PL3810283T3 - Postacie stałe soli winianowej 3-((1R,3R)-1-(2,6-difluoro-4-((1-(3-fluoropropylo)azetydyn-3-ylo)amino)fenylo)-3-metylo-1,3,4,9-tetrahydro-2H-pirydo[3,4-b]indol-2-ilo)-2,2-difluoropropan-1-olu, sposób ich otrzymywania i sposoby ich zastosowania w leczeniu nowotworów - Google Patents

Postacie stałe soli winianowej 3-((1R,3R)-1-(2,6-difluoro-4-((1-(3-fluoropropylo)azetydyn-3-ylo)amino)fenylo)-3-metylo-1,3,4,9-tetrahydro-2H-pirydo[3,4-b]indol-2-ilo)-2,2-difluoropropan-1-olu, sposób ich otrzymywania i sposoby ich zastosowania w leczeniu nowotworów

Info

Publication number: PL3810283T3
Authority: PL; Poland
Prior art keywords: difluoropropan; fluoropropyl; azetidin; pyrido; indol
Prior art date: 2018-06-21

Application number

PL19745335.0T

Other languages

English (en)

Inventor

Cheol Keun Chung

Jie Xu

Hans Iding

Kyle CLAGG

Michael DALZIEL

Alec Fettes

Francis Gosselin

Ngiap-Kie LIM

Andrew MCCLORY

Haiming Zhang

Paroma CHAKRAVARTY

Kartik NAGAPUDI

Sarah Robinson

Original Assignee

F. Hoffmann-La Roche Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2018-06-21

Filing date

2019-06-17

Publication date

2023-10-16

2019-06-17 Application filed by F. Hoffmann-La Roche Ag filed Critical F. Hoffmann-La Roche Ag

2023-10-16 Publication of PL3810283T3 publication Critical patent/PL3810283T3/pl

Links

238000000034 method Methods 0.000 title 2
GQCXHIKRWBIQMD-AKJBCIBTSA-N 3-[(1R,3R)-1-[2,6-difluoro-4-[[1-(3-fluoropropyl)azetidin-3-yl]amino]phenyl]-3-methyl-1,3,4,9-tetrahydropyrido[3,4-b]indol-2-yl]-2,2-difluoropropan-1-ol Chemical compound FC1=C(C(=CC(=C1)NC1CN(C1)CCCF)F)[C@H]1N([C@@H](CC2=C1NC1=CC=CC=C21)C)CC(CO)(F)F GQCXHIKRWBIQMD-AKJBCIBTSA-N 0.000 title 1
206010028980 Neoplasm Diseases 0.000 title 1
239000007787 solid Substances 0.000 title 1
150000003892 tartrate salts Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs

PL19745335.0T 2018-06-21 2019-06-17 Postacie stałe soli winianowej 3-((1R,3R)-1-(2,6-difluoro-4-((1-(3-fluoropropylo)azetydyn-3-ylo)amino)fenylo)-3-metylo-1,3,4,9-tetrahydro-2H-pirydo[3,4-b]indol-2-ilo)-2,2-difluoropropan-1-olu, sposób ich otrzymywania i sposoby ich zastosowania w leczeniu nowotworów PL3810283T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US201862687930P	2018-06-21	2018-06-21
US201862719896P	2018-08-20	2018-08-20
PCT/US2019/037492 WO2019245974A1 (en)	2018-06-21	2019-06-17	Solid forms of 3-((1r,3r)-1-(2,6-difluoro-4-((1-(3-fluoropropyl)azetidin-3-yl)amino)phenyl)-3-methyl-1,3,4,9-tetrahydro-2h-pyrido[3,4-b]indol-2-yl)-2,2-difluoropropan-1-ol and processes for preparing fused tricyclic compounds comprising a substituted phenyl or pyridinyl moiety, including methods of their use

Publications (1)

Publication Number	Publication Date
PL3810283T3 true PL3810283T3 (pl)	2023-10-16

Family

ID=67441580

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL19745335.0T PL3810283T3 (pl)	2018-06-21	2019-06-17	Postacie stałe soli winianowej 3-((1R,3R)-1-(2,6-difluoro-4-((1-(3-fluoropropylo)azetydyn-3-ylo)amino)fenylo)-3-metylo-1,3,4,9-tetrahydro-2H-pirydo[3,4-b]indol-2-ilo)-2,2-difluoropropan-1-olu, sposób ich otrzymywania i sposoby ich zastosowania w leczeniu nowotworów

Country Status (29)

Country	Link
US (2)	US10954234B2 (pl)
EP (2)	EP4295845A3 (pl)
JP (4)	JP6916969B1 (pl)
KR (2)	KR102564647B1 (pl)
CN (2)	CN117946107A (pl)
AU (3)	AU2019290545B2 (pl)
BR (1)	BR112020024073A2 (pl)
CA (1)	CA3098203A1 (pl)
CL (1)	CL2020003022A1 (pl)
CO (1)	CO2020014604A2 (pl)
CR (2)	CR20200621A (pl)
DK (1)	DK3810283T3 (pl)
ES (1)	ES2951829T3 (pl)
FI (1)	FI3810283T3 (pl)
HR (1)	HRP20230859T1 (pl)
HU (1)	HUE064542T2 (pl)
IL (1)	IL278063A (pl)
LT (1)	LT3810283T (pl)
MX (3)	MX2020011531A (pl)
PE (1)	PE20211207A1 (pl)
PH (1)	PH12020500676A1 (pl)
PL (1)	PL3810283T3 (pl)
PT (1)	PT3810283T (pl)
RS (1)	RS64429B1 (pl)
SG (1)	SG11202012171SA (pl)
SI (1)	SI3810283T1 (pl)
TW (1)	TW202016098A (pl)
UA (1)	UA128114C2 (pl)
WO (1)	WO2019245974A1 (pl)

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WO2022140744A1 (en) *	2020-12-23	2022-06-30	Recurium Ip Holdings, Llc	Estrogen receptor modulators
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CN116847839A (zh) *	2021-02-16	2023-10-03	基因泰克公司	使用包括gdc-9545和依帕他赛的组合疗法治疗乳腺癌
WO2023284837A1 (zh)	2021-07-15	2023-01-19	四川海思科制药有限公司	芳氨基衍生物***受体调节剂及其用途
CN114656444A (zh) *	2022-03-04	2022-06-24	河北松辰医药科技有限公司	一种2,2-二氟-1,3-丙基磺酸内酯的合成方法
WO2023209062A1 (en)	2022-04-28	2023-11-02	F. Hoffmann-La Roche Ag	Solid form of 3-((1r,3r)-1-(2,6-difluoro-4-((1-(3- fluoropropyl)azetidin-3-yl)amino)phenyl)-3-methyl-1,3,4,9- tetrahydro-2h-pyrido[3,4-b]indol-2-yl)-2,2-difluoropropan-1-ol tartrate
CN115872996B (zh) *	2023-02-21	2023-05-05	山东绿叶制药有限公司	一种***受体降解剂化合物及其制备方法和应用

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HUE064542T2 (hu)	2018-06-21	2024-03-28	Hoffmann La Roche	A 3-((1R,3R)1(2,6-difluoro-4-((1-(3-fluoropropil)azetidin-3-il)amino)fenil)-3-metil-1,3,4,9 -tetrahidro-2H-pirido[3,4-b]indol-2-il)-2,2-difluoropropán-1-ol tartarátsó szilárd formái, eljárás elõállításukra és rákos megbetegedések kezelésében történõ alkalmazási módszereik

2019
- 2019-06-17 HU HUE19745335A patent/HUE064542T2/hu unknown
- 2019-06-17 AU AU2019290545A patent/AU2019290545B2/en active Active
- 2019-06-17 PL PL19745335.0T patent/PL3810283T3/pl unknown
- 2019-06-17 HR HRP20230859TT patent/HRP20230859T1/hr unknown
- 2019-06-17 CN CN202410165649.2A patent/CN117946107A/zh active Pending
- 2019-06-17 ES ES19745335T patent/ES2951829T3/es active Active
- 2019-06-17 CN CN201980041221.4A patent/CN112437685A/zh active Pending
- 2019-06-17 TW TW108120952A patent/TW202016098A/zh unknown
- 2019-06-17 US US16/443,515 patent/US10954234B2/en active Active
- 2019-06-17 KR KR1020217001924A patent/KR102564647B1/ko active IP Right Grant
- 2019-06-17 MX MX2020011531A patent/MX2020011531A/es unknown
- 2019-06-17 RS RS20230634A patent/RS64429B1/sr unknown
- 2019-06-17 DK DK19745335.0T patent/DK3810283T3/da active
- 2019-06-17 KR KR1020237026161A patent/KR20230117761A/ko active IP Right Grant
- 2019-06-17 CR CR20200621A patent/CR20200621A/es unknown
- 2019-06-17 LT LTEPPCT/US2019/037492T patent/LT3810283T/lt unknown
- 2019-06-17 EP EP23178559.3A patent/EP4295845A3/en active Pending
- 2019-06-17 CA CA3098203A patent/CA3098203A1/en active Pending
- 2019-06-17 WO PCT/US2019/037492 patent/WO2019245974A1/en active Application Filing
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CR20230409A (es)	2023-09-25
MX2020011531A (es)	2021-03-25
AU2023229513A1 (en)	2023-10-05
EP4295845A3 (en)	2024-02-28
SG11202012171SA (en)	2021-01-28
JP2021522312A (ja)	2021-08-30
JP2024054111A (ja)	2024-04-16
DK3810283T3 (en)	2023-08-21
EP3810283A1 (en)	2021-04-28
US10954234B2 (en)	2021-03-23
BR112020024073A2 (pt)	2021-02-17
US11780834B2 (en)	2023-10-10
JP2021191751A (ja)	2021-12-16
PE20211207A1 (es)	2021-07-05
KR20210022701A (ko)	2021-03-03
MX2022016065A (es)	2023-02-02
CL2020003022A1 (es)	2021-06-04
EP3810283B1 (en)	2023-06-14
SI3810283T1 (sl)	2023-10-30
ES2951829T3 (es)	2023-10-25
UA128114C2 (uk)	2024-04-10
HRP20230859T1 (hr)	2023-11-10
JP2021191750A (ja)	2021-12-16
WO2019245974A1 (en)	2019-12-26
RS64429B1 (sr)	2023-09-29
AU2019290545B2 (en)	2022-04-14
WO2019245974A8 (en)	2020-11-05
CA3098203A1 (en)	2019-12-26
TW202016098A (zh)	2020-05-01
US20220041587A1 (en)	2022-02-10
AU2022202967B2 (en)	2024-02-22
IL278063A (en)	2020-11-30
AU2022202967A1 (en)	2022-05-26
KR102564647B1 (ko)	2023-08-11
AU2019290545A1 (en)	2020-11-19
MX2023006785A (es)	2023-06-20
HUE064542T2 (hu)	2024-03-28
CN117946107A (zh)	2024-04-30
CN112437685A (zh)	2021-03-02
EP4295845A2 (en)	2023-12-27
CO2020014604A2 (es)	2020-12-10
FI3810283T3 (fi)	2023-08-11
LT3810283T (lt)	2023-08-25
JP6916969B1 (ja)	2021-08-11
KR20230117761A (ko)	2023-08-09
PH12020500676A1 (en)	2021-06-14
US20200002331A1 (en)	2020-01-02
PT3810283T (pt)	2023-08-18
CR20200621A (es)	2021-02-03

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