BRPI0517734A - derivados de 1-[(6,7-alcoxiquinoxalinil substituìdo) aminocarbonil]-4- (hetero) arilpiperazina - Google Patents

derivados de 1-[(6,7-alcoxiquinoxalinil substituìdo) aminocarbonil]-4- (hetero) arilpiperazina

Info

Publication number
BRPI0517734A
BRPI0517734A BRPI0517734-0A BRPI0517734A BRPI0517734A BR PI0517734 A BRPI0517734 A BR PI0517734A BR PI0517734 A BRPI0517734 A BR PI0517734A BR PI0517734 A BRPI0517734 A BR PI0517734A
Authority
BR
Brazil
Prior art keywords
aminocarbonyl
hetero
arylpiperazine derivatives
alkoxyquinoxalinyl
substituted
Prior art date
Application number
BRPI0517734-0A
Other languages
English (en)
Inventor
Young-Dae Gong
Moon-Kook Jeon
Dong-Su Kim
Jae Yang Kong
Gun-Do Kim
Chang-Ho Ahn
Young Bok Lee
Original Assignee
Korea Res Inst Chem Tech
Rexahn Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36407350&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0517734(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from KR1020040094233A external-priority patent/KR100739233B1/ko
Priority claimed from KR1020040094232A external-priority patent/KR20060053788A/ko
Application filed by Korea Res Inst Chem Tech, Rexahn Pharmaceuticals Inc filed Critical Korea Res Inst Chem Tech
Publication of BRPI0517734A publication Critical patent/BRPI0517734A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40—Benzopyrazines
    • C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

DERIVADOS DE 1- ¢(6,7 -ALCOXIQUINOXALINIL SUBSTITUIDO) AMINOCARBONIL! -4- (HETERO) ARILPIPERAZINA. A presente invenção relaciona-se a novos compostos de quinoxalina-piperazina, derivados de 1-11(6,7-alcoxiquinoxalinil substituído) aminocarbonil! -4- (hetero) arilpiperazina e seus sais farmaceuticamente aceitáveis, um processo para sua preparação e composições que contêm tais compostos. Métodos terapêuticos para o tratamento de distúrbios hiperproliferativos, incluindo cânceres, por administração de compostos de quinoxalinapiperazina são também incluídos.
BRPI0517734-0A 2004-11-17 2005-10-18 derivados de 1-[(6,7-alcoxiquinoxalinil substituìdo) aminocarbonil]-4- (hetero) arilpiperazina BRPI0517734A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR1020040094233A KR100739233B1 (ko) 2004-11-17 2004-11-17 1-[(3-알콕시-6-치환-퀴녹살린-2-일)아미노카르보닐]-4-(헤테로)아릴피페라진 유도체
KR1020040094232A KR20060053788A (ko) 2004-11-17 2004-11-17 1-[(2-알콕시-6-치환-퀴녹살린-3-일)아미노카르보닐]-4-(헤테로)아릴피페라진 유도체
PCT/KR2005/003463 WO2006054830A1 (en) 2004-11-17 2005-10-18 1-[(6,7-substituted alkoxyquinoxalinyl)aminocarbonyl]-4-(hetero)arylpiperazine derivatives

Publications (1)

Publication Number Publication Date
BRPI0517734A true BRPI0517734A (pt) 2008-10-21

Family

ID=36407350

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0517734-0A BRPI0517734A (pt) 2004-11-17 2005-10-18 derivados de 1-[(6,7-alcoxiquinoxalinil substituìdo) aminocarbonil]-4- (hetero) arilpiperazina

Country Status (12)

Country Link
US (2) US8314100B2 (pt)
EP (1) EP1819698B1 (pt)
JP (1) JP6097946B2 (pt)
CN (1) CN103524436B (pt)
AT (1) ATE499366T1 (pt)
AU (1) AU2005307209B2 (pt)
BR (1) BRPI0517734A (pt)
CA (1) CA2587891C (pt)
DE (1) DE602005026557D1 (pt)
MX (1) MX2007005863A (pt)
PL (1) PL1819698T3 (pt)
WO (1) WO2006054830A1 (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1819698B1 (en) 2004-11-17 2011-02-23 Rexahn Pharmaceuticals, Inc. 1-[(6-substituted alkoxyquinoxalinyl)aminocarbonyl]-4-(hetero)arylpiperazine derivatives
KR101140133B1 (ko) 2010-02-17 2012-05-02 한국화학연구원 1-(6,7-다이플루오르-3-메톡시퀴녹살린-2-일)-3-［1-(헤테로아릴메틸)피페리딘-4-일］ 우레아 유도체, 그 제조방법 및 그의 용도
US9744167B2 (en) 2013-06-28 2017-08-29 Rexahn Pharmaceuticals, Inc. Nanoparticulate compositions and formulations of piperazine compounds
HUE046316T2 (hu) 2014-12-08 2020-02-28 Lsk Nrdo Co Ltd Új 4- (aril) -N- (2-alkoxi-tieno [3,2-B] pirazin-3-il) -piperazin-1-karboxamid-származék és annak antiproliferatív hatása
JP2018526392A (ja) * 2015-09-04 2018-09-13 レクサン ファーマシューティカルズ インコーポレイテッド キノキサリニル−ピペラジンアミドの使用方法
WO2017213452A1 (ko) * 2016-06-09 2017-12-14 동국대학교 산학협력단 신규한 4-(아릴)-n-(3-알콕시퓨로[2,3-b]피라진-2-일)-피페라진-1-카복스아미드 유도체 및 이의 항증식 효과
KR101872645B1 (ko) * 2016-06-09 2018-08-03 동국대학교 산학협력단 신규한 4-(아릴)-N-(3-알콕시퓨로[2,3-b]피라진-2-일)-피페라진-1-카복스아미드 유도체 및 이의 항증식 효과

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2448541A1 (fr) * 1979-02-09 1980-09-05 Roussel Uclaf Nouveaux derives de l'oxoimidazoquinoxaline et leurs sels, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant
IL59104A (en) * 1979-02-09 1984-02-29 Roussel Uclaf Heterotricyclic derivatives,process for their preparation and pharmaceutical compositions incorporating them
US6071697A (en) * 1992-08-03 2000-06-06 Max-Planck Gesellschaft Zur Forderung Der Wissenschaften E.V. Method for testing the differentiation status in pancreatic cells of a mammal
ATE241600T1 (de) * 1996-06-29 2003-06-15 Samjin Pharm Co Ltd Piperazin-derivate und verfahren zu ihrer herstellung
EP1424072A1 (en) * 1999-03-03 2004-06-02 Samjin Pharmaceutical Co., Ltd. N'-(pyridin-3-yl)-(4-phenylpiperazin-1-yl)-carboxyimidamide and -iminothiolate derivatives for the treatment of tumors
WO2001095856A2 (en) * 2000-06-15 2001-12-20 Chaconne Nsi Co., Ltd. Urea derivative useful as an anti-cancer agent and process for preparing same
AR043059A1 (es) * 2002-11-12 2005-07-13 Bayer Pharmaceuticals Corp Derivados de indolil pirazinona utiles para el tratamiento de trastornos hiper-proliferativos
CA2522079A1 (en) * 2003-04-16 2004-11-04 Astrazeneca Ab Quinazoline derivatives for treatment of cancer
EP1819698B1 (en) 2004-11-17 2011-02-23 Rexahn Pharmaceuticals, Inc. 1-[(6-substituted alkoxyquinoxalinyl)aminocarbonyl]-4-(hetero)arylpiperazine derivatives

Also Published As

Publication number Publication date
CN103524436B (zh) 2015-09-23
JP2008520653A (ja) 2008-06-19
EP1819698A1 (en) 2007-08-22
US8314100B2 (en) 2012-11-20
DE602005026557D1 (de) 2011-04-07
ATE499366T1 (de) 2011-03-15
CA2587891A1 (en) 2006-05-26
AU2005307209A1 (en) 2006-05-26
EP1819698B1 (en) 2011-02-23
US20080318963A1 (en) 2008-12-25
MX2007005863A (es) 2007-10-19
WO2006054830A1 (en) 2006-05-26
PL1819698T3 (pl) 2011-08-31
CN103524436A (zh) 2014-01-22
JP6097946B2 (ja) 2017-03-22
US20130053390A1 (en) 2013-02-28
US8598173B2 (en) 2013-12-03
AU2005307209B2 (en) 2009-11-19
CA2587891C (en) 2010-08-31

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements