PE20090733A1 - Derivados de pirazina como bloqueadores de los canales de sodio epitelial - Google Patents
Derivados de pirazina como bloqueadores de los canales de sodio epitelialInfo
- Publication number
- PE20090733A1 PE20090733A1 PE2008000782A PE2008000782A PE20090733A1 PE 20090733 A1 PE20090733 A1 PE 20090733A1 PE 2008000782 A PE2008000782 A PE 2008000782A PE 2008000782 A PE2008000782 A PE 2008000782A PE 20090733 A1 PE20090733 A1 PE 20090733A1
- Authority
- PE
- Peru
- Prior art keywords
- bis
- diil
- azan
- methylen
- alkyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
REFERIDA A UN COMPUESTO DERIVADO DE PIRAZINA DE FORMULA (I), DONDE M1 Y M2 SON UNA ESTRUCTURA DE FORMULA (a); R1, R2, R3 Y R4 SON H, ALQUILO C1-C8, HALOALQUILO C1-C8, ALCOXILO C1-C8, ENTRE OTROS; T ES H, HALOGENO, ALQUILO C1-C8, HALOALCOXILO C1-C8, ENTRE OTROS; L1 Y L2 SE SELECCIONAN DE (i) y (ii); R5, R5a Y R6 SON H, ALQUILO C1-C8, CN, ENTRE OTROS; W1 Y W2 SON ALQUILENO C2-C8; X1 Y X2 SON UN GRUPO HETEROCICLICO DE 4 A 14 MIEMBROS; Y1 Y Y2 SON ALQUILENO C0-C8 O ALQUILO C1-C8-AMINO; A ES UN GRUPO CARBOCICLICO AROMATICO DE 6 A 15 MIEMBROS, -C(=O), -CO-(ALQUILENO C1-C8)-CO-, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: N,N-(1,1'-(1,4-FENILEN-BIS-(METILEN))-BIS-(AZAN-DIIL)-BIS-(OXO-METILEN)-BIS-(PIPERIDIN-4,1-DIIL))-BIS-(AZAN-DIIL)-BIS-(IMINO-METILEN)-BIS-(3,5-DIAMINO-6-CLORO-PIRAZIN-2-CARBOXAMIDA), N,N-(1,1'-(1,4-FENILEN-BIS-(AZAN-DIIL))-BIS-(OXO-METILEN)-BIS-(PIPERIDIN-4,1-DIIL))-BIS-(AZAN-DIIL)-BIS-(IMINO-METILEN)-BIS-(3,5-DIAMINO-6-CLORO-PIRAZIN-2-CARBOXAMIDA), N,N-(1,1'-(CILOHEXAN-1,3-DIIL-BIS-(METILEN))-BIS-(AZAN-DIIL)-BIS-(OXO-METILEN)-BIS-(PIPERIDIN-4,1-DIIL))-BIS-(AZAN-DIIL)-BIS-(IMINO-METILEN)-BIS-(3,5-DIAMINO-6-CLORO-PIRAZIN-2-CARBOXAMIDA), ENTRE OTROS. TAMBIEN ESTA REFERIDA A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON BLOQUEADORES DEL CANAL DE SODIO EPITELIAL (ENaC) Y SON UTILES EN EL TRATAMIENTO DE FIBROSIS QUISTICA, DISQUINESIA CILIAR PRIMARIA, BROQUITIS CRONICA, CARCINOMA PULMONAR, ENTRE OTROS
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07107654 | 2007-05-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20090733A1 true PE20090733A1 (es) | 2009-07-17 |
Family
ID=38581916
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2008000782A PE20090733A1 (es) | 2007-05-07 | 2008-05-05 | Derivados de pirazina como bloqueadores de los canales de sodio epitelial |
Country Status (32)
Country | Link |
---|---|
US (1) | US8318935B2 (es) |
EP (2) | EP2155721B1 (es) |
JP (1) | JP5244904B2 (es) |
KR (1) | KR20100005730A (es) |
CN (1) | CN101687851B (es) |
AR (1) | AR066458A1 (es) |
AT (1) | ATE499363T1 (es) |
AU (1) | AU2008248598B2 (es) |
BR (1) | BRPI0811562A2 (es) |
CA (1) | CA2685546A1 (es) |
CL (1) | CL2008001301A1 (es) |
CO (1) | CO6290667A2 (es) |
CR (1) | CR11091A (es) |
DE (1) | DE602008005140D1 (es) |
EA (1) | EA200901489A1 (es) |
EC (1) | ECSP099718A (es) |
ES (1) | ES2361595T3 (es) |
GT (1) | GT200900289A (es) |
HK (1) | HK1141285A1 (es) |
HN (1) | HN2009003214A (es) |
IL (1) | IL201828A0 (es) |
MA (1) | MA31400B1 (es) |
MX (1) | MX2009012077A (es) |
NZ (1) | NZ580737A (es) |
PE (1) | PE20090733A1 (es) |
PL (1) | PL2155721T3 (es) |
PT (1) | PT2155721E (es) |
SV (1) | SV2009003406A (es) |
TN (1) | TN2009000469A1 (es) |
TW (1) | TWI351402B (es) |
WO (1) | WO2008135557A1 (es) |
ZA (1) | ZA200907491B (es) |
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US8759349B2 (en) * | 2011-11-02 | 2014-06-24 | Boehringer Ingelheim International Gmbh | Heterocyclic compounds, medicaments containing said compounds, use thereof and processes for the preparation thereof |
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US8841309B2 (en) | 2012-09-24 | 2014-09-23 | Boehringer Ingelheim International Gmbh | Substituted pyrazines and their use in the treatment of disease |
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