PE20061312A1 - Composiciones farmaceuticas que contienen camostato - Google Patents

Composiciones farmaceuticas que contienen camostato

Info

Publication number
PE20061312A1
PE20061312A1 PE2006000388A PE2006000388A PE20061312A1 PE 20061312 A1 PE20061312 A1 PE 20061312A1 PE 2006000388 A PE2006000388 A PE 2006000388A PE 2006000388 A PE2006000388 A PE 2006000388A PE 20061312 A1 PE20061312 A1 PE 20061312A1
Authority
PE
Peru
Prior art keywords
camostate
compositions containing
pharmaceutical compositions
camostat
excipients
Prior art date
Application number
PE2006000388A
Other languages
English (en)
Inventor
Henry Luke Danahay
David C Tully
Silvia Heuerding
Janet Catherine Maas
Jean-Louis Reber
Stephanie Monnier
Juergen Roettele
Dilraj Singh
Jennifer Leslie Harris
Darren Mark Legrand
Original Assignee
Novartis Ag
Irm Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag, Irm Llc filed Critical Novartis Ag
Publication of PE20061312A1 publication Critical patent/PE20061312A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C277/00—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C277/08—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups of substituted guanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/18—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE REFIERE A COMPOSICIONES FARMACEUTICAS QUE CONTIENEN: A) UNA SAL DE CAMOSTATO SELECCIONADO ENTRE SUCCINATO ACIDO DE CAMOSTATO, HIPURATO DE CAMOSTATO, ACETATO DE CAMOSTATO, ADIPATO DE CAMOSTATO, ENTRE OTROS; B) EXCIPIENTES FARMACEUTICAMENTE ACEPTABLES. DICHA COMPOSICION FARMACEUTICA ES DE FORMA LIOFILIZADA O DE NEBULIZADOR QUE ADEMAS COMPRENDE EXCIPIENTES ENMASCARADORES DE SABOR TALES COMO ASPARTAME, MENTOL Y POLIALCOHOLES, REGULADORES DE pH Y DE LA TONICIDAD, AGENTES QUELANTES, TENSOACTIVOS, ENTRE OTROS. LAS FORMULACIONES SON INHIBIDORES DE PROTEASA ACTIVADORA DE CANAL (CAP) UTILES EN EL TRATAMIENTO DE FIBROSIS QUISTICA Y ENFERMEDAD PULMONAR OBSTRUCTIVA CRONICA
PE2006000388A 2005-04-14 2006-04-12 Composiciones farmaceuticas que contienen camostato PE20061312A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0507577.5A GB0507577D0 (en) 2005-04-14 2005-04-14 Organic compounds

Publications (1)

Publication Number Publication Date
PE20061312A1 true PE20061312A1 (es) 2006-12-28

Family

ID=34611136

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006000388A PE20061312A1 (es) 2005-04-14 2006-04-12 Composiciones farmaceuticas que contienen camostato

Country Status (19)

Country Link
US (2) US20090203777A1 (es)
EP (3) EP2253612A1 (es)
JP (1) JP2008537750A (es)
KR (1) KR20070118257A (es)
CN (1) CN101160284A (es)
AR (1) AR053217A1 (es)
AU (1) AU2006233691B2 (es)
BR (1) BRPI0610551A2 (es)
CA (1) CA2601990A1 (es)
ES (1) ES2388683T3 (es)
GB (1) GB0507577D0 (es)
GT (1) GT200600139A (es)
MX (1) MX2007012700A (es)
PE (1) PE20061312A1 (es)
PL (1) PL1874726T3 (es)
PT (1) PT1874726E (es)
RU (1) RU2007141768A (es)
TW (1) TW200720236A (es)
WO (1) WO2006108643A2 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0016441D0 (en) * 2000-07-04 2000-08-23 Pharmagene Lab Limited Therapeutic method
AU2007253819B2 (en) 2006-05-23 2011-02-17 Irm Llc Compounds and compositions as channel activating protease inhibitors
EP2104535B9 (en) * 2007-01-10 2011-06-15 Irm Llc Compounds and compositions as channel activating protease inhibitors
GB2445920A (en) * 2007-01-25 2008-07-30 Mucokinetica Ltd Amidino compounds for treatment of respiratory disease
US8293915B2 (en) 2007-02-09 2012-10-23 Irm Llc Compounds and compositions as channel activating protease inhibitors
GB0808690D0 (en) * 2007-05-17 2008-06-18 Serentis Ltd Therapeutic use
EP2138178A1 (en) * 2008-06-28 2009-12-30 Bayer Schering Pharma Aktiengesellschaft Oxazolidninones for the treatment fo chronic obstructive pulmonary disease (COPD) and/or asthma
SG10201501349VA (en) 2010-02-25 2015-04-29 Bristol Myers Squibb Co Apixaban formulations
RU2657523C2 (ru) * 2011-11-03 2018-06-14 Олег Петрович Жирнов Фармацевтический аэрозольный состав ингибиторов протеаз с озон-сберегающим пропеллентом и его получение
JP2014074019A (ja) * 2012-09-11 2014-04-24 Daiichi Sankyo Healthcare Co Ltd 抗ロタウイルス剤
RU2019101889A (ru) 2013-03-15 2019-03-28 Версеон Корпорейшн Полизамещенные ароматические соединения в качестве ингибиторов сериновых протеаз
CN105209440B (zh) 2013-03-15 2019-07-23 维颂公司 作为凝血酶抑制剂的卤代吡唑
CN106687445A (zh) 2014-09-17 2017-05-17 维颂公司 作为丝氨酸蛋白酶抑制剂的吡唑基取代的吡啶酮化合物
EP3261639B1 (en) 2015-02-27 2022-08-24 Verseon International Corporation Substituted pyrazole compounds as serine protease inhibitors
US20230165826A1 (en) * 2020-03-18 2023-06-01 Memorial Sloan Kettering Cancer Center Inhalational therapy for covid-19
US20230218644A1 (en) 2020-04-16 2023-07-13 Som Innovation Biotech, S.A. Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus
IT202000014350A1 (it) * 2020-06-16 2021-12-16 Andrea Alimonti NUOVO APPROCCIO FARMACOLOGICO PER IL TRATTAMENTO DI SARS-CoV2 E VIRUS INFLUENZALI TRAMITE L’USO DI SPRAY NASALI
KR102664833B1 (ko) * 2020-09-24 2024-05-14 충북대학교 산학협력단 나파모스타트 또는 카모스타트를 포함하는 흡입용 제제
WO2022065860A1 (ko) * 2020-09-24 2022-03-31 충북대학교 산학협력단 나파모스타트 또는 카모스타트를 포함하는 흡입용 제제

Family Cites Families (186)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19706229A1 (de) 1997-02-18 1998-08-20 Boehringer Ingelheim Pharma Disubstituierte bicyclische Heterocyclen, ihre Herstellung und ihre Verwendung als Arzneimittel
GB1219606A (en) 1968-07-15 1971-01-20 Rech S Et D Applic Scient Soge Quinuclidinol derivatives and preparation thereof
GB1472700A (en) * 1974-11-01 1977-05-04 Ono Pharmaceutical Co Guanidinobehzoic acid derivatives and process for preparing the same
JPS57144224A (en) * 1981-03-02 1982-09-06 Mochida Pharmaceut Co Ltd Remedy for respiratory dieseases
ZA86746B (en) 1985-02-04 1986-09-24 Merrell Dow Pharma Novel peptidase inhibitors
JPS6235216A (ja) 1985-08-09 1987-02-16 Noritoshi Nakabachi 不均質物質層の層厚非破壊測定方法および装置
AU598750B2 (en) 1985-09-27 1990-07-05 Mitsubishi Chemical Corporation Phenylalanine derivative and proteinase inhibitor
JPH02243624A (ja) * 1988-07-11 1990-09-27 Banyu Pharmaceut Co Ltd 抗ウイルス剤
US4990537A (en) * 1988-07-11 1991-02-05 Banyu Pharmaceutical Co., Ltd. Anti influenza agent
JPH02289598A (ja) 1989-04-28 1990-11-29 Yamanouchi Pharmaceut Co Ltd Ｍｓ―１１４４物質
US5196404B1 (en) 1989-08-18 1996-09-10 Biogen Inc Inhibitors of thrombin
GB8923590D0 (en) 1989-10-19 1989-12-06 Pfizer Ltd Antimuscarinic bronchodilators
US5037819A (en) 1990-06-04 1991-08-06 Bristol-Myers Squibb Company Azetidin-2-one derivatives as serine protease inhibitors
US6060451A (en) 1990-06-15 2000-05-09 The National Research Council Of Canada Thrombin inhibitors based on the amino acid sequence of hirudin
GB9017694D0 (en) 1990-08-13 1990-09-26 Sandoz Ltd Improvements in or relating to organic chemistry
IL99527A (en) 1990-09-28 1997-08-14 Lilly Co Eli Tripeptide antithrombotic agents
US5468727A (en) * 1990-12-13 1995-11-21 Board Of Regents, The University Of Texas System Methods of normalizing metabolic parameters in diabetics
PT100441A (pt) 1991-05-02 1993-09-30 Smithkline Beecham Corp Pirrolidinonas, seu processo de preparacao, composicoes farmaceuticas que as contem e uso
DE4115468A1 (de) 1991-05-11 1992-11-12 Behringwerke Ag Amidinophenylalaninderivate, verfahren zu deren herstellung, deren verwendung und diese enthaltende mittel als antikoagulantien
JPH0525045A (ja) 1991-07-18 1993-02-02 Tanabe Seiyaku Co Ltd 経皮吸収製剤
SE9103612D0 (sv) 1991-12-04 1991-12-04 Astra Ab New peptide derivatives
JPH05213927A (ja) 1992-02-10 1993-08-24 Torii Yakuhin Kk 新規フランカルボン酸アミジノナフチルエステル誘導体およびその酸付加塩
TW223629B (es) 1992-03-06 1994-05-11 Hoffmann La Roche
WO1993018007A1 (en) 1992-03-13 1993-09-16 Tokyo Tanabe Company Limited Novel carbostyril derivative
WO1993019749A1 (en) 1992-04-02 1993-10-14 Smithkline Beecham Corporation Compounds useful for treating allergic and inflammatory diseases
JP3192424B2 (ja) 1992-04-02 2001-07-30 スミスクライン・ビーチャム・コーポレイション アレルギーまたは炎症疾患の治療用化合物
WO1993019751A1 (en) 1992-04-02 1993-10-14 Smithkline Beecham Corporation Compounds useful for treating inflammatory diseases and inhibiting production of tumor necrosis factor
US5432178A (en) 1992-09-18 1995-07-11 Ono Pharmaceutical Co., Ltd. Amidinophenol derivatives
FR2701951B1 (fr) 1993-02-24 1995-06-09 Adir Nouveaux derives peptidiques de l'acide boronique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
SK282537B6 (sk) 1993-03-12 2002-10-08 Axys Pharmaceuticals, Inc. Inhibítor tryptázy alebo jeho farmaceuticky prijateľná soľ, farmaceutický prostriedok s jeho obsahom a jeho použitie
JPH06340619A (ja) * 1993-05-03 1994-12-13 Bristol Myers Squibb Co グアニジニルまたはアミジニル置換メチルアミノ複素環トロンビン抑制剤
GB9322976D0 (en) 1993-11-08 1994-01-05 Pfizer Ltd Therapeutic agents
US5550139A (en) * 1994-01-03 1996-08-27 The Wichita State University Serine protease inhibitors
US5561146A (en) 1994-06-10 1996-10-01 Bristol-Myers Squibb Company Modified guanidino and amidino thrombin inhibitors
FR2721611B1 (fr) 1994-06-22 1996-09-27 Adir Nouveaux dérivés peptidiques de l'acide boronique, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent .
JPH0820570A (ja) 1994-07-06 1996-01-23 Teikoku Chem Ind Corp Ltd アルファ置換プロピオン酸エステル化合物
JPH0820597A (ja) 1994-07-07 1996-01-23 Meiji Seika Kaisha Ltd トロンビン阻害作用を有する複素環カルボニル化合物
US5510369A (en) 1994-07-22 1996-04-23 Merck & Co., Inc. Pyrrolidine thrombin inhibitors
GB9505538D0 (en) 1995-03-18 1995-05-03 Ciba Geigy Ag New compounds
KR0173034B1 (ko) 1995-04-28 1999-03-30 성재갑 선택적 트롬빈 억제제
JPH08333287A (ja) 1995-06-02 1996-12-17 Fuji Yakuhin Kogyo Kk 芳香環置換アルキルカルボン酸及びアルカノール誘導体とそれらを含有する抗血栓剤
US6022861A (en) 1995-06-07 2000-02-08 Cor Therapeutics, Inc. Ketoheterocyclic inhibitors of factor Xa
US5523308A (en) 1995-06-07 1996-06-04 Costanzo; Michael J. Peptidyl heterocycles useful in the treatment of thrombin related disorders
US6211154B1 (en) 1995-06-07 2001-04-03 Cor Therapeutics, Inc. Ketoheterocyclic inhibitors of factor Xa
WO1997001338A1 (en) 1995-06-27 1997-01-16 Merck & Co., Inc. Pyridinone-thrombin inhibitors
IT1277405B1 (it) 1995-08-01 1997-11-10 Menarini Farma Ind Derivati di lattami biciclici come inibitori della trombina
WO1997025033A1 (en) 1995-10-31 1997-07-17 Eli Lilly And Company Antithrombotic diamines
GB9522495D0 (en) 1995-11-02 1996-01-03 Pfizer Ltd Therapeutic agents
FR2745288B1 (fr) 1996-02-27 1998-04-17 Adir Nouveaux derives de l'acide boronique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
DE69736777T2 (de) 1996-03-29 2007-08-23 Ortho-Mcneil Pharmaceutical, Inc. Amidinohydrazone als protease-inhibitoren
EP0893437A4 (en) * 1996-04-10 2000-12-27 Ono Pharmaceutical Co GUANIDINO TRYPTASE INHIBITOR
DE69709727T2 (de) 1996-04-23 2002-08-08 Merck & Co Inc Parazinon thrombin inhibitoren
GB2312674A (en) * 1996-05-02 1997-11-05 Ciba Geigy Ag Tetrahydroquinoline inhibitors of trypsin and thrombin
JPH09309873A (ja) * 1996-05-22 1997-12-02 Jiyunsei Kagaku Kk メシル酸カモスタットの新規な製造法
KR100469028B1 (ko) 1996-05-31 2005-07-07 주식회사 씨앤드씨신약연구소 선택적트롬빈억제제로유용한방향족아미딘유도체
GB9611461D0 (en) 1996-06-01 1996-08-07 Ciba Geigy Ag New compounds
EP0960102A1 (en) 1996-07-08 1999-12-01 Du Pont Pharmaceuticals Company AMIDINOINDOLES, AMIDINOAZOLES, AND ANALOGS THEREOF AS INHIBITORS OF FACTOR Xa AND OF THROMBIN
IL121474A0 (en) 1996-08-23 1998-02-08 Akzo Nobel Nv Thrombin inhibitors
GB9622386D0 (en) 1996-10-28 1997-01-08 Sandoz Ltd Organic compounds
TW499412B (en) 1996-11-26 2002-08-21 Dimensional Pharm Inc Aminoguanidines and alkoxyguanidines as protease inhibitors
WO1998042342A1 (en) 1997-03-24 1998-10-01 Merck & Co., Inc. Thrombin inhibitors
IL123986A (en) 1997-04-24 2011-10-31 Organon Nv Medicinal compounds
US6166037A (en) 1997-08-28 2000-12-26 Merck & Co., Inc. Pyrrolidine and piperidine modulators of chemokine receptor activity
EP1017383A4 (en) 1997-09-23 2001-11-28 Merck & Co Inc THROMBIN INHIBITORS
WO1999016766A1 (fr) 1997-10-01 1999-04-08 Kyowa Hakko Kogyo Co., Ltd. Derives de benzodioxole
FR2773804B1 (fr) 1998-01-19 2000-02-18 Sanofi Sa Polysaccharides de synthese, procede pour leur preparation et compositions pharmaceutiques le contenant
US6541669B1 (en) 1998-06-08 2003-04-01 Theravance, Inc. β2-adrenergic receptor agonists
ID26614A (id) 1998-06-17 2001-01-25 Akzo Nobel Nv Senyawa-senyawa antithrombotik
DE69827673T2 (de) 1998-06-30 2005-04-21 Dow Global Technologies Inc Polymerpolyole und ein verfahren zu ihrer darstellung
DE19829964A1 (de) 1998-07-04 2000-01-05 Boehringer Ingelheim Pharma Benzimidazole, deren Herstellung und deren Verwendung als Arzneimittel
TWI248435B (en) 1998-07-04 2006-02-01 Boehringer Ingelheim Pharma Benzimidazoles, the preparation thereof and their use as pharmaceutical compositions
WO2000018762A1 (en) 1998-09-28 2000-04-06 Merck & Co., Inc. Thrombin inhibitors
KR20000047461A (ko) 1998-12-29 2000-07-25 성재갑 트롬빈 억제제
CZ20012722A3 (cs) 1999-01-27 2002-08-14 Ortho-Mcneil Pharmaceutical, Inc. Peptidylové heterocyklické ketony pouľitelné jako inhibitory typtasy
KR20000060566A (ko) 1999-03-17 2000-10-16 이경하 치환된 방향족 아미딘 유도체 및 이를 함유하는 의약조성물
GB9913083D0 (en) 1999-06-04 1999-08-04 Novartis Ag Organic compounds
RU2299206C9 (ru) 1999-05-04 2007-11-20 Шеринг Корпорейшн Производные пиперазина, фармацевтические композиции, их содержащие, и применение в качестве антагонистов ccr5
DK1175402T3 (da) 1999-05-04 2005-11-21 Schering Corp Piperidinderivater, der er nyttige som CCR5-antagonister
US6683115B2 (en) 1999-06-02 2004-01-27 Theravance, Inc. β2-adrenergic receptor agonists
UA58636C2 (uk) 1999-06-04 2003-08-15 Мерк Енд Ко., Інк. Піразинонові інгібітори тромбіну, фармацевтична композиція, спосіб інгібування утворення тромбів у крові, спосіб лікування станів, пов'язаних із тромбоутворенням
ES2165768B1 (es) 1999-07-14 2003-04-01 Almirall Prodesfarma Sa Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen.
US6294648B1 (en) * 1999-07-20 2001-09-25 Bayer Corporation Protein having proteinase inhibitor activity
IL147688A0 (en) 1999-08-21 2002-08-14 Byk Gulden Lomberg Chem Fab Synergistic combination
CA2384763A1 (en) * 1999-09-14 2001-03-22 Byk Gulden Lomberg Chemische Fabrik Gmbh Tryptase inhibitors
GB9923710D0 (en) * 1999-10-08 1999-12-08 Proteus Molecular Design Chemical compounds
WO2001038323A1 (en) 1999-11-23 2001-05-31 Merck & Co., Inc. Pyrazinone thrombin inhibitors
OA11558A (en) 1999-12-08 2004-06-03 Advanced Medicine Inc Beta 2-adrenergic receptor agonists.
AU783217B2 (en) * 1999-12-20 2005-10-06 Altana Pharma Ag Tryptase inhibitors
US6815557B2 (en) * 1999-12-20 2004-11-09 Altana Pharma Ag Tryptase inhibitors
FR2806722B1 (fr) 2000-03-23 2002-05-17 Sanofi Synthelabo Derives de n-(heterocyclylbutyl) benzene-ou pyridine sulfonamide, leur preparation et leur application en therapeutique
US6469026B2 (en) 2000-03-24 2002-10-22 Millennium Pharmaceuticals, Inc. Isoquinolone inhibitors of factor Xa
DE60117783T2 (de) 2000-04-25 2006-11-30 Abbott Laboratories, Abbott Park Naphthamidin-urokinaseinhibitoren
CA2405745A1 (en) 2000-04-27 2001-11-08 Boehringer Ingelheim Pharma Kg New betamimetics having a long-lasting activity, processes for preparingthem and their use as medicaments
WO2001098467A2 (en) * 2000-06-23 2001-12-27 Bayer Aktiengesellschaft Regulation of human prostasin-like serine protease
AU6610001A (en) 2000-06-27 2002-01-08 S A L V A T Lab Sa Carbamates derived from arylalkylamines
GB0015876D0 (en) 2000-06-28 2000-08-23 Novartis Ag Organic compounds
GB0016441D0 (en) * 2000-07-04 2000-08-23 Pharmagene Lab Limited Therapeutic method
WO2002006455A2 (en) * 2000-07-19 2002-01-24 Bayer Aktiengesellschaft Regulation of human airway trypsin protease-like enzyme
DE10038639A1 (de) 2000-07-28 2002-02-21 Schering Ag Nichtsteroidale Entzündungshemmer
NZ523958A (en) 2000-08-05 2004-11-26 Glaxo Group Ltd 17.beta.-carbothioate 17.alpha.-arylcarbonyloxyloxy androstane derviative as anti-inflammatory agents
GB0021497D0 (en) * 2000-09-01 2000-10-18 Novartis Res Foundation Compounds and their use
GB0028383D0 (en) 2000-11-21 2001-01-03 Novartis Ag Organic compounds
KR100869722B1 (ko) 2000-12-22 2008-11-21 알미랄 에이쥐 퀴누클리딘 카르바메이트 유도체 및 ｍ3 길항제로서 그의사용
SI20743A (sl) 2000-12-22 2002-06-30 Univerza V Ljubljani, Novi trombinski inhibitorji
HUP0303524A3 (en) 2000-12-28 2008-03-28 Almirall Ag Novel quinuclidine derivatives, process for their preparation and medicinal compositions containing the same and their use
CA2436068A1 (en) 2001-02-09 2002-08-22 Merck & Co., Inc. Thrombin inhibitors
GB0103630D0 (en) 2001-02-14 2001-03-28 Glaxo Group Ltd Chemical compounds
WO2002070490A1 (en) 2001-03-08 2002-09-12 Glaxo Group Limited Agonists of beta-adrenoceptors
WO2002074732A2 (en) * 2001-03-15 2002-09-26 Altana Pharma Ag Tryptase-inhibitors
EP1370521B1 (en) 2001-03-22 2007-12-19 Glaxo Group Limited Formanilide derivatives as beta2-adrenoreceptor agonists
MY137522A (en) 2001-04-30 2009-02-27 Glaxo Group Ltd Novel anti-inflammatory androstane derivatives.
ES2307751T3 (es) 2001-06-12 2008-12-01 Glaxo Group Limited Nuevos esteres heterociclicos centi-inflamatorios 17 alfa de derivados 17 beta de carbotioato de androstano.
CA2445046C (en) 2001-06-21 2009-11-24 Diversa Corporation Nitrilases
USRE44874E1 (en) 2001-09-14 2014-04-29 Glaxo Group Limited Phenethanolamine derivatives for treatment of respiratory diseases
WO2003033495A1 (en) 2001-10-17 2003-04-24 Ucb, S.A. Quinuclidine derivatives, processes for preparing them and their uses as m2 and/or m3 muscarinic receptor inhibitors
GB0125259D0 (en) 2001-10-20 2001-12-12 Glaxo Group Ltd Novel compounds
MY130622A (en) 2001-11-05 2007-07-31 Novartis Ag Naphthyridine derivatives, their preparation and their use as phosphodiesterase isoenzyme 4 (pde4) inhibitors
WO2003042160A1 (en) 2001-11-13 2003-05-22 Theravance, Inc. Aryl aniline beta-2 adrenergic receptor agonists
TWI249515B (en) 2001-11-13 2006-02-21 Theravance Inc Aryl aniline beta2 adrenergic receptor agonists
AU2002356759A1 (en) 2001-12-01 2003-06-17 Glaxo Group Limited 17.alpha. -cyclic esters of 16-methylpregnan-3,20-dione as anti-inflammatory agents
JP4505227B2 (ja) 2001-12-20 2010-07-21 キエシ・フアルマチエウテイチ・ソチエタ・ペル・アチオニ １−アルキル−１−アゾニアビシクロ［２．２．２］オクタンカルバメート誘導体およびムスカリンレセプターアンタゴニストとしてのそれらの使用
AU2003202044A1 (en) 2002-01-15 2003-09-09 Glaxo Group Limited 17.alpha-cycloalkyl/cycloylkenyl esters of alkyl-or haloalkyl-androst-4-en-3-on-11.beta.,17.alpha.-diol 17.beta.-carboxylates as anti-inflammatory agents
WO2003062259A2 (en) 2002-01-21 2003-07-31 Glaxo Group Limited Non-aromatic 17.alpha.-esters of androstane-17.beta.-carboxylate esters as anti-inflammatory agents
GB0202216D0 (en) 2002-01-31 2002-03-20 Glaxo Group Ltd Novel compounds
JP2003246730A (ja) * 2002-02-22 2003-09-02 Torii Yakuhin Kk トリプターゼ阻害剤
JP2003252754A (ja) * 2002-02-26 2003-09-10 Teijin Ltd Ａｓｔ阻害剤
GB0204719D0 (en) 2002-02-28 2002-04-17 Glaxo Group Ltd Medicinal compounds
EP1490317A1 (en) 2002-03-26 2004-12-29 Boehringer Ingelheim Pharmaceuticals Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
EA008830B1 (ru) 2002-03-26 2007-08-31 Бёрингер Ингельхайм Фармасьютиклз, Инк. Миметики глюкокортикоидов, способы их получения, фармацевтические композиции и их применение
EP1496892B1 (en) 2002-04-11 2011-01-26 Merck Sharp & Dohme Corp. 1h-benzo(f)indazol-5-yl derivatives as selective glucocorticoid receptor modulators
ES2206021B1 (es) 2002-04-16 2005-08-01 Almirall Prodesfarma, S.A. Nuevos derivados de pirrolidinio.
JP2005523920A (ja) 2002-04-25 2005-08-11 グラクソ　グループ　リミテッド フェネタノールアミン誘導体
WO2003099764A1 (en) 2002-05-28 2003-12-04 Theravance, Inc. ALKOXY ARYL β2 ADRENERGIC RECEPTOR AGONISTS
US7186864B2 (en) 2002-05-29 2007-03-06 Boehringer Ingelheim Pharmaceuticals, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
ES2201907B1 (es) 2002-05-29 2005-06-01 Almirall Prodesfarma, S.A. Nuevos derivados de indolilpiperidina como potentes agentes antihistaminicos y antialergicos.
DE10224888A1 (de) 2002-06-05 2003-12-24 Merck Patent Gmbh Pyridazinderivate
US7074806B2 (en) 2002-06-06 2006-07-11 Boehringer Ingelheim Pharmaceuticals, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
DE10225574A1 (de) 2002-06-10 2003-12-18 Merck Patent Gmbh Aryloxime
DE10227269A1 (de) 2002-06-19 2004-01-08 Merck Patent Gmbh Thiazolderivate
AU2003243870B2 (en) 2002-06-25 2008-11-20 Merck Frosst Canada Ltd 8-(biaryl) quinoline PDE4 inhibitors
WO2004005258A1 (en) 2002-07-02 2004-01-15 Merck Frosst Canada & Co. Di-aryl-substituted-ethane pyridone pde4 inhibitors
ES2204295B1 (es) 2002-07-02 2005-08-01 Almirall Prodesfarma, S.A. Nuevos derivados de quinuclidina-amida.
JP4503436B2 (ja) 2002-07-08 2010-07-14 ファイザー・プロダクツ・インク 糖質コルチコイド受容体のモジュレーター
GB0217225D0 (en) 2002-07-25 2002-09-04 Glaxo Group Ltd Medicinal compounds
AR040962A1 (es) 2002-08-09 2005-04-27 Novartis Ag Compuestos derivados de tiazol 1,3-2-ona, composicion farmaceutica y proceso de preparacion del compuesto
AU2003255376A1 (en) 2002-08-10 2004-03-11 Altana Pharma Ag Piperidine-derivatives as pde4 inhibitors
EP1556369A1 (en) 2002-08-10 2005-07-27 ALTANA Pharma AG Pyridazinone-derivatives as pde4 inhibitors
US20060094710A1 (en) 2002-08-10 2006-05-04 Altana Pharma Ag Piperidine-pyridazones and phthalazones as pde4 inhibitors
CA2494643A1 (en) 2002-08-10 2004-03-04 Altana Pharma Ag Piperidine-n-oxide-derivatives
PL374014A1 (en) 2002-08-17 2005-09-19 Altana Pharma Ag Novel phenanthridines having pde 3/4 inhibiting properties
RS20050117A (en) 2002-08-17 2007-06-04 Altana Pharma Ag., Novel benzonaphthyridines
ATE403648T1 (de) 2002-08-21 2008-08-15 Boehringer Ingelheim Pharma Substituierte dihydrochinoline als glucocorticoid-mmimetika,verfahren zu deren herstellung, pharmazeutische zubereitungen und deren verwendung
SE0202483D0 (sv) 2002-08-21 2002-08-21 Astrazeneca Ab Chemical compounds
CN1688544A (zh) 2002-08-23 2005-10-26 兰贝克赛实验室有限公司 作为蕈毒碱受体拮抗剂的含氟代和磺酰氨基的3,6－二取代的氮杂双环(3.1.0)己烷衍生物
WO2004019944A1 (en) 2002-08-29 2004-03-11 Altana Pharma Ag 2-hydroxy-6-phenylphenanthridines as pde-4 inhibitors
US7423046B2 (en) 2002-08-29 2008-09-09 Nycomed Gmbh 3-hydroxy-6-phenylphenanthridines as pde-4 inhibitors
BR0313923A (pt) 2002-08-29 2005-07-12 Boehringer Ingelheim Pharma Derivados de 3-(sulfonamidoetil)-indol para uso como miméticos de glicocorticóide no tratamento de doenças inflamatórias, alérgicas e proliferativas
EP1545611B1 (en) * 2002-09-06 2016-11-09 Alexion Pharmaceuticals, Inc. Method of treatment of asthma using antibodies to complement component c5
GB0220730D0 (en) 2002-09-06 2002-10-16 Glaxo Group Ltd Medicinal compounds
NZ538670A (en) * 2002-09-10 2007-01-26 Bayer Healthcare Ag Pyrimidinone derivatives as therapeutic agents against acute and chronic inflammatory, ischaemic and remodelling processes
JP2006096662A (ja) 2002-09-18 2006-04-13 Sumitomo Pharmaceut Co Ltd 新規６−置換ウラシル誘導体及びアレルギー性疾患の治療剤
BR0314304A (pt) 2002-09-18 2005-07-26 Ono Pharmaceutical Co Drogas e derivados de triazapiro[5.5]undecano compreendendo o mesmo como o ingrediente ativo
JP2004107299A (ja) 2002-09-20 2004-04-08 Japan Energy Corp 新規１−置換ウラシル誘導体及びアレルギー性疾患の治療剤
JP4520309B2 (ja) 2002-09-20 2010-08-04 メルク・シャープ・エンド・ドーム・コーポレイション 選択的糖質コルチコイド受容体調節剤としてのオクタヒドロ−２−Ｈ−ナフト［１，２−ｆ］インドール−４−カルボキサミド誘導体
DE10246374A1 (de) 2002-10-04 2004-04-15 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Betamimetika mit verlängerter Wirkungsdauer, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
EP1440966A1 (en) 2003-01-10 2004-07-28 Pfizer Limited Indole derivatives useful for the treatment of diseases
KR20050047552A (ko) 2002-10-11 2005-05-20 화이자 인코포레이티드 베타-2 작용제로서의 인돌 유도체
JP2006506373A (ja) 2002-10-22 2006-02-23 グラクソ　グループ　リミテッド 医薬アリールエタノールアミン化合物
CN100532374C (zh) 2002-10-23 2009-08-26 格兰马克药品有限公司 可用于治疗炎性和变应性病症的新的三环化合物:它们的制备方法以及包含它们的药物组合物
WO2004037773A1 (en) 2002-10-28 2004-05-06 Glaxo Group Limited Phenethanolamine derivative for the treatment of respiratory diseases
GB0225030D0 (en) 2002-10-28 2002-12-04 Glaxo Group Ltd Medicinal compounds
GB0225287D0 (en) 2002-10-30 2002-12-11 Glaxo Group Ltd Novel compounds
GB0225535D0 (en) 2002-11-01 2002-12-11 Glaxo Group Ltd Medicinal compounds
GB0225540D0 (en) 2002-11-01 2002-12-11 Glaxo Group Ltd Medicinal compounds
DE10253282A1 (de) 2002-11-15 2004-05-27 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Arzneimittel zur Behandlung von chronisch obstruktiver Lungenerkrankung
DE10253426B4 (de) 2002-11-15 2005-09-22 Elbion Ag Neue Hydroxyindole, deren Verwendung als Inhibitoren der Phosphodiesterase 4 und Verfahren zu deren Herstellung
DE10253220A1 (de) 2002-11-15 2004-05-27 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Dihydroxy-Methyl-Phenyl-Derivate, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
JP2004189659A (ja) * 2002-12-10 2004-07-08 Ono Pharmaceut Co Ltd 好中球エラスターゼ阻害剤を有効成分とする吸入剤
DE10261874A1 (de) 2002-12-20 2004-07-08 Schering Ag Nichtsteroidale Entzündungshemmer
US7732432B2 (en) 2003-01-21 2010-06-08 Merck Sharp & Dohme Corp. 17-carbamoyloxy cortisol derivatives as selective glucocorticoid receptor modulators
PE20040950A1 (es) 2003-02-14 2005-01-01 Theravance Inc DERIVADOS DE BIFENILO COMO AGONISTAS DE LOS RECEPTORES ADRENERGICOS ß2 Y COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS
EP1460064A1 (en) 2003-03-14 2004-09-22 Pfizer Limited Indole-2-carboxamide derivatives useful as beta-2 agonists
DE10347994A1 (de) 2003-10-15 2005-06-16 Pari GmbH Spezialisten für effektive Inhalation Wässrige Aerosol-Zubereitung
GB0511065D0 (en) * 2005-05-31 2005-07-06 Novartis Ag Organic compounds
PL2019837T3 (pl) * 2006-05-23 2011-09-30 Irm Llc Związki i kompozycje jako inhibitory proteazy aktywującej kanały
AU2007253819B2 (en) * 2006-05-23 2011-02-17 Irm Llc Compounds and compositions as channel activating protease inhibitors

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GT200600139A (es) 2006-11-24
AU2006233691A1 (en) 2006-10-19
GB0507577D0 (en) 2005-05-18
AU2006233691B2 (en) 2011-05-26
PT1874726E (pt) 2012-08-16
MX2007012700A (es) 2008-01-11
AR053217A1 (es) 2007-04-25
KR20070118257A (ko) 2007-12-14
JP2008537750A (ja) 2008-09-25
US20120208882A1 (en) 2012-08-16
WO2006108643A2 (en) 2006-10-19
PL1874726T3 (pl) 2012-10-31
US20090203777A1 (en) 2009-08-13
EP1874726A2 (en) 2008-01-09
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EP2305639A3 (en) 2011-06-29
CA2601990A1 (en) 2006-10-19
EP1874726B1 (en) 2012-05-16
EP2253612A1 (en) 2010-11-24
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TW200720236A (en) 2007-06-01
CN101160284A (zh) 2008-04-09

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