PE20090314A1 - DERIVADOS DE OXAZOLIDINONA COMO AGENTES INHIBIDORES DE LA TROMBINA Y EL FACTOR Xa - Google Patents

DERIVADOS DE OXAZOLIDINONA COMO AGENTES INHIBIDORES DE LA TROMBINA Y EL FACTOR Xa

Info

Publication number
PE20090314A1
PE20090314A1 PE2008000979A PE2008000979A PE20090314A1 PE 20090314 A1 PE20090314 A1 PE 20090314A1 PE 2008000979 A PE2008000979 A PE 2008000979A PE 2008000979 A PE2008000979 A PE 2008000979A PE 20090314 A1 PE20090314 A1 PE 20090314A1
Authority
PE
Peru
Prior art keywords
thrombin
factor
inhibiting agents
oxazolidinone derivatives
prophylaxis
Prior art date
Application number
PE2008000979A
Other languages
English (en)
Inventor
Swen Allerheiligen
Marcus Bauser
Hartmut Schirok
Ulrich Rester
Stefan Heitmeier
Christoph Gerdes
Georges Degenfeld
Elke Dittrich-Wengenroth
Uwe Saatmann
Julia Strassburger
Klaus Munter
Mark Jean Gnoth
Dieter Lang
Original Assignee
Bayer Healthcare Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39720731&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20090314(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Healthcare Ag filed Critical Bayer Healthcare Ag
Publication of PE20090314A1 publication Critical patent/PE20090314A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Steroid Compounds (AREA)

Abstract

REFERIDA A UN DERIVADO DE OXAZOLIDINONA DE FORMULA (I), DONDE n ES UN ENTERO DE 0 A 3; R1 ES CLORO, TRIFLUOROMETOXI, METILO, ETILO, n-PROPILO, METOXI, METOXIMETILO O ETOXIMETILO; R2 ES H O METILO. SON COMPUESTOS PREFERIDOS: 5-CLORO-N-[((5S)-3-{4-[3-(HIDROXIMETIL)-2-OXOPIRIDIN-1(2H)-IL]-3-METILFENIL}-2-OXO-1,3-OXAZOLIDIN-5-IL)METIL]TIOFENO-2-CARBOXAMIDA, 5-CLORO-N-[((5S)-3-{4-[3-(2-HIDROXIETIL)-2-OXOPIRIDIN-1(2H)-IL]-3-METILFENIL}-2-OXO-1,3-OXAZOLIDIN-5-IL)METIL]TIOFENO-2-CARBOXAMIDA, 5-CLORO-N-[((5S)-3-{4-[3-(3-HIDROXIETIL)-2-OXOPIRIDIN-1(2H)-IL]-3-METILFENIL}-2-OXO-1,3-OXAZOLIDIN-5-IL)METIL]TIOFENO-2-CARBOXAMIDA. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS INHIBEN LA TROMBINA Y EL FACTOR Xa Y SON UTILES EN EL TRATAMIENTO DE ENFERMEDADES TROMBOEMBOLICAS
PE2008000979A 2007-06-20 2008-06-10 DERIVADOS DE OXAZOLIDINONA COMO AGENTES INHIBIDORES DE LA TROMBINA Y EL FACTOR Xa PE20090314A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102007028407A DE102007028407A1 (de) 2007-06-20 2007-06-20 Substituierte Oxazolidinone und ihre Verwendung

Publications (1)

Publication Number Publication Date
PE20090314A1 true PE20090314A1 (es) 2009-04-09

Family

ID=39720731

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008000979A PE20090314A1 (es) 2007-06-20 2008-06-10 DERIVADOS DE OXAZOLIDINONA COMO AGENTES INHIBIDORES DE LA TROMBINA Y EL FACTOR Xa

Country Status (20)

Country Link
US (1) US8487111B2 (es)
EP (1) EP2173744B1 (es)
JP (1) JP5537422B2 (es)
KR (1) KR20100022988A (es)
CN (1) CN101743244B (es)
AT (1) ATE527256T1 (es)
AU (1) AU2008266526B2 (es)
CA (1) CA2692169C (es)
CL (1) CL2008001690A1 (es)
DE (1) DE102007028407A1 (es)
ES (1) ES2373500T3 (es)
HK (1) HK1144574A1 (es)
IL (1) IL202206A0 (es)
MX (1) MX2009013709A (es)
PE (1) PE20090314A1 (es)
RU (1) RU2481344C2 (es)
TW (1) TWI407958B (es)
UY (1) UY31131A1 (es)
WO (1) WO2008155033A1 (es)
ZA (1) ZA200908583B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
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DE102006039589A1 (de) * 2006-08-24 2008-03-06 Bayer Healthcare Ag Aminoacyl-Prodrugs II
DE102007028319A1 (de) * 2007-06-20 2008-12-24 Bayer Healthcare Ag Substituierte Oxazolidinone und ihre Verwendung
DE102010028362A1 (de) 2010-04-29 2011-11-03 Bayer Schering Pharma Aktiengesellschaft Herstellverfahren
CN102464658B (zh) * 2010-11-03 2014-04-16 天津药物研究院 噁唑烷酮衍生物及其制备方法和用途
WO2014183667A1 (zh) * 2013-05-17 2014-11-20 天津药物研究院 一种噁唑烷酮衍生物的乙酸溶剂化物及其制备方法和用途

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Also Published As

Publication number Publication date
TWI407958B (zh) 2013-09-11
CA2692169C (en) 2015-04-14
CL2008001690A1 (es) 2008-12-26
CA2692169A1 (en) 2008-12-24
JP5537422B2 (ja) 2014-07-02
DE102007028407A1 (de) 2008-12-24
EP2173744A1 (de) 2010-04-14
UY31131A1 (es) 2009-01-30
MX2009013709A (es) 2010-02-01
WO2008155033A1 (de) 2008-12-24
ZA200908583B (en) 2011-02-23
IL202206A0 (en) 2010-06-16
JP2010530384A (ja) 2010-09-09
US20100261759A1 (en) 2010-10-14
ES2373500T3 (es) 2012-02-06
AU2008266526B2 (en) 2013-08-22
ATE527256T1 (de) 2011-10-15
RU2010101303A (ru) 2011-07-27
US8487111B2 (en) 2013-07-16
CN101743244B (zh) 2013-08-21
KR20100022988A (ko) 2010-03-03
CN101743244A (zh) 2010-06-16
TW200911246A (en) 2009-03-16
RU2481344C2 (ru) 2013-05-10
EP2173744B1 (de) 2011-10-05
AU2008266526A1 (en) 2008-12-24
HK1144574A1 (en) 2011-02-25

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