AR105026A1 - ANTICUERPOS MADURADOS POR AFINIDAD Y HUMANIZADOS PARA FcRH5 Y MÉTODOS PARA SU USO - Google Patents

ANTICUERPOS MADURADOS POR AFINIDAD Y HUMANIZADOS PARA FcRH5 Y MÉTODOS PARA SU USO

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Publication number
AR105026A1
AR105026A1 ARP160101805A ARP160101805A AR105026A1 AR 105026 A1 AR105026 A1 AR 105026A1 AR P160101805 A ARP160101805 A AR P160101805A AR P160101805 A ARP160101805 A AR P160101805A AR 105026 A1 AR105026 A1 AR 105026A1
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AR
Argentina
Prior art keywords
hvr
seq
amino acid
acid sequence
fcrh5
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ARP160101805A
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English (en)
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Genentech Inc
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Publication of AR105026A1 publication Critical patent/AR105026A1/es

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    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
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    • C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
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Abstract

Reivindicación 1: Un anticuerpo similar al receptor anti-Fc 5 (FcRH5), en donde el anticuerpo anti-FcRH5 comprende un dominio de unión que comprende las seis regiones hipervariables (HVR) que siguen: (a) una HVR-H1 que comprende la secuencia de aminoácidos de la SEQ ID Nº 1; (b) una HVR-H2 que comprende la secuencia de aminoácidos de la SEQ ID Nº 2; (c) una HVR-H3 que comprende la secuencia de aminoácidos de la SEQ ID Nº 3; (d) una HVR-L1 que comprende la secuencia de aminoácidos de la SEQ ID Nº 4; (e) una HVR-L2 que comprende la secuencia de aminoácidos de la SEQ ID Nº 5; y (f) una HVR-L3 que comprende la secuencia de aminoácidos de la SEQ ID Nº 6. Reivindicación 9: El anticuerpo anti-FcRH5 de la reivindicación 1 en donde el anticuerpo anti-FcRH5 comprende un dominio de unión que comprende las seis HVR que siguen: (a) una HVR-H1 que comprende la secuencia de aminoácidos de la SEQ ID Nº 1; (b) una HVR-H2 que comprende la secuencia de aminoácidos de la SEQ ID Nº 8; (c) una HVR-H3 que comprende la secuencia de aminoácidos de la SEQ ID Nº 10; (d) una HVR-L1 que comprende la secuencia de aminoácidos de la SEQ ID Nº 14; (e) una HVR-L2 que comprende la secuencia de aminoácidos de la SEQ ID Nº 16; y (f) una HVR-L3 que comprende la secuencia de aminoácidos de la SEQ ID Nº 23. Reivindicación 266: Un ácido nucleico aislado que codifica el anticuerpo anti-FcRH5 de cualquiera de las reivindicaciones 1 - 265 o una parte de este que comprende un dominio de unión de este que se une a FcRH5. Reivindicación 273: Un método para producir el anticuerpo anti-FcRH5 de cualquiera de las reivindicaciones 1 - 265, en el que el método comprende cultivar la célula hospedadora de la reivindicación en un medio de cultivo. Reivindicación 295: Un método para tratar o retrasar el avance de un cáncer positivo para FcRH5 en un sujeto que lo necesita, en el que el método comprende administrarle al sujeto el anticuerpo anti-FcRH5 de cualquiera de las reivindicaciones 1 - 265. Reivindicación 334: Un kit que comprende el anticuerpo de cualquiera de las reivindicaciones 1 - 265 y un prospecto que comprende instrucciones para el uso del anticuerpo para mejorar la función inmunitaria en un sujeto que tiene un cáncer positivo a FcRH5.
ARP160101805A 2015-06-16 2016-06-16 ANTICUERPOS MADURADOS POR AFINIDAD Y HUMANIZADOS PARA FcRH5 Y MÉTODOS PARA SU USO AR105026A1 (es)

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ARP200102899A AR120262A2 (es) 2015-06-16 2020-10-20 Anticuerpos madurados por afinidad y humanizados para fcrh5 y métodos para su uso

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US (3) US10323094B2 (es)
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JP (4) JP6871874B2 (es)
KR (1) KR20180023952A (es)
CN (2) CN107849132B (es)
AR (2) AR105026A1 (es)
AU (2) AU2016280102B2 (es)
CA (1) CA2986928A1 (es)
CL (2) CL2017003195A1 (es)
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DK (1) DK3310814T3 (es)
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