PE20061294A1 - Formulacion de tableta estable que contiene polimorfo b de (6r)-l-eritro-tetra hidrobiopterina - Google Patents
Formulacion de tableta estable que contiene polimorfo b de (6r)-l-eritro-tetra hidrobiopterinaInfo
- Publication number
- PE20061294A1 PE20061294A1 PE2005001350A PE2005001350A PE20061294A1 PE 20061294 A1 PE20061294 A1 PE 20061294A1 PE 2005001350 A PE2005001350 A PE 2005001350A PE 2005001350 A PE2005001350 A PE 2005001350A PE 20061294 A1 PE20061294 A1 PE 20061294A1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Molecular Biology (AREA)
- Psychology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE COMPRENDE: A) UN POLIMORFO CRISTALINO DE (6R)-L-ERITRO-TETRAHIDROBIOPTERINA (POLIMORFO B) QUE PRESENTA UN PATRON DE DIFRACCION EN POLVO DE RAYOS X CON LOS SIGUIENTES PICOS EXPRESADOS EN (Å): 8.7 (vs), 5.63 (m), 4.76 (m), 4.40 (m), 4.00(s), 3.23 (s), 3.11 (vs), ENTRE OTROS, EN UNA CANTIDAD COMPRENDIDA ENTRE 30% A 40% EN PESO DE LA FORMULACION; B) UN AGLUTINANTE TAL COMO FOSFATO CALCICO DIBASICO ANHIDRO EN UNA CANTIDAD COMPRENDIDA ENTRE 1% A 5% POR PESO DE LA FORMULACION; C) UN AGENTE DE DESINTEGRACION TAL COMO CROSPOVIDONA EN UNA CANTIDAD COMPRENDIDA ENTRE 3% A 10% POR PESO DE LA FORMULACION; D) UN ANTIOXIDANTE ACIDO TAL COMO ACIDO ASCORBICO EN UNA CANTIDAD COMPRENDIDA ENTRE 1% A 3% POR PESO DE LA FORMULACION; E) UN LUBRICANTE TAL COMO FUMARATO DE ESTEARILO EN UNA CANTIDAD COMPRENDIDA ENTRE 0.1% A 2% POR PESO DE LA FORMULACION; Y F) ADEMAS COMPRENDE VITAMINA B2, B12, UN FOLATO Y ARGININA. LA COMPOSICION SE PRESENTA EN FORMA DE TABLETA Y RETIENE AL MENOS 95% DE LA CANTIDAD INICIAL DE (6R)-L-ERITRO-TETRAHIDROBIOPTERINA DESPUES DE SEIS A NUEVE MESES A TEMPERATURA AMBIENTE Y 60% DE HUMEDAD. DICHA FORMULACION ES UTIL EN EL TRATAMIENTO DE TRANSTORNOS METABOLICOS TALES COMO DIABETES, HIPERINSULINEMIA
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US62918904P | 2004-11-17 | 2004-11-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20061294A1 true PE20061294A1 (es) | 2006-12-18 |
Family
ID=35849290
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2005001350A PE20061294A1 (es) | 2004-11-17 | 2005-11-17 | Formulacion de tableta estable que contiene polimorfo b de (6r)-l-eritro-tetra hidrobiopterina |
Country Status (15)
Country | Link |
---|---|
US (2) | US8003126B2 (es) |
EP (2) | EP1845952A2 (es) |
JP (2) | JP2008520574A (es) |
KR (1) | KR20070084270A (es) |
CN (1) | CN101132776A (es) |
AR (1) | AR052238A1 (es) |
AU (1) | AU2005306686B2 (es) |
BR (1) | BRPI0517088A (es) |
CA (1) | CA2581814C (es) |
IL (1) | IL182161A (es) |
MX (1) | MX2007005039A (es) |
MY (1) | MY142120A (es) |
PE (1) | PE20061294A1 (es) |
TW (1) | TW200624120A (es) |
WO (1) | WO2006055511A2 (es) |
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DK1757293T3 (da) * | 2004-05-11 | 2012-10-22 | Daiichi Sankyo Co Ltd | Bh4-responsiv hyperphenylalaninæmi-medikamenter |
MX2007005039A (es) | 2004-11-17 | 2007-06-19 | Biomarin Pharm Inc | Formulacion de tableta estable. |
US20100009997A1 (en) * | 2007-01-12 | 2010-01-14 | Biomarin Pharmaceutical Inc. | Method of treating a metabolic or neuropsychiarty disorder with a bh4 derivative prodrug |
EP2114944A2 (en) * | 2007-01-12 | 2009-11-11 | BioMarin Pharmaceutical Inc. | Tetrahydrobiopterin prodrugs |
DK2139485T3 (da) | 2007-04-11 | 2013-01-21 | Biomarin Pharm Inc | Fremgangsmåder til admistration af tetrahydrobiopterin, associerede sammensætninger, og fremgangsmåder til måling |
ECSP077628A (es) * | 2007-05-03 | 2008-12-30 | Smithkline Beechman Corp | Nueva composición farmacéutica |
ES2524026T3 (es) * | 2008-01-03 | 2014-12-03 | Biomarin Pharmaceutical Inc. | Análogo de pterina para tratar una afección que responde a BH4 |
WO2010017570A2 (de) * | 2008-08-12 | 2010-02-18 | Orpha Swiss Gmbh | Pharmazeutische darreichungsform enthaltend tetrahydrobiopterin |
CN103458900A (zh) * | 2011-03-01 | 2013-12-18 | 鲁必康研究私人有限公司 | 四氢生物蝶呤的稳定组合物 |
WO2012127431A1 (en) * | 2011-03-24 | 2012-09-27 | Rubicon Research Private Limited | Stabilized compositions of tetrahydrobiopterin |
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CN109715650B (zh) | 2016-07-26 | 2024-03-08 | 生物马林药物股份有限公司 | 新颖腺相关病毒衣壳蛋白 |
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IL266955B2 (en) * | 2016-11-29 | 2023-09-01 | Ptc Therapeutics Mp Inc | Polymorphs of spiafatrin and its salts |
JP2020532535A (ja) * | 2017-09-01 | 2020-11-12 | ピーティーシー セラピューティクス エムピー,インコーポレイテッド | セピアプテリンを含む医薬組成物及びその使用 |
BR112020022722A8 (pt) | 2018-05-09 | 2022-01-18 | Biomarin Pharm Inc | Genoma e seu uso, vetor, partícula, molécula de ácido nucleico isolada, ácido nucleico, composição, tratamento, método |
TW202005978A (zh) | 2018-05-14 | 2020-02-01 | 美商拜奧馬林製藥公司 | 新穎肝靶向腺相關病毒載體 |
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TR201914406A2 (tr) * | 2019-09-23 | 2021-04-21 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Sapropteri̇n di̇hi̇droklorür ve en az bi̇r farmasöti̇k eksi̇pi̇yan i̇çeren kati oral farmasöti̇k formülasyonlar |
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- 2005-11-16 AU AU2005306686A patent/AU2005306686B2/en not_active Ceased
- 2005-11-16 EP EP05822282A patent/EP1845952A2/en not_active Withdrawn
- 2005-11-16 EP EP11171309A patent/EP2436379A1/en not_active Withdrawn
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- 2005-11-16 BR BRPI0517088-5A patent/BRPI0517088A/pt not_active IP Right Cessation
- 2005-11-16 US US10/563,418 patent/US8003126B2/en active Active
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- 2005-11-16 KR KR1020077011104A patent/KR20070084270A/ko not_active Application Discontinuation
- 2005-11-16 CA CA2581814A patent/CA2581814C/en active Active
- 2005-11-17 PE PE2005001350A patent/PE20061294A1/es not_active Application Discontinuation
- 2005-11-17 MY MYPI20055383A patent/MY142120A/en unknown
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US8003126B2 (en) | 2011-08-23 |
EP2436379A1 (en) | 2012-04-04 |
CA2581814A1 (en) | 2006-05-26 |
US20070270581A1 (en) | 2007-11-22 |
IL182161A0 (en) | 2007-07-24 |
KR20070084270A (ko) | 2007-08-24 |
JP2014012740A (ja) | 2014-01-23 |
BRPI0517088A (pt) | 2008-09-30 |
AU2005306686A1 (en) | 2006-05-26 |
CN101132776A (zh) | 2008-02-27 |
CA2581814C (en) | 2015-10-13 |
WO2006055511A2 (en) | 2006-05-26 |
US20080207626A1 (en) | 2008-08-28 |
AU2005306686B2 (en) | 2011-06-02 |
AR052238A1 (es) | 2007-03-07 |
TW200624120A (en) | 2006-07-16 |
EP1845952A2 (en) | 2007-10-24 |
JP2008520574A (ja) | 2008-06-19 |
MY142120A (en) | 2010-09-15 |
IL182161A (en) | 2011-08-31 |
US7566462B2 (en) | 2009-07-28 |
WO2006055511A3 (en) | 2006-10-05 |
MX2007005039A (es) | 2007-06-19 |
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