxy resin composition for sealing, and electronic component device using the same
MX2009013336A (en) Synthesis of substituted-3-aminopyrazoles.
MX2008002112A (en) Chemical process.
WO2008113661A3 (en) Process for preparing substituted phenylhydrazines
AR068925A1 (en) AN IMPROVED PROCESS TO PREPARE A DERIVATIVE OF 2.4. - TIAZOLIDINDIONA
WO2007117404A3 (en) Methods and materials for preparing organic compounds from primary amines
WO2009008424A1 (en) Method for producing silicon compound
TH100702B (en) Methods of preparing compounds based on imidazole.
AR065108A1 (en) PROCESS TO PREPARE (R) -5- (2-AMINOETIL) -1- (6,8-DIFLUOROCROMO-3-IL) -1,3-DIHYDROIMIDAZOL-2-TIONA
TW200802999A (en) Organic semiconductor material and semiconductor device
TW200722407A (en) Direct aminolysis
TH145987A (en) A new process for the synthesis of strontium ranelate and its hydrate.