PE20142400A1 - Compuestos novedosos - Google Patents

Compuestos novedosos

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Publication number
PE20142400A1
PE20142400A1 PE2014001780A PE2014001780A PE20142400A1 PE 20142400 A1 PE20142400 A1 PE 20142400A1 PE 2014001780 A PE2014001780 A PE 2014001780A PE 2014001780 A PE2014001780 A PE 2014001780A PE 20142400 A1 PE20142400 A1 PE 20142400A1
Authority
PE
Peru
Prior art keywords
alkyl
chr10
methylpropyl
dimethylphenyl
sulfonamide
Prior art date
Application number
PE2014001780A
Other languages
English (en)
Inventor
Veronique Birault
Amanda Jennifer Campbell
Stephen Anthony Harrison
Joelle Le
Lena Shukla
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1207403.5A external-priority patent/GB201207403D0/en
Priority claimed from GB201304596A external-priority patent/GB201304596D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of PE20142400A1 publication Critical patent/PE20142400A1/es

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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/112—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C07D295/116—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings with the doubly bound oxygen or sulfur atoms directly attached to a carbocyclic ring
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    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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    • C07D491/04—Ortho-condensed systems
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
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    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA (IA), DONDE R1 SE SELECCIONA DE H, ALQUILO C1-C3, ENTRE OTROS; R2, R3 Y R4 SON H; R5 ES ALQUILO C1-C3; R6 ES ALQUILO C3-C5, -CH2-CICLOALQUILO C3-C4; R7 SE SELCCIONA DE LA FORMULA (II) Y (III); R8 ES HALO, ALQUILO C1-C6, ALCOXI C1-C6, CICLOALQUILO C3-C6, ENTRE OTROS; R9 ES EL GRUPO -(CHR10)S-(X)T-(CHR10)U-R11; R10 ES H, CH3, OH, ENTRE OTROS; X ES CH2, NH, O; R11 ES HETEROCICLOALQUILO; R ES 0-2; S ES 0-2; T ES 0-1; U ES 0-2. SON COMPUESTOS PREFERIDOS N-(2,4-DIMETILFENIL)-N-(2-METILPROPIL)-3-[(OXAN-4-ILMETOXI) METIL] BENCENO-1-SULFONAMIDA; N-(2,4-DIMETILFENIL)-N-(2-METILPROPIL)-4-[2-(MORFOLIN-4-IL) ETOXI] BENCENO-1-SULFONAMIDA; ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA QUE ES UTIL EN EL TRATAMIENTO DE ENFERMEDADES INFLAMATORIAS, METABOLICAS Y AUTOINMUNITARIAS MEDIADAS RECEPTOR HUERFANO RETINOIDEO GAMMA (RORY).
PE2014001780A 2012-04-27 2013-04-25 Compuestos novedosos PE20142400A1 (es)

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