CY1116989T1 - C-28 αμινες c-3 τροποποιημενων παραγωγων βετουλινικου οξεος ως αναστολεις hiv ωριμανσης - Google Patents

C-28 αμινες c-3 τροποποιημενων παραγωγων βετουλινικου οξεος ως αναστολεις hiv ωριμανσης

Info

Publication number
CY1116989T1
CY1116989T1 CY20151101099T CY151101099T CY1116989T1 CY 1116989 T1 CY1116989 T1 CY 1116989T1 CY 20151101099 T CY20151101099 T CY 20151101099T CY 151101099 T CY151101099 T CY 151101099T CY 1116989 T1 CY1116989 T1 CY 1116989T1
Authority
CY
Cyprus
Prior art keywords
amines
modified
compound
formula
hiv patients
Prior art date
Application number
CY20151101099T
Other languages
English (en)
Inventor
Alicia Regueiro-Ren
Jacob Swidorski
Sing-Yuen Sit
Yan Chen
Jie Chen
Nicholas A Meanwell
Zheng Liu
Original Assignee
Bristol-Myers Squibb Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company
Publication of CY1116989T1 publication Critical patent/CY1116989T1/el

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Παρουσιάζονταν ενώσεις που έχουν φαρμακευτικές και βιοτροποποιητικές ιδιότητες, οι φαρμακευτικές συνθέσεις αυτών και μέθοδοι χρήσης. Πιο συγκεκριμένα, C-28 αμίνες C-3 τροποποιημένων παράγωγων βετουλινικού οξέος που εμφανίζουν μοναδική αντι-ιική δραστικότητα παρέχονται ως αναστολείς HIV ωρίμανσης. Οι ενώσεις αυτές είναι χρήσιμες για τη θεραπευτική αγωγή του HIV και του AIDS. Πιο συγκεκριμένα, στο κείμενο παρέχονται οι ακόλουθες ενώσεις, συμπεριλαμβανομένων των φαρμακευτικά αποδεκτών αλάτων αυτών: ένωση του τύπου (I), ένωση του τύπου (II), και ένωση του τύπου (III).
CY20151101099T 2011-01-31 2015-12-01 C-28 αμινες c-3 τροποποιημενων παραγωγων βετουλινικου οξεος ως αναστολεις hiv ωριμανσης CY1116989T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161437870P 2011-01-31 2011-01-31
EP12702946.0A EP2670764B1 (en) 2011-01-31 2012-01-27 C-28 amines of c-3 modified betulinic acid derivatives as hiv maturation inhibitors

Publications (1)

Publication Number Publication Date
CY1116989T1 true CY1116989T1 (el) 2017-04-05

Family

ID=45567146

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20151101099T CY1116989T1 (el) 2011-01-31 2015-12-01 C-28 αμινες c-3 τροποποιημενων παραγωγων βετουλινικου οξεος ως αναστολεις hiv ωριμανσης

Country Status (19)

Country Link
US (1) US8748415B2 (el)
EP (1) EP2670764B1 (el)
JP (1) JP6000283B2 (el)
CN (1) CN103339141B (el)
BR (1) BR112014010105A2 (el)
CA (1) CA2826257A1 (el)
CY (1) CY1116989T1 (el)
DK (1) DK2670764T3 (el)
EA (1) EA023578B1 (el)
ES (1) ES2552512T3 (el)
HR (1) HRP20151212T1 (el)
HU (1) HUE026371T2 (el)
MX (1) MX2013008359A (el)
PL (1) PL2670764T3 (el)
PT (1) PT2670764E (el)
RS (1) RS54352B1 (el)
SI (1) SI2670764T1 (el)
SM (1) SMT201500303B (el)
WO (1) WO2012106188A1 (el)

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JP2018528231A (ja) 2015-09-24 2018-09-27 グラクソスミスクライン、インテレクチュアル、プロパティー、（ナンバー２）、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ （Ｎｏ．２） Ｌｉｍｉｔｅｄ Ｈｉｖ成熟阻害活性を有する化合物
JP2019502728A (ja) 2016-01-20 2019-01-31 グラクソスミスクライン、インテレクチュアル、プロパティー、（ナンバー２）、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ （Ｎｏ．２） Ｌｉｍｉｔｅｄ Ｈｉｖ成熟阻害活性を有するルパンのアミン誘導体
AR107512A1 (es) 2016-02-04 2018-05-09 VIIV HEALTHCARE UK Nº 5 LTD Triterpenoides modificados en c-3 y c-17 como inhibidores del vih-1
EP3478703A1 (en) * 2016-06-30 2019-05-08 ViiV Healthcare UK (No.5) Limited Triterpenoid inhibitors of human immunodeficiency virus replication
WO2019055119A1 (en) 2017-09-14 2019-03-21 Phoenix Biotechnology, Inc. METHOD AND COMPOSITION FOR TREATING VIRAL INFECTION
CN111093673A (zh) * 2017-09-13 2020-05-01 艾蒙有限责任公司 熊果酸吗啉盐和熊果酸二乙醇胺盐
RU2758376C2 (ru) 2017-09-14 2021-10-28 Феникс Байотекнолоджи, Инк. Способ и улучшенная нейропротекторная композиция для лечения неврологических патологических состояний
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PL237998B1 (pl) 2018-05-28 2021-06-28 Narodowy Inst Lekow Fosfonowe pochodne kwasu 3-karboksyacylobetulinowego, sposób ich otrzymywania oraz ich zastosowanie
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Also Published As

Publication number Publication date
PT2670764E (pt) 2015-11-20
PL2670764T3 (pl) 2016-02-29
US20130029954A1 (en) 2013-01-31
ES2552512T3 (es) 2015-11-30
HRP20151212T1 (hr) 2015-12-04
WO2012106188A1 (en) 2012-08-09
EA201391098A1 (ru) 2013-12-30
EA023578B1 (ru) 2016-06-30
SI2670764T1 (sl) 2016-03-31
CA2826257A1 (en) 2012-08-09
DK2670764T3 (en) 2015-12-07
EP2670764A1 (en) 2013-12-11
BR112014010105A2 (pt) 2017-06-13
JP6000283B2 (ja) 2016-09-28
US8748415B2 (en) 2014-06-10
MX2013008359A (es) 2013-08-27
RS54352B1 (en) 2016-02-29
SMT201500303B (it) 2016-01-08
EP2670764B1 (en) 2015-09-02
HUE026371T2 (en) 2016-05-30
CN103339141A (zh) 2013-10-02
JP2014507422A (ja) 2014-03-27
CN103339141B (zh) 2016-08-24

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