PL2723882T3 - Sposób wytwarzania 3’-tiopodstawionych cefalosporyn z zastosowaniem acylazy penicyliny - Google Patents
Sposób wytwarzania 3’-tiopodstawionych cefalosporyn z zastosowaniem acylazy penicylinyInfo
- Publication number
- PL2723882T3 PL2723882T3 PL12733001T PL12733001T PL2723882T3 PL 2723882 T3 PL2723882 T3 PL 2723882T3 PL 12733001 T PL12733001 T PL 12733001T PL 12733001 T PL12733001 T PL 12733001T PL 2723882 T3 PL2723882 T3 PL 2723882T3
- Authority
- PL
- Poland
- Prior art keywords
- thiosubstituted
- acylase
- cephalosporins
- penicillin
- employing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
- C12P35/04—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by acylation of the substituent in the 7 position
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
- C12P17/184—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system containing a beta-lactam ring, e.g. thienamycin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/57—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with a further substituent in position 7, e.g. cephamycines
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11171178 | 2011-06-23 | ||
EP12733001.7A EP2723882B1 (en) | 2011-06-23 | 2012-06-21 | Process for preparing 3'-thiosubstituted cephalosporins employing a penicillin g acylase |
PCT/EP2012/061910 WO2012175585A1 (en) | 2011-06-23 | 2012-06-21 | Process for preparing 3'-thiosubstituted cephalosporins employing a penicillin g acylase |
Publications (1)
Publication Number | Publication Date |
---|---|
PL2723882T3 true PL2723882T3 (pl) | 2020-01-31 |
Family
ID=44910020
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL12733001T PL2723882T3 (pl) | 2011-06-23 | 2012-06-21 | Sposób wytwarzania 3’-tiopodstawionych cefalosporyn z zastosowaniem acylazy penicyliny |
Country Status (6)
Country | Link |
---|---|
US (1) | US20140200342A1 (pl) |
EP (1) | EP2723882B1 (pl) |
CN (1) | CN103635585A (pl) |
ES (1) | ES2729707T3 (pl) |
PL (1) | PL2723882T3 (pl) |
WO (1) | WO2012175585A1 (pl) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110241167B (zh) * | 2019-07-02 | 2023-12-26 | 苏州盛达药业有限公司 | 一种酶法制备头孢孟多酯钠衍生物的方法 |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5343597B1 (pl) | 1970-12-25 | 1978-11-21 | ||
JPS5548797B1 (pl) | 1971-04-02 | 1980-12-08 | ||
US3899394A (en) * | 1972-12-26 | 1975-08-12 | Bristol Myers Co | Production of antibacterial agents |
US3946003A (en) * | 1974-08-20 | 1976-03-23 | Eli Lilly And Company | Hydroxy substituted phenylglycylamido-3-heterocyclic thiomethyl cephalosporins |
JPS51133488A (en) | 1975-05-14 | 1976-11-19 | Shionogi & Co Ltd | Process for producing antibiotics enzymatically |
DE2600880C2 (de) | 1976-01-12 | 1984-09-13 | Toyama Chemical Co. Ltd., Tokio / Tokyo | Cephalosporinverbindungen |
PT83746B (pt) | 1985-11-15 | 1988-08-17 | Gist Brocades Nv | Processo para a preparacao de novos biocatalisadores imobilizados e para a producao de etanol por fermentacao |
ATE138690T1 (de) | 1988-04-26 | 1996-06-15 | Gist Brocades Nv | Verfahren zur enzymatischen herstellung von beta- lactamen |
WO1992001061A1 (en) | 1990-07-04 | 1992-01-23 | Novo Nordisk A/S | PROCESS FOR PREPARATION OF β-LACTAMS |
IT1243800B (it) | 1990-08-28 | 1994-06-28 | Sclavo Spa | Procedimento migliorato per la preparazione di cefalosporine |
GB9115203D0 (en) * | 1991-07-15 | 1991-08-28 | Biochemie Gmbh | Improvements in or relating to beta lactam production |
SK63894A3 (en) | 1991-12-19 | 1995-03-08 | Novo Nordisk As | Method of preparation of beta-lactam antibiotic |
DE69512917D1 (de) | 1994-07-18 | 1999-11-25 | Dsm Nv | Verfahren zur herstellung von beta-lactamen mit dauernd hochkonzentrierten reagenzien |
DE69514923T2 (de) | 1994-08-12 | 2000-11-02 | Dsm N.V., Heerlen | Mutierte penicillin-g-acylase gene |
JPH11503408A (ja) | 1995-02-02 | 1999-03-26 | ケムファーム ブイ.オー.エフ. | セファレキシンの回収方法 |
JP2001527381A (ja) | 1995-07-18 | 2001-12-25 | ギスト ブロカデス ベスローテン フェンノートシャップ | 改良固定化ペニシリンgアシラーゼ |
NL1006266C2 (nl) | 1997-06-10 | 1998-12-14 | Chemferm Vof | Werkwijze voor de bereiding van ampicilline. |
NL1007302C2 (nl) | 1997-10-17 | 1999-04-20 | Dsm Nv | Werkwijze voor de bereiding van een ß-lactam antibioticum. |
NL1010506C2 (nl) * | 1998-11-06 | 2000-05-09 | Dsm Nv | Werkwijze voor de bereiding van bêta-lactam antibiotica. |
JP2004537985A (ja) | 2001-04-19 | 2004-12-24 | ビオフェルマ ムルシア,エス.アー. | セファロスポリン誘導体を製造する方法 |
AU2002358777A1 (en) | 2001-12-27 | 2003-07-15 | Dsm N.V. | Process for the preparation of a beta-lactam antibiotic with mutated penicillin acylase |
AU2003304234A1 (en) | 2002-08-07 | 2005-01-13 | Steris Inc. | Decontamination system for mail and other articles |
EP1394262A1 (en) * | 2002-08-30 | 2004-03-03 | Bioferma Murcia, S.A. | An enzymatic process for preparing beta-lactams |
EP1831390B1 (en) | 2004-12-27 | 2014-11-19 | DSM Sinochem Pharmaceuticals Netherlands B.V. | Process for the synthesis of cefaclor |
BRPI0808685A2 (pt) | 2007-03-09 | 2014-08-19 | Dsm Ip Assets Bv | Processo para a preparação de derivados semissintéticos de beta-lactama. |
ES2403033T3 (es) | 2007-03-09 | 2013-05-13 | Dsm Sinochem Pharmaceuticals Netherlands B.V. | Procedimiento para la preparación de ésteres metílicos de aminoácidos |
WO2010072765A2 (en) * | 2008-12-23 | 2010-07-01 | Dsm Ip Assets B.V. | Mutant penicillin g acylases |
-
2012
- 2012-06-21 EP EP12733001.7A patent/EP2723882B1/en active Active
- 2012-06-21 PL PL12733001T patent/PL2723882T3/pl unknown
- 2012-06-21 CN CN201280031009.8A patent/CN103635585A/zh active Pending
- 2012-06-21 US US14/128,736 patent/US20140200342A1/en not_active Abandoned
- 2012-06-21 ES ES12733001T patent/ES2729707T3/es active Active
- 2012-06-21 WO PCT/EP2012/061910 patent/WO2012175585A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
CN103635585A (zh) | 2014-03-12 |
US20140200342A1 (en) | 2014-07-17 |
ES2729707T3 (es) | 2019-11-05 |
WO2012175585A1 (en) | 2012-12-27 |
EP2723882B1 (en) | 2019-05-01 |
EP2723882A1 (en) | 2014-04-30 |
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