PE20181331A1 - NUEVOS DERIVADOS DE IMIDAZO [4,5-b] PIRIDINA UN PROCESO PARA SU PREPRACION Y COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN - Google Patents
NUEVOS DERIVADOS DE IMIDAZO [4,5-b] PIRIDINA UN PROCESO PARA SU PREPRACION Y COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENENInfo
- Publication number
- PE20181331A1 PE20181331A1 PE2018000443A PE2018000443A PE20181331A1 PE 20181331 A1 PE20181331 A1 PE 20181331A1 PE 2018000443 A PE2018000443 A PE 2018000443A PE 2018000443 A PE2018000443 A PE 2018000443A PE 20181331 A1 PE20181331 A1 PE 20181331A1
- Authority
- PE
- Peru
- Prior art keywords
- imidazo
- pyridine
- pharmaceutical compositions
- prepration
- hydrogen
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Abstract
Se refiere a compuestos de formula (I), sus enantiomeros, diasteroisomeros y sus sales de adicion de los mismos farmaceuticamente aceptable; en la que R1 es un grupo ciano, un atomo de halogeno, un grupo alquilo(C1-C6), entre otros; R2 es hidrogeno, grupo alquilo(C1-C6) lineal o ramificado, entre otros; R3 es un atomo de hidrogeno, halogeno, entre otros; R4 y R5 cada uno independientemente de los otros, representan un atomo de hidrogeno o halogeno; estos compuestos son derivados de imidazo [4,5-b] piridina y son inhibidores de DYRK1/CLK1. Es compuesto preferido: 4-[2-metil-3-(3-fenilciclobutil)-3H-imidazo[4,5-b]piridin-5-il]piridina-2,6-diamina, entre otros. Tambien se refiere a procesos para su preparacion, composiciones farmaceuticas y usos de estas, en el tratamiento del cancer, trastornos neurodegenerativos o trastornos metabolicos.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR1559252A FR3041639B1 (fr) | 2015-09-30 | 2015-09-30 | NOUVEAUX DERIVES D'IMIDAZO[4,5-b]PYRIDINE, PROCEDE POUR LES PREPARER ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20181331A1 true PE20181331A1 (es) | 2018-08-20 |
Family
ID=54979755
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2018000443A PE20181331A1 (es) | 2015-09-30 | 2016-09-30 | NUEVOS DERIVADOS DE IMIDAZO [4,5-b] PIRIDINA UN PROCESO PARA SU PREPRACION Y COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN |
Country Status (26)
Country | Link |
---|---|
US (1) | US20180273528A1 (es) |
EP (1) | EP3356363A1 (es) |
JP (1) | JP2018535931A (es) |
KR (1) | KR20180054858A (es) |
CN (1) | CN108137581A (es) |
AU (1) | AU2016333505A1 (es) |
BR (1) | BR112018006157A2 (es) |
CA (1) | CA2999935A1 (es) |
CL (1) | CL2018000783A1 (es) |
CO (1) | CO2018003473A2 (es) |
CR (1) | CR20180181A (es) |
CU (1) | CU20180028A7 (es) |
DO (1) | DOP2018000083A (es) |
EA (1) | EA201890821A1 (es) |
EC (1) | ECSP18023253A (es) |
FR (1) | FR3041639B1 (es) |
HK (1) | HK1255804A1 (es) |
IL (1) | IL258341A (es) |
MA (1) | MA43020A (es) |
MX (1) | MX2018003860A (es) |
NI (1) | NI201800043A (es) |
PE (1) | PE20181331A1 (es) |
PH (1) | PH12018500650A1 (es) |
SV (1) | SV2018005657A (es) |
TN (1) | TN2018000090A1 (es) |
WO (1) | WO2017055530A1 (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108822103A (zh) * | 2018-07-28 | 2018-11-16 | 刘凤娟 | 一种咪唑并[4,5-b]吡啶化合物及其制备方法和应用 |
CN113164476A (zh) * | 2018-09-28 | 2021-07-23 | 代表亚利桑那大学的亚利桑那校董会 | Dyrk1/clk的小分子抑制剂及其用途 |
WO2020092528A1 (en) | 2018-10-31 | 2020-05-07 | Gilead Sciences, Inc. | Substituted 6-azabenzimidazole compounds having hpk1 inhibitory activity |
US11203591B2 (en) | 2018-10-31 | 2021-12-21 | Gilead Sciences, Inc. | Substituted 6-azabenzimidazole compounds |
EP3972695A1 (en) | 2019-05-23 | 2022-03-30 | Gilead Sciences, Inc. | Substituted exo-methylene-oxindoles which are hpk1/map4k1 inhibitors |
CA3153531A1 (en) * | 2019-09-11 | 2021-03-18 | Prelude Therapeutics Incorporated | Cdk inhibitors and their use as pharmaceuticals |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2016516710A (ja) * | 2013-03-13 | 2016-06-09 | アッヴィ・インコーポレイテッド | ピリジン系cdk9キナーゼ阻害薬 |
-
2015
- 2015-09-30 FR FR1559252A patent/FR3041639B1/fr not_active Expired - Fee Related
-
2016
- 2016-09-30 KR KR1020187012175A patent/KR20180054858A/ko unknown
- 2016-09-30 PE PE2018000443A patent/PE20181331A1/es unknown
- 2016-09-30 WO PCT/EP2016/073395 patent/WO2017055530A1/en active Application Filing
- 2016-09-30 US US15/763,248 patent/US20180273528A1/en not_active Abandoned
- 2016-09-30 EA EA201890821A patent/EA201890821A1/ru unknown
- 2016-09-30 MA MA043020A patent/MA43020A/fr unknown
- 2016-09-30 BR BR112018006157A patent/BR112018006157A2/pt not_active Application Discontinuation
- 2016-09-30 EP EP16774682.5A patent/EP3356363A1/en not_active Withdrawn
- 2016-09-30 CN CN201680058054.0A patent/CN108137581A/zh not_active Withdrawn
- 2016-09-30 CU CUP2018000028A patent/CU20180028A7/es unknown
- 2016-09-30 AU AU2016333505A patent/AU2016333505A1/en not_active Abandoned
- 2016-09-30 JP JP2018516194A patent/JP2018535931A/ja active Pending
- 2016-09-30 MX MX2018003860A patent/MX2018003860A/es unknown
- 2016-09-30 TN TNP/2018/000090A patent/TN2018000090A1/en unknown
- 2016-09-30 CR CR20180181A patent/CR20180181A/es unknown
- 2016-09-30 CA CA2999935A patent/CA2999935A1/en not_active Abandoned
-
2018
- 2018-03-22 SV SV2018005657A patent/SV2018005657A/es unknown
- 2018-03-23 NI NI201800043A patent/NI201800043A/es unknown
- 2018-03-23 PH PH12018500650A patent/PH12018500650A1/en unknown
- 2018-03-25 IL IL258341A patent/IL258341A/en unknown
- 2018-03-26 EC ECIEPI201823253A patent/ECSP18023253A/es unknown
- 2018-03-26 CL CL2018000783A patent/CL2018000783A1/es unknown
- 2018-03-27 DO DO2018000083A patent/DOP2018000083A/es unknown
- 2018-03-28 CO CONC2018/0003473A patent/CO2018003473A2/es unknown
- 2018-11-15 HK HK18114643.2A patent/HK1255804A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
DOP2018000083A (es) | 2018-10-15 |
CR20180181A (es) | 2018-06-22 |
MX2018003860A (es) | 2018-08-16 |
US20180273528A1 (en) | 2018-09-27 |
CL2018000783A1 (es) | 2018-09-21 |
CN108137581A (zh) | 2018-06-08 |
AU2016333505A1 (en) | 2018-04-19 |
TN2018000090A1 (en) | 2019-07-08 |
ECSP18023253A (es) | 2018-04-30 |
JP2018535931A (ja) | 2018-12-06 |
CA2999935A1 (en) | 2017-04-06 |
SV2018005657A (es) | 2018-07-31 |
CU20180028A7 (es) | 2018-07-05 |
EA201890821A1 (ru) | 2018-10-31 |
KR20180054858A (ko) | 2018-05-24 |
NI201800043A (es) | 2018-06-21 |
PH12018500650A1 (en) | 2018-10-01 |
EP3356363A1 (en) | 2018-08-08 |
BR112018006157A2 (pt) | 2018-10-09 |
FR3041639A1 (es) | 2017-03-31 |
IL258341A (en) | 2018-05-31 |
CO2018003473A2 (es) | 2018-07-10 |
WO2017055530A1 (en) | 2017-04-06 |
FR3041639B1 (fr) | 2019-01-25 |
MA43020A (fr) | 2018-08-08 |
HK1255804A1 (zh) | 2019-08-23 |
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