PE20140238A1 - Metodos y composiciones para inmunoterapia para enfermedad neural - Google Patents

Metodos y composiciones para inmunoterapia para enfermedad neural

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Publication number
PE20140238A1
PE20140238A1 PE2013000968A PE2013000968A PE20140238A1 PE 20140238 A1 PE20140238 A1 PE 20140238A1 PE 2013000968 A PE2013000968 A PE 2013000968A PE 2013000968 A PE2013000968 A PE 2013000968A PE 20140238 A1 PE20140238 A1 PE 20140238A1
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Peru
Prior art keywords
hvr
seq
immunotherapy
compositions
methods
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PE2013000968A
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English (en)
Inventor
Jasvinder Atwal
Yongmei Chen
Cecilia Pui Chi Chiu
Robert A Lazarus
Weiru Wang
Ryan J Watts
Yan Wu
Yingnan Zhang
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Genentech Inc
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Publication of PE20140238A1 publication Critical patent/PE20140238A1/es

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    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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Abstract

SE REFIERE A UN ANTICUERPO O SU FRAGMENTO QUE SE UNE A BACE 1, QUE COMPRENDE UNA SECUENCIA SELECCIONADA DE LA REGION HIPERVARIABLE (HVR) DEL GRUPO QUE CONSISTE EN i) HVR-H1 TIENE LA SECUENCIA DE AMINOACIDOS GFX30FX31X32X33X34IH( SEC ID NO: 45) ENTRE OTROS; DONDE X30= N, T; X31= S, L, Y; X32= G, Y; X33=Y, S; Y X34= A, G, S; ii) HVR-H2 COMPRENDE LA SECUENCIA X35X36ISPX37X38GX39TX40YADSVKG (SEC ID NO: 46) ENTRE OTRAS, DONDE X35 ES A , G; X36 ES W, S; X37 ES A, Y; X38 ES G, S; X39 ES S, Y; Y X40 ES D, S;iii) HVR-H3 COMPRENDE LA SECUENCIA X41PX42X43X44X45X46X47MDY ( SEC ID NO: 47) ENTRE OTRAS, DONDE X41 ES Q, G; X42 ES T, F; X43 ES H, S; X44 ES Y, P; X45 ES Y, W; X46 ES Y, V Y DONDE X47 INCLUYE YAKGYKA( SEC ID NO: 48; iv) HVR-L1 COMPRENDE RASQX17VX18X19X20X21A( SEC ID NO: 42) ENTRE OTRAS, DONDE X17 ES S, D, V; X18 ES S, A;X19 ES S, T, N; X20 ES A, S; X21 ES V, L; v) HVR-L2 COMPRENDE X22ASX23LYS (SEC ID NO: 43) ENTRE OTRAS, DONDE X22 ES S, W, Y, L; X23 ES F, S, W; vi) HVR-L3 COMPRENDE QQX24X25X26X27X28X29T( SEC ID NO: 44) ENTRE OTRS, DONDE X24 ES S, F, D, Y; X25 ES Y, P, S, A; X26 ES Y, T, N; X27 ES T, Y, D, S; X28 ES P, L Y X29 ES F, P, T. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA Y ES UTIL PARA EL TRATAMIENTO DE ENFERMEDADES NEUROLOGICAS.
PE2013000968A 2010-11-10 2011-11-09 Metodos y composiciones para inmunoterapia para enfermedad neural PE20140238A1 (es)

Applications Claiming Priority (4)

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US45664210P 2010-11-10 2010-11-10
US41831010P 2010-11-30 2010-11-30
US41885010P 2010-12-01 2010-12-01
US201061426425P 2010-12-22 2010-12-22

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PE20140238A1 true PE20140238A1 (es) 2014-03-07

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US (3) US8772457B2 (es)
EP (2) EP2638070B1 (es)
JP (2) JP6163429B2 (es)
KR (1) KR20130133205A (es)
CN (1) CN103228674B (es)
AR (1) AR083819A1 (es)
AU (1) AU2011326564A1 (es)
CA (1) CA2815840A1 (es)
CL (1) CL2013001290A1 (es)
CO (1) CO6690815A2 (es)
EA (1) EA201390669A1 (es)
EC (1) ECSP13012673A (es)
ES (1) ES2607086T3 (es)
IL (1) IL226106A0 (es)
MA (1) MA34722B1 (es)
MX (1) MX346500B (es)
PE (1) PE20140238A1 (es)
SG (1) SG190682A1 (es)
TW (1) TW201300417A (es)
WO (1) WO2012064836A1 (es)
ZA (1) ZA201302980B (es)

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US8772457B2 (en) 2014-07-08
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