PT100426A - Derivados 4-aril-3-heteroarilureidoquinolina uteis como agentes anti-hipercolesterolemicos e antiateroscleroticos - Google Patents

Derivados 4-aril-3-heteroarilureidoquinolina uteis como agentes anti-hipercolesterolemicos e antiateroscleroticos Download PDF

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Publication number
PT100426A
PT100426A PT100426A PT10042692A PT100426A PT 100426 A PT100426 A PT 100426A PT 100426 A PT100426 A PT 100426A PT 10042692 A PT10042692 A PT 10042692A PT 100426 A PT100426 A PT 100426A
Authority
PT
Portugal
Prior art keywords
chlorophenyl
ureido
bis
methylthio
quinoline
Prior art date
Application number
PT100426A
Other languages
English (en)
Portuguese (pt)
Inventor
Ernest S Hamanaka
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of PT100426A publication Critical patent/PT100426A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/36—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
PT100426A 1991-04-26 1992-04-24 Derivados 4-aril-3-heteroarilureidoquinolina uteis como agentes anti-hipercolesterolemicos e antiateroscleroticos PT100426A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US69232391A 1991-04-26 1991-04-26

Publications (1)

Publication Number Publication Date
PT100426A true PT100426A (pt) 1993-08-31

Family

ID=24780107

Family Applications (1)

Application Number Title Priority Date Filing Date
PT100426A PT100426A (pt) 1991-04-26 1992-04-24 Derivados 4-aril-3-heteroarilureidoquinolina uteis como agentes anti-hipercolesterolemicos e antiateroscleroticos

Country Status (20)

Country Link
EP (1) EP0590094A1 (fi)
JP (1) JPH0776215B2 (fi)
CN (1) CN1066068A (fi)
AU (1) AU1879792A (fi)
BR (1) BR9205939A (fi)
CA (1) CA2108014A1 (fi)
CZ (1) CZ395592A3 (fi)
DE (1) DE9290049U1 (fi)
FI (1) FI934710A0 (fi)
HU (1) HUT65748A (fi)
IE (1) IE921330A1 (fi)
IL (1) IL101627A0 (fi)
MX (1) MX9201916A (fi)
NO (1) NO933837L (fi)
NZ (1) NZ242493A (fi)
PT (1) PT100426A (fi)
TW (1) TW197436B (fi)
WO (1) WO1992019614A1 (fi)
YU (1) YU44592A (fi)
ZA (1) ZA922976B (fi)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3323393A (en) * 1992-01-23 1993-09-01 Pfizer Inc. 4-aryl-3-(heteroarylureido)-1,2-dihydro-2-oxo-quinoline derivatives as antihypercholesterolemic and antiatherosclerotic agents
US5565472A (en) * 1992-12-21 1996-10-15 Pfizer Inc. 4-aryl-3-(heteroarylureido)-1,2-dihydro-2-oxo-quinoline derivatives as antihypercholesterolemic and antiatherosclerotic agents
NZ264063A (en) * 1993-08-13 1995-11-27 Nihon Nohyaku Co Ltd N-(2-phenylpyrid-3-yl)- and n-(4-phenylpyrimidin-5-yl)-n'-phenylurea derivatives and pharmaceutical compositions
US5843957A (en) * 1995-05-19 1998-12-01 Sumitomo Pharmaceuticals Company, Ltd. Naphthyridine derivatives
ATE272635T1 (de) * 1995-05-31 2004-08-15 Sumitomo Pharma Neue naphthyridinderivate.
AU725276B2 (en) * 1996-11-26 2000-10-12 Sumitomo Pharmaceuticals Company, Limited Novel naphthyridine derivatives
EP1086948A4 (en) 1998-02-25 2004-03-10 Sumitomo Pharma PYRIDONE DERIVATIVES AND THEIR MANUFACTURING PROCESS
US6452008B2 (en) 1998-02-25 2002-09-17 Sumitomo Pharmaceuticals Company, Limited Pyridone derivatives and process for preparing the same
SV2005001973A (es) 2003-12-12 2005-11-04 Wyeth Corp Quinolinas utiles en el tratamiento de enfermedades cardiovasculares ref. wyth0090-504 (am101500)
CN103601677B (zh) * 2013-11-19 2015-11-18 清华大学 制备2-烷硫基喹啉衍生物的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE892088L (en) * 1988-07-12 1990-01-12 William Henry Deryk Morris Quinoline derivatives, their production and use
MX22406A (es) * 1989-09-15 1994-01-31 Pfizer Nuevos derivados de n-aril y n-heteroarilamidas y urea como inhibidores de acil coenzima a: acil transferasa del colesterol (acat).
TW205037B (fi) * 1989-10-06 1993-05-01 Takeda Pharm Industry Co Ltd

Also Published As

Publication number Publication date
AU1879792A (en) 1992-12-21
JPH06501025A (ja) 1994-01-27
MX9201916A (es) 1992-11-01
JPH0776215B2 (ja) 1995-08-16
HU9303025D0 (en) 1994-01-28
DE9290049U1 (de) 1994-01-05
WO1992019614A1 (en) 1992-11-12
CA2108014A1 (en) 1992-10-27
IE921330A1 (en) 1992-11-04
EP0590094A1 (en) 1994-04-06
ZA922976B (en) 1993-10-25
IL101627A0 (en) 1992-12-30
BR9205939A (pt) 1994-09-27
YU44592A (sh) 1994-12-28
CN1066068A (zh) 1992-11-11
NZ242493A (en) 1994-08-26
FI934710A (fi) 1993-10-25
NO933837L (no) 1993-10-25
FI934710A0 (fi) 1993-10-25
CZ395592A3 (en) 1994-02-16
TW197436B (fi) 1993-01-01
HUT65748A (en) 1994-07-28

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Legal Events

Date Code Title Description
BB1A Laying open of patent application

Effective date: 19930331

FC3A Refusal

Effective date: 19990607