PE20061316A1 - Derivados de pirazol como antagonistas del receptor de progesterona - Google Patents
Derivados de pirazol como antagonistas del receptor de progesteronaInfo
- Publication number
- PE20061316A1 PE20061316A1 PE2006000409A PE2006000409A PE20061316A1 PE 20061316 A1 PE20061316 A1 PE 20061316A1 PE 2006000409 A PE2006000409 A PE 2006000409A PE 2006000409 A PE2006000409 A PE 2006000409A PE 20061316 A1 PE20061316 A1 PE 20061316A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- receptor antagonists
- progesterone receptor
- oxy
- halo
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/28—Two oxygen or sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE R1 ES H, ALQUILO C1-C6, (ALQUILO C1-C6)-OXI, CICLOALQUILO C3-C8, HALO; R2 ES H, ALQUILO C1-C6 (SUSTITUIDO O NO CON R3), FENILO, HETEROARILO, ENTRE OTROS; R3 ES OH, CN, HETEROARILO, ENTRE OTROS; R8 ES ALQUILO C1-C6, CICLOALQUILO C3-C8, HALO, ENTRE OTROS; R9 Y R10 SON CADA UNO ALQUILO C1-C6, CF3, CN, HALO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 4-{[3,5-DICICLOPROPIL-1-(2-HIDROXIETIL)-1H-PIRAZOL-4-IL]OXI}-2,6-DIMETILBENZONITRILO; 4-{[1-(CIANOMETIL)-3,5-DIETIL-1H-PIRAZOL-4-IL]OXI}BENZONITRILO; 2-[4-(4-CIANOFENOXI)-3,5-DICICLOPROPIL-1H-PIRAZOL-1-IL]-N-METIL-ACETAMIDA; ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON ANTAGONISTAS DEL RECEPTOR DE PROGESTERONA UTILES EN EL TRATAMIENTO DE ENDOMETROSIS Y/O FIBROIDES UTERINOS
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US67354405P | 2005-04-20 | 2005-04-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20061316A1 true PE20061316A1 (es) | 2007-01-13 |
Family
ID=35044974
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2006000409A PE20061316A1 (es) | 2005-04-20 | 2006-04-19 | Derivados de pirazol como antagonistas del receptor de progesterona |
Country Status (12)
Country | Link |
---|---|
US (2) | US7482375B2 (es) |
EP (1) | EP1874732A1 (es) |
JP (1) | JP2008536910A (es) |
AR (1) | AR053587A1 (es) |
CA (1) | CA2604218A1 (es) |
DO (1) | DOP2006000088A (es) |
GT (1) | GT200600155A (es) |
NL (1) | NL1031626C2 (es) |
PE (1) | PE20061316A1 (es) |
TW (1) | TW200716609A (es) |
UY (1) | UY29486A1 (es) |
WO (1) | WO2006111856A1 (es) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK0934061T6 (en) | 1996-07-24 | 2015-01-26 | Warner Lambert Co | Isobutylgaba and its derivatives for the treatment of pain |
WO2008019048A1 (en) * | 2006-08-04 | 2008-02-14 | Meditrina Pharmaceuticals | Use of aromatase inhibitors for thining the endometrium or treating menorrhagia |
US20080096950A1 (en) * | 2006-10-19 | 2008-04-24 | Karl Richard Gibson | Compounds Useful In Therapy |
PE20081803A1 (es) * | 2007-03-09 | 2008-12-11 | Wyeth Corp | Sintesis y caracterizacion de la forma ii polimorfica de 4-(2-(4,4-dimetil-2-oxooxazolidin-3-il)tiazol-4-il)benzonitrilo |
WO2008135824A1 (en) * | 2007-05-02 | 2008-11-13 | Pfizer Limited | Oxyalkylpyrazole compounds useful in therapy |
WO2009075838A2 (en) * | 2007-12-10 | 2009-06-18 | Meditrina Pharmaceuticals, Inc. | Treatment of menorrhagia with aromatase inhibitor |
TW200944506A (en) * | 2008-03-26 | 2009-11-01 | Takeda Pharmaceutical | Substituted pyrazole derivatives and use thereof |
EP2116618A1 (en) * | 2008-05-09 | 2009-11-11 | Agency for Science, Technology And Research | Diagnosis and treatment of Kawasaki disease |
EP2350017A1 (en) * | 2008-09-18 | 2011-08-03 | Pfizer Limited | Amide compounds useful in therapy |
US20150272622A1 (en) | 2011-12-22 | 2015-10-01 | Previvo Genetics, Llc | Recovery and processing of human embryos formed in vivo |
US10328022B2 (en) | 2012-05-31 | 2019-06-25 | Repros Therapeutics Inc. | Formulations and methods for vaginal delivery of antiprogestins |
WO2014070517A1 (en) | 2012-11-02 | 2014-05-08 | Repros Therapeutics Inc. | Methods and compositions for treating progesterone-dependent conditions |
EP2929883A1 (en) | 2014-04-08 | 2015-10-14 | Institut Pasteur | Pyrazole derivatives as dihydroorotate dehydrogenase (DHODH) inhibitors |
US20170037014A1 (en) * | 2014-05-06 | 2017-02-09 | E. I. Du Pont De Nemours And Company | Fungicidal pyrazoles |
CN113559075A (zh) | 2014-11-17 | 2021-10-29 | 康泰科思特生物制药公司 | 奥那司酮延长释放组合物和方法 |
BR112018005999A2 (pt) | 2015-09-25 | 2019-01-08 | Context Biopharma Inc | métodos para a produção de intermediários de onapristona |
AU2016370499B2 (en) | 2015-12-15 | 2022-06-30 | Context Biopharma Inc. | Amorphous onapristone compositions and methods of making the same |
US20180148471A1 (en) | 2016-11-30 | 2018-05-31 | Arno Therapeutics, Inc. | Methods for onapristone synthesis dehydration and deprotection |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3621024C2 (de) * | 1986-06-20 | 1999-10-28 | Schering Ag | 11beta-Phenylestradiene, deren Herstellung und diese enthaltende pharmazeutische Präparate |
EP1377556B1 (en) * | 2001-04-10 | 2007-04-04 | Pfizer Limited | Pyrazole derivatives for treating hiv |
US6933312B2 (en) * | 2002-10-07 | 2005-08-23 | Agouron Pharmaceuticals, Inc. | Pyrazole derivatives |
-
2006
- 2006-04-10 JP JP2008507193A patent/JP2008536910A/ja active Pending
- 2006-04-10 WO PCT/IB2006/001096 patent/WO2006111856A1/en not_active Application Discontinuation
- 2006-04-10 EP EP06744619A patent/EP1874732A1/en not_active Withdrawn
- 2006-04-10 CA CA002604218A patent/CA2604218A1/en not_active Abandoned
- 2006-04-11 DO DO2006000088A patent/DOP2006000088A/es unknown
- 2006-04-18 US US11/408,286 patent/US7482375B2/en not_active Expired - Fee Related
- 2006-04-18 AR ARP060101529A patent/AR053587A1/es unknown
- 2006-04-19 GT GT200600155A patent/GT200600155A/es unknown
- 2006-04-19 TW TW095113963A patent/TW200716609A/zh unknown
- 2006-04-19 PE PE2006000409A patent/PE20061316A1/es not_active Application Discontinuation
- 2006-04-19 UY UY29486A patent/UY29486A1/es not_active Application Discontinuation
- 2006-04-19 NL NL1031626A patent/NL1031626C2/nl not_active IP Right Cessation
-
2008
- 2008-12-12 US US12/333,533 patent/US20090099209A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
GT200600155A (es) | 2007-04-18 |
CA2604218A1 (en) | 2006-10-26 |
NL1031626A1 (nl) | 2006-10-23 |
US20090099209A1 (en) | 2009-04-16 |
US20060241125A1 (en) | 2006-10-26 |
AR053587A1 (es) | 2007-05-09 |
EP1874732A1 (en) | 2008-01-09 |
NL1031626C2 (nl) | 2007-03-19 |
US7482375B2 (en) | 2009-01-27 |
JP2008536910A (ja) | 2008-09-11 |
DOP2006000088A (es) | 2006-10-31 |
TW200716609A (en) | 2007-05-01 |
WO2006111856A1 (en) | 2006-10-26 |
UY29486A1 (es) | 2006-11-30 |
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Legal Events
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FC | Refusal |