PE20120898A1 - Inhibidores de dihidroorotato deshidrogenasa como compuestos virostaticos - Google Patents

Inhibidores de dihidroorotato deshidrogenasa como compuestos virostaticos

Info

Publication number
PE20120898A1
PE20120898A1 PE2011001900A PE2011001900A PE20120898A1 PE 20120898 A1 PE20120898 A1 PE 20120898A1 PE 2011001900 A PE2011001900 A PE 2011001900A PE 2011001900 A PE2011001900 A PE 2011001900A PE 20120898 A1 PE20120898 A1 PE 20120898A1
Authority
PE
Peru
Prior art keywords
alkanyl
alkinyl
alkenyl
aryl
compound
Prior art date
Application number
PE2011001900A
Other languages
English (en)
Inventor
Daniel Vitt
Manfred Groeppel
Roland Baumgartner
Johann Leban
Original Assignee
4Sc Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43030861&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20120898(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 4Sc Ag filed Critical 4Sc Ag
Publication of PE20120898A1 publication Critical patent/PE20120898A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA (I) DONDE: A ES UN ANILLO HIDROCARBONADO AROMATICO O NO AROMATICO C5-C6 DONDE OPCIONALMENTE UNO O MAS ATOMOS DE CARBONO SE REEMPLAZAN POR UN GRUPO X; L ES UNA UNION SIMPLE, NH; D ES O, S, SO2, NR4, CH2; Z1 Y Z2 SON CADA UNO O, S, NR5; R1 ES H, HALOGENO, HALOALCANILO, HALOALQUENILO, ENTRE OTROS; R2 ES H, NH2, OH, ENTRE OTROS; R3 ES H, ALCANILO, ALQUENILO, ALQUINILO, CICLOALQUILO, ENTRE OTROS; R4 ES H, ARILO, HETEROARILO, CICLOALQUILO, ENTRE OTROS; R5 ES H, HO, ALCANILOXI, ALQUENILOXI, O-ARILO, ALCANILO, ENTRE OTROS; R8 ES H, ALCANILLO, ALQUENILO O ALQUINILO; X ES S, O, N, NR4, SO2, SO; Y ES H, HALOGENO, HALOALCANILO, HALOALCANILOXI, ENTRE OTROS; E ES ARILO, HETEROARILO, ALQUENILO, ALQUINILO O UN SISTEMA DE ANILLOS FUSIONADOS BICICLICO O TRICICLICO; m, n, q Y r SON CADA 0-1; t ES 0-3.UN COMPUESTO PREFERIDO ES ACIDO 3-(2,3,5,6-TETRAFLUORO-3'-TRIFLUOROMETOXI-BIFENIL-4-ILCARBAMOIL)-TIOFEN-3-CARBOXILICO. REFERIDA ADEMAS A UNA COMPOSICION FARMACEUTICA. DICHO COMPUESTO ES UN INHIBIDOR DE DIHIDROORATO DESHIDROGENASA UTILIZADO PARA EL TRATAMIENTO Y PREVENCION DE ENFERMEDADES VIRALES
PE2011001900A 2009-05-04 2010-05-04 Inhibidores de dihidroorotato deshidrogenasa como compuestos virostaticos PE20120898A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17552209P 2009-05-04 2009-05-04
EP09159358 2009-05-04

Publications (1)

Publication Number Publication Date
PE20120898A1 true PE20120898A1 (es) 2012-08-24

Family

ID=43030861

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2011001900A PE20120898A1 (es) 2009-05-04 2010-05-04 Inhibidores de dihidroorotato deshidrogenasa como compuestos virostaticos

Country Status (16)

Country Link
US (1) US8354433B2 (es)
EP (1) EP2427186B1 (es)
CN (1) CN102458389A (es)
AR (1) AR076837A1 (es)
AU (1) AU2010244462B2 (es)
CA (1) CA2761130C (es)
CO (1) CO6450622A2 (es)
ES (1) ES2909738T3 (es)
MX (1) MX2011011733A (es)
NZ (1) NZ596014A (es)
PE (1) PE20120898A1 (es)
SG (1) SG175854A1 (es)
TW (1) TWI530286B (es)
UY (1) UY32605A (es)
WO (1) WO2010128050A2 (es)
ZA (1) ZA201108131B (es)

Families Citing this family (16)

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Publication number Priority date Publication date Assignee Title
UA108760C2 (uk) * 2010-07-01 2015-06-10 Кальцієві солі сполуки як протизапальні, імуномодулюючі та антипроліферативні засоби
WO2013009678A2 (en) * 2011-07-08 2013-01-17 Indiana University Research And Technology Corporation Compositions and methods for the treatment of norovirus infection
CA2944570A1 (en) * 2014-04-11 2015-10-15 Panoptes Pharma Gmbh Anti-inflammatory agents as virostatic compounds
NZ725574A (en) * 2014-05-08 2022-08-26 Panoptes Pharma Ges M B H Compounds for treating ophthalmic diseases and disorders
TW201834649A (zh) 2017-03-02 2018-10-01 新加坡商亞獅康私人有限公司 癌症療法
EP3965753A1 (en) * 2019-05-07 2022-03-16 Universität Hamburg Dhodh inhibitors and their use as antiviral agents
AU2021260040A1 (en) * 2020-04-21 2022-11-17 Immunic Ag Vidofludimus for use in the treatment or prevention of viral diseases
JP2023543969A (ja) * 2020-08-31 2023-10-19 アスラン ファーマスーティカルズ ピーティーイー エルティーディー ウイルス感染の治療及び／又は予防
WO2022196236A1 (ja) * 2021-03-18 2022-09-22 国立大学法人 鹿児島大学 抗薬剤耐性インフルエンザウイルス剤及び抗薬剤耐性インフルエンザウイルス剤の製造のための化合物の使用
WO2022214691A1 (en) 2021-04-09 2022-10-13 Immunic Ag Deuterated dhodh inhibitors
EP4119138A1 (en) * 2021-07-12 2023-01-18 Universität Hamburg Dhodh inhibitors and their use as antiviral agents
TW202332433A (zh) 2021-12-23 2023-08-16 德商埃慕尼克股份公司 含羧酸生物電子等排體之dhodh抑制劑
WO2023168176A1 (en) * 2022-03-01 2023-09-07 Kiora Pharmaceuticals Gmbh Salts of a dihydroorotate dehydrogenase (dhod) inhibitor
US20230286938A1 (en) * 2022-03-09 2023-09-14 Kiora Pharmaceuticals Gmbh Polymorphs of a dihydroorotate dehydrogenase (dhod) inhibitor
WO2023232884A1 (en) 2022-06-01 2023-12-07 Immunic Ag Treatment of ulcerative colitis comprising vidofludimus or a pharmaceutically acceptable salt thereof
CN116803387A (zh) * 2023-07-25 2023-09-26 徐州医科大学 Vidofludimus在制备戊型肝炎药物中的应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19860802A1 (de) * 1998-12-30 2000-10-26 Virgene Pharmaceuticals Ag Herstellung eines Mittels gegen Hepatitis B-, HI-, Paramyxo und Orthomyxo-Viren
EP1237546A2 (en) * 1999-10-01 2002-09-11 Institute of Molecular and Cell Biology Dihydroorotate dehydrogenase inhibitors for the treatment of viral-mediated diseases
WO2003006424A1 (en) * 2001-07-10 2003-01-23 4Sc Ag Novel compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents
EP1581478A1 (en) * 2002-12-23 2005-10-05 4Sc Ag Dhodh-inhibitors and method for their identification
US7071355B2 (en) * 2002-12-23 2006-07-04 4 Sc Ag Compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents
EP1581477B1 (en) * 2002-12-23 2009-12-02 4Sc Ag Cycloalkene dicarboxylic acid compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents
WO2005018330A1 (en) * 2003-08-18 2005-03-03 Pharmasset, Inc. Dosing regimen for flaviviridae therapy
ES2319596B1 (es) 2006-12-22 2010-02-08 Laboratorios Almirall S.A. Nuevos derivados de los acidos amino-nicotinico y amino-isonicotinico.
UY31272A1 (es) 2007-08-10 2009-01-30 Almirall Lab Nuevos derivados de ácido azabifenilaminobenzoico

Also Published As

Publication number Publication date
TW201043228A (en) 2010-12-16
NZ596014A (en) 2013-06-28
WO2010128050A2 (en) 2010-11-11
UY32605A (es) 2010-12-31
US8354433B2 (en) 2013-01-15
CA2761130A1 (en) 2010-11-11
EP2427186B1 (en) 2022-01-12
CA2761130C (en) 2017-03-28
CO6450622A2 (es) 2012-05-31
MX2011011733A (es) 2012-02-01
CN102458389A (zh) 2012-05-16
AU2010244462B2 (en) 2015-07-02
AU2010244462A1 (en) 2011-11-17
SG175854A1 (en) 2011-12-29
WO2010128050A3 (en) 2011-05-05
ZA201108131B (en) 2012-07-25
US20100280081A1 (en) 2010-11-04
AR076837A1 (es) 2011-07-13
EP2427186A2 (en) 2012-03-14
ES2909738T3 (es) 2022-05-10
TWI530286B (zh) 2016-04-21

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