PE20191495A1 - Piridonamidas como moduladores de canales de sodio - Google Patents
Piridonamidas como moduladores de canales de sodioInfo
- Publication number
- PE20191495A1 PE20191495A1 PE2019001687A PE2019001687A PE20191495A1 PE 20191495 A1 PE20191495 A1 PE 20191495A1 PE 2019001687 A PE2019001687 A PE 2019001687A PE 2019001687 A PE2019001687 A PE 2019001687A PE 20191495 A1 PE20191495 A1 PE 20191495A1
- Authority
- PE
- Peru
- Prior art keywords
- pyridonamides
- sodium channel
- optionally substituted
- channel modulators
- halogen
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
- C07C65/24—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
Referido a un proceso para preparar un compuesto de formula I, o su sal farmaceuticamente aceptable, en donde R1, R2, R3 y R4 son independientemente H, halogeno, CN, alquilo C1-C6 opcionalmente sustituidos, entre otros; R5, R5', R6, R6' y R7 son independientemente H, halogeno, CN, o -X-Rx; X es un enlace o alquilo C1-C6 opcionalmente sustituido; Rx esta ausente, es H o cicloalifatico C3-C8 opcionalmente sustituido. Estos compuestos son piridonamidas moduladores de canales de sodio. Tambien se refiere su uso en el tratamiento de diversos trastornos, incluyendo dolor.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361759059P | 2013-01-31 | 2013-01-31 | |
PCT/US2014/013652 WO2014120808A1 (en) | 2013-01-31 | 2014-01-29 | Pyridone amides as modulators of sodium channels |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20191495A1 true PE20191495A1 (es) | 2019-10-21 |
Family
ID=50073531
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2015001572A PE20151781A1 (es) | 2013-01-31 | 2014-01-29 | Piridonamidas como moduladores de canales de sodio |
PE2019001687A PE20191495A1 (es) | 2013-01-31 | 2014-01-29 | Piridonamidas como moduladores de canales de sodio |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2015001572A PE20151781A1 (es) | 2013-01-31 | 2014-01-29 | Piridonamidas como moduladores de canales de sodio |
Country Status (34)
Country | Link |
---|---|
US (6) | US9051270B2 (es) |
EP (3) | EP2953931B1 (es) |
JP (4) | JP6389194B2 (es) |
KR (2) | KR102295748B1 (es) |
CN (2) | CN105026373B (es) |
AP (1) | AP2015008633A0 (es) |
AR (1) | AR094667A1 (es) |
AU (3) | AU2014212509B2 (es) |
BR (1) | BR112015018289A2 (es) |
CA (1) | CA2898866C (es) |
CL (1) | CL2015002147A1 (es) |
CY (1) | CY1119163T1 (es) |
DK (2) | DK3239134T3 (es) |
ES (2) | ES2857687T3 (es) |
GE (2) | GEP20207177B (es) |
HK (2) | HK1217693A1 (es) |
HR (2) | HRP20170787T1 (es) |
HU (2) | HUE053448T2 (es) |
IL (1) | IL240195B (es) |
LT (2) | LT2953931T (es) |
MX (2) | MX2021003687A (es) |
NZ (2) | NZ710270A (es) |
PE (2) | PE20151781A1 (es) |
PH (1) | PH12015501661A1 (es) |
PL (2) | PL3239134T3 (es) |
PT (2) | PT2953931T (es) |
RS (2) | RS56015B1 (es) |
RU (1) | RU2662223C2 (es) |
SG (2) | SG10201706206PA (es) |
SI (2) | SI3239134T1 (es) |
TW (2) | TWI714967B (es) |
UA (1) | UA120589C2 (es) |
UY (1) | UY35288A (es) |
WO (1) | WO2014120808A1 (es) |
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