PL2670764T3 - C-28 aminy zmodyfikowanych C-3 pochodnych kwasu betulinowego jako inhibitory dojrzewania HIV - Google Patents

C-28 aminy zmodyfikowanych C-3 pochodnych kwasu betulinowego jako inhibitory dojrzewania HIV

Info

Publication number: PL2670764T3
Authority: PL; Poland
Prior art keywords: amines; acid derivatives; betulinic acid; maturation inhibitors; hiv maturation
Prior art date: 2011-01-31

Application number

PL12702946T

Other languages

English (en)

Inventor

Alicia Regueiro-Ren

Jacob Swidorski

Sing-Yuen Sit

Yan Chen

Jie Chen

Nicholas A Meanwell

Zheng Liu

Original Assignee

Bristol Myers Squibb Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2011-01-31

Filing date

2012-01-27

Publication date

2016-02-29

2012-01-27 Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co

2016-02-29 Publication of PL2670764T3 publication Critical patent/PL2670764T3/pl

Links

150000001412 amines Chemical class 0.000 title 1
QGJZLNKBHJESQX-FZFNOLFKSA-N betulinic acid Chemical class C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CC[C@@H](C(=C)C)[C@@H]5[C@H]4CC[C@@H]3[C@]21C QGJZLNKBHJESQX-FZFNOLFKSA-N 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
230000035800 maturation Effects 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV

PL12702946T 2011-01-31 2012-01-27 C-28 aminy zmodyfikowanych C-3 pochodnych kwasu betulinowego jako inhibitory dojrzewania HIV PL2670764T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US201161437870P	2011-01-31	2011-01-31
EP12702946.0A EP2670764B1 (en)	2011-01-31	2012-01-27	C-28 amines of c-3 modified betulinic acid derivatives as hiv maturation inhibitors
PCT/US2012/022847 WO2012106188A1 (en)	2011-01-31	2012-01-27	C-28 amines of c-3 modified betulinic acid derivatives as hiv maturation inhibitors

Publications (1)

Publication Number	Publication Date
PL2670764T3 true PL2670764T3 (pl)	2016-02-29

Family

ID=45567146

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL12702946T PL2670764T3 (pl)	2011-01-31	2012-01-27	C-28 aminy zmodyfikowanych C-3 pochodnych kwasu betulinowego jako inhibitory dojrzewania HIV

Country Status (19)

Country	Link
US (1)	US8748415B2 (pl)
EP (1)	EP2670764B1 (pl)
JP (1)	JP6000283B2 (pl)
CN (1)	CN103339141B (pl)
BR (1)	BR112014010105A2 (pl)
CA (1)	CA2826257A1 (pl)
CY (1)	CY1116989T1 (pl)
DK (1)	DK2670764T3 (pl)
EA (1)	EA023578B1 (pl)
ES (1)	ES2552512T3 (pl)
HR (1)	HRP20151212T1 (pl)
HU (1)	HUE026371T2 (pl)
MX (1)	MX2013008359A (pl)
PL (1)	PL2670764T3 (pl)
PT (1)	PT2670764E (pl)
RS (1)	RS54352B1 (pl)
SI (1)	SI2670764T1 (pl)
SM (1)	SMT201500303B (pl)
WO (1)	WO2012106188A1 (pl)

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EA027371B1 (ru) *	2013-02-06	2017-07-31	Бристол-Майерс Сквибб Компани	C-19 модифицированные тритерпеноиды с ингибиторной активностью созревания вич
CN105102468A (zh)	2013-02-25	2015-11-25	百时美施贵宝公司	用于治疗hiv的c-3烷基和烯基修饰的桦木酸衍生物
NZ724644A (en)	2014-04-11	2023-07-28	Viiv Healthcare Uk No 4 Ltd	Triterpenoids with hiv maturation inhibitory activity, substituted in position 3 by a non-aromatic ring carrying a haloalkyl substituent
WO2015195776A1 (en) *	2014-06-19	2015-12-23	Bristol-Myers Squibb Company	Betulinic acid derivatives with hiv maturation inhibitory activity
CA2967601A1 (en) *	2014-11-14	2016-05-19	VIIV Healthcare UK (No.5) Limited	Extended betulinic acid analogs
US10047118B2 (en)	2014-11-14	2018-08-14	VIIV Healthcare UK (No.5) Limited	C17-aryl substituted betulinic acid analogs
CN107250153A (zh) *	2014-11-14	2017-10-13	Viiv保健英国第五有限公司	氧代羽扇豆烯衍生物
CA2981056A1 (en) *	2015-04-14	2016-10-20	ViiV Healthcare UK (No.4) Limited	Methods of producing an hiv maturation inhibitor
EP3328876A1 (en)	2015-07-28	2018-06-06	Glaxosmithkline Intellectual Property (No. 2) Limited	Betuin derivatives for preventing or treating hiv infections
BR112018001537A2 (pt)	2015-07-28	2018-09-18	Glaxosmithkline Ip No 2 Ltd	composto ou sal farmaceuticamente aceitável do mesmo, composição farmacêutica, métodos para tratamento e para prevenção de uma infecção por hiv em um indivíduo, e, uso de um composto ou sal
US20180273579A1 (en)	2015-09-24	2018-09-27	Glaxosmithkline Intellectual Property (No.2) Limited	Compounds with hiv maturation inhibitory activity
WO2017125870A1 (en)	2016-01-20	2017-07-27	Glaxosmithkline Intellectual Property (No.2) Limited	Amine derivatives of lupanes with hiv maturation inhibitory activity
AR107512A1 (es)	2016-02-04	2018-05-09	VIIV HEALTHCARE UK Nº 5 LTD	Triterpenoides modificados en c-3 y c-17 como inhibidores del vih-1
WO2018002849A1 (en) *	2016-06-30	2018-01-04	VIIV Healthcare UK (No.5) Limited	Triterpenoid inhibitors of human immunodeficiency virus replication
AU2018331280B2 (en) *	2017-09-13	2023-05-25	Emmyon, Inc.	Ursolic acid morpholine and diethanolamine salts
EP3681508A4 (en)	2017-09-14	2021-05-19	Phoenix Biotechnology, Inc.	METHOD AND COMPOSITION FOR THE TREATMENT OF VIRAL INFECTION
EP3681477A4 (en)	2017-09-14	2021-06-09	Phoenix Biotechnology, Inc.	IMPROVED METHOD AND COMPOSITION FOR THE TREATMENT OF CONDITIONS, DISEASES OR DISORDERS SENSITIVE TO TRITERPENES
PT3784349T (pt)	2018-04-24	2024-01-22	Viiv Healthcare Uk No 5 Ltd	Compostos com atividade inibidora de maturação do hiv
PL237998B1 (pl)	2018-05-28	2021-06-28	Narodowy Inst Lekow	Fosfonowe pochodne kwasu 3-karboksyacylobetulinowego, sposób ich otrzymywania oraz ich zastosowanie
US10343997B1 (en)	2018-12-04	2019-07-09	King Saud University	Ursolic acid derivatives
EP4295854A3 (en)	2020-03-31	2024-04-03	Phoenix Biotechnology, Inc.	Method and compositions for treating coronavirus infection
KR102464428B1 (ko)	2020-03-31	2022-11-04	피닉스 바이오테크놀러지 인코포레이티드.	코로나바이러스 감염 치료를 위한 방법 및 조성물

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US5869535A (en)	1995-03-21	1999-02-09	The Board Of Trustees Of The University Of Illinois	Method and composition for selectively inhibiting melanoma
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2012
- 2012-01-27 JP JP2013551360A patent/JP6000283B2/ja not_active Expired - Fee Related
- 2012-01-27 ES ES12702946.0T patent/ES2552512T3/es active Active
- 2012-01-27 EP EP12702946.0A patent/EP2670764B1/en active Active
- 2012-01-27 EA EA201391098A patent/EA023578B1/ru not_active IP Right Cessation
- 2012-01-27 DK DK12702946.0T patent/DK2670764T3/en active
- 2012-01-27 CA CA2826257A patent/CA2826257A1/en not_active Abandoned
- 2012-01-27 BR BR112014010105A patent/BR112014010105A2/pt unknown
- 2012-01-27 SI SI201230354T patent/SI2670764T1/sl unknown
- 2012-01-27 WO PCT/US2012/022847 patent/WO2012106188A1/en active Application Filing
- 2012-01-27 MX MX2013008359A patent/MX2013008359A/es active IP Right Grant
- 2012-01-27 PL PL12702946T patent/PL2670764T3/pl unknown
- 2012-01-27 PT PT127029460T patent/PT2670764E/pt unknown
- 2012-01-27 RS RS20150740A patent/RS54352B1/en unknown
- 2012-01-27 HU HUE12702946A patent/HUE026371T2/en unknown
- 2012-01-27 CN CN201280007020.0A patent/CN103339141B/zh not_active Expired - Fee Related
- 2012-01-27 US US13/359,680 patent/US8748415B2/en not_active Expired - Fee Related
2015
- 2015-11-11 HR HRP20151212TT patent/HRP20151212T1/hr unknown
- 2015-12-01 CY CY20151101099T patent/CY1116989T1/el unknown
- 2015-12-01 SM SM201500303T patent/SMT201500303B/it unknown

Also Published As

Publication number	Publication date
CN103339141B (zh)	2016-08-24
EA201391098A1 (ru)	2013-12-30
CN103339141A (zh)	2013-10-02
JP6000283B2 (ja)	2016-09-28
JP2014507422A (ja)	2014-03-27
EA023578B1 (ru)	2016-06-30
US20130029954A1 (en)	2013-01-31
MX2013008359A (es)	2013-08-27
SMT201500303B (it)	2016-01-08
SI2670764T1 (sl)	2016-03-31
BR112014010105A2 (pt)	2017-06-13
ES2552512T3 (es)	2015-11-30
EP2670764B1 (en)	2015-09-02
HUE026371T2 (en)	2016-05-30
PT2670764E (pt)	2015-11-20
CA2826257A1 (en)	2012-08-09
WO2012106188A1 (en)	2012-08-09
EP2670764A1 (en)	2013-12-11
DK2670764T3 (en)	2015-12-07
RS54352B1 (en)	2016-02-29
CY1116989T1 (el)	2017-04-05
HRP20151212T1 (hr)	2015-12-04
US8748415B2 (en)	2014-06-10

Publication	Publication Date	Title
SI2670764T1 (sl)	2016-03-31	C-28 amini derivatov c-3 modificirane betulinske kisline inhibitorjev zorenja hiv
SI2576586T1 (sl)	2015-11-30	C-28 amidi derivatov modificirane c-3 betulinske kisline kot inhibitorji zorenja hiv
HK1210180A1 (en)	2016-04-15	Derivatives of betulin
EP2576585B8 (en)	2016-12-21	Modified c-3 betulinic acid derivatives as hiv maturation inhibitors
AP3867A (en)	2016-10-31	Inhibitors of influenza viruses replication
SI2683731T1 (sl)	2019-07-31	C4-monometil triterpenoidni derivati in postopki njihove uporabe
IL221132A0 (en)	2012-09-24	Derivatives of betulin
EP2791102A4 (en)	2015-04-22	PROPENOATE DERIVATIVES OF BETULIN
ZA201403736B (en)	2015-11-25	Process for the preparation of sterol derivatives
EP2755990A4 (en)	2015-03-25	PROCESS FOR THE PREPARATION OF BETULINIC ACID
PL2755991T3 (pl)	2018-09-28	Sposób wytwarzania kwasu betulinowego
PL2755989T3 (pl)	2018-08-31	Sposób wytwarzania kwasu betulinowego
EP2782902A4 (en)	2015-08-26	DERIVATIVES FROM PHENOXYISOBUTTERIC ACID
AU2016202292A1 (en)	2016-05-12	Derivatives of betulin
PL393253A1 (pl)	2011-05-23	Nowe pochodne kwasu betulinowego i sposób ich otrzymywania