PE20201149A1 - Anticuerpos de union a hla-a2/wt1 - Google Patents
Anticuerpos de union a hla-a2/wt1Info
- Publication number
- PE20201149A1 PE20201149A1 PE2020000727A PE2020000727A PE20201149A1 PE 20201149 A1 PE20201149 A1 PE 20201149A1 PE 2020000727 A PE2020000727 A PE 2020000727A PE 2020000727 A PE2020000727 A PE 2020000727A PE 20201149 A1 PE20201149 A1 PE 20201149A1
- Authority
- PE
- Peru
- Prior art keywords
- hla
- wt1rmf
- peptide
- antibodies
- refers
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3038—Kidney, bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/54—F(ab')2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Abstract
Referido a un anticuerpo biespecifico, que se une a HLA-A2/WT1, en donde el anticuerpo se une a un epitopo de HLA-A2/WT1, particularmente HLA-A2/WT1RMF, que comprende al menos tres residuos de aminoacidos del peptido WT1, particularmente el peptido WT1RMF, en donde dichos residuos de aminoacidos se seleccionan de R1, M2, P4, N5, A6 e Y8 del peptido WT1RMF. Ademas, de moleculas de union a antigeno biespecificas que se unen a HLA-A2/WT1 y un antigeno activador de celulas T. Tambien se refiere a los polinucleotidos que codifican dichos anticuerpos, vectores de expresion, celulas huesped que comprenden dichos polinucleotidos, metodos de produccion de los anticuerpos y a los metodos de uso de estos en el tratamiento de enfermedades tales como el cancer.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP17209205 | 2017-12-21 | ||
PCT/EP2018/086055 WO2019122052A2 (en) | 2017-12-21 | 2018-12-20 | Antibodies binding to hla-a2/wt1 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20201149A1 true PE20201149A1 (es) | 2020-10-26 |
Family
ID=60702450
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2020000727A PE20201149A1 (es) | 2017-12-21 | 2018-12-20 | Anticuerpos de union a hla-a2/wt1 |
Country Status (19)
Country | Link |
---|---|
US (2) | US11192957B2 (es) |
EP (1) | EP3728317A2 (es) |
JP (2) | JP6933778B2 (es) |
KR (1) | KR102575787B1 (es) |
CN (1) | CN111527107A (es) |
AR (1) | AR114001A1 (es) |
AU (1) | AU2018390881A1 (es) |
BR (1) | BR112020011469A2 (es) |
CA (1) | CA3084105A1 (es) |
CL (1) | CL2020001629A1 (es) |
CO (1) | CO2020006600A2 (es) |
IL (1) | IL275471A (es) |
MA (1) | MA51302A (es) |
MX (1) | MX2020006119A (es) |
PE (1) | PE20201149A1 (es) |
PH (1) | PH12020550952A1 (es) |
SG (1) | SG11202005632SA (es) |
TW (1) | TWI805665B (es) |
WO (1) | WO2019122052A2 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR112022008652A2 (pt) | 2019-11-05 | 2022-07-19 | Hoffmann La Roche | Anticorpos biespecíficos hla-a2/wt1 x cd3, uso de um anticorpo biespecífico, método para tratar câncer em um indivíduo, kit e invenção |
EP4216998A1 (en) | 2020-09-24 | 2023-08-02 | F. Hoffmann-La Roche AG | Prevention or mitigation of t-cell bispecific antibody-related adverse effects |
WO2023073225A1 (en) | 2021-11-01 | 2023-05-04 | F. Hoffmann-La Roche Ag | Treatment of cancer using a hla-a2/wt1 x cd3 bispecific antibody and a 4-1bb (cd137) agonist |
CN114395047B (zh) * | 2021-12-07 | 2023-11-07 | 合肥天港免疫药物有限公司 | 双特异性抗体及其应用 |
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CN103738136B (zh) | 2014-01-27 | 2017-02-15 | 徐州重型机械有限公司 | 独立悬架***及具有该独立悬架***的起重机 |
WO2015130766A1 (en) | 2014-02-25 | 2015-09-03 | Memorial Sloan-Kettering Cancer Center | Antigen-binding proteins specific for hla-a2-restricted wilms tumor 1 peptide |
UA117289C2 (uk) | 2014-04-02 | 2018-07-10 | Ф. Хоффманн-Ля Рош Аг | Мультиспецифічне антитіло |
WO2016016299A1 (en) | 2014-07-29 | 2016-02-04 | F. Hoffmann-La Roche Ag | Multispecific antibodies |
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CN107787332B (zh) | 2015-04-24 | 2022-09-09 | 豪夫迈·罗氏有限公司 | 多特异性抗原结合蛋白 |
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JP7394058B2 (ja) | 2017-12-21 | 2023-12-07 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | 新規抗原結合部分の特異性試験のためのユニバーサルレポーター細胞アッセイ |
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- 2018-12-20 US US16/228,102 patent/US11192957B2/en active Active
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- 2018-12-20 TW TW107146108A patent/TWI805665B/zh active
- 2018-12-20 KR KR1020207020450A patent/KR102575787B1/ko active IP Right Grant
- 2018-12-20 EP EP18833866.9A patent/EP3728317A2/en active Pending
- 2018-12-20 MA MA051302A patent/MA51302A/fr unknown
- 2018-12-20 JP JP2020533185A patent/JP6933778B2/ja active Active
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- 2018-12-20 CN CN201880081252.8A patent/CN111527107A/zh active Pending
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2020
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US20190248916A1 (en) | 2019-08-15 |
AU2018390881A1 (en) | 2020-07-02 |
CA3084105A1 (en) | 2019-06-27 |
IL275471A (en) | 2020-08-31 |
CO2020006600A2 (es) | 2020-06-19 |
US20220411534A1 (en) | 2022-12-29 |
RU2020123129A (ru) | 2022-01-21 |
WO2019122052A2 (en) | 2019-06-27 |
PH12020550952A1 (en) | 2021-03-22 |
TWI805665B (zh) | 2023-06-21 |
KR102575787B1 (ko) | 2023-09-08 |
CN111527107A (zh) | 2020-08-11 |
JP2021129561A (ja) | 2021-09-09 |
TW201930356A (zh) | 2019-08-01 |
JP6933778B2 (ja) | 2021-09-08 |
MX2020006119A (es) | 2020-08-24 |
SG11202005632SA (en) | 2020-07-29 |
WO2019122052A3 (en) | 2019-08-01 |
AR114001A1 (es) | 2020-07-08 |
EP3728317A2 (en) | 2020-10-28 |
BR112020011469A2 (pt) | 2020-11-24 |
KR20200104331A (ko) | 2020-09-03 |
JP2021507698A (ja) | 2021-02-25 |
CL2020001629A1 (es) | 2020-11-27 |
MA51302A (fr) | 2021-03-31 |
US11192957B2 (en) | 2021-12-07 |
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