PL2473617T3 - Ulepszone oczyszczanie białka poprzez zmodyfikowaną elucję z białka A - Google Patents

Ulepszone oczyszczanie białka poprzez zmodyfikowaną elucję z białka A

Info

Publication number
PL2473617T3
PL2473617T3 PL10814394T PL10814394T PL2473617T3 PL 2473617 T3 PL2473617 T3 PL 2473617T3 PL 10814394 T PL10814394 T PL 10814394T PL 10814394 T PL10814394 T PL 10814394T PL 2473617 T3 PL2473617 T3 PL 2473617T3
Authority
PL
Poland
Prior art keywords
protein
elution
enhanced
modified
purification
Prior art date
Application number
PL10814394T
Other languages
English (en)
Inventor
Arick Brown
Christopher J. Dowd
Asha Nandini Radhamohan
Original Assignee
F. Hoffmann-La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43649614&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2473617(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by F. Hoffmann-La Roche Ag filed Critical F. Hoffmann-La Roche Ag
Publication of PL2473617T3 publication Critical patent/PL2473617T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
PL10814394T 2009-09-01 2010-09-01 Ulepszone oczyszczanie białka poprzez zmodyfikowaną elucję z białka A PL2473617T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US23886709P 2009-09-01 2009-09-01
US25343809P 2009-10-20 2009-10-20
PCT/US2010/047448 WO2011028753A1 (en) 2009-09-01 2010-09-01 Enhanced protein purification through a modified protein a elution
EP10814394.2A EP2473617B1 (en) 2009-09-01 2010-09-01 Enhanced protein purification through a modified protein a elution

Publications (1)

Publication Number Publication Date
PL2473617T3 true PL2473617T3 (pl) 2020-06-29

Family

ID=43649614

Family Applications (1)

Application Number Title Priority Date Filing Date
PL10814394T PL2473617T3 (pl) 2009-09-01 2010-09-01 Ulepszone oczyszczanie białka poprzez zmodyfikowaną elucję z białka A

Country Status (14)

Country Link
US (3) US9428548B2 (pl)
EP (2) EP2473617B1 (pl)
JP (1) JP5787891B2 (pl)
KR (1) KR101764449B1 (pl)
CN (2) CN108409829A (pl)
BR (1) BR112012004697B8 (pl)
CA (1) CA2772653C (pl)
ES (1) ES2787234T3 (pl)
HR (1) HRP20200581T1 (pl)
MX (1) MX2012002565A (pl)
PL (1) PL2473617T3 (pl)
RU (1) RU2571929C2 (pl)
SI (1) SI2473617T1 (pl)
WO (1) WO2011028753A1 (pl)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0716762A2 (pt) 2006-09-13 2013-09-24 Abbott Lab melhorias da cultura celular
US8911964B2 (en) 2006-09-13 2014-12-16 Abbvie Inc. Fed-batch method of making human anti-TNF-alpha antibody
EP2921501A1 (en) 2008-10-20 2015-09-23 Abbvie Inc. Isolation and purification of antibodies using Protein A affinity chromatography
KR101722423B1 (ko) 2008-10-20 2017-04-18 애브비 인코포레이티드 항체 정제 동안의 바이러스 불활성화
CN102712691A (zh) 2009-08-06 2012-10-03 弗·哈夫曼-拉罗切有限公司 蛋白质纯化中提高病毒去除的方法
CA2773428A1 (en) * 2009-09-10 2011-03-17 Lonza Biologics Plc Method and system for polypeptide purification
SG11201403437TA (en) 2011-12-22 2014-07-30 Genentech Inc Ion exchange membrane chromatography
WO2013147691A1 (en) * 2012-03-28 2013-10-03 Ge Healthcare Bio-Sciences Ab Affinity chromatography matrix
CN107188926B (zh) 2012-06-29 2021-02-09 Emd密理博公司 在蛋白纯化过程中灭活病毒的方法
US8921113B2 (en) 2012-12-21 2014-12-30 Dionex Corporation Buffer kit and method of generating a linear pH gradient
SG11201505901YA (en) * 2013-03-14 2015-08-28 Emd Millipore Corp Methods of increasing protein purity using protein a based chromatography
US10274466B2 (en) * 2013-07-12 2019-04-30 Genentech, Inc. Elucidation of ion exchange chromatography input optimization
EP4389157A2 (en) * 2013-11-15 2024-06-26 F. Hoffmann-La Roche AG Methods for viral inactivation using eco-friendly detergents
CN106103465B (zh) * 2014-03-10 2021-01-08 吉瑞工厂 使用预清洗步骤的免疫球蛋白纯化
GB2539420B (en) * 2015-06-16 2021-01-13 Cytiva Sweden Ab Determination of chromatography conditions
MX2020013348A (es) 2018-06-09 2021-03-09 Boehringer Ingelheim Int Anticuerpos biespecificos contra dll3-cd3.
US11022585B2 (en) 2019-06-09 2021-06-01 Dionex Corporation Methods and systems for optimizing buffer conditions with liquid chromatography

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
USRE30985E (en) 1978-01-01 1982-06-29 Serum-free cell culture media
FR2413974A1 (fr) 1978-01-06 1979-08-03 David Bernard Sechoir pour feuilles imprimees par serigraphie
US4515893A (en) 1979-04-26 1985-05-07 Ortho Pharmaceutical Corporation Hybrid cell line for producing complement-fixing monoclonal antibody to human T cells
US4560655A (en) 1982-12-16 1985-12-24 Immunex Corporation Serum-free cell culture medium and process for making same
US4657866A (en) 1982-12-21 1987-04-14 Sudhir Kumar Serum-free, synthetic, completely chemically defined tissue culture media
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
DD266710A3 (de) 1983-06-06 1989-04-12 Ve Forschungszentrum Biotechnologie Verfahren zur biotechnischen Herstellung van alkalischer Phosphatase
US4767704A (en) 1983-10-07 1988-08-30 Columbia University In The City Of New York Protein-free culture medium
US5672347A (en) 1984-07-05 1997-09-30 Genentech, Inc. Tumor necrosis factor antagonists and their use
US4879231A (en) 1984-10-30 1989-11-07 Phillips Petroleum Company Transformation of yeasts of the genus pichia
GB8516415D0 (en) 1985-06-28 1985-07-31 Celltech Ltd Culture of animal cells
US4676980A (en) 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
US5091178A (en) 1986-02-21 1992-02-25 Oncogen Tumor therapy with biologically active anti-tumor antibodies
US4927762A (en) 1986-04-01 1990-05-22 Cell Enterprises, Inc. Cell culture medium with antioxidant
GB8610600D0 (en) 1986-04-30 1986-06-04 Novo Industri As Transformation of trichoderma
IL85035A0 (en) 1987-01-08 1988-06-30 Int Genetic Eng Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
DE3850542T2 (de) 1987-09-23 1994-11-24 Bristol Myers Squibb Co Antikörper-Heterokonjugate zur Töting von HIV-infizierten Zellen.
US5091313A (en) 1988-08-05 1992-02-25 Tanox Biosystems, Inc. Antigenic epitopes of IgE present on B cell but not basophil surface
US5720937A (en) 1988-01-12 1998-02-24 Genentech, Inc. In vivo tumor detection assay
ATE113846T1 (de) 1988-06-21 1994-11-15 Genentech Inc Therapeutische zusammensetzungen für die behandlung von myocard-infarkten.
AU632065B2 (en) 1988-09-23 1992-12-17 Novartis Vaccines And Diagnostics, Inc. Cell culture medium for enhanced cell growth, culture longevity and product expression
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
EP0402226A1 (en) 1989-06-06 1990-12-12 Institut National De La Recherche Agronomique Transformation vectors for yeast yarrowia
WO1991000360A1 (en) 1989-06-29 1991-01-10 Medarex, Inc. Bispecific reagents for aids therapy
ATE130850T1 (de) 1989-07-28 1995-12-15 Wako Pure Chem Ind Ltd Fulgimidderivate.
US5122469A (en) 1990-10-03 1992-06-16 Genentech, Inc. Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins
WO1992020373A1 (en) 1991-05-14 1992-11-26 Repligen Corporation Heteroconjugate antibodies for treatment of hiv infection
ES2193136T3 (es) 1991-08-14 2003-11-01 Genentech Inc Variantes de inmunoglubina para receptores especificos de fc epsilon.
WO1993008829A1 (en) 1991-11-04 1993-05-13 The Regents Of The University Of California Compositions that mediate killing of hiv-infected cells
EP0625200B1 (en) 1992-02-06 2005-05-11 Chiron Corporation Biosynthetic binding protein for cancer marker
WO1994004188A1 (en) 1992-08-21 1994-03-03 Genentech, Inc. Method for treating an lfa-1-mediated disorder
US5736137A (en) 1992-11-13 1998-04-07 Idec Pharmaceuticals Corporation Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma
JP3507852B2 (ja) 1993-12-10 2004-03-15 ジェネンテク，インコーポレイテッド アレルギー診断法および抗アレルギー性治療剤のスクリーニング法
WO1995019181A1 (en) 1994-01-18 1995-07-20 Genentech, Inc. A METHOD OF TREATMENT OF PARASITIC INFECTION USING IgE ANTAGONISTS
WO1995023865A1 (en) 1994-03-03 1995-09-08 Genentech, Inc. Anti-il-8 monoclonal antibodies for treatment of inflammatory disorders
US5534615A (en) 1994-04-25 1996-07-09 Genentech, Inc. Cardiac hypertrophy factor and uses therefor
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
IL117645A (en) 1995-03-30 2005-08-31 Genentech Inc Vascular endothelial cell growth factor antagonists for use as medicaments in the treatment of age-related macular degeneration
WO1996040210A1 (en) 1995-06-07 1996-12-19 Imclone Systems Incorporated Antibody and antibody fragments for inhibiting the growth of tumors
AU724449B2 (en) 1996-01-23 2000-09-21 Genentech Inc. Anti-CD18 antibodies for use against stroke
US7147851B1 (en) 1996-08-15 2006-12-12 Millennium Pharmaceuticals, Inc. Humanized immunoglobulin reactive with α4β7 integrin
KR100532178B1 (ko) 1996-11-27 2005-12-01 제넨테크, 인크. 인간화 항-ＣＤ11ａ 항체
US20030109680A1 (en) * 2001-11-21 2003-06-12 Sunol Molecular Corporation Antibodies for inhibiting blood coagulation and methods of use thereof
PT1325932E (pt) 1997-04-07 2005-06-30 Genentech Inc Anticorpos anti-vegf
EP1860187B1 (en) 1997-05-15 2011-07-13 Genentech, Inc. Apo-2 receptor
US5994511A (en) 1997-07-02 1999-11-30 Genentech, Inc. Anti-IgE antibodies and methods of improving polypeptides
RU2145610C1 (ru) * 1998-12-09 2000-02-20 Общество с ограниченной ответственностью "Протеиновый контур" Способ очистки рекомбинантного эритропоэтина человека
US6946129B1 (en) 1999-06-08 2005-09-20 Seattle Genetics, Inc. Recombinant anti-CD40 antibody and uses thereof
ATE437655T1 (de) 1999-06-25 2009-08-15 Genentech Inc Humanisierte anti-erbb2 antikörper und behandlung mit anti-erbb2 antikörper
KR100490077B1 (ko) 1999-10-29 2005-05-17 제넨테크, 인크. 항-전립선 줄기세포 항원 (ｐｓｃａ) 항체 조성물 및 그의사용 방법
DK1578774T3 (da) * 2002-09-18 2014-02-03 Danisco Us Inc Oprensning af immunoglobuliner
CN101120017A (zh) * 2004-08-30 2008-02-06 英国龙沙生物医药股份有限公司 用于纯化抗体的亲和力加离子交换层析
EP1693108A1 (en) 2004-12-04 2006-08-23 MERCK PATENT GmbH Mixed-modal anion-exchange type separation material
EP1896504B1 (en) * 2005-06-17 2012-11-21 Wyeth LLC Methods of purifying fc region containing antibodies
EA017733B1 (ru) 2006-08-28 2013-02-28 Арес Трейдинг С.А. СПОСОБ ОЧИСТКИ Fc-СЛИТЫХ БЕЛКОВ
US20080167450A1 (en) * 2007-01-05 2008-07-10 Hai Pan Methods of purifying proteins
ATE526017T1 (de) 2007-01-22 2011-10-15 Genentech Inc Abscheidung von polyelektrolyten und reinigung von antikörpern
KR20120027055A (ko) * 2009-06-26 2012-03-20 리제네론 파라마큐티칼스 인코포레이티드 천연 면역글로불린 포맷을 가지는 용이하게 분리된 이중특이성 항체
WO2015198451A1 (ja) 2014-06-26 2015-12-30 楽天株式会社 情報処理装置、情報処理方法及び情報処理プログラム

Also Published As

Publication number Publication date
EP2473617B1 (en) 2020-02-26
RU2012112536A (ru) 2013-10-10
RU2571929C2 (ru) 2015-12-27
US9428548B2 (en) 2016-08-30
EP3736338A1 (en) 2020-11-11
CN108409829A (zh) 2018-08-17
EP2473617A4 (en) 2014-04-09
ES2787234T3 (es) 2020-10-15
HRP20200581T1 (hr) 2020-07-10
BR112012004697B8 (pt) 2021-05-25
SI2473617T1 (sl) 2020-07-31
BR112012004697B1 (pt) 2021-02-09
US20220081466A1 (en) 2022-03-17
WO2011028753A1 (en) 2011-03-10
JP2013503877A (ja) 2013-02-04
EP2473617A1 (en) 2012-07-11
CA2772653A1 (en) 2011-03-10
US20220324905A1 (en) 2022-10-13
MX2012002565A (es) 2012-05-29
KR101764449B1 (ko) 2017-08-02
KR20120106719A (ko) 2012-09-26
BR112012004697A2 (pt) 2015-09-08
CN102686738A (zh) 2012-09-19
US20130041139A1 (en) 2013-02-14
CA2772653C (en) 2019-06-25
JP5787891B2 (ja) 2015-09-30

Similar Documents

Publication Publication Date Title
EP2473617A4 (en) REINFORCED PROTEIN CLEANSING THROUGH MODIFIED PROTEIN-A-ELUTION
HRP20170138T1 (hr) Ponovno dobivanje proteina
HK1218558A1 (zh) 蛋白
HK1246330A1 (zh) 蛋白質純化
GB0914272D0 (en) Sorbent
PL2464655T3 (pl) Procesy chromatograficzne
ZA201200200B (en) Chimaeric protein
GB0900965D0 (en) Sorbents
IL216261A0 (en) IL-13 binding protein
GB0915403D0 (en) Protein glycosylation
PL2496596T3 (pl) Peptydy terapeutyczne
EP2480578A4 (en) MODIFICATION OF POLYPEPTIDE
GB0900241D0 (en) Saddle
GB0904842D0 (en) Protein labelling
ZA201109283B (en) Protein
ZA201108446B (en) FViII-DERIVED PEPTIDES
ZA201203722B (en) Peptide
GB0921691D0 (en) Sophorolpid transporter protien
EP2439209A4 (en) PEPTIDES BASED ON ENDOKININS C / D
GB0919013D0 (en) Easy rider
GB0909384D0 (en) Protein
GB0912524D0 (en) Comfy saddle
GB0902222D0 (en) Protein expression
GB0911790D0 (en) Peptides
GB0900964D0 (en) Sorbents