PE20161439A1 - Anticuerpos antagonistas dirigidos contra el peptido relacionado con el gen de calcitonina y metodos que usan los mismos - Google Patents

Anticuerpos antagonistas dirigidos contra el peptido relacionado con el gen de calcitonina y metodos que usan los mismos

Info

Publication number
PE20161439A1
PE20161439A1 PE2016001652A PE2016001652A PE20161439A1 PE 20161439 A1 PE20161439 A1 PE 20161439A1 PE 2016001652 A PE2016001652 A PE 2016001652A PE 2016001652 A PE2016001652 A PE 2016001652A PE 20161439 A1 PE20161439 A1 PE 20161439A1
Authority
PE
Peru
Prior art keywords
seq
methods
same
directed against
calcitonin gene
Prior art date
Application number
PE2016001652A
Other languages
English (en)
Inventor
Marcelo Bigal
Sarah Walter
Henry Stern
Michael Chang
Original Assignee
Teva Pharmaceuticals Int Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54141465&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20161439(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Teva Pharmaceuticals Int Gmbh filed Critical Teva Pharmaceuticals Int Gmbh
Publication of PE20161439A1 publication Critical patent/PE20161439A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • A61P5/22—Drugs for disorders of the endocrine system of the parathyroid hormones for decreasing, blocking or antagonising the activity of calcitonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Abstract

Se refiere a un anticuerpo monoclonal que comprende: a) tres regiones de cadena variable pesada CDRH1, CDRH2 y CDRH3 con una secuencia de aminoacidos SEQ ID NO: 3, SEQ ID NO:4 y SEQ ID NO:5, respectivamente; y b) tres regiones de cadena variable ligera CDRL1, CDRL2 y CDRL3 con una secuencia de aminoacidos SEQ ID NO: 6; SEQ ID NO: 7 y SEQ ID NO:8. Tambien se refiere a un metodo de tratamiento y a una composicion farmaceutica. Dicho anticuerpo es un antagonista anti-CGRP, siendo util en la prevencion o tratamiento de sintomas vasomotores y/o dolores de cabeza tal como migrana, dolor de cabeza en racimos, entre otros
PE2016001652A 2014-03-21 2015-03-20 Anticuerpos antagonistas dirigidos contra el peptido relacionado con el gen de calcitonina y metodos que usan los mismos PE20161439A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461968897P 2014-03-21 2014-03-21
US201462083809P 2014-11-24 2014-11-24
US201562119778P 2015-02-23 2015-02-23

Publications (1)

Publication Number Publication Date
PE20161439A1 true PE20161439A1 (es) 2017-01-26

Family

ID=54141465

Family Applications (2)

Application Number Title Priority Date Filing Date
PE2021001837A PE20220337A1 (es) 2014-03-21 2015-03-20 Anticuerpos antagonistas dirigidos contra el peptido relacionado con el gen de calcitonina y metodos que usan los mismos
PE2016001652A PE20161439A1 (es) 2014-03-21 2015-03-20 Anticuerpos antagonistas dirigidos contra el peptido relacionado con el gen de calcitonina y metodos que usan los mismos

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PE2021001837A PE20220337A1 (es) 2014-03-21 2015-03-20 Anticuerpos antagonistas dirigidos contra el peptido relacionado con el gen de calcitonina y metodos que usan los mismos

Country Status (24)

Country Link
US (3) US9896502B2 (es)
EP (2) EP3119431B1 (es)
JP (5) JP6568099B2 (es)
KR (3) KR102274964B1 (es)
CN (3) CN113244387A (es)
AU (1) AU2015230933B2 (es)
BR (1) BR112016021423A2 (es)
CA (1) CA2943551A1 (es)
CL (1) CL2016002375A1 (es)
DK (1) DK3119431T3 (es)
EA (1) EA201691787A1 (es)
FI (1) FI3119431T3 (es)
HK (1) HK1232129A1 (es)
HR (1) HRP20240159T1 (es)
IL (2) IL247853B (es)
LT (1) LT3119431T (es)
MX (2) MX2016012188A (es)
NZ (1) NZ761478A (es)
PE (2) PE20220337A1 (es)
PT (1) PT3119431T (es)
RS (1) RS65360B1 (es)
UA (1) UA123759C2 (es)
WO (1) WO2015143409A1 (es)
ZA (1) ZA201606745B (es)

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ES2433251T5 (es) 2005-11-14 2020-03-13 Teva Pharmaceuticals Int Gmbh Anticuerpos antagonistas dirigidos contra un péptido relacionado con el gen de la calcitonina y procedimientos que utilizan los mismos
NZ587292A (en) 2008-03-04 2012-09-28 Pfizer Ltd Use of anti-CGRP (calcitonin gene-related peptide) antagonists to treat chronic pain
US10556945B2 (en) 2014-03-21 2020-02-11 Teva Pharmaceuticals International Gmbh Antagonist antibodies directed against calcitonin gene-related peptide and methods using same
UA123759C2 (uk) 2014-03-21 2021-06-02 Тева Фармасьютікалз Інтернешнл Гмбх Застосування моноклонального антитіла, яке інгібує шлях пов'язаного з геном кальциноніну пептиду (cgrp), для лікування або зниження частоти випадків мігренозного головного болю у суб'єкта
JOP20200116A1 (ar) * 2015-04-24 2017-06-16 Amgen Inc طرق لعلاج أو الوقاية من الصداع النصفي
AR104847A1 (es) * 2015-06-17 2017-08-16 Lilly Co Eli Formulación de anticuerpo anti-cgrp
TW201725212A (zh) * 2015-12-10 2017-07-16 第一三共股份有限公司 特異性於降鈣素基因相關胜肽的新穎蛋白
US10392434B2 (en) * 2016-09-23 2019-08-27 Teva Pharmaceuticals International Gmbh Treating refractory migraine
US20190071490A1 (en) * 2017-03-02 2019-03-07 Beth Israel Deaconess Medical Center, Inc. Preventing Post-Ictal Headaches
EA202092335A1 (ru) 2018-04-02 2021-01-22 Эмджен Инк. Композиции на основе эренумаба и пути их применения
US10899826B1 (en) 2018-09-13 2021-01-26 Teva Pharmaceuticals International Gmbh Pharmaceutical compositions for an anti-CGRP antagonist antibody
AU2020206241A1 (en) 2019-01-08 2021-08-26 H. Lundbeck A/S Acute treatment and rapid treatment of headache using anti-CGRP antibodies
US20220110887A1 (en) * 2019-02-08 2022-04-14 Schedule 1 Therapeutics, Inc. Compositions comprising cannabinoids and methods of use thereof
JOP20210247A1 (ar) * 2019-05-02 2023-01-30 H Lundbeck As علاج الصداع باستخدام أجسام مضادة لـ cgrp
WO2020239014A1 (zh) * 2019-05-30 2020-12-03 山东博安生物技术有限公司 抗cgrp抗体及其应用
BR102020007149A8 (pt) * 2020-04-06 2023-09-26 H Lundbeck As Usos de um anticorpo anti-cgrp ou anti-cgrp-r ou um fragmento dos mesmos para melhorar o sintoma mais incômodo (mbs) e a impressão global de mudança (pgic) associados com enxaqueca

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