EA201890821A1 - НОВЫЕ ПРОИЗВОДНЫЕ ИМИДАЗО[4,5-b]ПИРИДИНА В КАЧЕСТВЕ ДВОЙСТВЕННЫХ ИНГИБИТОРОВ DYRK1/CLK1 - Google Patents

НОВЫЕ ПРОИЗВОДНЫЕ ИМИДАЗО[4,5-b]ПИРИДИНА В КАЧЕСТВЕ ДВОЙСТВЕННЫХ ИНГИБИТОРОВ DYRK1/CLK1

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Publication number
EA201890821A1
EA201890821A1 EA201890821A EA201890821A EA201890821A1 EA 201890821 A1 EA201890821 A1 EA 201890821A1 EA 201890821 A EA201890821 A EA 201890821A EA 201890821 A EA201890821 A EA 201890821A EA 201890821 A1 EA201890821 A1 EA 201890821A1
Authority
EA
Eurasian Patent Office
Prior art keywords
dyrk1
clk1
pyridine
dual inhibitors
new imidazo
Prior art date
Application number
EA201890821A
Other languages
English (en)
Inventor
Балаж Балинт
Андраш Кочи
Мелинда Шипош
Чаба Вебер
Николя Фолопп
Дэвид Уолмсли
Микаэль Франк Бёрбридж
Франсиско Умберто Крузалеги
Original Assignee
Ле Лаборатуар Сервье
Верналис (Р&Д) Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ле Лаборатуар Сервье, Верналис (Р&Д) Лимитед filed Critical Ле Лаборатуар Сервье
Publication of EA201890821A1 publication Critical patent/EA201890821A1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

Соединения формулы (I)где R, R, R, Rи Rимеют значения, как указано в описании. Лекарственные средства.
EA201890821A 2015-09-30 2016-09-30 НОВЫЕ ПРОИЗВОДНЫЕ ИМИДАЗО[4,5-b]ПИРИДИНА В КАЧЕСТВЕ ДВОЙСТВЕННЫХ ИНГИБИТОРОВ DYRK1/CLK1 EA201890821A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1559252A FR3041639B1 (fr) 2015-09-30 2015-09-30 NOUVEAUX DERIVES D'IMIDAZO[4,5-b]PYRIDINE, PROCEDE POUR LES PREPARER ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT
PCT/EP2016/073395 WO2017055530A1 (en) 2015-09-30 2016-09-30 New imidazo[4,5-b]pyridine derivatives as dual dyrk1/clk1 inhibitors

Publications (1)

Publication Number Publication Date
EA201890821A1 true EA201890821A1 (ru) 2018-10-31

Family

ID=54979755

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201890821A EA201890821A1 (ru) 2015-09-30 2016-09-30 НОВЫЕ ПРОИЗВОДНЫЕ ИМИДАЗО[4,5-b]ПИРИДИНА В КАЧЕСТВЕ ДВОЙСТВЕННЫХ ИНГИБИТОРОВ DYRK1/CLK1

Country Status (26)

Country Link
US (1) US20180273528A1 (ru)
EP (1) EP3356363A1 (ru)
JP (1) JP2018535931A (ru)
KR (1) KR20180054858A (ru)
CN (1) CN108137581A (ru)
AU (1) AU2016333505A1 (ru)
BR (1) BR112018006157A2 (ru)
CA (1) CA2999935A1 (ru)
CL (1) CL2018000783A1 (ru)
CO (1) CO2018003473A2 (ru)
CR (1) CR20180181A (ru)
CU (1) CU20180028A7 (ru)
DO (1) DOP2018000083A (ru)
EA (1) EA201890821A1 (ru)
EC (1) ECSP18023253A (ru)
FR (1) FR3041639B1 (ru)
HK (1) HK1255804A1 (ru)
IL (1) IL258341A (ru)
MA (1) MA43020A (ru)
MX (1) MX2018003860A (ru)
NI (1) NI201800043A (ru)
PE (1) PE20181331A1 (ru)
PH (1) PH12018500650A1 (ru)
SV (1) SV2018005657A (ru)
TN (1) TN2018000090A1 (ru)
WO (1) WO2017055530A1 (ru)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108822103A (zh) * 2018-07-28 2018-11-16 刘凤娟 一种咪唑并[4,5-b]吡啶化合物及其制备方法和应用
CN113164476A (zh) * 2018-09-28 2021-07-23 代表亚利桑那大学的亚利桑那校董会 Dyrk1/clk的小分子抑制剂及其用途
WO2020092528A1 (en) 2018-10-31 2020-05-07 Gilead Sciences, Inc. Substituted 6-azabenzimidazole compounds having hpk1 inhibitory activity
US11203591B2 (en) 2018-10-31 2021-12-21 Gilead Sciences, Inc. Substituted 6-azabenzimidazole compounds
EP3972695A1 (en) 2019-05-23 2022-03-30 Gilead Sciences, Inc. Substituted exo-methylene-oxindoles which are hpk1/map4k1 inhibitors
CA3153531A1 (en) * 2019-09-11 2021-03-18 Prelude Therapeutics Incorporated Cdk inhibitors and their use as pharmaceuticals

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016516710A (ja) * 2013-03-13 2016-06-09 アッヴィ・インコーポレイテッド ピリジン系ｃｄｋ９キナーゼ阻害薬

Also Published As

Publication number Publication date
DOP2018000083A (es) 2018-10-15
CR20180181A (es) 2018-06-22
MX2018003860A (es) 2018-08-16
US20180273528A1 (en) 2018-09-27
CL2018000783A1 (es) 2018-09-21
CN108137581A (zh) 2018-06-08
AU2016333505A1 (en) 2018-04-19
TN2018000090A1 (en) 2019-07-08
ECSP18023253A (es) 2018-04-30
JP2018535931A (ja) 2018-12-06
CA2999935A1 (en) 2017-04-06
PE20181331A1 (es) 2018-08-20
SV2018005657A (es) 2018-07-31
CU20180028A7 (es) 2018-07-05
KR20180054858A (ko) 2018-05-24
NI201800043A (es) 2018-06-21
PH12018500650A1 (en) 2018-10-01
EP3356363A1 (en) 2018-08-08
BR112018006157A2 (pt) 2018-10-09
FR3041639A1 (ru) 2017-03-31
IL258341A (en) 2018-05-31
CO2018003473A2 (es) 2018-07-10
WO2017055530A1 (en) 2017-04-06
FR3041639B1 (fr) 2019-01-25
MA43020A (fr) 2018-08-08
HK1255804A1 (zh) 2019-08-23

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