PE20181048A1 - Amino triazoles sustituidos utiles como inhibidores de la quintinasa humana - Google Patents

Amino triazoles sustituidos utiles como inhibidores de la quintinasa humana

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Publication number
PE20181048A1
PE20181048A1 PE2018000314A PE2018000314A PE20181048A1 PE 20181048 A1 PE20181048 A1 PE 20181048A1 PE 2018000314 A PE2018000314 A PE 2018000314A PE 2018000314 A PE2018000314 A PE 2018000314A PE 20181048 A1 PE20181048 A1 PE 20181048A1
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PE
Peru
Prior art keywords
alkyl
diseases
halo
inhibitors
alkoxy
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PE2018000314A
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English (en)
Inventor
Marzena Mazur
Robert Koralewski
Bartlomiej Borek
Sylwia Olejniczak
Wojciech J Czestkowski
Michal C Piotrowicz
Jacek P Olczak
Adam A Golebiowski
Agnieszka Bartoszewicz
Elzbieta Pluta
Michal L Kowalski
Original Assignee
Oncoarendi Therapeutics Sa
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Application filed by Oncoarendi Therapeutics Sa filed Critical Oncoarendi Therapeutics Sa
Publication of PE20181048A1 publication Critical patent/PE20181048A1/es

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Abstract

Referido a un compuesto de Formula I, en donde W es halo, alquilo (C1-C3), alcoxi (C1-C3) o alquiltio (C1-C3); X es un enlace simple, -CH2- -Ch2-Ch2-, entre otros; Y es un enlace simple, -CH-, -CH2-CH-, -N-, entre otros; R1 es H, OH, alquilo(C1-C6), haloalquilo(C1-C6), entre otros; Z es -CH-, -C(O)-, -C(alquilo(C1-C3))- o -C(=CH2)-; R2 es H, OH halo, alquilo(C1-C6), alcoxi(C1-C6), entre otros; R3 es H, alquilo(C1-C3), alcoxi(C1-C3)alquilo(C1-C3), entre otros; R4 es H, alquilo(C1-C3), alquiltio(C1-C3) alquilo(C1-C3), entre otros; R5 es H, halo, -NO2, -CN, alquilo(C1-C6), entre otros; R6 H, halo, -OH, -NH2, o -SH. Este compuesto amino triazol sustituido con un anillo de piperidinilo que en si mismo esta sustituido con un anillo heterociclico, son inhibidores de la quitinasa de mamifero acida y quitotriosidasa. Tambien se describen metodos para usar estos compuestos para el tratamiento de enfermedades alergicas, asi como enfermedades inflamatorias agudas y cronicas, enfermedades autoinmunes, enfermedades dentales, enfermedades neurologicas, enfermedades metabolicas, enfermedades hepaticas, sindrome de ovario poliquistico, endometriosis y cancer.
PE2018000314A 2015-09-04 2016-09-02 Amino triazoles sustituidos utiles como inhibidores de la quintinasa humana PE20181048A1 (es)

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US201562214299P 2015-09-04 2015-09-04
PL415078A PL415078A1 (pl) 2015-09-04 2015-12-04 Podstawione aminotriazole przydatne jako inhibitory kwaśnej chitynazy ssaków

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PE20181048A1 true PE20181048A1 (es) 2018-07-03

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