PL2188268T3 - Podstawione piperazynylopirazyny i -pirydyny jako antagoniści receptora 5-HT7 - Google Patents
Podstawione piperazynylopirazyny i -pirydyny jako antagoniści receptora 5-HT7Info
- Publication number
- PL2188268T3 PL2188268T3 PL08798144T PL08798144T PL2188268T3 PL 2188268 T3 PL2188268 T3 PL 2188268T3 PL 08798144 T PL08798144 T PL 08798144T PL 08798144 T PL08798144 T PL 08798144T PL 2188268 T3 PL2188268 T3 PL 2188268T3
- Authority
- PL
- Poland
- Prior art keywords
- pyridines
- receptor antagonists
- substituted piperazinyl
- pyrazines
- piperazinyl pyrazines
- Prior art date
Links
- HCGFLVDMFDHYJD-UHFFFAOYSA-N 2-piperazin-1-ylpyrazine Chemical class C1CNCCN1C1=CN=CC=N1 HCGFLVDMFDHYJD-UHFFFAOYSA-N 0.000 title 1
- 108091005436 5-HT7 receptors Proteins 0.000 title 1
- 150000003222 pyridines Chemical class 0.000 title 1
- 239000002464 receptor antagonist Substances 0.000 title 1
- 229940044551 receptor antagonist Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US96834407P | 2007-08-28 | 2007-08-28 | |
| US4875208P | 2008-04-29 | 2008-04-29 | |
| EP08798144A EP2188268B1 (en) | 2007-08-28 | 2008-08-19 | Substituted piperazinyl pyrazines and pyridines as 5-ht7 receptor antagonists |
| PCT/US2008/073543 WO2009029439A1 (en) | 2007-08-28 | 2008-08-19 | Substituted piperazinyl pyrazines and pyridines as 5-ht7 receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2188268T3 true PL2188268T3 (pl) | 2011-12-30 |
Family
ID=39873874
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL08798144T PL2188268T3 (pl) | 2007-08-28 | 2008-08-19 | Podstawione piperazynylopirazyny i -pirydyny jako antagoniści receptora 5-HT7 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US8048884B2 (pl) |
| EP (1) | EP2188268B1 (pl) |
| JP (1) | JP5290293B2 (pl) |
| KR (1) | KR101148616B1 (pl) |
| CN (1) | CN101790522B (pl) |
| AR (1) | AR068111A1 (pl) |
| AT (1) | ATE520673T1 (pl) |
| AU (1) | AU2008293715B2 (pl) |
| BR (1) | BRPI0816468A2 (pl) |
| CA (1) | CA2694911C (pl) |
| CY (1) | CY1111848T1 (pl) |
| DK (1) | DK2188268T3 (pl) |
| EA (1) | EA017809B1 (pl) |
| HR (1) | HRP20110624T1 (pl) |
| MX (1) | MX2010002352A (pl) |
| PE (1) | PE20090629A1 (pl) |
| PL (1) | PL2188268T3 (pl) |
| PT (1) | PT2188268E (pl) |
| SI (1) | SI2188268T1 (pl) |
| TW (1) | TW200914020A (pl) |
| WO (1) | WO2009029439A1 (pl) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI118473B (fi) | 2006-02-17 | 2007-11-30 | Outotec Oyj | Menetelmä kuparin talteenottamiseksi kuparisulfidimalmista |
| CN101821257B (zh) * | 2007-10-12 | 2013-05-22 | 伊莱利利公司 | 5-ht7受体拮抗剂 |
| JP5826822B2 (ja) | 2010-04-16 | 2015-12-02 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ | 有害生物防除薬としての新規な複素環化合物 |
| CN103857670B (zh) | 2011-10-11 | 2016-03-23 | Ucb医药有限公司 | 2-氧代-哌啶基衍生物 |
| FR2995605B1 (fr) | 2012-09-18 | 2014-09-19 | Sanofi Sa | Derives de macrolides, leur preparation et leur application therapeutique. |
| EP3083563A1 (en) | 2013-12-20 | 2016-10-26 | Laboratorios Del. Dr. Esteve, S.A. | Piperazine derivatives having multimodal activity against pain |
| US11505529B2 (en) | 2017-03-03 | 2022-11-22 | National Taiwan University | 8-phenyl-isoquinolines and pharmaceutical composition thereof used in the treatment of irritable bowel syndrome |
| KR102014335B1 (ko) * | 2017-12-01 | 2019-08-26 | 한국과학기술연구원 | 5-ht7 수용체의 조절제로 작용하는 아릴피라졸릴피페라진 또는 아릴피라졸릴다이아제페인의 유도체 및 이를 포함하는 중추신경계 질환 치료 또는 예방용 약학 조성물 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20010102003A (ko) * | 1999-02-10 | 2001-11-15 | 피터 지. 스트링거 | 5-ｈｔ1ｆ 효능제 |
| US20030008880A1 (en) * | 2001-05-02 | 2003-01-09 | Pfizer Inc. | 4-(2-Pyridyl) piperizines having 5HT7 receptor agonist activity |
| US7153858B2 (en) | 2003-01-31 | 2006-12-26 | Epix Delaware, Inc. | Arylpiperazinyl compounds |
| WO2004067703A2 (en) * | 2003-01-31 | 2004-08-12 | Pfizer Products Inc. | 5ht7 antagonists and inverse agonists |
-
2008
- 2008-08-01 TW TW097129418A patent/TW200914020A/zh unknown
- 2008-08-19 DK DK08798144.5T patent/DK2188268T3/da active
- 2008-08-19 SI SI200830392T patent/SI2188268T1/sl unknown
- 2008-08-19 CA CA2694911A patent/CA2694911C/en not_active Expired - Fee Related
- 2008-08-19 US US12/447,546 patent/US8048884B2/en not_active Expired - Fee Related
- 2008-08-19 AT AT08798144T patent/ATE520673T1/de active
- 2008-08-19 AU AU2008293715A patent/AU2008293715B2/en not_active Ceased
- 2008-08-19 PT PT08798144T patent/PT2188268E/pt unknown
- 2008-08-19 BR BRPI0816468 patent/BRPI0816468A2/pt not_active Application Discontinuation
- 2008-08-19 MX MX2010002352A patent/MX2010002352A/es active IP Right Grant
- 2008-08-19 EA EA201070321A patent/EA017809B1/ru not_active IP Right Cessation
- 2008-08-19 WO PCT/US2008/073543 patent/WO2009029439A1/en active Application Filing
- 2008-08-19 KR KR1020107004378A patent/KR101148616B1/ko not_active IP Right Cessation
- 2008-08-19 PL PL08798144T patent/PL2188268T3/pl unknown
- 2008-08-19 EP EP08798144A patent/EP2188268B1/en not_active Not-in-force
- 2008-08-19 JP JP2010523034A patent/JP5290293B2/ja not_active Expired - Fee Related
- 2008-08-19 CN CN2008801048354A patent/CN101790522B/zh not_active Expired - Fee Related
- 2008-08-27 AR ARP080103721A patent/AR068111A1/es unknown
- 2008-08-27 PE PE2008001449A patent/PE20090629A1/es not_active Application Discontinuation
-
2011
- 2011-08-30 HR HR20110624T patent/HRP20110624T1/hr unknown
- 2011-09-20 CY CY20111100910T patent/CY1111848T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK2188268T3 (da) | 2011-10-03 |
| BRPI0816468A2 (pt) | 2015-03-24 |
| EA017809B1 (ru) | 2013-03-29 |
| CN101790522B (zh) | 2012-06-27 |
| KR101148616B1 (ko) | 2012-05-21 |
| WO2009029439A1 (en) | 2009-03-05 |
| PE20090629A1 (es) | 2009-05-16 |
| KR20100038117A (ko) | 2010-04-12 |
| JP2010537994A (ja) | 2010-12-09 |
| PT2188268E (pt) | 2011-10-03 |
| EA201070321A1 (ru) | 2010-08-30 |
| JP5290293B2 (ja) | 2013-09-18 |
| MX2010002352A (es) | 2010-08-04 |
| EP2188268B1 (en) | 2011-08-17 |
| US20100075976A1 (en) | 2010-03-25 |
| AU2008293715B2 (en) | 2013-09-19 |
| AU2008293715A1 (en) | 2009-03-05 |
| AR068111A1 (es) | 2009-11-04 |
| ATE520673T1 (de) | 2011-09-15 |
| CY1111848T1 (el) | 2015-10-07 |
| CA2694911C (en) | 2013-05-07 |
| CN101790522A (zh) | 2010-07-28 |
| CA2694911A1 (en) | 2009-03-05 |
| HRP20110624T1 (hr) | 2011-09-30 |
| EP2188268A1 (en) | 2010-05-26 |
| TW200914020A (en) | 2009-04-01 |
| SI2188268T1 (sl) | 2011-11-30 |
| US8048884B2 (en) | 2011-11-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PT2188268E (pt) | Piperazinil-piperazinas e piridinas substituídas como antagonistas do recetor 5-ht7 | |
| ZA200808191B (en) | Pyridine and pyrimidine derivatives as MGLUR2 antagonists | |
| EP2184981A4 (en) | PYRIDINECARBOXAMIDE OREXIN RECEPTOR ANTAGONISTS | |
| PL2155717T3 (pl) | 2-[4-(PIRAZOL-4-ILOALKILO)PIPERAZYN-1-YLO]-3-FENYLO PIRAZYNY I PIRYDYNY I 3-[4-(PIRAZOL-4-ILOALKILO)PIPERAZYN-1-YLO]-2-FENYLO PIRYDYNY JAKO ANTAGONIŚĆI RECEPTORA 5-HT<sub>7</sub> | |
| BRPI0817245A2 (pt) | Derivados e quinolina como antagonistas receptores de 5ht5a | |
| PT2129654E (pt) | Antagonistas do receptor de glucagina | |
| IL225521A0 (en) | 1trpv antagonists and their uses | |
| ZA201100866B (en) | Tripyridyl carboxamide orexin receptor antagonists | |
| EP2438041A4 (en) | PYRAZINE-carboxamide-orexin receptor Antagonist | |
| EP2131654A4 (en) | BIPYRIDINE CARBOXAMIDES, ANTAGONISTS OF THE OREXIN RECEPTOR | |
| IL215690A0 (en) | Thiazole derivatives and their use as p2y12 receptor antagonists | |
| IL205608A0 (en) | Triazole -substituted arylamide derivatives and their use as p2x3 and/or p2x2/3purinergic receptor antagonists | |
| ZA201000395B (en) | Substituted piperazines as cb1 antagonists | |
| ATE493400T1 (de) | Pyridin- und pyrimidinderivate als mglur2- antagonisten | |
| ZA200900303B (en) | Cinnamoyl-piperazine derivatives and their use as par-i antagonists | |
| ZA200903574B (en) | 2-Phenyl-6-Aminocarbonyl-Pyrimidine derivatives and their use as P2Y12 Receptor antagonists | |
| HK1158640A1 (en) | Substituted 6-(1-piperazinyl)-pyridazines as 5-ht6 receptor antagonists 5-ht6 6-(1-)- | |
| EP2125724A4 (en) | NAPHTHALENE DERIVATIVES AND QUINOLINE SULFONYLUREA AS ANTAGONISTS OF THE EP4 RECEPTOR | |
| EP2654423A4 (en) | AZAINDANE ANTAGONISTS HETEROCYCLIC CARBOXAMIDES MERGED FROM CGRP RECEPTORS | |
| IL215483A0 (en) | Composition of 2,4,6-trifluoro-n-[6-(1-methyl-piperidin-4-carbonyl)-pyridin-2-yl]-benzamide | |
| IL205749A0 (en) | Modified il-4 mutein receptor antagonists | |
| HK1179619A1 (en) | (3 -methylpyrrolidin- 3 - yl) methyl pyridinyl ether derivatives and their use as nk-3 receptor antagonists (3---3-)- nk-3 | |
| IL199439A0 (en) | Pyridine compounds and their use as p2y12 antagonists | |
| IL204759A0 (en) | 2 - s - benzyl substituted pyrimidines as crth2 antagonists | |
| IL241743A0 (en) | Non-competitive nicotinic receptor antagonists |