PE20131117A1 - Derivados de bencimidazol como inhibidores de prostaglandinas - Google Patents

Derivados de bencimidazol como inhibidores de prostaglandinas

Info

Publication number
PE20131117A1
PE20131117A1 PE2013000266A PE2013000266A PE20131117A1 PE 20131117 A1 PE20131117 A1 PE 20131117A1 PE 2013000266 A PE2013000266 A PE 2013000266A PE 2013000266 A PE2013000266 A PE 2013000266A PE 20131117 A1 PE20131117 A1 PE 20131117A1
Authority
PE
Peru
Prior art keywords
alkyl
methyl
phenylamine
cyclohex
trifluoromethyl
Prior art date
Application number
PE2013000266A
Other languages
English (en)
Inventor
Hennig Prieke
Henri Doods
Raimund Kuelzer
Roland Pfau
Dirk Stenkamp
Benjamin Pelcman
Robert Roenn
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43332838&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20131117(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of PE20131117A1 publication Critical patent/PE20131117A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P37/00—Drugs for immunological or allergic disorders
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    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/29—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
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    • C07C211/52—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
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    • C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/35—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/36—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
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    • C07C233/62—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
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    • C07C271/20—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C331/00—Derivatives of thiocyanic acid or of isothiocyanic acid
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    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
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  • Pain & Pain Management (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Abstract

REFERIDA A UN DERIVADO DE BENCIMIDAZOL DE FORMULA (I), DONDE R1 Y R2 SON HALO, ALQUILO C1-C3 OPCIONALMENTE SUSTITUIDO CON FLUOR; W ES C(O), C(O)O; M ES ALQUILO C1-C6, CICLOALQUILO C3-C7, ENTRE OTROS; R8 ES H, HALOGENO, ALQUILO C1-C3, ENTRE OTROS; R6 ES H, ALQUILO C1-C5, CICLOALQUILO C3-C5-ALQUILO C0-C2, ENTRE OTROS; R7 ES HALO, O-ALQUILO C1-C5, ENTRE OTROS; A ES ALQUILO C1-C8, FENILO, INDANILO, NAFTILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: AMIDA DEL ACIDO N(TRANS-4-TRIFLUOROMETIL-CICLOHEX-1-IL)-2-{2,6-DICLORO-3-[(2,2-DIMETIL-PROPIONILAMINO)-METIL]-FENILAMINO}-6-(2,2-DIFLUORO-ETOXI)-1-METIL-1H-BENCIMIDAZOL-5-CARBOXILICO, AMIDA DEL ACIDO N-(TRANS-4-TRIFLUOROMETIL-CICLOHEX-1-IL)-2-{2,2-DIMETIL-PROPIONILAMINO)-METIL]-FENILAMINO}-6-(2,2-DIFLUOROETOXI)-1H-BENCIMIDAZOL-5-CARBOXILICO, AMIDA DEL ACIDO N-(TRANS-4-TRIFLUOROMETIL-CICLOHEX-1-IL)-2-{2,6-DICLORO-3-[2,2-DIMETIL-PROPIONILAMINO)-METIL]-FENILAMINO}-6-FLUORO-1-METIL-1H-BENCIMIDAZOL-5-CARBOXILICO, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA PROSTAGLANDINA E2 SINTASA-1 MICROSOMICA (mPGES-1) Y SON UTILES EN EL TRATAMIENTO DE ENFERMEDADES INFLAMATORIAS Y AFECCIONES ASOCIADAS TALES COMO EL DOLOR INFLAMATORIO
PE2013000266A 2010-08-20 2011-08-19 Derivados de bencimidazol como inhibidores de prostaglandinas PE20131117A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP10173501 2010-08-20

Publications (1)

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PE20131117A1 true PE20131117A1 (es) 2013-10-13

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ID=43332838

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PE2013000266A PE20131117A1 (es) 2010-08-20 2011-08-19 Derivados de bencimidazol como inhibidores de prostaglandinas

Country Status (33)

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US (1) US8759537B2 (es)
EP (1) EP2606036B1 (es)
JP (1) JP5650844B2 (es)
KR (1) KR101891494B1 (es)
CN (1) CN103097359B (es)
AP (1) AP2012006641A0 (es)
AR (1) AR082508A1 (es)
AU (1) AU2011290725C1 (es)
BR (1) BR112013003753A2 (es)
CA (1) CA2804575C (es)
CL (1) CL2013000304A1 (es)
CO (1) CO6680683A2 (es)
CY (1) CY1116034T1 (es)
DK (1) DK2606036T3 (es)
EA (1) EA021433B1 (es)
EC (1) ECSP13012499A (es)
ES (1) ES2528751T3 (es)
GE (1) GEP20146197B (es)
HR (1) HRP20150004T1 (es)
IL (1) IL223466A (es)
MA (1) MA35576B1 (es)
ME (1) ME01982B (es)
MX (1) MX356010B (es)
PE (1) PE20131117A1 (es)
PL (1) PL2606036T3 (es)
PT (1) PT2606036E (es)
RS (1) RS53836B1 (es)
SG (1) SG187110A1 (es)
SI (1) SI2606036T1 (es)
SM (1) SMT201500054B (es)
TW (1) TW201302716A (es)
UY (1) UY33564A (es)
WO (1) WO2012022793A1 (es)

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