PT1147087E - Feantridina-n-oxidos com actividade de inibicao de pde-iv - Google Patents
Feantridina-n-oxidos com actividade de inibicao de pde-ivInfo
- Publication number
- PT1147087E PT1147087E PT00901089T PT00901089T PT1147087E PT 1147087 E PT1147087 E PT 1147087E PT 00901089 T PT00901089 T PT 00901089T PT 00901089 T PT00901089 T PT 00901089T PT 1147087 E PT1147087 E PT 1147087E
- Authority
- PT
- Portugal
- Prior art keywords
- oxides
- feantridine
- pde
- inhibition activity
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/10—Aza-phenanthrenes
- C07D221/12—Phenanthridines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP99100707 | 1999-01-15 | ||
PCT/EP2000/000150 WO2000042017A1 (en) | 1999-01-15 | 2000-01-12 | Phenanthridine-n-oxides with pde-iv inhibiting activity |
Publications (1)
Publication Number | Publication Date |
---|---|
PT1147087E true PT1147087E (pt) | 2005-09-30 |
Family
ID=8237354
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT00901089T PT1147087E (pt) | 1999-01-15 | 2000-01-12 | Feantridina-n-oxidos com actividade de inibicao de pde-iv |
Country Status (12)
Country | Link |
---|---|
US (1) | US6538005B2 (pt) |
EP (1) | EP1147087B1 (pt) |
JP (1) | JP2002534505A (pt) |
AT (1) | ATE295352T1 (pt) |
AU (1) | AU2107700A (pt) |
CA (1) | CA2359404A1 (pt) |
DE (1) | DE60020079T2 (pt) |
DK (1) | DK1147087T3 (pt) |
ES (1) | ES2242594T3 (pt) |
PT (1) | PT1147087E (pt) |
SI (1) | SI1147087T1 (pt) |
WO (1) | WO2000042017A1 (pt) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE60024581T2 (de) * | 1999-01-15 | 2006-08-10 | Altana Pharma Ag | 6-phenylphenanthridine mit pde-iv hemmender wirkung |
ATE394378T1 (de) | 2000-01-11 | 2008-05-15 | Nycomed Gmbh | Phenanthridin -n- oxide |
WO2002006239A1 (en) * | 2000-07-14 | 2002-01-24 | Altana Pharma Ag | Phenanthridine n-oxides |
AU2001283935B2 (en) | 2000-07-14 | 2006-07-13 | Altana Pharma Ag | Novel 6-heteroarylphenanthridines |
WO2004019945A1 (en) | 2002-08-29 | 2004-03-11 | Altana Pharma Ag | 3-hydroxy-6-phenylphenanthridines as pde-4 inhibitors |
WO2005077906A1 (en) | 2004-02-18 | 2005-08-25 | Altana Pharma Ag | Novel guanidinyl-substituted hydroxy-6-phenylphenenthridines as effective phosphodiesterase (pde) 4 inhibitors |
AR049419A1 (es) * | 2004-03-03 | 2006-08-02 | Altana Pharma Ag | Hidroxi-6-fenilfenantridinas sustituidas con heterociclilo |
PL2589599T4 (pl) | 2004-03-03 | 2015-06-30 | Takeda Gmbh | Nowe hydroksy-6-heteroarylofenantrydyny i ich zastosowanie jako inhibitorów PDE4 |
US20070185149A1 (en) * | 2004-03-10 | 2007-08-09 | Altana Pharma Ag | Novel amido-substituted hydroxy-6-phenylphenanthridines and their use as pde4 inhibtors |
WO2006027345A2 (en) * | 2004-09-08 | 2006-03-16 | Altana Pharma Ag | Novel 3-thia-10-aza-phenanthrene derivatives |
US7718668B2 (en) | 2005-03-02 | 2010-05-18 | Nycomed Gmbh | Salts of 6-heterocycle substituted hexahydrophenanthridine derivatives |
CA2599368A1 (en) * | 2005-03-09 | 2006-09-14 | Nycomed Gmbh | Amido-substituted 6-phenylphenanthridines |
MX2010003155A (es) | 2007-10-04 | 2010-04-01 | Hoffmann La Roche | Derivados de ciclopropil aril amida y uso de los mismos. |
EP2804603A1 (en) | 2012-01-10 | 2014-11-26 | President and Fellows of Harvard College | Beta-cell replication promoting compounds and methods of their use |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5455252A (en) * | 1993-03-31 | 1995-10-03 | Syntex (U.S.A.) Inc. | Optionally substituted 6,8-quinolines |
US5475003A (en) * | 1994-03-03 | 1995-12-12 | Syntex (U.S.A.) Inc. | 8-phenylcyclopentenoquinoline and 8-phenylcyclohexenoquinoline derivatives |
CA2143143A1 (en) * | 1994-03-08 | 1995-09-09 | Toshihiko Tanaka | 3-phenylpyrrolidine derivatives |
US5466697A (en) * | 1994-07-13 | 1995-11-14 | Syntex (U.S.A.) Inc. | 8-phenyl-1,6-naphthyridin-5-ones |
US6191138B1 (en) * | 1996-01-31 | 2001-02-20 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Phenanthridines |
US6127378A (en) | 1996-03-26 | 2000-10-03 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Phenanthridines substituted in the 6 position |
JP4141501B2 (ja) * | 1996-03-26 | 2008-08-27 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規の6位置換フェナントリジン |
GB9622386D0 (en) * | 1996-10-28 | 1997-01-08 | Sandoz Ltd | Organic compounds |
EA001551B1 (ru) | 1996-11-11 | 2001-04-23 | Бык Гюльден Ломберг Хемише Фабрик Гмбх | Бензонафтиридины в качестве бронхиальных терапевтических средств |
GB9626643D0 (en) | 1996-12-21 | 1997-02-12 | Astra Pharma Prod | Compounds |
AU6825898A (en) | 1997-03-07 | 1998-09-29 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Novel tetrazoles |
ES2193539T3 (es) * | 1997-06-03 | 2003-11-01 | Altana Pharma Ag | Benzonaftiridinas. |
ES2189235T3 (es) * | 1997-07-25 | 2003-07-01 | Altana Pharma Ag | 6-fenilfenantridinas sustituidas. |
CA2297923A1 (en) | 1997-07-25 | 1999-02-04 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Novel tetrazole-substituted 6-phenyl-pheanathridines as pde inhibitors |
AU5970199A (en) | 1998-08-31 | 2000-03-21 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Benzonaphthyridine-n-oxides comprising a pde3 and pde4 inhibiting activity |
-
2000
- 2000-01-12 AT AT00901089T patent/ATE295352T1/de not_active IP Right Cessation
- 2000-01-12 CA CA002359404A patent/CA2359404A1/en not_active Abandoned
- 2000-01-12 WO PCT/EP2000/000150 patent/WO2000042017A1/en active IP Right Grant
- 2000-01-12 DK DK00901089T patent/DK1147087T3/da active
- 2000-01-12 AU AU21077/00A patent/AU2107700A/en not_active Abandoned
- 2000-01-12 PT PT00901089T patent/PT1147087E/pt unknown
- 2000-01-12 SI SI200030717T patent/SI1147087T1/xx unknown
- 2000-01-12 EP EP00901089A patent/EP1147087B1/en not_active Expired - Lifetime
- 2000-01-12 ES ES00901089T patent/ES2242594T3/es not_active Expired - Lifetime
- 2000-01-12 DE DE60020079T patent/DE60020079T2/de not_active Expired - Fee Related
- 2000-01-12 JP JP2000593585A patent/JP2002534505A/ja not_active Withdrawn
-
2001
- 2001-01-12 US US09/889,142 patent/US6538005B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JP2002534505A (ja) | 2002-10-15 |
AU2107700A (en) | 2000-08-01 |
ATE295352T1 (de) | 2005-05-15 |
SI1147087T1 (en) | 2005-10-31 |
EP1147087B1 (en) | 2005-05-11 |
CA2359404A1 (en) | 2000-07-20 |
DE60020079D1 (de) | 2005-06-16 |
DK1147087T3 (da) | 2005-09-05 |
WO2000042017A1 (en) | 2000-07-20 |
EP1147087A1 (en) | 2001-10-24 |
US6538005B2 (en) | 2003-03-25 |
ES2242594T3 (es) | 2005-11-16 |
US20020183350A1 (en) | 2002-12-05 |
DE60020079T2 (de) | 2006-01-19 |
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