PT1364030E - Peptidos supersecretaveis, processos para a sua producao e melhoramento paralelo da forma secretada de um ou mais de outros polipeptidos - Google Patents

Peptidos supersecretaveis, processos para a sua producao e melhoramento paralelo da forma secretada de um ou mais de outros polipeptidos

Info

Publication number
PT1364030E
PT1364030E PT02716745T PT02716745T PT1364030E PT 1364030 E PT1364030 E PT 1364030E PT 02716745 T PT02716745 T PT 02716745T PT 02716745 T PT02716745 T PT 02716745T PT 1364030 E PT1364030 E PT 1364030E
Authority
PT
Portugal
Prior art keywords
protein
dna sequence
codon
lys
arg
Prior art date
Application number
PT02716745T
Other languages
English (en)
Inventor
Habermann Dr Paul
Original Assignee
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Publication of PT1364030E publication Critical patent/PT1364030E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
PT02716745T 2001-02-20 2002-02-08 Peptidos supersecretaveis, processos para a sua producao e melhoramento paralelo da forma secretada de um ou mais de outros polipeptidos PT1364030E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10108100A DE10108100A1 (de) 2001-02-20 2001-02-20 Verwendung supersekretierbarer Peptide in Verfahren zu deren Herstellung und paralleler Verbesserung der Exportate eines oder mehrerer anderer Polypeptide von Interesse

Publications (1)

Publication Number Publication Date
PT1364030E true PT1364030E (pt) 2006-05-31

Family

ID=7674831

Family Applications (1)

Application Number Title Priority Date Filing Date
PT02716745T PT1364030E (pt) 2001-02-20 2002-02-08 Peptidos supersecretaveis, processos para a sua producao e melhoramento paralelo da forma secretada de um ou mais de outros polipeptidos

Country Status (21)

Country Link
EP (1) EP1364030B1 (pt)
JP (1) JP4243103B2 (pt)
KR (1) KR100858008B1 (pt)
CN (1) CN100575493C (pt)
AT (1) ATE320498T1 (pt)
AU (1) AU2002247696B2 (pt)
BR (1) BR0207385A (pt)
CA (1) CA2438935C (pt)
CY (1) CY1105696T1 (pt)
DE (2) DE10108100A1 (pt)
DK (1) DK1364030T3 (pt)
ES (1) ES2258619T3 (pt)
HK (1) HK1065818A1 (pt)
IL (1) IL157415A0 (pt)
MX (1) MXPA03007115A (pt)
NO (1) NO331375B1 (pt)
NZ (1) NZ527641A (pt)
PE (1) PE20020875A1 (pt)
PT (1) PT1364030E (pt)
WO (1) WO2002066628A2 (pt)
ZA (1) ZA200305867B (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE514718T1 (de) * 2003-04-04 2011-07-15 Univ Lausanne Peptabody für krebsbehandlung
DE102006031962A1 (de) 2006-07-11 2008-01-17 Sanofi-Aventis Deutschland Gmbh Amidiertes Insulin Glargin
DE102006031955A1 (de) 2006-07-11 2008-01-17 Sanofi-Aventis Deutschland Gmbh Verfahren zur Herstellung von Insulinanaloga mit dibasischem B-Kettenende
RS56632B1 (sr) 2008-10-17 2018-03-30 Sanofi Aventis Deutschland Kombinacija insulina i glp-1-agonista
CN102711804B (zh) 2009-11-13 2015-09-16 赛诺菲-安万特德国有限公司 包含glp-1激动剂和甲硫氨酸的药物组合物
AU2010317995B2 (en) 2009-11-13 2014-04-17 Sanofi-Aventis Deutschland Gmbh Pharmaceutical composition comprising a GLP-1 agonist, an insulin, and methionine
JP6199186B2 (ja) 2010-08-30 2017-09-20 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング ２型糖尿病の治療用の医薬の製造のためのａｖｅ００１０の使用
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
JP6367115B2 (ja) 2011-08-29 2018-08-01 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング ２型糖尿病患者の血糖コントロールに使用する組合せ医薬
TWI559929B (en) 2011-09-01 2016-12-01 Sanofi Aventis Deutschland Pharmaceutical composition for use in the treatment of a neurodegenerative disease
MX2017007699A (es) 2014-12-12 2017-09-18 Sanofi Aventis Deutschland Formulacion de proporcion fija de insulina glargina/lixisenatida.
TWI748945B (zh) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患治療
TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患之治療
CN108866205A (zh) * 2018-07-25 2018-11-23 中国食品药品检定研究院 基于分子生物学方法鉴别菲牛蛭的特异性引物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE58906966D1 (de) * 1988-06-23 1994-03-24 Hoechst Ag Mini-Proinsulin, seine Herstellung und Verwendung.
GB8927722D0 (en) * 1989-12-07 1990-02-07 British Bio Technology Proteins and nucleic acids
FI92601C (fi) * 1992-03-11 1994-12-12 Marja Makarow Menetelmä hyötyproteiinien erittämiseksi hiivoista

Also Published As

Publication number Publication date
MXPA03007115A (es) 2003-11-18
BR0207385A (pt) 2004-02-10
DE10108100A1 (de) 2002-08-29
WO2002066628A3 (en) 2002-11-14
ATE320498T1 (de) 2006-04-15
PE20020875A1 (es) 2002-10-31
ES2258619T3 (es) 2006-09-01
DK1364030T3 (da) 2006-07-17
NO20033671D0 (no) 2003-08-19
EP1364030A2 (en) 2003-11-26
KR100858008B1 (ko) 2008-09-11
CN100575493C (zh) 2009-12-30
CY1105696T1 (el) 2010-12-22
NO20033671L (no) 2003-10-17
NZ527641A (en) 2005-03-24
NO331375B1 (no) 2011-12-12
KR20030074832A (ko) 2003-09-19
CA2438935C (en) 2012-01-24
AU2002247696B2 (en) 2006-10-12
JP2004518442A (ja) 2004-06-24
CA2438935A1 (en) 2002-08-29
HK1065818A1 (en) 2005-03-04
EP1364030B1 (en) 2006-03-15
CN1527882A (zh) 2004-09-08
ZA200305867B (en) 2004-06-29
DE60209883T2 (de) 2006-09-07
DE60209883D1 (de) 2006-05-11
JP4243103B2 (ja) 2009-03-25
IL157415A0 (en) 2004-03-28
WO2002066628A2 (en) 2002-08-29

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