PE20110829A1 - Derivados aminoester de alcaloides y composicion medicinal de los mismos - Google Patents
Derivados aminoester de alcaloides y composicion medicinal de los mismosInfo
- Publication number
- PE20110829A1 PE20110829A1 PE2011001258A PE2011001258A PE20110829A1 PE 20110829 A1 PE20110829 A1 PE 20110829A1 PE 2011001258 A PE2011001258 A PE 2011001258A PE 2011001258 A PE2011001258 A PE 2011001258A PE 20110829 A1 PE20110829 A1 PE 20110829A1
- Authority
- PE
- Peru
- Prior art keywords
- phenylamine
- cycloalkyl
- aryl
- phenyl
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/77—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
- C07C233/80—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/42—Oxygen atoms attached in position 3 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D223/08—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pulmonology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
- Pyrrole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE REFIERE A COMPUESTOS DERIVADOS AMINOESTER DE ALCALOIDES DE FORMULA (I) DONDE R1 ES H, ALQUILO(C1-C10), ARILO, CICLOALQUILO(C3-C8), ENTRE OTROS; R2 ES ALQUILO(C1-C10), CICLOALQUILO(C3-C8), ARILALQUILO, ENTRE OTROS; R3 ES H, ARILO, HETEROARILO, ARILALQUILO, ENTRE OTROS; R6 ES UN COMPUESTO DE FORMULA (i), (ii), (iii), ENTRE OTROS, EN DONDE m Y n SON DE 1 A 3; A- ES UN ANION; R4 ES -(CH2)p-P-(CH2)q-W, EN DONDE p Y q SON DE 0 A 4; P ESTA AUSENTE O ES O, S, SO, CO, ENTRE OTROS; W ES H, ALQUILO(C1-C6), CICLOALQUILO(C3-C8), ARILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 2-FENIL-2-(FENILAMINO)ACETATO DE (R)-QUINUCLIDIN-3-ILO; ESTER (R)-(1-AZA-BICICLO[2.2.2]OCT-3-ILICO) DE ACIDO 3-FENIL-2-FENILAMINO-PROPIONICO; TRIFLUOROACETATO DE (R)-1-(2-FENOXIETIL)-3-(2-FENIL-2-(FENILAMINO)ACETOXI)-1-AZONIA-BICICLO[2.2.2]OCTANO; ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS SIENDO UTILES EN EL TRATAMIENTO DE ASMA, BRONQUITIS CRONICA, ENFERMEDAD PULMONAR OBSTRUCTIVA CRONICA
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08172818A EP2206712A1 (en) | 2008-12-23 | 2008-12-23 | "Alkaloid aminoester derivatives and medicinal composition thereof" |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20110829A1 true PE20110829A1 (es) | 2011-11-19 |
Family
ID=40578441
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2011001258A PE20110829A1 (es) | 2008-12-23 | 2009-12-11 | Derivados aminoester de alcaloides y composicion medicinal de los mismos |
Country Status (25)
Country | Link |
---|---|
US (2) | US8455646B2 (es) |
EP (2) | EP2206712A1 (es) |
JP (1) | JP2012513420A (es) |
KR (1) | KR101414333B1 (es) |
CN (1) | CN102264734B (es) |
AR (1) | AR074855A1 (es) |
AU (1) | AU2009331945A1 (es) |
BR (1) | BRPI0918206A2 (es) |
CA (1) | CA2748100A1 (es) |
CO (1) | CO6400144A2 (es) |
EA (1) | EA020974B1 (es) |
GE (1) | GEP20146154B (es) |
HK (1) | HK1162174A1 (es) |
IL (1) | IL213712A0 (es) |
MA (1) | MA32979B1 (es) |
ME (1) | ME01185B (es) |
MX (1) | MX2011006642A (es) |
MY (1) | MY150823A (es) |
NZ (1) | NZ593695A (es) |
PE (1) | PE20110829A1 (es) |
SG (1) | SG172316A1 (es) |
TN (1) | TN2011000282A1 (es) |
TW (1) | TW201028412A (es) |
UA (1) | UA107334C2 (es) |
WO (1) | WO2010072338A1 (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2154136A1 (en) | 2008-08-08 | 2010-02-17 | CHIESI FARMACEUTICI S.p.A. | Quinuclidine carbonate derivatives and medicinal compositions thereof |
EP2206712A1 (en) | 2008-12-23 | 2010-07-14 | CHIESI FARMACEUTICI S.p.A. | "Alkaloid aminoester derivatives and medicinal composition thereof" |
EP2585458B1 (en) | 2010-06-22 | 2015-01-07 | Chiesi Farmaceutici S.p.A. | Alkaloid aminoester derivatives and medicinal compositions thereof |
CA2803459A1 (en) | 2010-06-22 | 2011-12-29 | Chiesi Farmaceutici S.P.A. | Alkaloid aminoester derivatives and medicinal compositions thereof |
CN102947298B (zh) * | 2010-06-22 | 2016-03-02 | 奇斯药制品公司 | 生物碱氨基酯衍生物及其药物组合物 |
RU2585767C2 (ru) * | 2010-11-26 | 2016-06-10 | КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. | Производные глицина и их применение в качестве антагонистов мускариновых рецепторов |
US20120220557A1 (en) * | 2011-02-17 | 2012-08-30 | Chiesi Farmaceutici S.P.A. | Liquid propellant-free formulation comprising an antimuscarinic drug |
RU2611627C2 (ru) * | 2011-04-29 | 2017-02-28 | КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. | Алкалоидный эфир и карбаматные производные и их медицинские композиции |
CN104011043B (zh) | 2011-12-30 | 2016-11-16 | 奇斯药制品公司 | 作为抗毒蕈碱剂的1-氮杂杂环基乙酸的奎宁环酯、它们的制备方法及其药用组合物 |
HU230368B1 (hu) | 2012-11-16 | 2016-03-29 | Magyar Tudományos Akadémia Szegedi Biológiai Kutatóközpont | Új módszer az emlős mesterséges kromoszóma több génnel való feltöltésére |
US9427376B2 (en) | 2013-10-10 | 2016-08-30 | Chiesi Farmaceutici S.P.A. | Process for preparing pharmaceutical formulations for inhalation comprising a high-dosage strength active ingredient |
ES2832711T3 (es) | 2014-10-31 | 2021-06-11 | Abbvie Biotherapeutics Inc | Anticuerpos anti-CS1 y conjugados anticuerpo fármaco |
CN104876854B (zh) * | 2015-04-16 | 2017-03-01 | 御盛隆堂药业有限责任公司 | 羟基乙酸酯衍生物及其用途 |
EP3625232B1 (en) | 2017-05-19 | 2021-06-23 | Council of Scientific and Industrial Research | Substituted methanopyrido [2, 1-a]isoindolones as machr modulators for treating various associated pathophysiological conditions and process for preparation thereof |
CA3208361A1 (en) | 2021-02-19 | 2022-08-25 | Anjali Pandey | Tyk2 inhibitors and uses thereof |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2824106A (en) * | 1958-02-18 | Quaternary tropeine compounds and a process of making same | ||
US2856407A (en) * | 1956-08-08 | 1958-10-14 | Lakeside Lab Inc | Aminoacid esters of n-substituted 3 and 4-piperidinols |
GB8923590D0 (en) * | 1989-10-19 | 1989-12-06 | Pfizer Ltd | Antimuscarinic bronchodilators |
IT1255323B (it) * | 1992-07-08 | 1995-10-31 | Fidia Spa | Composti ad attivita' analgesica e nootropa |
AU685225B2 (en) * | 1994-02-10 | 1998-01-15 | Yamanouchi Pharmaceutical Co., Ltd. | Novel carbamate derivative and medicinal composition containing the same |
US6169075B1 (en) * | 1996-09-10 | 2001-01-02 | British Biotech Pharmaceuticals Limited | Cytostatic agents |
JP2001520222A (ja) * | 1997-10-22 | 2001-10-30 | ゼネカ・リミテッド | イミダゾール誘導体およびファルネシルタンパク質トランスフェラーゼインヒビターとしてのそれらの使用 |
IL156499A0 (en) * | 2000-12-22 | 2004-01-04 | Almirall Prodesfarma Ag | Quinuclidine carbamate derivatives and their use as m3 antagonists |
MXPA04006206A (es) | 2001-12-20 | 2004-12-06 | S A L V A T Lab Sa | Derivados de 1-alquil-azoniabiciclo(2.2.2(octano carbamato y su uso como antagonistas del receptor musrcarinico. |
GB0424284D0 (en) * | 2004-11-02 | 2004-12-01 | Novartis Ag | Organic compounds |
EP1882691A1 (en) | 2006-07-26 | 2008-01-30 | CHIESI FARMACEUTICI S.p.A. | Quinuclidine derivatives as M3 antagonists |
GB0621830D0 (en) * | 2006-11-02 | 2006-12-13 | Chroma Therapeutics Ltd | Inhibitors of p38 mitogen-activated protein kinase |
TW200825084A (en) * | 2006-11-14 | 2008-06-16 | Astrazeneca Ab | New compounds 521 |
ES2385681T3 (es) * | 2006-12-19 | 2012-07-30 | Astrazeneca Ab | Derivados de quinuclidinol como antagonistas de receptores muscarínicos |
WO2008075006A1 (en) * | 2006-12-19 | 2008-06-26 | Astrazeneca Ab | Piperldinum compounds for treatment of obstructive pulmonary diseases ( copd) |
EP2154136A1 (en) | 2008-08-08 | 2010-02-17 | CHIESI FARMACEUTICI S.p.A. | Quinuclidine carbonate derivatives and medicinal compositions thereof |
EP2206712A1 (en) | 2008-12-23 | 2010-07-14 | CHIESI FARMACEUTICI S.p.A. | "Alkaloid aminoester derivatives and medicinal composition thereof" |
AU2011269238A1 (en) | 2010-06-22 | 2013-01-10 | Chiesi Farmaceutici S.P.A. | Dry powder formulation comprising an antimuscarinic drug |
CN102947298B (zh) | 2010-06-22 | 2016-03-02 | 奇斯药制品公司 | 生物碱氨基酯衍生物及其药物组合物 |
EP2585458B1 (en) | 2010-06-22 | 2015-01-07 | Chiesi Farmaceutici S.p.A. | Alkaloid aminoester derivatives and medicinal compositions thereof |
CA2803459A1 (en) | 2010-06-22 | 2011-12-29 | Chiesi Farmaceutici S.P.A. | Alkaloid aminoester derivatives and medicinal compositions thereof |
KR20130140672A (ko) | 2010-10-20 | 2013-12-24 | 키에시 파르마슈티시 엣스. 피. 에이. | 기침 치료용 카보네이트 유도체 |
US20120220557A1 (en) | 2011-02-17 | 2012-08-30 | Chiesi Farmaceutici S.P.A. | Liquid propellant-free formulation comprising an antimuscarinic drug |
RU2611627C2 (ru) | 2011-04-29 | 2017-02-28 | КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. | Алкалоидный эфир и карбаматные производные и их медицинские композиции |
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2008
- 2008-12-23 EP EP08172818A patent/EP2206712A1/en not_active Withdrawn
-
2009
- 2009-12-11 CN CN200980152004.9A patent/CN102264734B/zh active Active
- 2009-12-11 GE GEAP200912268A patent/GEP20146154B/en unknown
- 2009-12-11 SG SG2011045689A patent/SG172316A1/en unknown
- 2009-12-11 EA EA201190017A patent/EA020974B1/ru not_active IP Right Cessation
- 2009-12-11 WO PCT/EP2009/008870 patent/WO2010072338A1/en active Application Filing
- 2009-12-11 CA CA2748100A patent/CA2748100A1/en not_active Abandoned
- 2009-12-11 BR BRPI0918206A patent/BRPI0918206A2/pt not_active IP Right Cessation
- 2009-12-11 NZ NZ593695A patent/NZ593695A/en not_active IP Right Cessation
- 2009-12-11 EP EP20090778904 patent/EP2376489B1/en active Active
- 2009-12-11 MY MYPI20112934 patent/MY150823A/en unknown
- 2009-12-11 ME MEP-2011-114A patent/ME01185B/me unknown
- 2009-12-11 KR KR1020117014392A patent/KR101414333B1/ko not_active IP Right Cessation
- 2009-12-11 PE PE2011001258A patent/PE20110829A1/es not_active Application Discontinuation
- 2009-12-11 MA MA34030A patent/MA32979B1/fr unknown
- 2009-12-11 MX MX2011006642A patent/MX2011006642A/es active IP Right Grant
- 2009-12-11 UA UAA201106921A patent/UA107334C2/ru unknown
- 2009-12-11 AU AU2009331945A patent/AU2009331945A1/en not_active Abandoned
- 2009-12-11 JP JP2011542695A patent/JP2012513420A/ja active Pending
- 2009-12-22 AR ARP090105049A patent/AR074855A1/es unknown
- 2009-12-22 TW TW098144158A patent/TW201028412A/zh unknown
- 2009-12-22 US US12/644,322 patent/US8455646B2/en active Active
-
2011
- 2011-05-31 TN TN2011000282A patent/TN2011000282A1/fr unknown
- 2011-06-22 CO CO11078448A patent/CO6400144A2/es not_active Application Discontinuation
- 2011-06-22 IL IL213712A patent/IL213712A0/en unknown
-
2012
- 2012-03-14 HK HK12102580.8A patent/HK1162174A1/xx unknown
-
2013
- 2013-03-14 US US13/827,101 patent/US8835682B2/en active Active
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CN102264734B (zh) | 2015-06-17 |
GEP20146154B (en) | 2014-09-10 |
EP2376489A1 (en) | 2011-10-19 |
MX2011006642A (es) | 2011-07-29 |
WO2010072338A1 (en) | 2010-07-01 |
KR101414333B1 (ko) | 2014-07-02 |
AR074855A1 (es) | 2011-02-16 |
US20130196978A1 (en) | 2013-08-01 |
US8835682B2 (en) | 2014-09-16 |
EP2206712A1 (en) | 2010-07-14 |
JP2012513420A (ja) | 2012-06-14 |
US20100173880A1 (en) | 2010-07-08 |
EA201190017A1 (ru) | 2012-02-28 |
EP2376489B1 (en) | 2015-04-22 |
CO6400144A2 (es) | 2012-03-15 |
IL213712A0 (en) | 2011-07-31 |
US8455646B2 (en) | 2013-06-04 |
SG172316A1 (en) | 2011-07-28 |
HK1162174A1 (en) | 2012-08-24 |
UA107334C2 (ru) | 2014-12-25 |
ME01185B (me) | 2013-03-20 |
EA020974B1 (ru) | 2015-03-31 |
AU2009331945A1 (en) | 2011-07-14 |
BRPI0918206A2 (pt) | 2015-12-08 |
KR20110097883A (ko) | 2011-08-31 |
TW201028412A (en) | 2010-08-01 |
CN102264734A (zh) | 2011-11-30 |
MA32979B1 (fr) | 2012-01-02 |
CA2748100A1 (en) | 2010-07-01 |
NZ593695A (en) | 2014-01-31 |
TN2011000282A1 (en) | 2012-12-17 |
MY150823A (en) | 2014-02-28 |
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