PL3013814T3 - Podstawione związki tetrahydrokarbazolu i karbazolu karboksamidu użyteczne jako inhibitory kinazy - Google Patents

Podstawione związki tetrahydrokarbazolu i karbazolu karboksamidu użyteczne jako inhibitory kinazy

Info

Publication number: PL3013814T3
Authority: PL; Poland
Prior art keywords: kinase inhibitors; compounds useful; carboxamide compounds; carbazole carboxamide; substituted tetrahydrocarbazole
Prior art date: 2013-06-25

Application number

PL14740094T

Other languages

English (en)

Inventor

Joseph A. Tino

Anurag S. Srivastava

Soo Sung Ko

Michael A. Galella

Charles M. Langevine

George V. Delucca

Qingjie Liu

Douglas G. Batt

Scott Hunter Watterson

Qing Shi

Myra Beaudoin Bertrand

Original Assignee

Bristol-Myers Squibb Company

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2013-06-25

Filing date

2014-06-25

Publication date

2017-11-30

2014-06-25 Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company

2017-11-30 Publication of PL3013814T3 publication Critical patent/PL3013814T3/pl

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Rheumatology (AREA)
Biomedical Technology (AREA)
Transplantation (AREA)
Hospice & Palliative Care (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Indole Compounds (AREA)

PL14740094T 2013-06-25 2014-06-25 Podstawione związki tetrahydrokarbazolu i karbazolu karboksamidu użyteczne jako inhibitory kinazy PL3013814T3 (pl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US201361839141P	2013-06-25	2013-06-25
EP14740094.9A EP3013814B1 (en)	2013-06-25	2014-06-25	Substituted tetrahydrocarbazole and carbazole carboxamide compounds useful as kinase inhibitors

Publications (1)

Publication Number	Publication Date
PL3013814T3 true PL3013814T3 (pl)	2017-11-30

Family

ID=51210830

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL14740094T PL3013814T3 (pl)	2013-06-25	2014-06-25	Podstawione związki tetrahydrokarbazolu i karbazolu karboksamidu użyteczne jako inhibitory kinazy

Country Status (31)

Country	Link
US (6)	US9334290B2 (pl)
EP (1)	EP3013814B1 (pl)
JP (1)	JP6353529B2 (pl)
KR (1)	KR102346508B1 (pl)
CN (1)	CN105358546B (pl)
AR (1)	AR096721A1 (pl)
AU (1)	AU2014302548B2 (pl)
BR (1)	BR112015030723A8 (pl)
CA (1)	CA2916500A1 (pl)
CL (1)	CL2015003635A1 (pl)
CY (1)	CY1119371T1 (pl)
DK (1)	DK3013814T3 (pl)
EA (1)	EA026729B1 (pl)
ES (1)	ES2636652T3 (pl)
HK (1)	HK1223359A1 (pl)
HR (1)	HRP20171031T1 (pl)
HU (1)	HUE034460T2 (pl)
IL (1)	IL243296B (pl)
LT (1)	LT3013814T (pl)
MA (1)	MA38648B1 (pl)
MY (1)	MY176631A (pl)
PE (1)	PE20160519A1 (pl)
PH (1)	PH12015502630A1 (pl)
PL (1)	PL3013814T3 (pl)
PT (1)	PT3013814T (pl)
RS (1)	RS56371B1 (pl)
SI (1)	SI3013814T1 (pl)
TN (1)	TN2015000529A1 (pl)
TW (1)	TWI648272B (pl)
UY (1)	UY35625A (pl)
WO (1)	WO2014210085A1 (pl)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR102345381B1 (ko)	2013-06-25	2021-12-29	브리스톨-마이어스 스큅 컴퍼니	키나제 억제제로서 유용한 카르바졸 카르복스아미드 화합물
SI3461821T1 (sl)	2014-10-24	2020-09-30	Bristol-Myers Squibb Company	Spojine indol karboksamida, uporabne kot kinazni inhibitorji
EA032361B1 (ru) *	2014-10-24	2019-05-31	Бристол-Майерс Сквибб Компани	Трициклические соединения
KR102519536B1 (ko)	2014-10-24	2023-04-06	브리스톨-마이어스 스큅 컴퍼니	트리시클릭 회전장애이성질체 화합물
MX2018015793A (es)	2016-07-01	2019-03-21	Brio Device Llc	Estilete de intubación con alimentación de video.
CN108101905A (zh) *	2016-11-24	2018-06-01	中国科学院上海药物研究所	嘧啶并[5,4-b]吲嗪或嘧啶并[5,4-b]吡呤化合物、其制备方法及用途
US11590167B2 (en)	2016-12-03	2023-02-28	Juno Therapeutic, Inc.	Methods and compositions for use of therapeutic T cells in combination with kinase inhibitors
CN110312713B (zh) *	2016-12-20	2022-08-12	百时美施贵宝公司	用于制备四氢咔唑甲酰胺化合物的方法
WO2019208805A1 (ja)	2018-04-27	2019-10-31	小野薬品工業株式会社	Ｂｔｋ阻害活性を有する化合物を有効成分として含む自己免疫疾患の予防および／または治療剤
CA3224945A1 (en)	2018-07-31	2020-02-06	Loxo Oncology, Inc.	Spray-dried dispersions, formulations, and polymorphs of (s)-5-amino-3-(4-((5-fluoro-2-methoxybenzamido)methyl)phenyl)-1-(1,1,1-trifluoropropan-2-yl)-1h-pyrazole-4-carboxamide
WO2022140246A1 (en)	2020-12-21	2022-06-30	Hangzhou Jijing Pharmaceutical Technology Limited	Methods and compounds for targeted autophagy
WO2022212893A1 (en)	2021-04-02	2022-10-06	Biogen Ma Inc.	Combination treatment methods of multiple sclerosis
AU2023220628A1 (en) *	2022-02-15	2024-05-23	F. Hoffmann-La Roche Ag	Processes for the preparation of 1,2,3,5,6,7-hexahydro-s-indacene derivatives

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4200750A (en)	1977-01-07	1980-04-29	Westwood Pharmaceuticals Inc.	4-Substituted imidazo [1,2-a]quinoxalines
CA2140722A1 (en)	1994-01-24	1995-07-25	Joseph A. Jakubowski	Beta-carboline thromboxane synthase inhibitors
US7405295B2 (en)	2003-06-04	2008-07-29	Cgi Pharmaceuticals, Inc.	Certain imidazo[1,2-a]pyrazin-8-ylamines and method of inhibition of Bruton's tyrosine kinase by such compounds
US7393848B2 (en)	2003-06-30	2008-07-01	Cgi Pharmaceuticals, Inc.	Certain heterocyclic substituted imidazo[1,2-A]pyrazin-8-ylamines and methods of inhibition of Bruton's tyrosine kinase by such compounds
US20050288295A1 (en)	2003-11-11	2005-12-29	Currie Kevin S	Certain imidazo[1,2-a]pyrazin-8-ylamines, method of making, and method of use thereof
US7713973B2 (en)	2004-10-15	2010-05-11	Takeda Pharmaceutical Company Limited	Kinase inhibitors
SG159549A1 (en)	2004-11-10	2010-03-30	Cgi Pharmaceuticals Inc	Imidazo[1,2-a] pyrazin-8-ylamines useful as modulators of kinase activity
KR101317119B1 (ko)	2004-12-17	2013-10-11	그렌마크 파머수티칼스 에스. 아.	염증성 및 알레르기성 장애의 치료에 유용한 신규한헤테로사이클릭 화합물
BRPI0608252A2 (pt)	2005-03-10	2010-04-06	Cgi Pharmaceuticals Inc	entidades quìmicas, composições farmacêuticas compreendendo as mesmas, métodos utilizando as referidas entidades quìmicas e uso das referidas entidades quìmicas
MX2008003202A (es)	2005-09-16	2008-03-25	Serenex Inc	Derivados de carbazol.
US20070078136A1 (en)	2005-09-22	2007-04-05	Bristol-Myers Squibb Company	Fused heterocyclic compounds useful as kinase modulators
US7723336B2 (en)	2005-09-22	2010-05-25	Bristol-Myers Squibb Company	Fused heterocyclic compounds useful as kinase modulators
AU2006316322B2 (en)	2005-11-22	2011-08-25	Merck Canada Inc.	Tricyclic compounds useful as inhibitors of kinases
WO2008033858A2 (en)	2006-09-11	2008-03-20	Cgi Pharmaceuticals, Inc.	Kinase inhibitors, and methods of using and identifying kinase inhibitors
SG174810A1 (en)	2006-09-11	2011-10-28	Matrix Lab Ltd	Dibenzofuran derivatives as inhibitors of pde-4 and pde-10
US20090062251A1 (en)	2007-08-17	2009-03-05	Astrazeneca Ab	Novel Compounds 002
WO2009075830A1 (en)	2007-12-13	2009-06-18	Merck & Co., Inc.	Inhibitors of janus kinases
US8318132B2 (en)	2008-02-14	2012-11-27	Siemens Medical Solutions Usa, Inc.	Imaging agents for detecting neurological dysfunction
GB0809360D0 (en)	2008-05-22	2008-07-02	Isis Innovation	Calcium modulation
EP2151441A1 (en)	2008-08-06	2010-02-10	Julius-Maximilians-Universität Würzburg	Beta-carbolin-derivates as substrates for an enzyme
KR20110098827A (ko) *	2008-12-19	2011-09-01	브리스톨-마이어스 스큅 컴퍼니	키나제 억제제로서 유용한 카르바졸 카르복스아미드 화합물
CN101475571B (zh)	2009-01-21	2011-06-22	中国药科大学	β-咔啉类细胞周期蛋白依赖性激酶2抑制剂及其用途
US8242260B2 (en)	2009-08-28	2012-08-14	Novartis Ag	Compounds and compositions as protein kinase inhibitors
CN102822171B (zh)	2010-03-26	2015-09-02	默克专利有限公司	作为自分泌运动因子抑制剂的苯并萘啶胺类
EP2582668B1 (en) *	2010-06-16	2016-01-13	Bristol-Myers Squibb Company	Carboline carboxamide compounds useful as kinase inhibitors
EP2455378A1 (en)	2010-11-03	2012-05-23	Philip Morris Products S.A.	Carbazole and carboline derivatives, and preparation and therapeutic applications thereof
WO2012066442A1 (en)	2010-11-15	2012-05-24	Pfizer Limited	Inhibitors of hiv replication
CA2834077A1 (en)	2011-05-17	2012-11-22	F. Hoffmann-La Roche Ag	Inhibitors of bruton's tyrosine kinase
WO2013054185A1 (en)	2011-10-13	2013-04-18	Pfizer, Inc.	Pyrimidine and pyridine derivatives useful in therapy

2014
- 2014-06-24 UY UY0001035625A patent/UY35625A/es unknown
- 2014-06-24 TW TW103121681A patent/TWI648272B/zh not_active IP Right Cessation
- 2014-06-24 AR ARP140102388A patent/AR096721A1/es unknown
- 2014-06-25 MA MA38648A patent/MA38648B1/fr unknown
- 2014-06-25 EP EP14740094.9A patent/EP3013814B1/en active Active
- 2014-06-25 JP JP2016523869A patent/JP6353529B2/ja active Active
- 2014-06-25 RS RS20170904A patent/RS56371B1/sr unknown
- 2014-06-25 US US14/314,602 patent/US9334290B2/en active Active
- 2014-06-25 KR KR1020167001632A patent/KR102346508B1/ko active IP Right Grant
- 2014-06-25 BR BR112015030723A patent/BR112015030723A8/pt not_active Application Discontinuation
- 2014-06-25 ES ES14740094.9T patent/ES2636652T3/es active Active
- 2014-06-25 CA CA2916500A patent/CA2916500A1/en not_active Abandoned
- 2014-06-25 PL PL14740094T patent/PL3013814T3/pl unknown
- 2014-06-25 HU HUE14740094A patent/HUE034460T2/en unknown
- 2014-06-25 PE PE2015002665A patent/PE20160519A1/es active IP Right Grant
- 2014-06-25 SI SI201430268T patent/SI3013814T1/sl unknown
- 2014-06-25 DK DK14740094.9T patent/DK3013814T3/en active
- 2014-06-25 CN CN201480035611.8A patent/CN105358546B/zh active Active
- 2014-06-25 MY MYPI2015704738A patent/MY176631A/en unknown
- 2014-06-25 PT PT147400949T patent/PT3013814T/pt unknown
- 2014-06-25 WO PCT/US2014/043978 patent/WO2014210085A1/en active Application Filing
- 2014-06-25 TN TN2015000529A patent/TN2015000529A1/en unknown
- 2014-06-25 AU AU2014302548A patent/AU2014302548B2/en not_active Ceased
- 2014-06-25 LT LTEP14740094.9T patent/LT3013814T/lt unknown
- 2014-06-25 EA EA201592287A patent/EA026729B1/ru not_active IP Right Cessation
2015
- 2015-11-26 PH PH12015502630A patent/PH12015502630A1/en unknown
- 2015-12-15 CL CL2015003635A patent/CL2015003635A1/es unknown
- 2015-12-22 IL IL243296A patent/IL243296B/en active IP Right Grant
2016
- 2016-03-11 US US15/067,915 patent/US20160194338A1/en not_active Abandoned
- 2016-10-04 HK HK16111549.5A patent/HK1223359A1/zh not_active IP Right Cessation
2017
- 2017-06-16 US US15/625,417 patent/US9850258B2/en active Active
- 2017-07-05 HR HRP20171031TT patent/HRP20171031T1/hr unknown
- 2017-09-06 CY CY20171100943T patent/CY1119371T1/el unknown
- 2017-11-10 US US15/809,437 patent/US10106559B2/en active Active
2018
- 2018-09-25 US US16/140,750 patent/US10435415B2/en active Active
2019
- 2019-08-22 US US16/547,675 patent/US20190382416A1/en not_active Abandoned

Also Published As

Publication number	Publication date
CN105358546A (zh)	2016-02-24
MY176631A (en)	2020-08-19
WO2014210085A9 (en)	2015-12-23
US20170283438A1 (en)	2017-10-05
JP2016523907A (ja)	2016-08-12
BR112015030723A8 (pt)	2020-01-07
BR112015030723A2 (pt)	2017-07-25
IL243296B (en)	2018-05-31
US20180079758A1 (en)	2018-03-22
HK1223359A1 (zh)	2017-07-28
PT3013814T (pt)	2017-08-10
CY1119371T1 (el)	2018-02-14
TWI648272B (zh)	2019-01-21
RS56371B1 (sr)	2017-12-29
US20140378475A1 (en)	2014-12-25
TW201536774A (zh)	2015-10-01
PE20160519A1 (es)	2016-05-21
JP6353529B2 (ja)	2018-07-04
MA38648A1 (fr)	2017-09-29
EP3013814B1 (en)	2017-06-14
HUE034460T2 (en)	2018-02-28
AU2014302548A1 (en)	2016-02-11
AU2014302548B2 (en)	2018-05-10
US10435415B2 (en)	2019-10-08
WO2014210085A1 (en)	2014-12-31
CN105358546B (zh)	2017-10-31
AR096721A1 (es)	2016-01-27
SI3013814T1 (sl)	2017-08-31
TN2015000529A1 (en)	2017-04-06
DK3013814T3 (en)	2017-09-25
US20190023719A1 (en)	2019-01-24
LT3013814T (lt)	2017-08-10
UY35625A (es)	2014-12-31
EA026729B1 (ru)	2017-05-31
MA38648B1 (fr)	2018-06-29
US9334290B2 (en)	2016-05-10
US20160194338A1 (en)	2016-07-07
US20190382416A1 (en)	2019-12-19
ES2636652T3 (es)	2017-10-06
KR20160022889A (ko)	2016-03-02
HRP20171031T1 (hr)	2017-10-06
US9850258B2 (en)	2017-12-26
KR102346508B1 (ko)	2022-01-03
CA2916500A1 (en)	2014-12-31
EA201592287A1 (ru)	2016-06-30
PH12015502630A1 (en)	2016-03-07
EP3013814A1 (en)	2016-05-04
CL2015003635A1 (es)	2016-07-29
US10106559B2 (en)	2018-10-23

Publication	Publication Date	Title
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