PE20091390A1 - Composiciones farmaceuticas de accion doble basadas en el bloqueo de los receptores de angiotensina y la inhibicion de la endopeptidasa neutral - Google Patents

Composiciones farmaceuticas de accion doble basadas en el bloqueo de los receptores de angiotensina y la inhibicion de la endopeptidasa neutral

Info

Publication number
PE20091390A1
PE20091390A1 PE2008001886A PE2008001886A PE20091390A1 PE 20091390 A1 PE20091390 A1 PE 20091390A1 PE 2008001886 A PE2008001886 A PE 2008001886A PE 2008001886 A PE2008001886 A PE 2008001886A PE 20091390 A1 PE20091390 A1 PE 20091390A1
Authority
PE
Peru
Prior art keywords
blockage
inhibition
pharmaceutical compositions
methyl
compositions based
Prior art date
Application number
PE2008001886A
Other languages
English (en)
Inventor
Suliman Al-Fayoumi
Jiahui Hu
Natrajan Kumaraperumal
Alan Edward Royce
Colleen Ruegger
Erika Aina Zannou
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40451030&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20091390(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PE20091390A1 publication Critical patent/PE20091390A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE COMPRENDE: A) COMPLEJO SUPRAMOLECULAR PROPIONATO-(S)-3'-METIL-2'-(PENTANOIL-{2''-(TETRAZOL-5-ILATO)-BIFENIL-4'-IL-METIL}-AMINO)-BUTIRATO]-HEMIPENTAHIDRATO DE [3-((1S,3R)-1-BIFENIL-4-IL-METIL-3-ETOXI-CARBONIL-1-BUTIL-CARBAMOILO) DE TRISODIO DE ACCION DOBLE QUE SE ENCUENTRA EN UNA CANTIDAD DE ENTRE 4% AL 90% EN PESO DE LA COMPOSICION; B) AL MENOS UN EXCIPIENTE FARMACEUTICAMENTE ACEPTABLE. SE REFIERE TAMBIEN A UN A UN PROCESO DE COMPACTACION, TAL COMO COMPACTACION CON RODILLOS. DICHA COMPOSICION ESTA FORMULADA EN UNA SOLA UNIDAD DE DOSIFICACION PARA SU ADMINISTRACION POR VIA ORAL EN FORMA DE TABLETAS QUE PERMITEN UNA RAPIDA LIBERACION DEL AGENTE TERAPEUTICO
PE2008001886A 2007-11-06 2008-11-04 Composiciones farmaceuticas de accion doble basadas en el bloqueo de los receptores de angiotensina y la inhibicion de la endopeptidasa neutral PE20091390A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US98566807P 2007-11-06 2007-11-06

Publications (1)

Publication Number Publication Date
PE20091390A1 true PE20091390A1 (es) 2009-10-13

Family

ID=40451030

Family Applications (2)

Application Number Title Priority Date Filing Date
PE2013002393A PE20141072A1 (es) 2007-11-06 2008-11-04 Composiciones farmaceuticas de accion doble basadas en el bloqueo de los receptores de angiotensina y la inhibicion de la endopeptidasa neutral
PE2008001886A PE20091390A1 (es) 2007-11-06 2008-11-04 Composiciones farmaceuticas de accion doble basadas en el bloqueo de los receptores de angiotensina y la inhibicion de la endopeptidasa neutral

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PE2013002393A PE20141072A1 (es) 2007-11-06 2008-11-04 Composiciones farmaceuticas de accion doble basadas en el bloqueo de los receptores de angiotensina y la inhibicion de la endopeptidasa neutral

Country Status (34)

Country Link
US (3) US20100267786A1 (es)
EP (4) EP2295035B1 (es)
JP (2) JP5653218B2 (es)
KR (2) KR101700062B1 (es)
CN (2) CN103251587A (es)
AR (1) AR069184A1 (es)
AU (1) AU2008324878B2 (es)
BR (1) BRPI0823505A2 (es)
CA (1) CA2703598C (es)
CL (1) CL2008003298A1 (es)
CY (2) CY1116280T1 (es)
DK (3) DK2217205T3 (es)
EC (1) ECSP10010160A (es)
ES (3) ES2536514T3 (es)
FI (1) FI3067043T3 (es)
GT (1) GT201000131A (es)
HK (3) HK1143529A1 (es)
HR (3) HRP20230178T3 (es)
HU (2) HUE028866T2 (es)
IL (3) IL262990B2 (es)
JO (1) JOP20080499B1 (es)
MA (1) MA31797B1 (es)
MX (1) MX2010004930A (es)
MY (1) MY153730A (es)
NZ (1) NZ584686A (es)
PE (2) PE20141072A1 (es)
PL (3) PL2295035T3 (es)
PT (3) PT2295035T (es)
RU (1) RU2493844C3 (es)
SG (1) SG185951A1 (es)
SI (3) SI3067043T1 (es)
TN (1) TN2010000200A1 (es)
TW (1) TWI484982B (es)
WO (1) WO2009061713A1 (es)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20230178T3 (hr) 2007-11-06 2023-03-31 Novartis Ag Farmaceutski pripravci temeljeni na nadgradnjama antagonista/blokatora angiotenzinskog receptora (arb) i inhibitoru neutralne endopeptidaze (nep)
EP2435402B1 (en) 2009-05-28 2016-04-13 Novartis AG Substituted aminobutyric derivatives as neprilysin inhibitors
NZ596304A (en) 2009-05-28 2014-01-31 Novartis Ag Substituted aminopropionic derivatives as neprilysin inhibitors
JO2967B1 (en) 2009-11-20 2016-03-15 نوفارتس ايه جي Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors
US20130158088A1 (en) 2010-08-24 2013-06-20 Novartis Ag Treatment of hypertension and/or prevention or treatment of heart failure in a mammal receiving anti-coagulant therapy
US8673974B2 (en) 2010-11-16 2014-03-18 Novartis Ag Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors
KR20200111822A (ko) 2012-08-24 2020-09-29 노파르티스 아게 심방 확장 또는 재형성을 특징으로 하는 질환을 치료하기 위한 nep 억제제
EP2956445A1 (en) 2013-02-14 2015-12-23 Novartis AG Substituted bisphenyl butanoic acid derivatives as nep inhibitors with improved in vivo efficacy
LT2956464T (lt) 2013-02-14 2018-07-10 Novartis Ag Pakeisti bisfenilbutanoinės fosfonrūgšties dariniai, kaip nep (neutralios endopeptidazės) inhibitoriai
SI3038654T1 (sl) 2013-08-26 2020-02-28 Novartis Ag Nova uporaba
JP2016530282A (ja) * 2013-08-26 2016-09-29 ノバルティス アーゲー 新規使用
WO2015154673A1 (en) * 2014-04-10 2015-10-15 Zhaoyin Wang Novel prodrugs and combinations for treatment of hypertension and cardiovascular diseases
CN105461647B (zh) * 2014-09-28 2018-06-29 四川海思科制药有限公司 缬沙坦沙库比曲三钠盐复合物的固态形式及其制备方法和用途
CN105873586B (zh) 2014-12-08 2019-09-13 苏州晶云药物科技股份有限公司 一种包含缬沙坦和ahu377的三钠盐超分子复合物的晶型及其制备方法
CN104473938B (zh) * 2014-12-30 2017-06-09 北京瑞都医药科技有限公司 一种治疗慢性心衰药物及其制备方法
CN104826115A (zh) * 2015-04-19 2015-08-12 浙江巨泰药业有限公司 一种抗心衰药物组合物及其制备方法
FI3294283T3 (fi) 2015-05-11 2023-05-24 Novartis Ag Sakubitriili-valsartaani-annostusohjelma sydämen vajaatoiminnan hoitamiseksi
JP2018516267A (ja) 2015-05-29 2018-06-21 ノバルティス アーゲー 代謝性疾患を治療するためのサクビトリルおよびバルサルタン
CN106309388A (zh) * 2015-06-30 2017-01-11 深圳信立泰药业股份有限公司 一种用于心衰治疗的药物组合物及其制备方法
WO2017006254A1 (en) 2015-07-08 2017-01-12 Novartis Ag Drug combination comprising an angiotensin ii receptor antagonist, a neutral endopeptidase inhibitor and a mineralcorticoid receptor antagonist
CN106176724A (zh) * 2015-07-11 2016-12-07 凌莉 一种稳定的固体药物组合物及其制备方法
CN106176725A (zh) * 2015-07-11 2016-12-07 凌莉 一种提高稳定性的药物组合物及其制备方法和用途
CN105997994A (zh) * 2015-07-11 2016-10-12 凌莉 一种固体口服型制剂及其制备方法
CN106074421A (zh) * 2015-07-11 2016-11-09 凌莉 一种提高稳定性的药物组合物
CN105997993B (zh) * 2015-07-11 2018-03-30 麦丽芳 一种用于心血管疾病治疗的固体口服型制剂及其制备方法
CN106176723A (zh) * 2015-07-11 2016-12-07 凌莉 一种固体药物组合物及其制备方法
WO2017012600A1 (en) 2015-07-20 2017-01-26 Zentiva, K.S. A pharmaceutical composition containing valsartan and sacubitril and methods for preparation and stabilization thereof
CN106397249A (zh) * 2015-08-03 2017-02-15 深圳信立泰药业股份有限公司 一种高稳定性lcz696结晶粉末及其制备方法
WO2017037596A1 (en) * 2015-08-28 2017-03-09 Dr. Reddy's Laboratories Limited Amorphous solid dispersion of lcz-696
EP3355880A1 (en) 2015-08-28 2018-08-08 Novartis AG New use
US20180303799A1 (en) * 2015-10-16 2018-10-25 Shenzhen Salubris Pharmaceuticals Co., Ltd An Oral Preparation for the Treatment of Cardiovascular Disease and Its Preparation Method
CN105669581B (zh) * 2015-11-09 2017-03-22 成都苑东生物制药股份有限公司 一种血管紧张受体拮抗剂和中性内肽酶抑制剂复合物
WO2017085573A1 (en) * 2015-11-20 2017-05-26 Lupin Limited Amorphous sacubitril-valsartan complex and process for preparation thereof
CN105330609B (zh) * 2015-12-07 2017-12-22 南京正大天晴制药有限公司 一种制备lcz696的方法
CN105929031B (zh) * 2015-12-18 2018-08-21 重庆两江药物研发中心有限公司 一种血管紧张素受体拮抗剂和nep抑制剂的复合物中杂质的分离方法
CN105935358B (zh) * 2015-12-18 2019-06-07 重庆两江药物研发中心有限公司 一种沙库比曲缬沙坦缓释剂及其制备方法
CN106905253B (zh) * 2015-12-23 2020-01-03 正大天晴药业集团股份有限公司 一种超分子复合物的结晶
CN108601741B (zh) * 2016-02-03 2022-05-24 诺华股份有限公司 有机化合物的盖伦制剂
US10722471B2 (en) * 2016-02-03 2020-07-28 Novartis Ag Galenic formulations of organic compounds
CN105748420B (zh) * 2016-03-04 2018-11-06 山东省药学科学院 一种治疗心力衰竭的lcz696缓释骨架片的制备方法
CN105902506A (zh) * 2016-06-12 2016-08-31 佛山市腾瑞医药科技有限公司 一种沙卡布曲缬沙坦制剂及其应用
WO2018069937A1 (en) 2016-10-13 2018-04-19 Mylan Laboratories Limited Solid dispersions of trisodium sacubitril valsartan and process for the preparation thereof
ES2890573T3 (es) * 2017-03-31 2022-01-20 Tiefenbacher Alfred E Gmbh & Co Kg Producto extruido de fusión en caliente estable que contiene valsartán y sacubitrilo
WO2018178295A1 (en) 2017-03-31 2018-10-04 Alfred E. Tiefenbacher (Gmbh & Co. Kg) Stable hot-melt extrudate containing valsartan and sacubitril
WO2018211479A1 (en) 2017-05-19 2018-11-22 Lupin Limited Stabilized compositions of angiotensin ii inhibitors and neutral endopeptidase inhibitors and process for preparation thereof
US11382866B2 (en) 2017-07-06 2022-07-12 Mankind Pharma Ltd. Fixed dose pharmaceutical composition of valsartan and sacubitril
PL3658122T3 (pl) 2017-07-28 2021-10-18 Synthon B.V. Kompozycja farmaceutyczna zawierająca sakubitryl i walsartan
WO2019073062A1 (en) 2017-10-13 2019-04-18 Alfred E. Tiefenbacher (Gmbh & Co. Kg) TABLET CONTAINING VALSARTAN AND SACUBITRIL
WO2019180735A1 (en) * 2018-03-19 2019-09-26 Natco Pharma Limited Stable pharmaceutical compositions comprising sacubitril-valsartan complex
WO2019246503A1 (en) 2018-06-22 2019-12-26 Ideaz, Llc Diphenyl tablets and methods of preparing the same
CA3110152A1 (en) 2018-08-23 2020-02-27 Novartis Ag New pharmaceutical use for the treatment of heart failure
WO2020039394A1 (en) 2018-08-24 2020-02-27 Novartis Ag New drug combinations
EP3766484B1 (en) 2019-07-19 2021-08-25 Zentiva, K.S. Solid pharmaceutical dosage form comprising valsartan and sacubitril
KR102545274B1 (ko) 2020-02-26 2023-06-20 에리슨제약(주) 사쿠비트릴 및 발사르탄을 포함하는 심부전 치료용 서방성 제제, 및 이를 포함하는 다중방출 복합제제와 이의 제조방법
KR20210120560A (ko) 2020-03-27 2021-10-07 주식회사 유영제약 고함량의 주성분을 포함하는 정제 및 그 제조방법
KR20210138510A (ko) 2020-05-12 2021-11-19 에리슨제약(주) 사쿠비트릴, 발사르탄 및 네비보롤을 포함하는 심부전 및 허혈성 심질환의 예방 또는 치료용 약제학적 조성물 및 이를 포함하는 약제학적 복합제제
KR20220091767A (ko) 2020-12-24 2022-07-01 주식회사 보령 사쿠비트릴 발사르탄 하이브리드 화합물 또는 그 약제학적으로 허용되는 염을 유효성분으로 포함하는 약제학적 조성물
KR102486815B1 (ko) 2021-01-20 2023-01-10 주식회사 대웅제약 Nep 저해제 및 arb를 포함하는 약학 조성물 및 이의 제조 방법

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US607893A (en) 1898-07-26 Automatic switch-operating machine
US607355A (en) 1898-07-12 Carrier for bicycles
US608220A (en) 1898-08-02 Mechanical movement
US735093A (en) 1903-01-31 1903-08-04 Oscar Greenwald Elevator-cable guard.
GB9613470D0 (en) 1996-06-27 1996-08-28 Ciba Geigy Ag Small solid oral dosage form
US6558699B2 (en) * 1997-11-17 2003-05-06 Smithkline Beecham Corporation High drug load immediate and modified release oral dosage formulations and processes for their manufacture
KR100597922B1 (ko) * 1997-11-17 2006-07-10 스미스클라인 비참 코포레이션 고용량 약물 로딩 속효성 및 변형 방출형 경구 투여용제형 및 그의 제조 방법
WO1999065500A1 (en) * 1998-06-17 1999-12-23 Bristol-Myers Squibb Company Preventing cerebral infarction through administration of adp-receptor antiplatelet and antihypertensive drugs in combination
TR200805741T2 (tr) * 1998-12-23 2008-10-21 Novartis Ag At-1 veya at-2 reseptörlerindeki artışın neden olduğu hastalıkların tedavisi için at-1 reseptör antagonisti veya at-2 reseptör modülatörünün kullanımı@
DE60135560D1 (de) 2000-07-19 2008-10-09 Novartis Ag Valsartan salze
SI1467728T1 (sl) 2002-01-17 2008-02-29 Novartis Ag Farmacevtski sestavki vkljucujoci valsartan in NEP inhibitorje
US7468390B2 (en) * 2002-01-17 2008-12-23 Novartis Ag Methods of treatment and pharmaceutical composition
JP3751287B2 (ja) * 2002-03-27 2006-03-01 バイエル薬品株式会社 小型化されたニフェジピン有核錠剤
WO2003089417A1 (en) 2002-04-15 2003-10-30 Dr. Reddy's Laboratories Limited Novel crystalline forms of (s)-n-(1-carboxy-2-methyl-prop-1-yl) -n-pentanoyl-n- [2’-(1h-tetrazol-5-yl-)- biphenyl-4-yl methyl] amine (valsartan)
GB0209265D0 (en) 2002-04-23 2002-06-05 Novartis Ag Organic compounds
ATE393764T1 (de) 2003-03-17 2008-05-15 Teva Pharma Polymorphe formen von valsartan
JP2009513543A (ja) * 2003-07-16 2009-04-02 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング クロルタリドンの組み合わせ
GB0402262D0 (en) * 2004-02-02 2004-03-10 Novartis Ag Process for the manufacture of organic compounds
GT200600371A (es) 2005-08-17 2007-03-21 Formas de dosis sólidas de valsartan y amlodipina y método para hacer las mismas
AU2006307470A1 (en) * 2005-10-27 2007-05-03 Lupin Limited Pharmaceutical formulation of losartan
WO2007052307A2 (en) 2005-10-31 2007-05-10 Lupin Limited Stable solid oral dosage forms of valsartan
WO2007056342A2 (en) 2005-11-07 2007-05-18 Stryker Corporation Patient handling device including local status indication, one-touch fowler angle adjustment, and power-on alarm configuration
AU2006311723A1 (en) 2005-11-08 2007-05-18 Novartis Ag Combination of an angiotensin II receptor blocker, a calcium channel blocker and another active agent
AR057882A1 (es) * 2005-11-09 2007-12-26 Novartis Ag Compuestos de accion doble de bloqueadores del receptor de angiotensina e inhibidores de endopeptidasa neutra
EP1897537A1 (en) * 2006-09-04 2008-03-12 Novartis AG Composition comprising an angiotensin II receptor antagonist
HRP20230178T3 (hr) 2007-11-06 2023-03-31 Novartis Ag Farmaceutski pripravci temeljeni na nadgradnjama antagonista/blokatora angiotenzinskog receptora (arb) i inhibitoru neutralne endopeptidaze (nep)

Also Published As

Publication number Publication date
MY153730A (en) 2015-03-13
CA2703598A1 (en) 2009-05-14
DK2217205T3 (en) 2015-05-11
HUE028866T2 (en) 2017-01-30
RU2493844C2 (ru) 2013-09-27
CY1117883T1 (el) 2017-05-17
MA31797B1 (fr) 2010-10-01
HK1149721A1 (zh) 2011-10-14
KR20100085087A (ko) 2010-07-28
KR101700062B9 (ko) 2022-11-23
KR101589317B1 (ko) 2016-01-28
DK2295035T3 (en) 2016-08-29
HRP20160988T1 (hr) 2016-10-07
BRPI0823505A2 (pt) 2015-06-16
TWI484982B (zh) 2015-05-21
EP2217205A1 (en) 2010-08-18
PT2217205E (pt) 2015-06-08
PE20141072A1 (es) 2014-09-10
AR069184A1 (es) 2010-01-06
EP3067043B1 (en) 2022-11-30
PL2295035T3 (pl) 2016-11-30
IL205208A0 (en) 2010-12-30
ES2939163T3 (es) 2023-04-19
HRP20150459T1 (hr) 2015-07-17
EP4186491A1 (en) 2023-05-31
US20210085631A1 (en) 2021-03-25
SI3067043T1 (sl) 2023-04-28
SG185951A1 (en) 2012-12-28
AU2008324878A1 (en) 2009-05-14
SI2217205T1 (sl) 2015-10-30
MX2010004930A (es) 2010-05-27
JP2011503082A (ja) 2011-01-27
IL249922A0 (en) 2017-03-30
EP2217205B1 (en) 2015-03-04
HK1224195A1 (zh) 2017-08-18
EP2295035A2 (en) 2011-03-16
HUE061321T2 (hu) 2023-06-28
PL3067043T3 (pl) 2023-05-08
EP2295035A3 (en) 2012-08-08
KR20150139624A (ko) 2015-12-11
ES2587336T3 (es) 2016-10-24
TN2010000200A1 (en) 2011-11-11
JP2015038069A (ja) 2015-02-26
ES2536514T3 (es) 2015-05-26
IL205208A (en) 2017-01-31
SI2295035T1 (sl) 2016-09-30
US20100267786A1 (en) 2010-10-21
HRP20230178T3 (hr) 2023-03-31
CL2008003298A1 (es) 2009-06-26
RU2493844C3 (ru) 2017-07-05
US20240115536A1 (en) 2024-04-11
PL2217205T3 (pl) 2015-07-31
KR101700062B1 (ko) 2017-01-26
ECSP10010160A (es) 2010-06-29
HK1143529A1 (en) 2011-01-07
GT201000131A (es) 2012-04-30
JOP20080499B1 (ar) 2022-09-15
AU2008324878B2 (en) 2013-04-18
CN101848700A (zh) 2010-09-29
IL262990B1 (en) 2023-06-01
EP2295035B1 (en) 2016-05-18
CY1116280T1 (el) 2017-03-15
WO2009061713A1 (en) 2009-05-14
IL262990A (en) 2018-12-31
FI3067043T3 (fi) 2023-03-18
DK3067043T3 (da) 2023-02-27
RU2010123027A (ru) 2011-12-20
IL262990B2 (en) 2023-10-01
JP5653218B2 (ja) 2015-01-14
PT2295035T (pt) 2016-08-22
TW200936183A (en) 2009-09-01
CA2703598C (en) 2016-08-09
CN103251587A (zh) 2013-08-21
KR101589317B9 (ko) 2022-11-23
PT3067043T (pt) 2023-03-01
NZ584686A (en) 2013-03-28
EP3067043A1 (en) 2016-09-14

Similar Documents

Publication Publication Date Title
PE20091390A1 (es) Composiciones farmaceuticas de accion doble basadas en el bloqueo de los receptores de angiotensina y la inhibicion de la endopeptidasa neutral
CO6400186A2 (es) Tabletas de acetato de ulipristal
AR078846A1 (es) Composicion para el tratamiento de la enfermedad de alzheimer
PE20061449A1 (es) Composiciones farmaceuticas comprendiendo imatinib y un retardador de liberacion
MX2012003082A (es) Composiciones farmaceuticas para reducir la absorcion rapida de la dosis inducida por el alcohol.
GT200500309A (es) Derivados de sulfonilbencilimidazol
CO6241104A2 (es) "composiciones farmaceuticas que comprende {4-(6-fluoro-7-metilamino-2,4-dioxo-1,4-dihidro-2h-quinazolin-3-il)-fenil}-5-cloro-tiofen-2-il-sulfonilurea o sales de la misma para la inhibicion de la agregacion de plaquetas inducidas por adp"
ECSP10010224A (es) Formulaciones líquidas de hormona luteinizante (lh).
UY31314A1 (es) Amidas heterociclicas y sus métodos de uso-976
MA34083B1 (fr) Compositions pharmaceutques de composé spiro-oxindole pour administration topique et leur utilisation en tant qu'agents thérapeutiques
AR077546A1 (es) Formulaciones de comprimidos de 3-cianoquinolina y usos de los mismos
EA201071039A1 (ru) Новые производные 1-бензил-3-гидроксиметилиндазола и их применение для лечения заболеваний, основанных на экспрессии mcp-1, cx3cr1 и p40
PE20121131A1 (es) Composicion farmaceutica oral solida en comprimido monocapa que comprende irbesartan y besilato de amlodipina
AR059423A1 (es) Administracion oral de agentes terapeuticos usando agonistas de uniones impermeables
AR051589A1 (es) Agentes terapeuticos
CO6270217A2 (es) Formulaciones galenicas de alisquireno y valsartan
MX347927B (es) Vitamina c y vitamina k libre de cromo, y composiciones de estas para tratar un estado o enfermedad en las que interviene nfkb.
ECSP10010553A (es) Uso de dronedarona o una sal aceptable farmaceuticamente de esta, para la preparacion de un medicamento para regular el nivel de potasio en la sangre
MA33563B1 (fr) 5-(3,4-dichloro-phényl)-n-(2-hydroxy-cyclohexyl)-6-(2,2,2-trifluoro-éthoxy)-nicotinamide et ses sels utilisés comme agents augmentant le cholestérol hdl
AR080256A1 (es) Formulaciones farmaceuticas solidas de ramipril y besilato de amlodipino y su preparacion
AR048958A1 (es) Medicamento en forma de pelicula para administracion por via oral, que contiene estriol
GT201000064A (es) Formulaciones galénicas de alisquireno
AR074246A1 (es) Derivados de 1-amino-alquilciclohexano para el tratamiento de trastornos del sueno
CL2008002465A1 (es) Composición farmacéutica anhidra tópica, que comprende derivados de niacina y un portador aceptable, su aplicacón permite un bienestar sexual mejorado.
ATE474558T1 (de) Pharmazeutische formulierungen mit irbesartan

Legal Events

Date Code Title Description
FC Refusal