PE20110802A1 - Un anticuerpo antagonista de pcsk9 - Google Patents

Un anticuerpo antagonista de pcsk9

Info

Publication number
PE20110802A1
PE20110802A1 PE2011000618A PE2011000618A PE20110802A1 PE 20110802 A1 PE20110802 A1 PE 20110802A1 PE 2011000618 A PE2011000618 A PE 2011000618A PE 2011000618 A PE2011000618 A PE 2011000618A PE 20110802 A1 PE20110802 A1 PE 20110802A1
Authority
PE
Peru
Prior art keywords
seq
pcsk9
antagonist antibody
cdr1
cdr2
Prior art date
Application number
PE2011000618A
Other languages
English (en)
Inventor
Hong Liang
Yasmina Noubia Abdiche
Riggers Javier Fernando Chaparro
Bruce Charles Gomes
Julie Jia Li Hawkins
Jaume Pons
Xiayang Qiu
Pavel Strop
Yuli Wang
Original Assignee
Pfizer
Rinat Neuroscience Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer, Rinat Neuroscience Corp filed Critical Pfizer
Publication of PE20110802A1 publication Critical patent/PE20110802A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE REFIERE A ANTICUERPOS HUMANIZADOS O QUIMERICOS, PORCIONES DE UNION DE LOS MISMOS Y PEPTIDOS O APTAMEROS QUE COMPRENDE a) UNA REGION VL CON LA SEC ID Nº 53, 14 O 15 QUE COMPRENDE: CDR1 CON LA SEC ID Nº11, CDR2 CON LA SEC ID Nº 12 Y/O CDR3 CON LA SEC ID Nº13; b) UNA REGION VH CON LA SEC ID Nº 14, 15 O 54 QUE COMPRENDE: CDR1 CON LA SEC ID Nº 59 QUE PUEDE ESTAR SUSTITUIDA EN EL AMINOACIDO 8 O SEC ID Nº 58, 59 O 60, CDR2 CON LA SEC ID Nº 9 QUE COMPRENDE SUSTITUCIONES EN LAS POSICIONES DE AMINOACIDOS 3, 4, 5, 6, Y 7 O SEC ID Nº 61 Y/O CDR3 CON LA SEC ID Nº 10 QUE COMPRENDE SUSTITUCIONES EN LOS AMINOACIDOS 7 Y 9. DIHOS ANTICUERPOS ANTAGONIZAN LA ACTIVIDAD DE LA SUBTILISINA KESINA DE TIPO 9 (PCSK9) Y SON UTILES EN EL TRATAMIENTO DE HIPERCOLESTEROLEMIA
PE2011000618A 2008-09-12 2009-09-11 Un anticuerpo antagonista de pcsk9 PE20110802A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9671608P 2008-09-12 2008-09-12
US23216109P 2009-08-07 2009-08-07
US23564309P 2009-08-20 2009-08-20

Publications (1)

Publication Number Publication Date
PE20110802A1 true PE20110802A1 (es) 2011-10-27

Family

ID=42005569

Family Applications (2)

Application Number Title Priority Date Filing Date
PE2015002084A PE20151952A1 (es) 2008-09-12 2009-09-11 Antagonista de pcsk9
PE2011000618A PE20110802A1 (es) 2008-09-12 2009-09-11 Un anticuerpo antagonista de pcsk9

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PE2015002084A PE20151952A1 (es) 2008-09-12 2009-09-11 Antagonista de pcsk9

Country Status (20)

Country Link
US (5) US8080243B2 (es)
EP (1) EP2344194A2 (es)
JP (4) JP4898976B2 (es)
KR (1) KR101230675B1 (es)
CN (1) CN102333542B (es)
AR (1) AR073292A1 (es)
AU (1) AU2009290438B2 (es)
BR (1) BRPI0919289A2 (es)
CA (1) CA2736349C (es)
CO (1) CO6351752A2 (es)
HK (1) HK1161136A1 (es)
IL (2) IL211519A (es)
MX (1) MX2011002726A (es)
NZ (1) NZ591541A (es)
PE (2) PE20151952A1 (es)
PH (1) PH12014501261A1 (es)
RU (2) RU2528735C2 (es)
TW (2) TWI445716B (es)
WO (1) WO2010029513A2 (es)
ZA (1) ZA201101688B (es)

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