PL2723882T3 - Sposób wytwarzania 3’-tiopodstawionych cefalosporyn z zastosowaniem acylazy penicyliny - Google Patents

Sposób wytwarzania 3’-tiopodstawionych cefalosporyn z zastosowaniem acylazy penicyliny

Info

Publication number
PL2723882T3
PL2723882T3 PL12733001T PL12733001T PL2723882T3 PL 2723882 T3 PL2723882 T3 PL 2723882T3 PL 12733001 T PL12733001 T PL 12733001T PL 12733001 T PL12733001 T PL 12733001T PL 2723882 T3 PL2723882 T3 PL 2723882T3
Authority
PL
Poland
Prior art keywords
thiosubstituted
acylase
cephalosporins
penicillin
employing
Prior art date
Application number
PL12733001T
Other languages
English (en)
Inventor
Harold Monro Moody
Claudia Cusan
Edwin Gerard Ijpeij
Original Assignee
Centrient Pharmaceuticals Netherlands B.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centrient Pharmaceuticals Netherlands B.V. filed Critical Centrient Pharmaceuticals Netherlands B.V.
Publication of PL2723882T3 publication Critical patent/PL2723882T3/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C12P35/04Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by acylation of the substituent in the 7 position
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/182Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
    • C12P17/184Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system containing a beta-lactam ring, e.g. thienamycin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D501/00Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/207-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/577-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with a further substituent in position 7, e.g. cephamycines

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Cephalosporin Compounds (AREA)
PL12733001T 2011-06-23 2012-06-21 Sposób wytwarzania 3’-tiopodstawionych cefalosporyn z zastosowaniem acylazy penicyliny PL2723882T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11171178 2011-06-23
EP12733001.7A EP2723882B1 (en) 2011-06-23 2012-06-21 Process for preparing 3'-thiosubstituted cephalosporins employing a penicillin g acylase
PCT/EP2012/061910 WO2012175585A1 (en) 2011-06-23 2012-06-21 Process for preparing 3'-thiosubstituted cephalosporins employing a penicillin g acylase

Publications (1)

Publication Number Publication Date
PL2723882T3 true PL2723882T3 (pl) 2020-01-31

Family

ID=44910020

Family Applications (1)

Application Number Title Priority Date Filing Date
PL12733001T PL2723882T3 (pl) 2011-06-23 2012-06-21 Sposób wytwarzania 3’-tiopodstawionych cefalosporyn z zastosowaniem acylazy penicyliny

Country Status (6)

Country Link
US (1) US20140200342A1 (pl)
EP (1) EP2723882B1 (pl)
CN (1) CN103635585A (pl)
ES (1) ES2729707T3 (pl)
PL (1) PL2723882T3 (pl)
WO (1) WO2012175585A1 (pl)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110241167B (zh) * 2019-07-02 2023-12-26 苏州盛达药业有限公司 一种酶法制备头孢孟多酯钠衍生物的方法

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5343597B1 (pl) 1970-12-25 1978-11-21
JPS5548797B1 (pl) 1971-04-02 1980-12-08
US3899394A (en) * 1972-12-26 1975-08-12 Bristol Myers Co Production of antibacterial agents
US3946003A (en) * 1974-08-20 1976-03-23 Eli Lilly And Company Hydroxy substituted phenylglycylamido-3-heterocyclic thiomethyl cephalosporins
JPS51133488A (en) 1975-05-14 1976-11-19 Shionogi & Co Ltd Process for producing antibiotics enzymatically
DE2600880C2 (de) 1976-01-12 1984-09-13 Toyama Chemical Co. Ltd., Tokio / Tokyo Cephalosporinverbindungen
PT83746B (pt) 1985-11-15 1988-08-17 Gist Brocades Nv Processo para a preparacao de novos biocatalisadores imobilizados e para a producao de etanol por fermentacao
ATE138690T1 (de) 1988-04-26 1996-06-15 Gist Brocades Nv Verfahren zur enzymatischen herstellung von beta- lactamen
WO1992001061A1 (en) 1990-07-04 1992-01-23 Novo Nordisk A/S PROCESS FOR PREPARATION OF β-LACTAMS
IT1243800B (it) 1990-08-28 1994-06-28 Sclavo Spa Procedimento migliorato per la preparazione di cefalosporine
GB9115203D0 (en) * 1991-07-15 1991-08-28 Biochemie Gmbh Improvements in or relating to beta lactam production
SK63894A3 (en) 1991-12-19 1995-03-08 Novo Nordisk As Method of preparation of beta-lactam antibiotic
DE69512917D1 (de) 1994-07-18 1999-11-25 Dsm Nv Verfahren zur herstellung von beta-lactamen mit dauernd hochkonzentrierten reagenzien
DE69514923T2 (de) 1994-08-12 2000-11-02 Dsm N.V., Heerlen Mutierte penicillin-g-acylase gene
JPH11503408A (ja) 1995-02-02 1999-03-26 ケムファーム ブイ.オー.エフ. セファレキシンの回収方法
JP2001527381A (ja) 1995-07-18 2001-12-25 ギスト ブロカデス ベスローテン フェンノートシャップ 改良固定化ペニシリンgアシラーゼ
NL1006266C2 (nl) 1997-06-10 1998-12-14 Chemferm Vof Werkwijze voor de bereiding van ampicilline.
NL1007302C2 (nl) 1997-10-17 1999-04-20 Dsm Nv Werkwijze voor de bereiding van een ß-lactam antibioticum.
NL1010506C2 (nl) * 1998-11-06 2000-05-09 Dsm Nv Werkwijze voor de bereiding van bêta-lactam antibiotica.
JP2004537985A (ja) 2001-04-19 2004-12-24 ビオフェルマ ムルシア,エス.アー. セファロスポリン誘導体を製造する方法
AU2002358777A1 (en) 2001-12-27 2003-07-15 Dsm N.V. Process for the preparation of a beta-lactam antibiotic with mutated penicillin acylase
AU2003304234A1 (en) 2002-08-07 2005-01-13 Steris Inc. Decontamination system for mail and other articles
EP1394262A1 (en) * 2002-08-30 2004-03-03 Bioferma Murcia, S.A. An enzymatic process for preparing beta-lactams
EP1831390B1 (en) 2004-12-27 2014-11-19 DSM Sinochem Pharmaceuticals Netherlands B.V. Process for the synthesis of cefaclor
BRPI0808685A2 (pt) 2007-03-09 2014-08-19 Dsm Ip Assets Bv Processo para a preparação de derivados semissintéticos de beta-lactama.
ES2403033T3 (es) 2007-03-09 2013-05-13 Dsm Sinochem Pharmaceuticals Netherlands B.V. Procedimiento para la preparación de ésteres metílicos de aminoácidos
WO2010072765A2 (en) * 2008-12-23 2010-07-01 Dsm Ip Assets B.V. Mutant penicillin g acylases

Also Published As

Publication number Publication date
CN103635585A (zh) 2014-03-12
US20140200342A1 (en) 2014-07-17
ES2729707T3 (es) 2019-11-05
WO2012175585A1 (en) 2012-12-27
EP2723882B1 (en) 2019-05-01
EP2723882A1 (en) 2014-04-30

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