PE20010634A1 - Imidazo-3-il-aminas biciclicas, procedimiento para su preparacion y medicamentos que las contienen - Google Patents

Imidazo-3-il-aminas biciclicas, procedimiento para su preparacion y medicamentos que las contienen

Info

Publication number
PE20010634A1
PE20010634A1 PE2000001064A PE0010642000A PE20010634A1 PE 20010634 A1 PE20010634 A1 PE 20010634A1 PE 2000001064 A PE2000001064 A PE 2000001064A PE 0010642000 A PE0010642000 A PE 0010642000A PE 20010634 A1 PE20010634 A1 PE 20010634A1
Authority
PE
Peru
Prior art keywords
phenyl
imidazo
cycloalkyl
butyl
alkyl
Prior art date
Application number
PE2000001064A
Other languages
English (en)
Inventor
Matthias Gerlach
Corinna Maul
Original Assignee
Gruenenthal Chemie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE1999148438 external-priority patent/DE19948438B4/de
Priority claimed from DE19948434A external-priority patent/DE19948434A1/de
Application filed by Gruenenthal Chemie filed Critical Gruenenthal Chemie
Publication of PE20010634A1 publication Critical patent/PE20010634A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures

Abstract

SE REFIERE A IMIDAZO-3-ILAMINAS BICICLICAS SUSTITUIDAS DE FORMULA I, DONDE X E Y SON CH, N, X E Y NO SON N A LA VEZ; R1 ES BUTILO, (CH2)nCN, FENILO, CICLOALQUILO C4-C8, CH2CH2R, CH2Ra, 1,1,3,3-TETRAMETILBUTILO, ENTRE OTROS; n ES 4-6; R ES 4-MORFOLINO; Ra ES H, OH, ALQUILO C1-C8, FENILO, ENTRE OTROS; R2 ES H, CORb; Rb ES ALQUILO C1-C4, CICLOALQUILO C3-C8, CH2CH2CO(ORc); Rc ES ALQUILO C1-C4, ADAMANTILO, FENILO, 1-NAFTILO, TIAZOLILO, CH2CH2Rd, ENTRE OTROS; Rd ES FENILO, CONHRe; Re ES ALQUILO C1-C8, CICLOALQUILO C3-C8, FENILO; R3 ES METILO, ETILO, BUTILO, CICLOALQUILO C3-C8, ENTRE OTROS; CON LA CONDICION QUE R3 NO ES n-PROPILO, CICLOHEXILO, FENILO; CUANDO R1 ES t-BUTILO, n-PROPILO, n-BUTILO, CH2CH2R, ENTRE OTROS Y R2 ES H, CO-METILO Y R2 NO ES H CUANDO R1 ES BENCILO Y R3 ES METILO O R1 ES CH2COBUTILO Y R3 ES FENILO. SON COMPUESTOS PREFERIDOS (6-ISOCIANO-HEXIL)-2-PIRIDIN-2-IL-IMIDAZO[1,3-a]PIRIDIN-3-IL)AMINA, (2-FURAN-2-IL-IMIDAZO[1,2-a]PIRIDIN-3-IL)-(6-ISOCIANO-HEXIL)-AMINA, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. EL COMPUESTO I PUEDE SER UTIL PARA EL TRATAMIENTO DEL DOLOR
PE2000001064A 1999-10-08 2000-10-06 Imidazo-3-il-aminas biciclicas, procedimiento para su preparacion y medicamentos que las contienen PE20010634A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE1999148438 DE19948438B4 (de) 1999-10-08 1999-10-08 Bicyclische Imidazo-3-aminderivate
DE19948434A DE19948434A1 (de) 1999-10-08 1999-10-08 Substanzbibliothek enthaltend bicyclische Imidazo-5-amine und/oder bicyclische Imidazo-3-amine

Publications (1)

Publication Number Publication Date
PE20010634A1 true PE20010634A1 (es) 2001-07-07

Family

ID=26055218

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2000001064A PE20010634A1 (es) 1999-10-08 2000-10-06 Imidazo-3-il-aminas biciclicas, procedimiento para su preparacion y medicamentos que las contienen

Country Status (26)

Country Link
US (1) US6638933B2 (es)
EP (1) EP1218382B1 (es)
JP (1) JP2003511451A (es)
KR (1) KR100756592B1 (es)
CN (1) CN1257169C (es)
AR (1) AR025962A1 (es)
AT (1) ATE258554T1 (es)
AU (1) AU779197B2 (es)
BR (1) BR0014818A (es)
CA (1) CA2382919C (es)
CO (1) CO5251378A1 (es)
CZ (1) CZ20021210A3 (es)
DE (1) DE50005155D1 (es)
DK (1) DK1218382T3 (es)
ES (1) ES2213611T3 (es)
HK (1) HK1047747B (es)
HU (1) HUP0203052A3 (es)
NO (1) NO322754B1 (es)
NZ (2) NZ518439A (es)
PE (1) PE20010634A1 (es)
PL (1) PL355206A1 (es)
PT (1) PT1218382E (es)
RU (1) RU2264402C2 (es)
SK (1) SK286788B6 (es)
UY (1) UY26372A1 (es)
WO (1) WO2001027111A2 (es)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040077605A1 (en) * 2001-06-20 2004-04-22 Salvati Mark E. Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
DE10043845A1 (de) * 2000-09-06 2002-03-14 Gruenenthal Gmbh Verfahren zur Messung der Aktivität der NO-Synthase
EP1854798A3 (en) 2000-09-19 2007-11-28 Bristol-Myers Squibb Company Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
WO2002048146A2 (de) * 2000-12-13 2002-06-20 Basf Aktiengesellschaft Verwendung von substituierten imidazoazinen, neue imidazoazine, verfahren zu deren herstellung, sowie sie enthaltende mittel
US20040087548A1 (en) 2001-02-27 2004-05-06 Salvati Mark E. Fused cyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
DE102004021716A1 (de) * 2004-04-30 2005-12-01 Grünenthal GmbH Substituierte Imidazo[1,2-a]pyridin-Verbindungen und Arzneimittel enthaltend substituierte Imidazo[1,2-a]pyridin-Verbindungen
CA2570073A1 (en) * 2004-06-09 2005-12-22 Oncalis Ag Protein kinase inhibitors
US7923041B2 (en) * 2005-02-03 2011-04-12 Signum Biosciences, Inc. Compositions and methods for enhancing cognitive function
KR100968989B1 (ko) * 2005-03-23 2010-07-09 에프. 호프만-라 로슈 아게 ｍＧｌｕＲ2 길항제로서 아세틸렌일-피라졸로-피리미딘 유도체
JP2008540674A (ja) * 2005-05-20 2008-11-20 アレイ バイオファーマ、インコーポレイテッド Ｒａｆ阻害化合物およびその使用方法
ATE480239T1 (de) * 2005-06-09 2010-09-15 Oncalis Ag Angiogeneseinhibitoren
EP1928237A4 (en) 2005-09-02 2011-03-09 Abbott Lab NEW HETEROCYCLES BASED ON IMIDAZO
EP1845098A1 (en) * 2006-03-29 2007-10-17 Ferrer Internacional, S.A. Imidazo[1,2-b]pyridazines, their processes of preparation and their use as GABA receptor ligands
DE602007006010D1 (de) * 2006-05-31 2010-06-02 Galapagos Nv Triazolopyrazinverbindungen zur behandlung von degenerations- und entzündungskrankheiten
US8227603B2 (en) * 2006-08-01 2012-07-24 Cytokinetics, Inc. Modulating skeletal muscle
WO2008016648A2 (en) * 2006-08-01 2008-02-07 Cytokinetics, Incorporated Certain chemical entities, compositions and methods
PT2583970E (pt) * 2006-08-02 2016-02-08 Cytokinetics Inc Certas entidades químicas, composições e métodos compreendendo imidazopirimidinas
US8299248B2 (en) 2006-08-02 2012-10-30 Cytokinetics, Incorporated Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols and methods for their use
EP1974729A1 (en) * 2007-03-28 2008-10-01 Santhera Pharmaceuticals (Schweiz) AG Substituted imidazopyridine derivates as melanocortin- 4 receptor antagonists
WO2008121333A1 (en) * 2007-03-30 2008-10-09 Cytokinetics, Incorporated Certain chemical entities, compositions and methods
GB0708188D0 (en) * 2007-04-27 2007-06-06 Merck Sharp & Dohme Therapeutic compounds
NZ588376A (en) * 2008-04-15 2011-06-30 Eisai R&D Man Co Ltd 3-phenylpyrazolo[5,1-b]thiazole compound having antagonism against corticotropin-releasing factor (CRF) receptor
MX2011000355A (es) * 2008-07-10 2011-04-07 Southern Res Inst Compuestos de 5-quinolinona e imidazopirimidina y utilizacion de los mismos.
EP2334675B1 (en) * 2008-09-16 2014-03-26 Csir Imidazopyridines and imidazopyrimidines as hiv-i reverse transcriptase inhibitors
MX2011005886A (es) 2008-12-05 2011-07-28 Inviragen Inc Composiciones, métodos y usos para inducir el crecimiento viral.
AR078521A1 (es) * 2009-10-08 2011-11-16 Eisai R&D Man Co Ltd Compuesto pirazolotiazol
CN109316480A (zh) 2011-07-13 2019-02-12 赛特凯恩蒂克公司 组合als疗法
RU2015118985A (ru) * 2012-11-14 2017-01-10 Ф. Хоффманн-Ля Рош Аг Производные имидазопиридина
HUE035966T2 (en) * 2013-03-14 2018-05-28 Galapagos Nv Compounds and compositions for the treatment of inflammatory diseases
US10653681B2 (en) 2016-03-16 2020-05-19 Recurium Ip Holdings, Llc Analgesic compounds
CA3057684A1 (en) 2017-04-28 2018-11-01 Dana-Farber Cancer Institute, Inc. Inhibitors of trim33 and methods of use
EP3692052A4 (en) 2017-10-04 2021-03-17 Dana Farber Cancer Institute, Inc. INHIBITION BY SMALL MOLECULES OF THE TRANSCRIPTION FACTOR SALL4 AND ITS USES

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3269604D1 (en) 1981-06-26 1986-04-10 Schering Corp Novel imidazo(1,2-a)pyridines and pyrazines, processes for their preparation and pharmaceutical compositions containing them
NZ221996A (en) * 1986-10-07 1989-08-29 Yamanouchi Pharma Co Ltd Imidazo-pyridine derivatives and pharmaceutical compositions
TW274551B (es) * 1991-04-16 1996-04-21 Takeda Pharm Industry Co Ltd
DE4327027A1 (de) * 1993-02-15 1994-08-18 Bayer Ag Imidazoazine
CN1064360C (zh) * 1995-04-21 2001-04-11 新日本药品株式会社 稠合咪唑并[1,2－a]吡啶类
WO2002002557A2 (en) * 2000-06-30 2002-01-10 Neurogen Corporation 2-phenylimidazo[1,2-a]pyridine derivatives: a new class of gaba brain receptor ligands

Also Published As

Publication number Publication date
AU7777100A (en) 2001-04-23
NO20021565L (no) 2002-05-27
EP1218382B1 (de) 2004-01-28
DE50005155D1 (de) 2004-03-04
NZ518390A (en) 2003-10-31
NZ518439A (en) 2003-10-31
AU779197B2 (en) 2005-01-13
CN1257169C (zh) 2006-05-24
CZ20021210A3 (cs) 2002-08-14
NO20021565D0 (no) 2002-04-03
US20030018032A1 (en) 2003-01-23
BR0014818A (pt) 2002-06-18
UY26372A1 (es) 2000-12-29
SK4362002A3 (en) 2002-08-06
ES2213611T3 (es) 2004-09-01
SK286788B6 (sk) 2009-05-07
KR100756592B1 (ko) 2007-09-10
JP2003511451A (ja) 2003-03-25
RU2264402C2 (ru) 2005-11-20
NO322754B1 (no) 2006-12-04
PT1218382E (pt) 2004-06-30
KR20020038805A (ko) 2002-05-23
CN1391573A (zh) 2003-01-15
CO5251378A1 (es) 2003-02-28
US6638933B2 (en) 2003-10-28
DK1218382T3 (da) 2004-03-22
HUP0203052A2 (hu) 2003-01-28
HK1047747B (zh) 2004-12-03
EP1218382A2 (de) 2002-07-03
HK1047747A1 (en) 2003-03-07
ATE258554T1 (de) 2004-02-15
CA2382919A1 (en) 2001-04-19
WO2001027111A3 (de) 2001-06-14
CA2382919C (en) 2008-12-09
PL355206A1 (en) 2004-04-05
HUP0203052A3 (en) 2004-06-28
AR025962A1 (es) 2002-12-26
WO2001027111A2 (de) 2001-04-19

Similar Documents

Publication Publication Date Title
PE20010634A1 (es) Imidazo-3-il-aminas biciclicas, procedimiento para su preparacion y medicamentos que las contienen
PE20070218A1 (es) COMPUESTOS DE CICLOALQUILO AMINO-HIDANTOINA Y USO DE ESTOS PARA LA MODULACION DE ß-SECRETASA
ATE58059T1 (de) Arylcyclobutylalkylamin-derivat zur behandlung von morbus parkinson.
AR003976A1 (es) Un compuesto derivado de pirazol, un procedimiento para producirlo, uso del mismo, una formulacion parasiticida veterinaria y una formulacion farmaceutica que comprenden dicho compuesto derivado y un procedimiento para tratar una infestacion por parasitos en un lugar
PE20010706A1 (es) Biblioteca de sustancias que contiene imidazo-5-il-aminas biciclicas y/o imidazo-3-il-aminas biciclicas, procedimiento para la preparacion de esta biblioteca de sustancias, y uso de sustancias de esta biblioteca para la preparacion de medicamentos pa
PE20010631A1 (es) Imidazo-3-il-aminas biciclicas, procedimiento para su preparacion y medicamentos que las contienen
AR050261A2 (es) Aminoacidos con afinidad por la proteina alfa-2-delta y composiciones farmaceuticas que los contienen y su uso para preparar un medicamento
DE60130023D1 (de) Behandlung der nebenwirkungen von statinen
EA200501820A1 (ru) Терапевтические средства для лечения боли
PE20061490A1 (es) Derivados de ciclohexanosulfonilo como inhibidores del transportador de glicina glyt1
PE20010638A1 (es) Imidazo-5-il-aminas biciclicas, medicamentos que las contienen, su uso para la preparacion de medicamentos y procedimiento para su preparacion
PE20011089A1 (es) Tioamidas de oxazolidinona con sustituyentes de piperazin-amida
ES2183441T3 (es) Mezclas fungicidas a base de compuestos de amida.
RU97117350A (ru) Ингибитор гипертрофии интимы, применение оксиндолового производного для получения ингибитора гипертрофии интимы, композиция для ингибирования гипертрофии интимы, способ предупреждения и лечения гипертрофии интимы
AR052885A1 (es) Metodos para el control del intervalo qt
YU67703A (sh) Karbamatna jedinjenja za upotrebu u sprečavanju ili lečenju poremećaja kretanja
PE20020906A1 (es) Inhibidores de peptido-deformilasa
AR002761A1 (es) Un compuesto derivado del triazol, su uso, una composicion farmaceutica que lo contiene, un metodo de tratamiento o prevencion de una infeccion fungica enun paciente humano mediante dicho compuesto o composicion, y procedimiento y compuestos intermedios para prepararlo.
PE20050587A1 (es) Derivados de diazindol-dicarbonilo-piperazinilo como agentes antivirales
RS67603A (en) Carbamate compounds for use in the treatment of pain
DE60210976D1 (de) Carbamatverbindungen zur verwendung bei der prävention oder behandlung der bipolaren erkrankung
PE20040669A1 (es) Derivados de fenilalanina enamida
NO20014855L (no) N-(2-fenyl-4-aminobutyl)-1-naftamider som neurokinin-1- reseptorantagonister
AR044175A1 (es) Compuestos de cefemo
AR046022A1 (es) Aminoacidos con afinidad por la proteina alfa 2 gamma. composiciones farmaceuticas.

Legal Events

Date Code Title Description
FC Refusal